The Lunar Lander Neutron and Dosimetry (LND) Experiment on Chang'E 4

Chang'E 4 is the first mission to the far side of the Moon and consists of a lander, a rover, and a relay spacecraft. Lander and rover were launched at 18:23 UTC on December 7, 2018 and landed in the von K\'arm\'an crater at 02:26 UTC on January 3, 2019. Here we describe the Lunar Lander Neutron \& Dosimetry experiment (LND) which is part of the Chang'E 4 Lander scientific payload. Its chief scientific goal is to obtain first active dosimetric measurements on the surface of the Moon. LND also provides observations of fast neutrons which are a result of the interaction of high-energy particle radiation with the lunar regolith and of their thermalized counterpart, thermal neutrons, which are a sensitive indicator of subsurface water content.Comment: 38 pages, submitted to Space Science Review

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

On determining the zenith angle dependence of the Martian radiation environment at Gale Crater altitudes

We report the zenith angle dependence of the radiation environment at Gale Crater on Mars. This is the first determination of this dependence on another planet than Earth and is important for future human exploration of Mars and understanding radiation effects in the Martian regolith

The charged particle radiation environment on Mars measured by MSL/RAD from November 15, 2015 to January 15, 2016

The Radiation Assessment Detector (RAD) on board the Mars Science Laboratory (MSL) Curiosity rover has been measuring the radiation environment in Gale crater on Mars since August, 2012. These first in-situ measurements provide an important data set for assessing the radiation-associated health risks for future manned missions to Mars. Mainly, the radiation field on the Martian surface stems from Galactic Cosmic Rays (GCRs) and secondary particles created by the GCRs’ interactions with the Martian atmosphere and soil. RAD is capable of measuring differential particle fluxes for lower-energy ions and isotopes of hydrogen and helium (up to hundreds of MeV/nuc). Additionally, RAD also measures integral particle fluxes for higher energies of these ions. Besides providing insight on the current Martian radiation environment, these fluxes also present an essential input for particle transport codes that are used to model the radiation to be encountered during future manned missions to Mars. Comparing simulation results with actual ground-truth measurements helps to validate these transport codes and identify potential areas of improvements in the underlying physics of these codes. At the First Mars Radiation Modeling Workshop (June 2016 in Boulder, CO), different groups of modelers were asked to calculate the Martian surface radiation environment for the time of November 15, 2015 to January 15, 2016. These model results can then be compared with in-situ measurements of MSL/RAD conducted during the same time frame. In this publication, we focus on presenting the charged particle fluxes measured by RAD between November 15, 2015 and January 15, 2016, providing the necessary data set for the comparison to model outputs from the modeling workshop. We also compare the fluxes to initial GCR intensities, as well as RAD measurements from an earlier time period (August 2012 to January 2013). Furthermore, we describe how changes and updates in RAD on board processing and the on ground analysis tools effect and improve the flux calculations. An in-depth comparison of modeling results from the workshop and RAD fluxes of this publication is presented elsewhere in this issue (Matthiä et al., 2017)

Charged particle spectra measured during the transit to Mars with the Mars Science Laboratory Radiation Assessment Detector (MSL/RAD)

The Mars Science Laboratory (MSL) started its 253-day cruise to Mars on November 26, 2011. During cruise the Radiation Assessment Detector (RAD), situated on board the Curiosity rover, conducted mea- surements of the energetic-particle radiation environment inside the spacecraft. This environment con- sists mainly of galactic cosmic rays (GCRs), as well as secondary particles created by interactions of these GCRs with the spacecraft. The RAD measurements can serve as a proxy for the radiation environment a human crew would encounter during a transit to Mars, for a given part of the solar cycle, assuming that a crewed vehicle would have comparable shielding. The measurements of radiological quantities made by RAD are important in themselves, and, the same data set allow for detailed analysis of GCR-induced particle spectra inside the spacecraft. This provides important inputs for the evaluation of current trans- port models used to model the free-space (and spacecraft) radiation environment for different spacecraft shielding and different times in the solar cycle. Changes in these conditions can lead to significantly different radiation fields and, thus, potential health risks, emphasizing the need for validated transport codes. Here, we present the first measurements of charged particle fluxes inside a spacecraft during the transit from Earth to Mars. Using data obtained during the last two month of the cruise to Mars (June 11–July 14, 2012), we have derived detailed energy spectra for low-Z particles stopping in the instru- ment’s detectors, as well as integral fluxes for penetrating particles with higher energies. Furthermore, we analyze the temporal changes in measured proton fluxes during quiet solar periods (i.e., when no so- lar energetic particle events occurred) over the duration of the transit (December 9, 2011–July 14, 2012) and correlate them with changing heliospheric conditions

Unusually long path length for a nearly scatter-free solar particle event observed by Solar Orbiter at 0.43 au

Context. After their acceleration and release at the Sun, solar energetic particles (SEPs) are injected into the interplanetary medium and are bound to the interplanetary magnetic field (IMF) by the Lorentz force. The expansion of the IMF close to the Sun focuses the particle pitch-angle distribution, and scattering counteracts this focusing. Solar Orbiter observed an unusual solar particle event on 9 April 2022 when it was at 0.43 astronomical units (au) from the Sun. Aims. We show that the inferred IMF along which the SEPs traveled was about three times longer than the nominal length of the Parker spiral and provide an explanation for this apparently long path. Methods. We used velocity dispersion analysis (VDA) information to infer the spiral length along which the electrons and ions traveled and infer their solar release times and arrival direction. Results. The path length inferred from VDA is approximately three times longer than the nominal Parker spiral. Nevertheless, the pitch-angle distribution of the particles of this event is highly anisotropic, and the electrons and ions appear to be streaming along the same IMF structures. The angular width of the streaming population is estimated to be approximately 30 degrees. The highly anisotropic ion beam was observed for more than 12 h. This may be due to the low level of fluctuations in the IMF, which in turn is very probably due to this event being inside an interplanetary coronal mass ejection The slow and small rotation in the IMF suggests a flux-rope structure. Small flux dropouts are associated with very small changes in pitch angle, which may be explained by different flux tubes connecting to different locations in the flare region. Conclusions. The unusually long path length along which the electrons and ions have propagated virtually scatter-free together with the short-term flux dropouts offer excellent opportunities to study the transport of SEPs within interplanetary structures. The 9 April 2022 solar particle event offers an especially rich number of unique observations that can be used to limit SEP transport models