12 research outputs found
On the Use of Perceptual Properties for Melody Estimation
- Publication venue
- HAL CCSD
- Publication date
- 01/01/2011
- Field of study
cote interne IRCAM: Liao11aInternational audienceThis paper is about the use of perceptual principles for melody estimation. The melody stream is understood as generated by the most dominant source. Since the source with the strongest energy may not be perceptually the most dominant one, it is proposed to study the perceptual properties for melody estimation: loudness, masking effect and timbre similarity. The related criteria are integrated into a melody estimation system and their respective contributions are evaluated. The effectiveness of these perceptual criteria is confirmed by the evaluation results using more than one hundred excerpts of music recordings
Local Periodicity-Based Beat Tracking for Expressive Classical Piano Music
- Publication venue
- Publication date
- 20/08/2023
- Field of study
To model the periodicity of beats, state-of-the-art beat tracking systems use
"post-processing trackers" (PPTs) that rely on several empirically determined
global assumptions for tempo transition, which work well for music with a
steady tempo. For expressive classical music, however, these assumptions can be
too rigid. With two large datasets of Western classical piano music, namely the
Aligned Scores and Performances (ASAP) dataset and a dataset of Chopin's
Mazurkas (Maz-5), we report on experiments showing the failure of existing PPTs
to cope with local tempo changes, thus calling for new methods. In this paper,
we propose a new local periodicity-based PPT, called predominant local
pulse-based dynamic programming (PLPDP) tracking, that allows for more flexible
tempo transitions. Specifically, the new PPT incorporates a method called
"predominant local pulses" (PLP) in combination with a dynamic programming (DP)
component to jointly consider the locally detected periodicity and beat
activation strength at each time instant. Accordingly, PLPDP accounts for the
local periodicity, rather than relying on a global tempo assumption. Compared
to existing PPTs, PLPDP particularly enhances the recall values at the cost of
a lower precision, resulting in an overall improvement of F1-score for beat
tracking in ASAP (from 0.473 to 0.493) and Maz-5 (from 0.595 to 0.838).Comment: Accepted to IEEE/ACM Transactions on Audio, Speech, and Language
Processing (July 2023
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
- Borislav C Rusev
- Bradly G Wouters
- Brandi N Davis-Dusenbery
- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
- Carl Morrison
- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos López-Otín
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
- Charles David Imbusch
- Charles M Perou
- Charles Saller
- Charles Short
- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
- Chen Ye
- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
- Chip Stewart
- Choon Kiat Ong
- Chris Lawerenz
- Chris Mitchell
- Chris Sander
- Christian von Mering
- Christiane Buchholz
- Christina K Yung
- Christina K Yung
- Christina Yau
- Christine A Iacobuzio-Donahue
- Christine Chomienne
- Christine Desmedt
- Christine P'ng
- Christof von Kalle
- Christoph Borst
- Christoph Plass
- Christopher A Miller
- Christopher Benz
- Christopher J Scarlett
- Christopher J Yoon
- Christopher K Wong
- Christopher M Lalansingh
- Christopher M Lalansingh
- Christopher Ogden
- Christopher S Foster
- Christopher Umbricht
- Christopher W Toon
- Christos Sotiriou
- Cindy Bell
- Cinzia Cantù
- Ciyue Shen
- Claes Wadelius
- Clare Verrill
- Clarissa Gerhauser
- Claudia Calabrese
- Claudio Bassi
- Claudio Luchini
- Claudiu Farcas
- Clemency Jolly
- Colin A Purdie
- Colin A Semple
- Colin C Collins
- Colin S Cooper
- Conrad R Leonard
- Constance H Li
- Corbin D Jones
- Craig Shriver
- Cristina López
- Cyriac Kandoth
- Cyril Fisher
- D Neil Hayes
- Dai-Ying Wu
- Daiming Fan
- Daisuke Komura
- Dale W Garsed
- Daniel A Leongamornlert
- Daniel Baumhoer
- Daniel Hübschmann
- Daniel J Turner
- Daniel J Weisenberger
- Daniel M Berney
- Daniel Rosebrock
- Daniel S Brewer
- Daniela S Gerhard
- Danielle Pasternack
- Darell Bigner
- Dariush Etemadmoghadam
- Darlene Lee
- Darrin F Taylor
- Dave Larson
- David A Wheeler
- David A Wheeler
- David C Wedge
- David Craft
- David D L Bowtell
- David E Neal
- David Haan
- David Haussler
- David Haussler
- David Hedley
- David Huntsman
- David I Heiman
- David J Adams
- David J Van Den Berg
- David K Chang
- David K Miller
- David Khoo
- David Mutch
- David N Louis
- David Nicol
- David Ocana
- David R Jones
- David R Jones
- David Scott
- David T Bowen
- David T W Jones
- David Tamborero
- David Torrents
- David Torrents
- David Townend
- David Vicente
- Davide Antonello
- Declan Cahill
- Denis Larsimont
- Denis Yuen
- Denise Brooks
- Deniz Demircioğlu
- Dennis C Sgroi
- Dennis Karsch
- Dennis T Maglinte
- Dennis Wigle
- Derek W Wright
- Dianne E Chadwick
- Dido Lenze
- Dieter Kube
- Dieter Weichenhan
- Dilip D Giri
- Dimitri Livitz
- Dimitri Livitz
- Dimple Chakravarty
- Ding
- Dirk Schadendorf
- Dmitry A Gordenin
- Dominik Glodzik
- Don Chalmers
- Dong Guanlan
- Dongbing Liu
- Donghoon Lee
- Donghui Tan
- Donna M Muzny
- Dorthe Grabau
- Douglas A Levine
- Douglas F Easton
- Douglas Voet
- Duncan Beardsmore
- Dursi Lewis Jonathan
- Edward W Rowe
- Eigo Shimizu
- Ekta Khurana
- Elaine R Mardis
- Electron Kebebew
- Elena Piñeiro-Yáñez
- Elena Provenzano
- Elias Campo
- Elisabet Barrera
- Elisabetta Sereni
- Elizabeth A Musgrove
- Elizabeth L Appelbaum
- Elizabeth L Christie
- Elli Papaemmanuil
- Ellrott Kyle
- Emilie Lalonde
- Eoghan Harrington
- Eric Chuah
- Eric Green
- Eric Lander
- Eric Minwei Liu
- Eric Z Ma
- Eric Z Ma
- Erik Garrison
- Erik Larsson
- Erik Mayer
- Erik N Bergstrom
- Erin Curley
- Ermin Hodzic
- Erwin G Van Meir
- Esa Pitkänen
- Esther Rheinbay
- Esther Rheinbay
- Eun Pyo Hong
- Eunjung Alice Lee
- Eva G Alvarez
- Eva Hellstrom-Lindberg
- Ewan Birney
- F Germán Rodríguez-González
- Fabien C Lamaze
- Fabien Calvo
- Fabio C P Navarro
- Faiyaz Notta
- Fan Yang
- Fan Zhang
- Faraz Hach
- Faraz Hach
- Faridah Mbabaali
- Fatima Al-Shahrour
- Federico Abascal
- Fei-Fei Liu
- Felicity Newell
- Fenglin Liu
- Fernanda Amary
- Ferran Muiños
- Florian Markowetz
- Fouad Yousif
- Francesc Muyas
- Francesco Favero
- Francisco M De La Vega
- Francisco Sanchez-Vega
- Fraser R Duthie
- Fred Sweep
- Freddie C Hamdy
- Fruzsina Molnár-Gábor
- Fumie Hosoda
- G Petur Nielsen
- G Steven Bova
- Gad Getz
- Gad Getz
- Gad Getz
- Gaetan MacGrogan
- Gaetano Finocchiaro
- Gary D Bader
- Gavin Ha
- Gavin W Wilson
- Genta Nagae
- Geoff Macintyre
- George B Hanna
- George L Mihaiescu
- Georgia Escaramis
- Georgina V Long
- Gerd Nettekoven
- German M Demidov
- German Ott
- Gerrit K Hooijer
- Gerstein Mark B
- Gert G Van den Eynden
- Getz Gad
- Ghislaine Scelo
- Giada Bonizzato
- Giampaolo Tortora
- Gilles Romieu
- Gilles Thomas
- Giovanni Marchegiani
- Gisela Mir Arnau
- Giuseppe Malleo
- Gloria M Petersen
- Gordon B Mills
- Gordon B Mills
- Gordon Saksena
- Gordon Saksena
- Gordon Saksena
- Grace Tiao
- Grace Tiao
- Graham J Mann
- Grant Sanders
- Gu Kong
- Guanming Wu
- Guido Reifenberger
- Guido Sauter
- Guillaume Bourque
- Gulietta M Pupo
- Gun Ho Jang
- Gunes Gundem
- Gunnar Rätsch
- Gurnit Atwal
- Hailei Zhang
- Haiyan Irene Li
- Han Liang
- Hana Susak
- Hans Binder
- Hans Lehrach
- Hans-Jörg Warnatz
- Hardeep K Nahal-Bose
- Hark Kyun Kim
- HarshaVardhan Doddapaneni
- Hartmut Juhl
- Harvey Pass
- Hayley C Whitaker
- Hayley J Luxton
- Hazel Burke
- Heather K Schmidt
- Heather Thorne
- Hee Jin Lee
- Heidi J Sofia
- Heidi Sofia
- Helen Davies
- Helena Kilpinen
- Helene Kretzmer
- Heng Xiong
- Henk G Stunnenberg
- Henrik Hornshøj
- Henry Lee-Six
- Hideki Ohdan
- Hidenori Ojima
- Hidewaki Nakagawa
- Hikmat Al-Ahmadie
- Hilda A Pickett
- Hirofumi Rokutan
- Hirokazu Taniguchi
- Hiroki Yamaue
- Hiroko Tanaka
- Hiromi Nakamura
- Hiroshi Aikata
- Hiroto Katoh
- Hiroyuki Aburatani
- Hitoshi Katai
- Hitoshi Nakagama
- Hojabr Kakavand
- Holger Sültmann
- Holmfridur Hilmarsdottir
- Hong Su
- Hong Xue
- Hong Xue
- Hongtu Zhu
- Hongwei Zhang
- Hongxin Zhang
- Hsiao-Wei Chen
- Huanming Yang
- Hugh Barr
- Hui Shen
- Husen M Umer
- Huy Q Dinh
- Hyung-Lae Kim
- Hyung-Lae Kim
- Hyung-Yong Kim
- Hyunghwan Kim
- Ian J Davis
- Ian Welch
- Ignacio Vázquez-García
- Ignaty Leshchiner
- Ignaty Leshchiner
- Ignaty Leshchiner
- Iker Reyes-Salazar
- Ilinca Lungu
- Ilse Rooman
- Ilya Shmulevich
- Iman Sarrafi
- Iman Sarrafi
- Ina Felau
- Ioana Cutcutache
- Irene Papatheodorou
- Irinel Popescu
- Iris Pauporté
- Iris Selander
- Isabelle Treilleux
- Isidro Cortés-Ciriano
- Ivan Borozan
- Ivana Cataldo
- Ivica Letunic
- Ivica Letunic
- Ivo Buchhalter
- Ivo Buchhalter
- Ivo G Gut
- Ivo G Gut
- Ivon Harliwong
- Izar Villasante
- Iñigo Martincorena
- J Lynn Fink
- J Robert O'Neill
- J Todd Auman
- Jaclyn Smith
- Jacqueline Boultwood
- Jacqueline E Schein
- Jaegil Kim
- Jake June-Koo Lee
- Jakob Skou Pedersen
- Jakob Skou Pedersen
- James E Haber
- James G Kench
- James Gossage
- James S Wilmott
- Jan Komorowski
- Jan O Korbel
- Janae V Simons
- Jane E Brock
- Janet S Graham
- Janet S Rader
- Jared T Simpson
- Jared T Simpson
- Jason Huse
- Jaswinder S Samra
- Javier Bartolome
- Javier Bartolomé Rodriguez
- Javier Temes
- Jean C Zenklusen
- Jean Y Yang
- Jean-Rémi Trotta
- Jeffrey A Wintersinger
- Jeffrey Boyd
- Jeffrey E Gershenwald
- Jeffrey Marks
- Jeffrey Roach
- Jenna Eagles
- Jennifer L Jennings
- Jeong-Yeon Lee
- Jeremiah A Wala
- Jeremiah A Wala
- Jeremy Chien
- Jeremy Johns
- Jerome Myers
- Jesper Lagergren
- Jessica I Hoell
- Jessica K Miller
- Ji Wan Park
- Jia Liu
- Jian Wang
- Jianhong Hu
- Jianjiong Gao
- Jianmin Wu
- Jiashan Zhang
- Jiayin Wang
- Jiayin Wang
- Jieming Chen
- Jihoon Kim
- Jill Barnholtz-Sloan
- Jillian A Hung
- Jing Zhang
- Jingchun Zhu
- Joachim Weischenfeldt
- Joachim Weischenfeldt
- Joan Frigola
- Joana Carlevaro-Fita
- Jocelyne Jacquemier
- Joel S Parker
- Johan Staaf
- Johann S De Bono
- Johanna Bertl
- Johannes Werner
- Johannes Werner
- John A Demchok
- John A Foekens
- John Bartlett
- John Busanovich
- John D McPherson
- John F Thompson
- John Letaw
- John N Weinstein
- John N Weinstein
- John R McPherson
- John V Pearson
- John W M Martens
- Jon G Jonasson
- Jon W Teague
- Jon W Teague
- Jonas Demeulemeester
- Jonathan Barenboim
- Jonathan Cebon
- Jonathan D Kay
- Jonathan Göke
- Jonathan Hinton
- Jonathan Hinton
- Jonathan Nicholson
- Jonathan R Stretch
- Jonathan Spring
- Jonathan Warrell
- Jong K Kim
- Jongsun Jung
- Jongsun Jung
- Jongwhi H Hong
- Joong-Won Park
- Jordi Deu-Pons
- Jorge Reis-Filho
- Jorge Zamora
- Jorunn E Eyfjord
- Jos Jonkers
- Jose I Martin-Subero
- Jose M C Tubio
- Jose M G Izarzugaza
- Josep L L Gelpi
- Josep L L Gelpi
- Joshua Armenia
- Joshua M Stuart
- Joshua M Stuart
- Joshy George
- José María Heredia-Genestar
- Joy C Jayaseelan
- Juergen Eils
- Juhee Lee
- Jules N A Kerssemakers
- Julia Markowski
- Julia Richter
- Julian M Hess
- Julian M Hess
- Julian M Hess
- Juliann Shih
- Julie Livingstone
- Julie M Wilson
- Jun Li
- Jun Yu
- Jung Kyoon Choi
- Junjun Zhang
- Junjun Zhang
- Juok Cho
- Juris Viksna
- Justin P Whalley
- Jyoti Nangalia
- Jörg Tost
- Jüri Reimand
- K Vijay Raghavan
- Kadir C Akdemir
- Kai Ye
- Kai Ye
- Kai Ye
- Kaixian Yu
- Kami Chiotti
- Kamna Ramakrishnan
- Kaoru Nakano
- Karen McCune
- Karen Mungall
- Karen Smith-McCune
- Karin A Oien
- Karin S Kassahn
- Karine Jegalian
- Karolina Czajka
- Karsten Rippe
- Katalin Karaszi
- Katarzyna O Sikora
- Katayoon Kasaian
- Katayoon Kasaian
- Katherine A Hoadley
- Kathleen H Burns
- Kathleen Marchal
- Kathryn Alsop
- Katia Nones
- Kazuaki Chayama
- Kazuhiro Maejima
- Kazuhiro Ohi
- Ke Yuan
- Keiran M Raine
- Keiran M Raine
- Keith A Boroevich
- Kelso Sean
- Ken Chen
- Ken Chen
- Ken Dutton-Regester
- Kenji Tatsuno
- Kenneth Aldape
- Keren Isaev
- Kerstin Haase
- Keun Soo Ahn
- Keunchil Park
- Kevin J Dawson
- Kevin Thai
- Kiejung Park
- Kin Chan
- Kiran Kumar
- Kirsten Kübler
- Kiyo Shimizu
- Kjong-Van Lehmann
- Klev Diamanti
- Koji Arihiro
- Koo Jeong Kang
- Kortine Kleinheinz
- Kortine Kleinheinz
- Kristian Cibulskis
- Kuan-Lin Huang
- Kui Wu
- Kunihito Gotoh
- Kwun M Fong
- Kyle Covington
- Kyle Covington
- Kyle Ellrott
- Kyle Ellrott
- Kyle Ellrott
- L Van't Veer
- Lara Jerman
- Lara Urban
- Lars Feuerbach
- Larsson Omberg
- Laura Planko
- Laurence B Lovat
- Laurent Arnould
- Lauri A Aaltonen
- Lawrence E Heisler
- Layla Oesper
- Lee E Timms
- Lei Song
- Leigh B Thorne
- Leng Han
- Leonidas Salichos
- Leslie Cope
- Leszek J Klimczak
- Levi Garraway
- Lewis Jonathan Dursi
- Lewis Jonathan Dursi
- Lewis R Roberts
- Li Ding
- Li Ding
- Li Ding
- Li Shantao
- Liang Wen-Wei
- Liangtao Zheng
- Lieven P C Verbeke
- Lihua Zou
- Liis Uusküla-Reimand
- Liliana Greger
- Liming Yang
- Lin Li
- Lina Sieverling
- Lina Wadi
- Lincoln D Stein
- Linda Mileshkin
- Linghua Wang
- LiRehan Akbani
- Lisa Lype
- Lisa Mirabello
- Lisle E Mose
- Liu Xi
- Liu Xi
- Lixing Yang
- Lora Lewis
- Lorenz H P Trümper
- Loretta M S Lau
- Lori Boice
- Loris Mularoni
- Lorraine A Chantrill
- Louis Letourneau
- Luc Dirix
- Luca Landoni
- Luca Malcovati
- Lucas Lochovsky
- Lucila Ohno-Machado
- Lucinda A Fulton
- Lucy Matthews
- Lucy Stebbings
- Lucy Stebbings
- Lucy Yates
- Ludmil B Alexandrov
- Ludmila Danilova
- Luisa Mantovani-Löffler
- Luke Marsden
- Maciej Wiznerowicz
- Malcolm Brock
- Malcolm J Moore
- Malene Juul
- Malik Alawi
- Mamoru Kato
- Manasa Ramakrishna
- Manaswi Gupta
- Manolis Kellis
- Manuel Prinz
- Mara Rosenberg
- Marat D Kazanov
- Marc D Perry
- Marc D Perry
- Marc J van de Vijver
- Marc Zapatka
- Marcel Kool
- Marcel Smid
- Marcin Imielinski
- Marco A Marra
- Marco Miotto
- Marcus Bosenberg
- Marek Cmero
- Maria Elisabeth Goebler
- Maria Keays
- Maria O'Donovan
- Maria Scardoni
- Maria Vittoria Davi
- Marie-Laure Yaspo
- Marina Pajic
- Mario Berrios
- Mario Cazzola
- Marius Rohde
- Mark A Rubin
- Mark B Gerstein
- Mark B Gerstein
- Mark H Wright
- Mark Lathrop
- Mark P Hamilton
- Mark Phillips
- Mark Pinese
- Mark Shackleton
- Markus B Schilhabel
- Markus Kreuz
- Markus Loeffler
- Markus Ringnér
- Marta Aymerich
- Marta Gut
- Marta Paczkowska
- Marta Tojo
- Martin Hansmann
- Martin L Ferguson
- Martin Peifer
- Mary J Goldman
- Masakazu Yamamoto
- Masaki Ueno
- Masashi Fujita
- Masashi Fukayama
- Matteo Fassan
- Matthew A Field
- Matthew A Reyna
- Matthew D Wilkerson
- Matthew Eldridge
- Matthew G Cordes
- Matthew G Soloway
- Matthew H Bailey
- Matthew H Bailey
- Matthew H Bailey
- Matthew J Anderson
- Matthew Meyerson
- Matthew R Huska
- Matthew Ringel
- Matthew W Fittall
- Matthias Bieg
- Matthias Bieg
- Matthias Schlesner
- Matthias Schlesner
- Mattia Bosio
- Maxime Tarabichi
- Maximillian G Marin
- Mayuko Furuta
- Mei Huang
- Melpomeni Kasapi
- Meyerson William U
- Mi Ni Huang
- Mia Nastic
- Michael A Hollingsworth
- Michael Birrer
- Michael C Heinold
- Michael C Heinold
- Michael C Quinn
- Michael C Wendl
- Michael C Wendl
- Michael D McLellan
- Michael D McLellan
- Michael D McLellan
- Michael Dunn
- Michael Fraser
- Michael H A Roehrl
- Michael Hummel
- Michael Ittmann
- Michael Kneba
- Michael Koscher
- Michael Mayo
- Michael R Stratton
- Michael S Lawrence
- Michael S Noble
- Michele Milella
- Michele Simbolo
- Michelle Chan-Seng-Yue
- Michelle Sam
- Michelle T Dow
- Miguel Betancourt
- Miguel Vazquez
- Mihoko Saito-Adachi
- Milana Frenkel-Morgenstern
- Milena Kovacevic
- Ming Ta Michael Lee
- Ming Tsao
- Miranda D Stobbe
- Miranda D Stobbe
- Miriam R Aure
- Miruna Balasundaram
- Mitsuhiro Komura
- Mohamed Helmy
- Mohammed Ghori
- Moiz S Bootwalla
- Monika Szczepanowski
- Monique Albert
- Montserrat Puiggròs
- Montserrat Puiggròs
- Morgan L Taschuk
- Moritz Gerstung
- Morten Muhlig Nielsen
- Morten Muhlig Nielsen
- Murat Iskar
- Myron Peto
- Myron Peto
- Nadia Traficante
- Nagarajan Paramasivam
- Nagarajan Paramasivam
- Naoki Miyoshi
- Naomi Livni
- Naoto T Ueno
- Narong Khuntikeo
- Nasa Sinnott-Armstrong
- Nasra H Giama
- Natalie Jäger
- Natalie Jäger
- Natalie R Davidson
- Natalie S Fox
- Natalie Saini
- Nathan A Pennell
- Natsuko Hama
- Naveen Vasudev
- Nebojsa Tijanic
- Neesha C Dhani
- Neil D Merrett
- Neil E Fleshner
- Nening M Dennis
- Niall J Byrne
- Nic Jones
- Nicholas D Socci
- Nicholas J Haradhvala
- Nicholas K Hayward
- Nicholas Petrelli
- Nicholas van As
- Nick M Waddell
- Nicola D Roberts
- Nicola Grehan
- Nicola Sperandio
- Nicola Waddell
- Nicole Cloonan
- Nidhan K Biswas
- Niedzica Camacho
- Nigel B Jamieson
- Nikita Desai
- Nikolajs Zeps
- Nikolaus Schultz
- Nikos Sidiropoulos
- Nilanjan Chatterjee
- Nilgun Donmez
- Nils Gehlenborg
- Nimish C Shah
- Nina Habermann
- Nina Thiessen
- Nischalan Pillay
- Nishant Agrawal
- Nobuyoshi Hiraoka
- Nodirjon Fayzullaev
- Noreen Dhalla
- Nuno A Fonseca
- Ofer Shapira
- Ola Myklebost
- Ole Ammerpohl
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- Xiuqing Zheng
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- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
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- Yann Joly
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- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Nature Communications
- Publication date
- 01/01/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- A Gordon Robertson
- Abdullah Kahraman
- Abel Gonzalez-Perez
- Adam A Margolin
- Adam Abeshouse
- Adam Grundhoff
- Adam J Struck
- Adam J Struck
- Adam J Wright
- Adam Lambert
- Adam P Butler
- Adam P Butler
- Adel El-Naggar
- Adnan M Nagrial
- Adrian Ally
- Adrian Baez-Ortega
- Adrian Thorogood
- Adriana Salcedo
- Adrienne M Flanagan
- Ake Borg
- Akihiro Fujimoto
- Akihiro Suzuki
- Akinyemi I Ojesina
- Alain Viari
- Alan J Robertson
- Alan P Hoyle
- Alan Thompson
- Alasdair Stenhouse
- Alastair M Thompson
- Aldo Scarpa
- Alessandro Pastore
- Alex Buchanan
- Alex Buchanan
- Alexander Claviez
- Alexander J Lazar
- Alexander Martinez-Fundichely
- Alfonso Muñoz
- Alfonso Valencia
- Aliaksei Z Holik
- Alice Meng
- Alicia L Bruzos
- Allison Creason
- Allison P Heath
- Alvin Wei Tian Ng
- Alvis Brazma
- Amaro Taylor-Weiner
- Amber L Johns
- Amie Radenbaugh
- Amit G Deshwar
- Ana Dueso-Barroso
- Ana Mijalkovic Mijalkovic-Lazic
- Ana Milovanovic
- Ana Milovanovic
- Andre Kahles
- Andrea Haake
- Andrea Holbrook
- Andrea L Richardson
- Andrea Mafficini
- Andrea Ruzzenente
- Andreas Behren
- Andreas Rosenwald
- Andreia V Pinho
- Andrew Berchuck
- Andrew D Cherniack
- Andrew J Dunford
- Andrew J Mungall
- Andrew J Spillane
- Andrew Menzies
- Andrew Menzies
- Andrew P Barbour
- Andrew Tutt
- Andrew V Biankin
- Andrey Korshunov
- Andrés Lanzós
- Andy Cafferkey
- Andy G Lynch
- Angela Chou
- Angela N Brooks
- Angela Tam
- Angelica Ochoa
- Angelika N Christ
- Angelo P Dei Tos
- Anieta M Sieuwerts
- Anil K Sood
- Anita Langerød
- Anja Füllgrabe
- Anke K Bergmann
- Ann-Marie Patch
- Anna deFazio
- Anna Ehinger
- Anna Fitzgerald
- Anne Hamilton
- Anne Vincent-Salomon
- Anne Y Warren
- Anne-Lise Børresen-Dale
- Annegien Broeks
- Anthony DiBiase
- Anthony J Gill
- Anthony Ng
- Anthony R Green
- Antonia L Pritchard
- Antonio Pea
- Antonios Koures
- Aparna Prasad
- Apurva M Hegde
- Aquila Fatima
- Arcadi Navarro
- Arie B Brinkman
- Arif O Harmanci
- Arindam Maitra
- Armando Lopez-Guillermo
- Arndt Borkhardt
- Arnoud Boot
- Asger Hobolth
- Ashley Williams
- Ashton A Connor
- Atul J Butte
- Aurélien Chateigner
- Austin J Hepperla
- Axel Aretz
- Aya Sasaki-Oku
- Ayellet V Segre
- B F Francis Ouellette
- Bailey Matthew H
- Barbara Hutter
- Barbara Hutter
- Barbara Kremeyer
- Bartha M Knoppers
- Beifang Niu
- Beifang Niu
- Beifang Niu
- Benedikt Brors
- Benita Kiat Tee Tan
- Benjamin J Raphael
- Benjamin P Berman
- Benjamin Raeder
- Bernardo Rodriguez-Martin
- Bernhard Radlwimmer
- Bernice H Wong
- Beth Karlan
- Bin Tean Teh
- Bin Zhu
- Birgit Burkhardt
- Bishoy M Faltas
- Bodil Bjerkehagen
- Bogdan Czerniak
- Boris Winterhoff
- Borislav C Rusev
- Bradly G Wouters
- Brandi N Davis-Dusenbery
- Brian Craft
- Brian D O'Connor
- Brian Patrick O'Neill
- Brice Aminou
- Calvin Wing Yiu Chan
- Cameron M Soulette
- Carl Herrmann
- Carl Morrison
- Carlo Gambacorti-Passerini
- Carlos Caldas
- Carlos D Bustamante
- Carlos López-Otín
- Carlota Rubio-Perez
- Carmen Gomez
- Carolien H M van Deurzen
- Carolyn M Hutter
- Carolyn M Hutter
- Carrie Cibulskis
- Caterina Vicentini
- Catherine A Shang
- Catherine D Moser
- Catherine J Kennedy
- Catrina C Fronick
- Chad J Creighton
- Chandra Sekhar Pedamallu
- Chang Li
- Charles David Imbusch
- Charles M Perou
- Charles Saller
- Charles Short
- Charlie E Massie
- Chawalit Pairojkul
- Chen Hong
- Chen Ye
- Cheng-Zhong Zhang
- Chin-Lee Wu
- Chip Stewart
- Chip Stewart
- Chip Stewart
- Choon Kiat Ong
- Chris Lawerenz
- Chris Mitchell
- Chris Sander
- Christian von Mering
- Christiane Buchholz
- Christina K Yung
- Christina K Yung
- Christina Yau
- Christine A Iacobuzio-Donahue
- Christine Chomienne
- Christine Desmedt
- Christine P'ng
- Christof von Kalle
- Christoph Borst
- Christoph Plass
- Christopher A Miller
- Christopher Benz
- Christopher J Scarlett
- Christopher J Yoon
- Christopher K Wong
- Christopher M Lalansingh
- Christopher M Lalansingh
- Christopher Ogden
- Christopher S Foster
- Christopher Umbricht
- Christopher W Toon
- Christos Sotiriou
- Cindy Bell
- Cinzia Cantù
- Ciyue Shen
- Claes Wadelius
- Clare Verrill
- Clarissa Gerhauser
- Claudia Calabrese
- Claudio Bassi
- Claudio Luchini
- Claudiu Farcas
- Clemency Jolly
- Colin A Purdie
- Colin A Semple
- Colin C Collins
- Colin S Cooper
- Conrad R Leonard
- Constance H Li
- Corbin D Jones
- Craig Shriver
- Cristina López
- Cyriac Kandoth
- Cyril Fisher
- D Neil Hayes
- Dai-Ying Wu
- Daiming Fan
- Daisuke Komura
- Dale W Garsed
- Daniel A Leongamornlert
- Daniel Baumhoer
- Daniel Hübschmann
- Daniel J Turner
- Daniel J Weisenberger
- Daniel M Berney
- Daniel Rosebrock
- Daniel S Brewer
- Daniela S Gerhard
- Danielle Pasternack
- Darell Bigner
- Dariush Etemadmoghadam
- Darlene Lee
- Darrin F Taylor
- Dave Larson
- David A Wheeler
- David A Wheeler
- David C Wedge
- David Craft
- David D L Bowtell
- David E Neal
- David Haan
- David Haussler
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- David Hedley
- David Huntsman
- David I Heiman
- David J Adams
- David J Van Den Berg
- David K Chang
- David K Miller
- David Khoo
- David Mutch
- David N Louis
- David Nicol
- David Ocana
- David R Jones
- David R Jones
- David Scott
- David T Bowen
- David T W Jones
- David Tamborero
- David Torrents
- David Torrents
- David Townend
- David Vicente
- Davide Antonello
- Declan Cahill
- Denis Larsimont
- Denis Yuen
- Denise Brooks
- Deniz Demircioğlu
- Dennis C Sgroi
- Dennis Karsch
- Dennis T Maglinte
- Dennis Wigle
- Derek W Wright
- Dianne E Chadwick
- Dido Lenze
- Dieter Kube
- Dieter Weichenhan
- Dilip D Giri
- Dimitri Livitz
- Dimitri Livitz
- Dimple Chakravarty
- Ding
- Dirk Schadendorf
- Dmitry A Gordenin
- Dominik Glodzik
- Don Chalmers
- Dong Guanlan
- Dongbing Liu
- Donghoon Lee
- Donghui Tan
- Donna M Muzny
- Dorthe Grabau
- Douglas A Levine
- Douglas F Easton
- Douglas Voet
- Duncan Beardsmore
- Dursi Lewis Jonathan
- Edward W Rowe
- Eigo Shimizu
- Ekta Khurana
- Elaine R Mardis
- Electron Kebebew
- Elena Piñeiro-Yáñez
- Elena Provenzano
- Elias Campo
- Elisabet Barrera
- Elisabetta Sereni
- Elizabeth A Musgrove
- Elizabeth L Appelbaum
- Elizabeth L Christie
- Elli Papaemmanuil
- Ellrott Kyle
- Emilie Lalonde
- Eoghan Harrington
- Eric Chuah
- Eric Green
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- Eric Z Ma
- Eric Z Ma
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- Erin Curley
- Ermin Hodzic
- Erwin G Van Meir
- Esa Pitkänen
- Esther Rheinbay
- Esther Rheinbay
- Eun Pyo Hong
- Eunjung Alice Lee
- Eva G Alvarez
- Eva Hellstrom-Lindberg
- Ewan Birney
- F Germán Rodríguez-González
- Fabien C Lamaze
- Fabien Calvo
- Fabio C P Navarro
- Faiyaz Notta
- Fan Yang
- Fan Zhang
- Faraz Hach
- Faraz Hach
- Faridah Mbabaali
- Fatima Al-Shahrour
- Federico Abascal
- Fei-Fei Liu
- Felicity Newell
- Fenglin Liu
- Fernanda Amary
- Ferran Muiños
- Florian Markowetz
- Fouad Yousif
- Francesc Muyas
- Francesco Favero
- Francisco M De La Vega
- Francisco Sanchez-Vega
- Fraser R Duthie
- Fred Sweep
- Freddie C Hamdy
- Fruzsina Molnár-Gábor
- Fumie Hosoda
- G Petur Nielsen
- G Steven Bova
- Gad Getz
- Gad Getz
- Gad Getz
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- Gaetano Finocchiaro
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- Genta Nagae
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- German Ott
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- Gerstein Mark B
- Gert G Van den Eynden
- Getz Gad
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- Giada Bonizzato
- Giampaolo Tortora
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- Gilles Thomas
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- Giuseppe Malleo
- Gloria M Petersen
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- Gordon B Mills
- Gordon Saksena
- Gordon Saksena
- Gordon Saksena
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- Grace Tiao
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- Grant Sanders
- Gu Kong
- Guanming Wu
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- Guido Sauter
- Guillaume Bourque
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- Gun Ho Jang
- Gunes Gundem
- Gunnar Rätsch
- Gurnit Atwal
- Hailei Zhang
- Haiyan Irene Li
- Han Liang
- Hana Susak
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- Hans Lehrach
- Hans-Jörg Warnatz
- Hardeep K Nahal-Bose
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- Hartmut Juhl
- Harvey Pass
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- Hayley J Luxton
- Hazel Burke
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- Heather Thorne
- Hee Jin Lee
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- Heidi Sofia
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- Helena Kilpinen
- Helene Kretzmer
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- Henrik Hornshøj
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- Hideki Ohdan
- Hidenori Ojima
- Hidewaki Nakagawa
- Hikmat Al-Ahmadie
- Hilda A Pickett
- Hirofumi Rokutan
- Hirokazu Taniguchi
- Hiroki Yamaue
- Hiroko Tanaka
- Hiromi Nakamura
- Hiroshi Aikata
- Hiroto Katoh
- Hiroyuki Aburatani
- Hitoshi Katai
- Hitoshi Nakagama
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- Holmfridur Hilmarsdottir
- Hong Su
- Hong Xue
- Hong Xue
- Hongtu Zhu
- Hongwei Zhang
- Hongxin Zhang
- Hsiao-Wei Chen
- Huanming Yang
- Hugh Barr
- Hui Shen
- Husen M Umer
- Huy Q Dinh
- Hyung-Lae Kim
- Hyung-Lae Kim
- Hyung-Yong Kim
- Hyunghwan Kim
- Ian J Davis
- Ian Welch
- Ignacio Vázquez-García
- Ignaty Leshchiner
- Ignaty Leshchiner
- Ignaty Leshchiner
- Iker Reyes-Salazar
- Ilinca Lungu
- Ilse Rooman
- Ilya Shmulevich
- Iman Sarrafi
- Iman Sarrafi
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- Irinel Popescu
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- Ivica Letunic
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- Ivo Buchhalter
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- Ivo G Gut
- Ivon Harliwong
- Izar Villasante
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- Jared T Simpson
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- Wan Choi
- Wanding Zhou
- Wang Liang-Bo
- Weerasinghe Amila
- Wei Jiao
- Wendl Michael C
- Wenyi Wang
- Wenyi Wang
- Wenyi Wang
- Wheeler David A
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- Winghing Wong
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- Xinyue Li
- Xiuqing Zhang
- Xiuqing Zheng
- Xose S Puente
- Xuan Le
- Xuanping Zhang
- Xuemei Luo
- Xueqing Zou
- Yan Shi
- Yan Zhang
- Yang Wu
- Yang Yang
- Yann Joly
- Yanxun Xu
- Yao He
- Yasin Senbabaoglu
- Yassen Assenov
- Yasser Riazalhosseini
- Yasuhito Arai
- Yasushi Rino
- Yasushi Totoki
- Yeng Ang
- Yi Huang
- Yi Huang
- Yifei Men
- Yiling Lu
- Yilong Li
- Yingyan Yu
- Yiwen Chen
- Yogesh Kumar
- Yogesh Kumar
- Yoke-Eng Chiew
- Yong Hou
- Yong Zhou
- Yong-Jie Lu
- Yongzhan Nie
- Yosef E Maruvka
- Yosef E Maruvka
- Yoshiiku Kawakami
- Young Seok Ju
- Youngchoon Woo
- Youngil Koh
- Youngwook Kim
- Youyong Lu
- Yu Fan
- Yu Fan
- Yu Fan
- Yu-Jia Shiah
- Yuan Ji
- Yuan Yuan
- Yuichi Shiraishi
- Yulia Newton
- Yulia Rubanova
- Yumeng Wang
- Yupeng Cun
- Yussanne Ma
- Zachary Heins
- Zechen Chong
- Zechen Chong
- Zemin Zhang
- Zhaohong Chen
- Zhenggang Wu
- Zhenggang Wu
- Zhining Wang
- Zhongming Zhao
- Ziao Lin
- Zsofia Kote-Jarai
- Ólafur Andri Stefánsson
- Øystein Garred
- Publication venue
- Publication date
- 01/01/2020
- Field of study
The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts.The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that -80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAFPeer reviewe
Recommended from our members
Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples
- Author
- Aaltonen Lauri A.
- Abascal Federico
- Abeshouse Adam
- Aburatani Hiroyuki
- Adams David J.
- Agrawal Nishant
- Ahn Keun Soo
- Ahn Sung-Min
- Aikata Hiroshi
- Akbani Rehan
- Akdemir Kadir C.
- Al-Ahmadie Hikmat
- Al-Sedairy Sultan T.
- Al-Shahrour Fatima
- Alawi Malik
- Albert Monique
- Aldape Kenneth
- Alexandrov Ludmil B.
- Ally Adrian
- Alsop Kathryn
- Alvarez Eva G.
- Amary Fernanda
- Amin Samirkumar B.
- Aminou Brice
- Ammerpohl Ole
- Anderson Matthew J.
- Ang Yeng
- Antonello Davide
- Anur Pavana
- Aparicio Samuel
- Appelbaum Elizabeth L.
- Arai Yasuhito
- Aretz Axel
- Arihiro Koji
- Ariizumi Shun-ichi
- Armenia Joshua
- Arnau Gisela Mir
- Arnould Laurent
- Asa Sylvia
- Assenov Yassen
- Atwal Gurnit
- Aukema Sietse
- Auman J. Todd
- Aure Miriam R.
- Awadalla Philip
- Aymerich Marta
- Bader Gary D.
- Baez-Ortega Adrian
- Bailey Matthew H.
- Bailey Peter J.
- Balasundaram Miruna
- Balu Saianand
- Bandopadhayay Pratiti
- Banks Rosamonde E.
- Barbi Stefano
- Barbour Andrew P.
- Barenboim Jonathan
- Barnholtz-Sloan Jill
- Barr Hugh
- Barrera Elisabet
- Bartlett John
- Bartolome Javier
- Bassi Claudio
- Bathe Oliver F.
- Baumhoer Daniel
- Bavi Prashant
- Baylin Stephen B.
- Bazant Wojciech
- Beardsmore Duncan
- Beck Timothy A.
- Behjati Sam
- Behren Andreas
- Bell Cindy
- Beltran Sergi
- Benz Christopher
- Berchuck Andrew
- Bergmann Anke K.
- Bergstrom Erik N.
- Berman Benjamin P.
- Berney Daniel M.
- Bernhart Stephan H.
- Beroukhim Rameen
- Berrios Mario
- Bersani Samantha
- Bertl Johanna
- Betancourt Miguel
- Bhandari Vinayak
- Bhosle Shriram G.
- Biankin Andrew V.
- Bieg Matthias
- Bigner Darell
- Bin Zhu
- Binder Hans
- Birney Ewan
- Birrer Michael
- Biswas Nidhan K.
- Bjerkehagen Bodil
- Bodenheimer Tom
- Boice Lori
- Bonizzato Giada
- Boot Arnoud
- Bootwalla Moiz S.
- Borg Ake
- Borkhardt Arndt
- Boroevich Keith A.
- Borozan Ivan
- Borst Christoph
- Bosenberg Marcus
- Bosio Mattia
- Boultwood Jacqueline
- Bourque Guillaume
- Boutros Paul C.
- Bova G. Steven
- Bowen David T.
- Bowlby Reanne
- Bowtell David D. L.
- Boyault Sandrine
- Boyce Rich
- Boyd Jeffrey
- Brazma Alvis
- Brennan Paul
- Brewer Daniel S.
- Brinkman Arie B.
- Bristow Robert G.
- Broaddus Russell R.
- Brock Jane E.
- Brock Malcolm
- Broeks Annegien
- Brooks Angela N.
- Brooks Denise
- Brors Benedikt
- Brunak Søren
- Bruxner Timothy J. C.
- Bruzos Alicia L.
- Buchanan Alex
- Buchhalter Ivo
- Buchholz Christiane
- Bullman Susan
- Burke Hazel
- Burkhardt Birgit
- Burns Kathleen H.
- Busanovich John
- Bustamante Carlos D.
- Butler Adam P.
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- Urban Lara
- Urushidate Tomoko
- Ushiku Tetsuo
- Uusküla-Reimand Liis
- Valencia Alfonso
- van As Nicholas
- van de Vijver Marc J.
- Van Den Berg David J.
- Van den Eynden Gert G.
- Van der Kwast Theodorus
- van Deurzen Carolien H. M.
- Van Laere Steven
- Van Loo Peter
- Van Meir Erwin G.
- van’t Veer L.
- Vasudev Naveen
- Vazquez Miguel
- Vedururu Ravikiran
- Veluvolu Umadevi
- Vembu Shankar
- Verbeke Lieven P. C.
- Vermeulen Peter
- Verrill Clare
- Viari Alain
- Vicente David
- Vicentini Caterina
- Viksna Juris
- Vilain Ricardo E.
- Villasante Izar
- Vincent-Salomon Anne
- Visakorpi Tapio
- Voet Douglas
- von Kalle Christof
- von Mering Christian
- Vyas Paresh
- Vázquez-García Ignacio
- Waddell Nick M.
- Waddell Nicola
- Wadelius Claes
- Wadi Lina
- Wagener Rabea
- Wala Jeremiah A.
- Wang Jian
- Wang Jiayin
- Wang Liang-Bo
- Wang Linghua
- Wang Qi
- Wang Wenyi
- Wang Yumeng
- Wang Zhining
- Waring Paul M.
- Warnatz Hans-Jörg
- Warrell Jonathan
- Warren Anne Y.
- Waszak Sebastian M.
- Wedge David C.
- Weerasinghe Amila
- Weichenhan Dieter
- Weinberger Paul
- Weinstein John N.
- Weischenfeldt Joachim
- Weisenberger Daniel J.
- Welch Ian
- Wendl Michael C.
- Werner Johannes
- Whalley Justin P.
- Wheeler David A.
- Whitaker Hayley C.
- Wigle Dennis
- Wilkerson Matthew D.
- Williams Ashley
- Wilmott James S.
- Wilson Gavin W.
- Wilson Julie M.
- Wilson Richard K.
- Winterhoff Boris
- Wintersinger Jeffrey A.
- Wiznerowicz Maciej
- Wolf Stephan
- Wong Bernice H.
- Wong Christopher K.
- Wong Tina
- Wong Winghing
- Woo Youngchoon
- Wood Scott
- Wouters Bradly G.
- Wright Adam J.
- Wright Derek W.
- Wright Mark H.
- Wu Chin-Lee
- Wu Dai-Ying
- Wu Guanming
- Wu Jianmin
- Wu Kui
- Wu Yang
- Wu Zhenggang
- Xi Liu
- Xia Tian
- Xiang Qian
- Xiao Xiao
- Xing Rui
- Xiong Heng
- Xu Qinying
- Xu Yanxun
- Xue Hong
- Yachida Shinichi
- Yakneen Sergei
- Yamaguchi Rui
- Yamaguchi Takafumi N.
- Yamamoto Masakazu
- Yamamoto Shogo
- Yamaue Hiroki
- Yang Fan
- Yang Huanming
- Yang Jean Y.
- Yang Liming
- Yang Lixing
- Yang Shanlin
- Yang Tsun-Po
- Yang Yang
- Yao Xiaotong
- Yaspo Marie-Laure
- Yates Lucy
- Yau Christina
- Ye Chen
- Ye Kai
- Yellapantula Venkata D.
- Yoon Christopher J.
- Yoon Sung-Soo
- Yousif Fouad
- Yu Jun
- Yu Kaixian
- Yu Willie
- Yu Yingyan
- Yuan Ke
- Yuan Yuan
- Yuen Denis
- Yugawa Takashi
- Yung Christina K.
- Zaikova Olga
- Zamora Jorge
- Zapatka Marc
- Zenklusen Jean C.
- Zenz Thorsten
- Zeps Nikolajs
- Zhang Cheng-Zhong
- Zhang Fan
- Zhang Hailei
- Zhang Hongwei
- Zhang Hongxin
- Zhang Jiashan
- Zhang Jing
- Zhang Junjun
- Zhang Xiuqing
- Zhang Xuanping
- Zhang Yan
- Zhang Zemin
- Zhao Zhongming
- Zheng Liangtao
- Zheng Xiuqing
- Zhou Wanding
- Zhou Yong
- Zhu Hongtu
- Zhu Jingchun
- Zhu Shida
- Zou Lihua
- Zou Xueqing
- Publication venue
- Nature Communications
- Publication date
- 21/09/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts
Fungal diversity notes 491–602: taxonomic and phylogenetic contributions to fungal taxa.
- Author
- Aamir S.Aamir, S.
- Acharya KrishnenduAcharya, Krishnendu
- Adhikari SinchanAdhikari, Sinchan
- Antonín VladimírAntonín, Vladimír
- Ariyawansa Hiran A.Ariyawansa, Hiran A.
- Baghela AbhishekBaghela, Abhishek
- Bahkali Ali H.Bahkali, Ali H.
- Bandyopadhyay Tapas KumarBandyopadhyay, Tapas Kumar
- Bhat D. JayaramaBhat, D. Jayarama
- Bhatt R. P.Bhatt, R. P.
- Boonmee SaranyaphatBoonmee, Saranyaphat
- Bulgakov Timur S.Bulgakov, Timur S.
- Camporesi ErioCamporesi, Erio
- Chakrabarty DebasisChakrabarty, Debasis
- Chakraborty DyutiparnaChakraborty, Dyutiparna
- Chethana K. W. ThiliniChethana, K. W. Thilini
- Chomnunti PutarakChomnunti, Putarak
- da Silva Gladstone Alvesda Silva, Gladstone Alves
- Daranagama Dinushani A.Daranagama, Dinushani A.
- Das KanadDas, Kanad
- Dayarathne Monika C.Dayarathne, Monika C.
- de Azevedo Santiago André Luiz Cabral Monteirode Azevedo Santiago, André Luiz Cabral Monteiro
- de Oliveira Rafael José Vilelade Oliveira, Rafael José Vilela
- de Silva N. I.de Silva, N. I.
- de Souza Carlos Alberto Fragosode Souza, Carlos Alberto Fragoso
- Dissanayake Asha J.Dissanayake, Asha J.
- Doilom MingkwanDoilom, Mingkwan
- Dong WeiDong, Wei
- Dutta Arun KumarDutta, Arun Kumar
- Ekanayaka Anusha HasiniEkanayaka, Anusha Hasini
- Elgorban Abdallah M.Elgorban, Abdallah M.
- Ercole EnricoErcole, Enrico
- Gibertoni Tatiana B.Gibertoni, Tatiana B.
- Goonasekara Ishani D.Goonasekara, Ishani D.
- Hapuarachchi Kalani KanchanaHapuarachchi, Kalani Kanchana
- Hongsanan SinangHongsanan, Sinang
- Hosen Md. IqbalHosen, Md. Iqbal
- Hu KaifengHu, Kaifeng
- Hyde Kevin D.Hyde, Kevin D.
- Indoliya YuvrajIndoliya, Yuvraj
- Jadan MargitaJadan, Margita
- Jayasiri Subashini C.Jayasiri, Subashini C.
- Jayawardena Ruvishika S.Jayawardena, Ruvishika S.
- Jeewon RajeshJeewon, Rajesh
- Ji-Chuan KangJi-Chuan, Kang
- Jones E. B. GarethJones, E. B. Gareth
- Kaewchai SaithongKaewchai, Saithong
- Karmakar JoydeepKarmakar, Joydeep
- Karunarathna Samantha C.Karunarathna, Samantha C.
- Khan SehroonKhan, Sehroon
- Kim Nam KyuKim, Nam Kyu
- Kirk Paul M.Kirk, Paul M.
- Konta SirinapaKonta, Sirinapa
- Kušan IvanaKušan, Ivana
- Latha K. P. DeepnaLatha, K. P. Deepna
- Lee Hyang BurmLee, Hyang Burm
- Lee HyunLee, Hyun
- Li JunfuLi, Junfu
- Li Wen-JingLi, Wen-Jing
- Lim Young WoonLim, Young Woon
- Lima Diogo XavierLima, Diogo Xavier
- Lin Chuan-GenLin, Chuan-Gen
- Liu Jian-KuiLiu, Jian-Kui
- Luangsa-ard JenniferLuangsa-ard, Jennifer
- Luo Zong-LongLuo, Zong-Long
- Maharachchikumbura Sajeewa S. N.Maharachchikumbura, Sajeewa S. N.
- Manawasinghe Ishara S.Manawasinghe, Ishara S.
- Manimohan PatinjareveettilManimohan, Patinjareveettil
- Mapook AusanaMapook, Ausana
- Marathe Sayali D.Marathe, Sayali D.
- Matočec NevenMatočec, Neven
- McKenzie Eric H. C.McKenzie, Eric H. C.
- Mehmood TahirMehmood, Tahir
- Meiras-Ottoni AngelinaMeiras-Ottoni, Angelina
- Mešić ArminMešić, Armin
- Mikšík MichalMikšík, Michal
- Mortimer Peter E.Mortimer, Peter E.
- Nguyen Thi Thuong ThuongNguyen, Thi Thuong Thuong
- Nontachaiyapoom SureepornNontachaiyapoom, Sureeporn
- Norphanphoun ChadaNorphanphoun, Chada
- Perera Rekhani H.Perera, Rekhani H.
- Phillips Alan J. L.Phillips, Alan J. L.
- Phookamsak RungtiwaPhookamsak, Rungtiwa
- Phukhamsakda ChayanardPhukhamsakda, Chayanard
- Plautz Helio LongoniPlautz, Helio Longoni
- Promputtha ItthayakornPromputtha, Itthayakorn
- Raj K. N. AnilRaj, K. N. Anil
- Rajeshkumar Kunhiraman C.Rajeshkumar, Kunhiraman C.
- Richter ChristianRichter, Christian
- Ryvarden LeifRyvarden, Leif
- Samarakoon Milan C.Samarakoon, Milan C.
- Semwal Kamal C.Semwal, Kamal C.
- Senanayake Indunil C.Senanayake, Indunil C.
- Simonini GiampaoloSimonini, Giampaolo
- Singh Paras NathSingh, Paras Nath
- Singh Sanjay K.Singh, Sanjay K.
- Soares Adriene MayraSoares, Adriene Mayra
- Song JieSong, Jie
- Stadler MarcStadler, Marc
- Su Hong-YanSu, Hong-Yan
- Sun JingzuSun, Jingzu
- Svetasheva Tatyana Yu.Svetasheva, Tatyana Yu.
- Sysouphanthong PhongeunSysouphanthong, Phongeun
- Tang Alvin M. C.Tang, Alvin M. C.
- Tennakoon Danushka S.Tennakoon, Danushka S.
- Thambugala Kasun M.Thambugala, Kasun M.
- Thongbai BenjarongThongbai, Benjarong
- Tian QingTian, Qing
- Tibpromma SaowaluckTibpromma, Saowaluck
- Tkalčec ZdenkoTkalčec, Zdenko
- Tulloss Rodham E.Tulloss, Rodham E.
- Vasquez GianricoVasquez, Gianrico
- Vizzini AlfredoVizzini, Alfredo
- Voigt KerstinVoigt, Kerstin
- Wanasinghe Dhanushka N.Wanasinghe, Dhanushka N.
- Wang YongWang, Yong
- Wen Ting-ChiWen, Ting-Chi
- Wijayawardene Nalin N.Wijayawardene, Nalin N.
- Wu FangWu, Fang
- Xiao YuanpinXiao, Yuanpin
- Xu JianchuXu, Jianchu
- Yan JiyeYan, Jiye
- Yang Jun-BoYang, Jun-Bo
- Zhang HuangZhang, Huang
- Zhao QiZhao, Qi
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 04/05/2017
- Field of study
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- Abdel-Aziz Amal Kamal
- Abdelfatah Sara
- Abdellatif Mahmoud
- Abdoli Asghar
- Abel Steffen
- Abeliovich Hagai
- Abildgaard Marie H
- Abudu Yakubu Princely
- Acevedo-Arozena Abraham
- Adamopoulos Iannis E
- Adeli Khosrow
- Adolph Timon E
- Adornetto Annagrazia
- Aflaki Elma
- Afshar Elham Ghasemipour
- Agam Galila
- Agarwal Anupam
- Aggarwal Bharat B
- Agnello Maria
- Agostinis Patrizia
- Agrewala Javed N
- Agrotis Alexander
- Aguilar Patricia V
- Ahmad S Tariq
- Ahmed Zubair M
- Ahumada-Castro Ulises
- Aits Sonja
- Aizawa Shu
- Akkoc Yunus
- Akoumianaki Tonia
- Akpinar Hafize Aysin
- Al-Abd Ahmed M
- Al-Akra Lina
- Al-Bari M Abdul Alim
- Al-Gharaibeh Abeer
- Alaoui-Jamali Moulay A
- Alberti Simon
- Alcocer-Gomez Elisabet
- Alcon Soledad Porte
- Alessandri Cristiano
- Ali Muhammad
- Aliwaini Saeb
- Alizadeh Javad
- Almacellas Eugenia
- Almasan Alexandru
- Alonso Alicia
- Alonso Guillermo D
- Altan-Bonnet Nihal
- Altieri Dario C
- Alvarez Elida MC
- Alves Sara
- Alzaharna Mazen M
- Amadio Marialaura
- Amantini Consuelo
- Amaral Cristina
- Ambrosio Susanna
- Amer Amal O
- Ammanathan Veena
- An Zhenyi
- Andersen Stig U
- Andrabi Shaida A
- Andrade-Silva Magaiver
- Andres Allen M
- Angelini Sabrina
- Ann David
- Anozie Uche C
- Ansari Mohammad Y
- Antas Pedro
- Antebi Adam
- Anton Zurine
- Anwar Tahira
- Apetoh Lionel
- Apostolova Nadezda
- Araki Toshiyuki
- Araki Yasuhiro
- Arasaki Kohei
- Araujo Thais Fenz
- Araujo Wagner L
- Araya Jun
- Arden Catherine
- Arevalo Maria-Angeles
- Arguelles Sandro
- Arias Esperanza
- Arikkath Jyothi
- Arimoto Hirokazu
- Ariosa Aileen R
- Armstrong-James Darius
- Arnaune-Pelloquin Laetitia
- Aroca Angeles
- Arroyo Daniela S
- Arsov Ivica
- Artero Ruben
- Asaro Dalia Maria Lucia
- Aschner Michael
- Ashrafizadeh Milad
- Ashur-Fabian Osnat
- Atanasov Atanas G
- Au Alicia K
- Auberger Patrick
- Auner Holger W
- Aurelian Laure
- Autelli Riccardo
- Avagliano Laura
- Avalos Yenniffer
- Aveic Sanja
- Aveleira Celia Alexandra
- AvinWittenberg Tamar
- Aydin Yucel
- Ayton Scott
- Ayyadevara Srinivas
- Azzopardi Maria
- Baba Misuzu
- Backer Jonathan M
- Backues Steven K
- Bae Dong-Hun
- Bae Ok-Nam
- Bae Soo Han
- Baehrecke Eric H
- Baek Ahruem
- Baek Seung-Hoon
- Baek Sung Hee
- Bagetta Giacinto
- Bagniewska-Zadworna Agnieszka
- Bai Hua
- Bai Jie
- Bai Xiyuan
- Bai Yidong
- Bairagi Nandadulal
- Baksi Shounak
- Balazadeh Salma
- Balbi Teresa
- Baldari Cosima T
- Balduini Walter
- Ballabio Andrea
- Ballester Maria
- Balzan Rena
- Bandopadhyay Rina
- Banerjee Sreeparna
- Banerjee Sulagna
- Bao Yan
- Baptista Mauricio S
- Baracca Alessandra
- Barbati Cristiana
- Bargiela Ariadna
- Barila Daniela
- Barlow Peter G
- Barmada Sami J
- Barreiro Esther
- Barrera Miguel Calvo-Rubio
- Barreto George E
- Bartek Jiri
- Bartel Bonnie
- Bartolome Alberto
- Barve Gaurav R
- Basagoudanavar Suresh H
- Bassham Diane C
- Basu Alakananda
- Batoko Henri
- Batten Isabella
- Baulieu Etienne E
- Baumgarner Bradley L
- Bayry Jagadeesh
- Beale Rupert
- Beau Isabelle
- Beaumatin Florian
- Bechara Luiz RG
- Beck George R Jr
- Beers Michael F
- Begun Jakob
- Behl Christian
- Behrends Christian
- Behrens Georg MN
- Bei Roberto
- Bejarano Eloy
- Bel Shai
- Belaid Amine
- Belgareh-Touze Naima
- Bellarosa Cristina
- Belleudi Francesca
- Bello Perez Melissa
- Bello-Morales Raquel
- Beltran Sebastian
- Benbrook Doris Mangiaracina
- Bendorius Mykolas
- Benitez Bruno A
- Benito-Cuesta Irene
- Bensalem Julien
- Berchtold Martin W
- Berezowska Sabina
- Bergamaschi Daniele
- Bergami Matteo
- Bergmann Andreas
- Berliocchi Laura
- Berlioz-Torrent Clarisse
- Bernard Amelie
- Berthoux Lionel
- Besirli Cagri G
- Besteiro Sebastien
- Betin Virginie M
- Beyaert Rudi
- Bezbradica Jelena S
- Bharath MM Srinivas
- Bhaskar Kiran
- Bhatia-Kissova Ingrid
- Bhattacharya Resham
- Bhattacharya Sujoy
- Bhattacharyya Shalmoli
- Bhuiyan Md Shenuarin
- Bhutia Sujit Kumar
- Bi Lanrong
- Bi Xiaolin
- Biden Trevor J
- Bijian Krikor
- Billes Viktor A
- Binart Nadine
- Bincoletto Claudia
- Birgisdottir Asa B
- Bjorkoy Geir
- Blanco Gonzalo
- Blas-Garcia Ana
- Blasiak Janusz
- Blomgran Robert
- Blomgren Klas
- Blum Janice S
- Boada-Romero Emilio
- Boban Mirta
- BoeszeBattaglia Kathleen
- Boeuf Philippe
- Boland Barry
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- Bonaldo Paolo
- Bonam Srinivasa Reddy
- Bonfili Laura
- Bonifacino Juan S
- Boone Brian A
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- Borner Christoph
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- Bosch Jurgen
- Bose Santanu
- Botana Luis M
- Botas Juan
- Boulanger Chantal M
- Boulton Michael E
- Bourdenx Mathieu
- Bourgeois Benjamin
- Bourke Nollaig M
- Bousquet Guilhem
- Boya Patricia
- Bozhkov Peter V
- Bozi Luiz HM
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- Brackney Doug E
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- Brandts Christian H
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- Briones-Herrera Alfredo
- Broaddus V Courtney
- Brodersen Peter
- Brodsky Jeffrey L
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- Castillo Eliseo F
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- Chen ChangShi
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- Chen Quan
- Chen Ruey-Hwa
- Chen Shi
- Chen Wei
- Chen Weiqiang
- Chen XinMing
- Chen Xiong-Wen
- Chen Xu
- Chen Yan
- Chen Ye-Guang
- Chen Yingyu
- Chen Yongqiang
- Chen Yue-Qin
- Chen YuJen
- Chen Zhefan Stephen
- Chen Zhi
- Chen Zhi-Hua
- Chen Zhijian J
- Chen Zhixiang
- Chen Zhong
- Cheng Hanhua
- Cheng Jun
- Cheng Shi-Yuan
- Cheng Wei
- Cheng Xiaodong
- Cheng Xiu-Tang
- Cheng Yiyun
- Cheng Zhiyong
- Cheong Heesun
- Cheong Jit Kong
- Chernyak Boris V
- Cherry Sara
- Cheung Chi Fai Randy
- Cheung Chun Hei Antonio
- Cheung King-Ho
- Chevet Eric
- Chi Richard J
- Chiang Alan Kwok Shing
- Chiaradonna Ferdinando
- Chiarelli Roberto
- Chiariello Mario
- Chica Nathalia
- Chiocca Susanna
- Chiong Mario
- Chiou Shih-Hwa
- Chiramel Abhilash I
- Chiurchiu Valerio
- Cho Dong-Hyung
- Choe Seong-Kyu
- Choi Augustine MK
- Choi Mary E
- Choudhury Kamalika Roy
- Chow Norman S
- Chu Charleen T
- Chua Jason P
- Chua John Jia En
- Chung Hyewon
- Chung Kin Pan
- Chung Seockhoon
- Chung So-Hyang
- Chung Yuen-Li
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- Ciechomska Iwona A
- Cifuentes Mariana
- Cinque Laura
- Cirak Sebahattin
- Cirone Mara
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- Clarke Robert
- Clementi Emilio
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- Comincini Sergio
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- Compagnoni Giacomo Monzio
- Consiglio Antonella
- Conte Andrea
- Conti Fabrizio
- Contu Viorica Raluca
- Cookson Mark R
- Coombs Kevin M
- Coppens Isabelle
- Corasaniti Maria Tiziana
- Cordes Nils
- Corkery Dale P
- Cortese Katia
- Costa Maria do Carmo
- Costantino Sarah
- Costelli Paola
- Coto-Montes Ana
- Crack Peter J
- Crespo Jose L
- Criollo Alfredo
- Crippa Valeria
- Cristofani Riccardo
- Csizmadia Tamas
- Cuadrado Antonio
- Cui Bing
- Cui Jun
- Cui Yixian
- Cui Yong
- Culetto Emmanuel
- Cumino Andrea C
- Cybulsky Andrey V
- Czaja Mark J
- Czuczwar Stanislaw J
- D'Adamo Stefania
- D'Amelio Marcello
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- D'Lugos Andrew C
- D'Orazi Gabriella
- da Costa Cristine Alves
- da Silva James A
- Dafsari Hormos Salimi
- Dagda Ruben K
- Dagdas Yasin
- Daglia Maria
- Dai Xiaoxia
- Dai Yun
- Dai Yuyuan
- Dal Col Jessica
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- Kroemer Guido
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- Wang Jundong
- Wang Kui
- Wang Lianrong
- Wang Liming
- Wang Maggie Haitian
- Wang Meiqing
- Wang Nanbu
- Wang Peipei
- Wang Pengwei
- Wang Ping
- Wang Ping
- Wang Qing
- Wang Qing Jun
- Wang Qing Kenneth
- Wang Qiong A
- Wang Wen-Tao
- Wang Wuyang
- Wang Xinnan
- Wang Xuejun
- Wang Yan
- Wang Yanchang
- Wang Yanzhuang
- Wang YenYun
- Wang Yihua
- Wang Yipeng
- Wang Yu
- Wang Yuqi
- Wang Zhe
- Wang Zhenyu
- Wang Zhouguang
- Warnes Gary
- Warnsmann Verena
- Watada Hirotaka
- Watanabe Eizo
- Watchon Maxinne
- Weaver Timothy E
- Wegrzyn Grzegorz
- Wehman Ann M
- Wei Huafeng
- Wei Lei
- Wei Taotao
- Wei Yongjie
- Weiergraber Oliver H
- Weihl Conrad C
- Weindl Gunther
- Weiskirchen Ralf
- Wells Alan
- Wen Runxia H
- Wen Xin
- Werner Antonia
- Weykopf Beatrice
- Wheatley Sally P
- Whitton J Lindsay
- Whitworth Alexander J
- Wiktorska Katarzyna
- Wildenberg Manon E
- Wileman Tom
- Wilkinson Simon
- Willbold Dieter
- Williams Brett
- Williams Robin SB
- Williams Roger L
- Williamson Peter R
- Wilson Richard A
- Winner Beate
- Winsor Nathaniel J
- Witkin Steven S
- Wodrich Harald
- Woehlbier Ute
- Wollert Thomas
- Wong Esther
- Wong Jack Ho
- Wong Richard W
- Wong Vincent Kam Wai
- Wong W Wei-Lynn
- Wu An-Guo
- Wu Chengbiao
- Wu Jian
- Wu Junfang
- Wu Kenneth K
- Wu Min
- Wu Shan-Ying
- Wu Shengzhou
- Wu Shufang
- Wu ShuYan
- Wu William KK
- Wu Xiaohong
- Wu Xiaoqing
- Wu Yao-Wen
- Wu Yihua
- Xavier Ramnik J
- Xia Hongguang
- Xia Lixin
- Xia Zhengyuan
- Xiang Ge
- Xiang Jin
- Xiang Mingliang
- Xiang Wei
- Xiao Bin
- Xiao Guozhi
- Xiao Hengyi
- Xiao Hong-tao
- Xiao Jian
- Xiao Lan
- Xiao Shi
- Xiao Yin
- Xie Baoming
- Xie Chuan-Ming
- Xie Min
- Xie Yuxiang
- Xie Zhiping
- Xie Zhonglin
- Xilouri Maria
- Xu Congfeng
- Xu En
- Xu Haoxing
- Xu Jing
- Xu JinRong
- Xu Liang
- Xu Wen Wen
- Xu Xiulong
- Xue Yu
- Yakhine-Diop Sokhna MS
- Yamaguchi Masamitsu
- Yamaguchi Osamu
- Yamamoto Ai
- Yamashina Shunhei
- Yan Shengmin
- Yan Shian-Jang
- Yan Zhen
- Yanagi Yasuo
- Yang Chuanbin
- Yang Dun-Sheng
- Yang Huan
- Yang Huang-Tian
- Yang Hui
- Yang Jin-Ming
- Yang Jing
- Yang Jingyu
- Yang Ling
- Yang Liu
- Yang Ming
- Yang Pei-Ming
- Yang Qian
- Yang Seungwon
- Yang Shu
- Yang Shun-Fa
- Yang Wannian
- Yang Wei Yuan
- Yang Xiaoyong
- Yang Xuesong
- Yang Yi
- Yang Ying
- Yao Honghong
- Yao Shenggen
- Yao Xiaoqiang
- Yao Yong-Gang
- Yao Yong-Ming
- Yasui Takahiro
- Yazdankhah Meysam
- Yen Paul M
- Yi Cong
- Yin Xiao-Ming
- Yin Yanhai
- Yin Zhangyuan
- Yin Ziyi
- Ying Meidan
- Ying Zheng
- Yip Calvin K
- Yiu Stephanie Pei Tung
- Yoo Young H
- Yoshida Kiyotsugu
- Yoshii Saori R
- Yoshimori Tamotsu
- Yousefi Bahman
- Yu Boxuan
- Yu Haiyang
- Yu Jun
- Yu Jun
- Yu Li
- Yu Ming-Lung
- Yu Seong-Woon
- Yu Victor C
- Yu W Haung
- Yu Zhengping
- Yu Zhou
- Yuan Junying
- Yuan Ling-Qing
- Yuan Shilin
- Yuan Shyng-Shiou F
- Yuan Yanggang
- Yuan Zengqiang
- Yue Jianbo
- Yue Zhenyu
- Yun Jeanho
- Yung Raymond L
- Zacks David N
- Zaffagnini Gabriele
- Zambelli Vanessa O
- Zanella Isabella
- Zang Qun S
- Zanivan Sara
- Zappavigna Silvia
- Zaragoza Pilar
- Zarbalis Konstantinos S
- Zarebkohan Amir
- Zarrouk Amira
- Zeitlin Scott O
- Zeng Jialiu
- Zeng Ju-deng
- Zerovnik Eva
- Zhan Lixuan
- Zhang Bin
- Zhang Donna D
- Zhang Hanlin
- Zhang Hong
- Zhang Hong
- Zhang Honghe
- Zhang Huafeng
- Zhang Huaye
- Zhang Hui
- Zhang Hui-Ling
- Zhang Jianbin
- Zhang Jianhua
- Zhang Jing-Pu
- Zhang Kalin YB
- Zhang Leshuai W
- Zhang Lin
- Zhang Lisheng
- Zhang Lu
- Zhang Luoying
- Zhang Menghuan
- Zhang Peng
- Zhang Sheng
- Zhang Wei
- Zhang Xiangnan
- Zhang Xiao-Wei
- Zhang Xiaolei
- Zhang Xiaoyan
- Zhang Xin
- Zhang Xinxin
- Zhang Xu Dong
- Zhang Yang
- Zhang Yanjin
- Zhang Yi
- Zhang Ying-Dong
- Zhang Yingmei
- Zhang Yuan-Yuan
- Zhang Yuchen
- Zhang Zhe
- Zhang Zhengguang
- Zhang Zhibing
- Zhang Zhihai
- Zhang Zhiyong
- Zhang Zili
- Zhao Haobin
- Zhao Lei
- Zhao Shuang
- Zhao Tongbiao
- Zhao Xiao-Fan
- Zhao Ying
- Zhao Yongchao
- Zhao Yongliang
- Zhao Yuting
- Zheng Guoping
- Zheng Kai
- Zheng Ling
- Zheng Shizhong
- Zheng Xi-Long
- Zheng Yi
- Zheng Zu-Guo
- Zhivotovsky Boris
- Zhong Qing
- Zhou Ao
- Zhou Ben
- Zhou Cefan
- Zhou Gang
- Zhou Hao
- Zhou Hong
- Zhou Hongbo
- Zhou Jie
- Zhou Jing
- Zhou Jing
- Zhou Jiyong
- Zhou Kailiang
- Zhou Rongjia
- Zhou Xu-Jie
- Zhou Yanshuang
- Zhou Yinghong
- Zhou Yubin
- Zhou Zheng-Yu
- Zhou Zhou
- Zhu Binglin
- Zhu Changlian
- Zhu Guo-Qing
- Zhu Haining
- Zhu Hongxin
- Zhu Hua
- Zhu WeiGuo
- Zhu Yanping
- Zhu Yushan
- Zhuang Haixia
- Zhuang Xiaohong
- Zientara-Rytter Katarzyna
- Zimmermann Christine M
- Ziviani Elena
- Zoladek Teresa
- Zong Wei-Xing
- Zorov Dmitry B
- Zorzano Antonio
- Zou Weiping
- Zou Zhen
- Zou Zhengzhi
- Zuryn Steven
- Zwerschke Werner
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
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- Author
- Aaltonen Lauri A.
- Abascal Federico
- Abeshouse Adam
- Aburatani Hiroyuki
- Adams David J.
- Agrawal Nishant
- Ahn Keun Soo
- Ahn Sung-Min
- Aikata Hiroshi
- Akbani Rehan
- Akdemir Kadir C.
- Al-Ahmadie Hikmat
- Al-Sedairy Sultan T.
- Al-Shahrour Fatima
- Alawi Malik
- Albert Monique
- Aldape Kenneth
- Alexandrov Ludmil B.
- Ally Adrian
- Alsop Kathryn
- Alvarez Eva G.
- Amary Fernanda
- Amin Samirkumar B.
- Aminou Brice
- Ammerpohl Ole
- Anderson Matthew J.
- Ang Yeng
- Antonello Davide
- Anur Pavana
- Aparicio Samuel
- Appelbaum Elizabeth L.
- Arai Yasuhito
- Aretz Axel
- Arihiro Koji
- Ariizumi Shun-ichi
- Armenia Joshua
- Arnau Gisela Mir
- Arnould Laurent
- Asa Sylvia
- Assenov Yassen
- Atwal Gurnit
- Aukema Sietse
- Auman J. Todd
- Aure Miriam R.
- Awadalla Philip
- Aymerich Marta
- Bader Gary D.
- Baez-Ortega Adrian
- Bailey Matthew H.
- Bailey Peter J.
- Balasundaram Miruna
- Balu Saianand
- Bandopadhayay Pratiti
- Banks Rosamonde E.
- Barbi Stefano
- Barbour Andrew P.
- Barenboim Jonathan
- Barnholtz-Sloan Jill
- Barr Hugh
- Barrera Elisabet
- Bartlett John
- Bartolome Javier
- Bassi Claudio
- Bathe Oliver F.
- Baumhoer Daniel
- Bavi Prashant
- Baylin Stephen B.
- Bazant Wojciech
- Beardsmore Duncan
- Beck Timothy A.
- Behjati Sam
- Behren Andreas
- Bell Cindy
- Beltran Sergi
- Benz Christopher
- Berchuck Andrew
- Bergmann Anke K.
- Bergstrom Erik N.
- Berman Benjamin P.
- Berney Daniel M.
- Bernhart Stephan H.
- Beroukhim Rameen
- Berrios Mario
- Bersani Samantha
- Bertl Johanna
- Betancourt Miguel
- Bhandari Vinayak
- Bhosle Shriram G.
- Biankin Andrew V.
- Bieg Matthias
- Bigner Darell
- Bin Zhu
- Binder Hans
- Birney Ewan
- Birrer Michael
- Biswas Nidhan K.
- Bjerkehagen Bodil
- Bodenheimer Tom
- Boice Lori
- Bonizzato Giada
- Boot Arnoud
- Bootwalla Moiz S.
- Borg Ake
- Borkhardt Arndt
- Boroevich Keith A.
- Borozan Ivan
- Borst Christoph
- Bosenberg Marcus
- Bosio Mattia
- Boultwood Jacqueline
- Bourque Guillaume
- Boutros Paul C.
- Bova G. Steven
- Bowen David T.
- Bowlby Reanne
- Bowtell David D. L.
- Boyault Sandrine
- Boyce Rich
- Boyd Jeffrey
- Brazma Alvis
- Brennan Paul
- Brewer Daniel S.
- Brinkman Arie B.
- Bristow Robert G.
- Broaddus Russell R.
- Brock Jane E.
- Brock Malcolm
- Broeks Annegien
- Brooks Angela N.
- Brooks Denise
- Brors Benedikt
- Brunak Søren
- Bruxner Timothy J. C.
- Bruzos Alicia L.
- Buchanan Alex
- Buchhalter Ivo
- Buchholz Christiane
- Bullman Susan
- Burke Hazel
- Burkhardt Birgit
- Burns Kathleen H.
- Busanovich John
- Bustamante Carlos D.
- Butler Adam P.
- Butte Atul J.
- Byrne Niall J.
- Børresen-Dale Anne-Lise
- Caesar-Johnson Samantha J.
- Cafferkey Andy
- Cahill Declan
- Calabrese Claudia
- Caldas Carlos
- Calvo Fabien
- Camacho Niedzica
- Campbell Peter J.
- Campo Elias
- Cantù Cinzia
- Cao Shaolong
- Carey Thomas E.
- Carlevaro-Fita Joana
- Carlsen Rebecca
- Cataldo Ivana
- Cazzola Mario
- Cebon Jonathan
- Cerfolio Robert
- Chadwick Dianne E.
- Chakravarty Dimple
- Chalmers Don
- Chan Calvin Wing Yiu
- Chan Kin
- Chan-Seng-Yue Michelle
- Chandan Vishal S.
- Chang David K.
- Chanock Stephen J.
- Chantrill Lorraine A.
- Chateigner Aurélien
- Chatterjee Nilanjan
- Chayama Kazuaki
- Chen Hsiao-Wei
- Chen Jieming
- Chen Ken
- Chen Yiwen
- Chen Zhaohong
- Cherniack Andrew D.
- Chien Jeremy
- Chiew Yoke-Eng
- Chin Suet-Feung
- Chiotti Kami
- Cho Juok
- Cho Sunghoon
- Choi Jung Kyoon
- Choi Wan
- Chomienne Christine
- Chong Zechen
- Choo Su Pin
- Chou Angela
- Christ Angelika N.
- Christie Elizabeth L.
- Chuah Eric
- Cibulskis Carrie
- Cibulskis Kristian
- Cingarlini Sara
- Clapham Peter
- Claviez Alexander
- Cleary Sean
- Cloonan Nicole
- Cmero Marek
- Collins Colin C.
- Connor Ashton A.
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- Cooper Colin S.
- Cope Leslie
- Corbo Vincenzo
- Cordes Matthew G.
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- Covington Kyle
- Cowin Prue A.
- Craft Brian
- Craft David
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- Creighton Chad J.
- Cun Yupeng
- Curley Erin
- Cutcutache Ioana
- Czajka Karolina
- Czerniak Bogdan
- Dagg Rebecca A.
- Danilova Ludmila
- Davi Maria Vittoria
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- Davis Ian J.
- Davis-Dusenbery Brandi N.
- Dawson Kevin J.
- De Bono Johann S.
- De La Vega Francisco M.
- De Paoli-Iseppi Ricardo
- deFazio Anna
- Defreitas Timothy
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- Demidov German M.
- Demircioğlu Deniz
- Dennis Nening M.
- Denroche Robert E.
- Dentro Stefan C.
- Desai Nikita
- Deshpande Vikram
- Deshwar Amit G.
- Desmedt Christine
- Deu-Pons Jordi
- Dhalla Noreen
- Dhani Neesha C.
- Dhingra Priyanka
- Dhir Rajiv
- Diamanti Klev
- DiBiase Anthony
- Ding Li
- Ding Shuai
- Dinh Huy Q.
- Dirix Luc
- Doddapaneni HarshaVardhan
- Dong Guanlan
- Donmez Nilgun
- Dow Michelle T.
- Drapkin Ronny
- Drechsel Oliver
- Drews Ruben M.
- Dudderidge Tim
- Dueso-Barroso Ana
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- Eagles Jenna
- Easton Douglas F.
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- Ellrott Kyle
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- Escaramis Georgia
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- Estivill Xavier
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- Eyfjord Jorunn E.
- Faltas Bishoy M.
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- Fan Yu
- Faquin William C.
- Farcas Claudiu
- Fassan Matteo
- Fatima Aquila
- Favero Francesco
- Fayzullaev Nodirjon
- Felau Ina
- Fereday Sian
- Ferguson Martin L.
- Ferretti Vincent
- Feuerbach Lars
- Field Matthew A.
- Fink J. Lynn
- Finocchiaro Gaetano
- Fisher Cyril
- Fittall Matthew W.
- Fitzgerald Anna
- Fitzgerald Rebecca C.
- Flanagan Adrienne M.
- Fleshner Neil E.
- Flicek Paul
- Foekens John A.
- Foltz Steven
- Fong Kwun M.
- Fonseca Nuno A.
- Foster Christopher S.
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- Fraser Michael
- Frazer Scott
- Frenkel-Morgenstern Milana
- Friedman William
- Frigola Joan
- Fronick Catrina C.
- Fujimoto Akihiro
- Fujita Masashi
- Fukayama Masashi
- Fulton Lucinda A.
- Fulton Robert S.
- Furuta Mayuko
- Futreal P. Andrew
- Füllgrabe Anja
- Gabriel Stacey B.
- Gallinger Steven
- Gambacorti-Passerini Carlo
- Gao Jianjiong
- Gao Shengjie
- Garraway Levi
- Garred Øystein
- Garrison Erik
- Garsed Dale W.
- Gehlenborg Nils
- Gelpi Josep L. l.
- George Joshy
- Gerhard Daniela S.
- Gerhauser Clarissa
- Gershenwald Jeffrey E.
- Gerstein Mark B.
- Gerstung Moritz
- Getz Gad
- Ghori Mohammed
- Ghossein Ronald
- Giama Nasra H.
- Gibbs Richard A.
- Gill Anthony J.
- Gill Pelvender
- Giri Dilip D.
- Glodzik Dominik
- Gnanapragasam Vincent J.
- Goebler Maria Elisabeth
- Goldman Mary J.
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- Gonzalez-Perez Abel
- Gordenin Dmitry A.
- Gossage James
- Gotoh Kunihito
- Govindan Ramaswamy
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- Greger Liliana
- Grehan Nicola
- Grimaldi Sonia
- Grimmond Sean M.
- Grossman Robert L.
- Grundhoff Adam
- Gundem Gunes
- Guo Qianyun
- Gupta Manaswi
- Gupta Shailja
- Gut Ivo G.
- Gut Marta
- Göke Jonathan
- Ha Gavin
- Haake Andrea
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- Haas Siegfried
- Haase Kerstin
- Haber James E.
- Habermann Nina
- Hach Faraz
- Haider Syed
- Hale Walker
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- Hamdy Freddie C.
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- Hanna George B.
- Hansmann Martin
- Haradhvala Nicholas J.
- Harismendy Olivier
- Harliwong Ivon
- Harmanci Arif O.
- Harrington Eoghan
- Hasegawa Takanori
- Haussler David
- Hawkins Steve
- Hayami Shinya
- Hayashi Shuto
- Hayes D. Neil
- Hayes Stephen J.
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- Hazell Steven
- He Yao
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- Hedley David
- Hegde Apurva M.
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- Heinold Michael C.
- Heins Zachary
- Heisler Lawrence E.
- Hellstrom-Lindberg Eva
- Helmy Mohamed
- Heo Seong Gu
- Hepperla Austin J.
- Heredia-Genestar José María
- Herrmann Carl
- Hersey Peter
- Hess Julian M.
- Hilmarsdottir Holmfridur
- Hinton Jonathan
- Hirano Satoshi
- Hiraoka Nobuyoshi
- Hoadley Katherine A.
- Hobolth Asger
- Hodzic Ermin
- Hoell Jessica I.
- Hoffmann Steve
- Hofmann Oliver
- Holbrook Andrea
- Holik Aliaksei Z.
- Hollingsworth Michael A.
- Holmes Oliver
- Holt Robert A.
- Hong Chen
- Hong Eun Pyo
- Hong Jongwhi H.
- Hooijer Gerrit K.
- Hornshøj Henrik
- Hosoda Fumie
- Hou Yong
- Hovestadt Volker
- Howat William
- Hoyle Alan P.
- Hruban Ralph H.
- Hu Jianhong
- Hu Taobo
- Hua Xing
- Huang Kuan-lin
- Huang Mei
- Huang Mi Ni
- Huang Vincent
- Huang Yi
- Huber Wolfgang
- Hudson Thomas J.
- Hummel Michael
- Hung Jillian A.
- Huntsman David
- Hupp Ted R.
- Huse Jason
- Huska Matthew R.
- Hutter Barbara
- Hutter Carolyn M.
- Hübschmann Daniel
- Iacobuzio-Donahue Christine A.
- Imbusch Charles David
- Imielinski Marcin
- Imoto Seiya
- Isaacs William B.
- Isaev Keren
- Ishikawa Shumpei
- Iskar Murat
- Islam S. M. Ashiqul
- Ittmann Michael
- Ivkovic Sinisa
- Izarzugaza Jose M. G.
- Jacquemier Jocelyne
- Jakrot Valerie
- Jamieson Nigel B.
- Jan Komorowski
- Jang Gun Ho
- Jang Se Jin
- Jayaseelan Joy C.
- Jayasinghe Reyka
- Jefferys Stuart R.
- Jegalian Karine
- Jennings Jennifer L.
- Jeon Seung-Hyup
- Jerman Lara
- Ji Yuan
- Jiao Wei
- Johansson Peter A.
- Johns Amber L.
- Johns Jeremy
- Johnson Rory
- Johnson Todd A.
- Jolly Clemency
- Joly Yann
- Jonasson Jon G.
- Jonathan Dursi Lewis
- Jones Corbin D.
- Jones David R.
- Jones David T. W.
- Jones Nic
- Jones Steven J. M.
- Jonkers Jos
- Ju Young Seok
- Juhl Hartmut
- Jung Jongsun
- Juul Malene
- Juul Randi Istrup
- Juul Sissel
- Jäger Natalie
- Kabbe Rolf
- Kahles Andre
- Kahraman Abdullah
- Kaiser Vera B.
- Kakavand Hojabr
- Kalimuthu Sangeetha
- Kandoth Cyriac
- Kang Koo Jeong
- Karaszi Katalin
- Karlan Beth
- Karlić Rosa
- Karsch Dennis
- Kasaian Katayoon
- Kasapi Melpomeni
- Kassahn Karin S.
- Katai Hitoshi
- Kato Mamoru
- Katoh Hiroto
- Kawakami Yoshiiku
- Kay Jonathan D.
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- Kazanov Marat D.
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- Kebebew Electron
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- Kelso Sean
- Kench James G.
- Kennedy Catherine J.
- Kerssemakers Jules N. A.
- Khoo David
- Khoo Vincent
- Khuntikeo Narong
- Khurana Ekta
- Kilpinen Helena
- Kim Hark Kyun
- Kim Hyung-Lae
- Kim Hyung-Yong
- Kim Hyunghwan
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- Kim Jihoon
- Kim Jong K.
- Kim Youngwook
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- Kleinheinz Kortine
- Klimczak Leszek J.
- Knappskog Stian
- Kneba Michael
- Knoppers Bartha M.
- Koh Youngil
- Komura Daisuke
- Komura Mitsuhiro
- Kong Gu
- Kool Marcel
- Korbel Jan O.
- Korchina Viktoriya
- Korshunov Andrey
- Koscher Michael
- Koster Roelof
- Kote-Jarai Zsofia
- Koures Antonios
- Kovacevic Milena
- Kremeyer Barbara
- Kretzmer Helene
- Kreuz Markus
- Krishnamurthy Savitri
- Kube Dieter
- Kumar Kiran
- Kumar Pardeep
- Kumar Sushant
- Kumar Yogesh
- Kundra Ritika
- Kübler Kirsten
- Küppers Ralf
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- Laird Peter W.
- Lakhani Sunil R.
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- Lalonde Emilie
- Lamaze Fabien C.
- Lambert Adam
- Lander Eric
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- Larsimont Denis
- Larson Dave
- Larsson Erik
- Lathrop Mark
- Lau Loretta M. S.
- Lawerenz Chris
- Lawlor Rita T.
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lee Darlene
- Lee Donghoon
- Lee Eunjung Alice
- Lee Hee Jin
- Lee Jake June-Koo
- Lee Jeong-Yeon
- Lee Juhee
- Lee Ming Ta Michael
- Lee-Six Henry
- Lehmann Kjong-Van
- Lehrach Hans
- Lenze Dido
- Leonard Conrad R.
- Leongamornlert Daniel A.
- Leshchiner Ignaty
- Letaw John
- Letourneau Louis
- Letunic Ivica
- Levine Douglas A.
- Lewis Lora
- Ley Tim
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- Li Constance H.
- Li Haiyan Irene
- Li Jun
- Li Lin
- Li Shantao
- Li Siliang
- Li Xiaobo
- Li Xiaotong
- Li Xinyue
- Li Yilong
- Li Yize
- Liang Han
- Liang Sheng-Ben
- Liang Wen-Wei
- Lichter Peter
- Lin Pei
- Lin Ziao
- Linehan W. M.
- Lingjærde Ole Christian
- Liu Dongbing
- Liu Eric Minwei
- Liu Fei-Fei
- Liu Fenglin
- Liu Jia
- Liu Xingmin
- Livingstone Julie
- Livitz Dimitri
- Livni Naomi
- Lochovsky Lucas
- Loeffler Markus
- Long Georgina V.
- Lopez-Guillermo Armando
- Lou Shaoke
- Louis David N.
- Lovat Laurence B.
- Lu Yiling
- Lu Yong-Jie
- Lu Youyong
- Luchini Claudio
- Lungu Ilinca
- Luo Xuemei
- Luxton Hayley J.
- Lynch Andy G.
- Lype Lisa
- López Cristina
- López-Otín Carlos
- Ma Eric Z.
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- Yaspo Marie-Laure
- Yates Lucy
- Yau Christina
- Ye Chen
- Ye Kai
- Yellapantula Venkata D.
- Yoon Christopher J.
- Yoon Sung-Soo
- Yousif Fouad
- Yu Jun
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- Yuan Yuan
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- Yugawa Takashi
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- Zaikova Olga
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- Zapatka Marc
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- Zhang Hongwei
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- Zhang Junjun
- Zhang Xiuqing
- Zhang Xuanping
- Zhang Yan
- Zhang Zemin
- Zhao Zhongming
- Zheng Liangtao
- Zheng Xiuqing
- Zhou Wanding
- Zhou Yong
- Zhu Hongtu
- Zhu Jingchun
- Zhu Shida
- Zou Lihua
- Zou Xueqing
- Publication venue
- Nature Communications
- Publication date
- 01/12/2020
- Field of study
Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts