INDIGENOUS SUSTAINABLE FINANCE AND SUSTAINABLE DEVELOPMENT GOALS: CONTRIBUTIONS FROM REDD+ IN BRAZIL

Indigenous sustainable finance has emerged as a promising research field to understand how indigenous communities can address sustainable governance and economic development issues based on their relationship with the land and cultural aspects. Furthermore, the SDGs have offered a development guide for economies worldwide whilst it pushes forward the applied efforts in pursuing a sustainable future based on its 17 principles. Indigenous territories, in this case, can be understood as an essential asset that can contribute to maintaining biodiversity and remunerating communities for preserving forests, with REDD+ projects constituting a vital initiative to encourage compensation processes for economic activities. This study describes a case of Indigenous Sustainable Finance in Brazil using REDD++ and provides linkages to the Sustainable Development Goals Agenda. Results reveal that new parameters that can contribute to REDD+ processes developed by indigenous communities in Brazil should be set, facilitating the organizational strategy, credit access and territory governance status. Implications for sustainable finance are centred on developing successful constellations of stakeholder action towards social good through green, transitional and heritage bonds

Arterial Pressure Management in a Reconstructive Microsurgery Patients by Dopamine Infusion in a Nonintensive Care Ward

Free flap perfusion and arterial pressure management have always had a crucial role in free flap reconstruction. Blood pressure values requested can be reached either by using vasoactive agents or fluid replacement or the combination of both.1,2 In contrast to the most frequently tested phenylephrine, norepinephrine, and dobutamine,3,4 this work evaluates dopamine efficacy in perioperative blood pressure management. In our institution, dopamine infusion is the only vasoactive agent authorized in a non-intensive care unit department. This drug stimulates \u3b1- and \u3b2-adrenergic receptors with positive chronotropic and inotropic effects and reduces peripheral vascular resistance helping in this way to achieve an increase of blood pressure and free flap perfusion.

The influence of naturalness of the landscape structure on children’s connectedness to Nature in north-eastern Italy

Connectedness to Nature and the ability to perceive the restorative value of places characterised by the presence of natural elements are personal characteristics that, when appropriately measured, make it possible to predict an individual’s attitude towards pro-environmental behaviour. While these characteristics have an innate basis, they are also shaped by personal experiences and various cognitive, affective and sociocultural factors. In this exploratory study in North-eastern Italy, we delve into an interdisciplinary field that explores the relationship between the environment of the residential area and its impact on children's attitudes toward Nature. To do so, we conducted a comprehensive questionnaire amongst 533 primary schoolchildren, aged 6-11 years, to gauge their connectedness to Nature, their perceptions of restorativeness in surrounding natural settings, and their schoolyard environment. Drawing from optical satellite imageries, we calculated a combined multispectral index to assess the naturalness degree of participants' residential areas, focusing on their 68 residential areas, located in three administrative Italian Regions (Trentino Alto Adige, Friuli Venezia Giulia and Veneto), which were classified into four different classes with respect to their level of presence of natural areas ("coastal," "low," "average," "high"). By performing non-parametric tests for multiple comparisons amongst groups, we detected a significantly higher level of connectedness to Nature amongst children living in areas with high naturalness, compared to those living in areas with average or low naturalness. Perceived restorativeness scores exhibit a similar trend to that of connectedness to Nature, reinforcing the importance of natural spaces in fostering positive attitudes towards the environment. This result confirms that accessibility and the viewability of natural spaces, even semi-natural ones, seemed to play a crucial role in children's preference for these environments. However, schoolyards were consistently perceived as less regenerative than natural places, regardless of the naturalness of the neighbourhood. These findings raise intriguing questions about the potential consequences of inadequate exposure to Nature on children's affiliation to the natural world and possible subsequent effects on pro-environmental behaviour in adulthood. By shedding light on the complex interplay between personal characteristics, environment and attitudes towards Nature, our study underscores the significance of fostering a deeper connection with natural spaces to nurture a sustainable and environmentally conscious society

Carbamazepine-induced thrombocytopenic purpura in a child: Insights from a genomic analysis

To the Editor, Carbamazepine is an effective anticonvulsant and has a relatively low incidence of adverse effects, although it occasionally causes hema- tologic disorders. We herein describe a patient with carbamazepine- induced thrombocytopenic purpura that was investigated by pharma- cological, immunological and genomic assays

Neurofibromin Deficiency and Extracellular Matrix Cooperate to Increase Transforming Potential through FAK-Dependent Signaling

Simple SummaryNeurofibromatosis type 1 is a genetic disease that predisposes to tumors of the nervous system, primarily the neurofibroma. Plexiform neurofibromas (Pnfs) are of the greatest concern because of location, size, and frequent progression to malignancy. Although research is making great progress, the lack of in-depth understanding of the molecular mechanisms driving neoplastic progression results in the absence of prognostic indicators and therapeutic targets. We document that cell-cell cooperativity and the dynamics of the extracellular matrix play important roles in the growth and transformation of Pnf cells, directly through the cooperation of RAS and focal adhesion kinase (FAK) signaling. In turn, we found that treatment of Pnf cells with both MEK and FAK inhibitors is effective in abolishing the transforming ability of these cells.Plexiform neurofibromas (Pnfs) are benign peripheral nerve sheath tumors that are major features of the human genetic syndrome, neurofibromatosis type 1 (NF1). Pnfs are derived from Schwann cells (SCs) undergoing loss of heterozygosity (LOH) at the NF1 locus in an NF1(+/-) milieu and thus are variably lacking in the key Ras-controlling protein, neurofibromin (Nfn). As these SCs are embedded in a dense desmoplastic milieu of stromal cells and abnormal extracellular matrix (ECM), cell-cell cooperativity (CCC) and the molecular microenvironment play essential roles in Pnf progression towards a malignant peripheral nerve sheath tumor (MPNST). The complexity of Pnf biology makes treatment challenging. The only approved drug, the MEK inhibitor Selumetinib, displays a variable and partial therapeutic response. Here, we explored ECM contributions to the growth of cells lacking Nfn. In a 3D in vitro culture, NF1 loss sensitizes cells to signals from a Pnf-mimicking ECM through focal adhesion kinase (FAK) hyperactivation. This hyperactivation correlated with phosphorylation of the downstream effectors, Src, ERK, and AKT, and with colony formation. Expression of the GAP-related domain of Nfn only partially decreased activation of this signaling pathway and only slowed down 3D colony growth of cells lacking Nfn. However, combinatorial treatment with both the FAK inhibitor Defactinib (VS-6063) and Selumetinib (AZD6244) fully suppressed colony growth. These observations pave the way for a new combined therapeutic strategy simultaneously interfering with both intracellular signals and the interplay between the various tumor cells and the ECM

Ischemic wound revascularization by the stromal vascular fraction relies on host-donor hybrid vessels

Nonhealing wounds place a significant burden on both quality of life of affected patients and health systems. Skin substitutes are applied to promote the closure of nonhealing wounds, although their efficacy is limited by inadequate vascularization. The stromal vascular fraction (SVF) from the adipose tissue is a promising therapy to overcome this limitation. Despite a few successful clinical trials, its incorporation in the clinical routine has been hampered by their inconsistent results. All these studies concluded by warranting pre-clinical work aimed at both characterizing the cell types composing the SVF and shedding light on their mechanism of action. Here, we established a model of nonhealing wound, in which we applied the SVF in combination with a clinical-grade skin substitute. We purified the SVF cells from transgenic animals to trace their fate after transplantation and observed that it gave rise to a mature vascular network composed of arteries, capillaries, veins, as well as lymphatics, structurally and functionally connected with the host circulation. Then we moved to a human-in-mouse model and confirmed that SVF-derived endothelial cells formed hybrid human-mouse vessels, that were stabilized by perivascular cells. Mechanistically, SVF-derived endothelial cells engrafted and expanded, directly contributing to the formation of new vessels, while a population of fibro-adipogenic progenitors stimulated the expansion of the host vasculature in a paracrine manner. These data have important clinical implications, as they provide a steppingstone toward the reproducible and effective adoption of the SVF as a standard care for nonhealing wounds

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe