Erstellung der Adjektivliste für eine englische Version des Big Five Plus One

Analog zu dem Persönlichkeitsverfahren Big Five Plus One (Kurz: B5PO; Holocher-Ertl, Kubinger & Menghin, 2003) und dessen Grundlage, die Diplomarbeit von Holocher-Ertl (2003), wurde eine Adjektivliste in englischer Sprache erstellt. Zunächst wurden dafür über 400 Adjektivpaare mit einem Fragebogen erhoben, der auf dem Repertory-Grid von Kelly (1955) beruht, . Nach einer Auswahl, unter anderem durch englische Muttersprachler, entstand eine Liste von 67 Adjektivpaaren, die besonders geeignet erschienen, Personen adäquat zu beschreiben und damit potentielle Items für den B5PO-English waren. Diese wurden schließlich in einem eigens dafür programmierten Online-Verfahren englischsprachigen Personen vorgegeben. Die Teilnehmer sollten sich, wie bei der Ursprungsversion des B5PO mittels einer Analogskala, einem der beiden Adjektive zuordnen und damit eine Selbsteinschätzung ihrer Person vornehmen. Insgesamt wurden 208 Teilnehmer mit gültige Datensätze erhoben, wobei nur Personen im Altersbereich von 16 bis 35 Jahren berücksichtigt wurden. Bei der statistischen Auswertung der Ergebnisse (Faktorenanalyse und Rasch-Modell Analysen) stellte sich heraus, dass die Adjektivpaare letztendlich in die folgenden sechs Dimensionen eingeteilt werden konnten: Agreeableness, Emotional Stability, Extraversion, Conscientiousness, Openness und Empathy, womit die Dimensionen von Holocher-Ertl (2003) auch für die englische Version des B5PO bestätigt wurden. Darüber hinaus sind die sechs Dimensionen der Adjektivliste ebenfalls Rasch-Modell-konform. Die neue endgültige Itemliste für den B5PO-English umfasst 61 bipolare Items, die Persönlichkeitseigenschaften eindimensional erheben.Based on the personality inventory Big Five Plus One (B5PO) (Holocher-Ertl, Kubinger & Menghin, 2003) and the diploma thesis of Holocher-Ertl (2003) a new list of English adjectives was created. At first a questionnaire, based on Kelly’s Repertory-Grid (1955), ascertained more than 400 pairs of adjectives. Pairs, describing people adequately, were selected by native English speakers, resulting in a list of 67 pairs of adjectives, which are possibly new items of the B5PO-English. These pairs of adjectives were presented to English speakers in an online-survey. Like in the original version of the B5PO, participants had to choose one of the two adjectives, which they thought would describe themselves, using an analog scale. A total sample of 208 participants with valid data sets was collected, including persons aged between 16 and 35 years. The results of the statistical analysis (factor analysis and Rasch model analysis) showed that the adjectives revealed the six dimensions: Agreeableness, Emotional Stability, Extraversion, Conscientious, Openness and Empathy. These results approve the dimensions Holocher-Ertl has assumed in her thesis, also for the English version of the B5PO. Furthermore each of the six dimensions also conforms to the Rasch model. The final list of items for the B5PO-English contains 61 bipolar items, which survey personality traits unidimensionally

A multibranch, multitarget neural network for rapid point-source inversion in a microseismic environment: examples from the Hengill Geothermal Field, Iceland

Despite advanced seismological techniques, automatic source characterization for microseismic earthquakes remains difficult and challenging since current inversion and modelling of high-frequency signals are complex and time consuming. For real-time applications such as induced seismicity monitoring, the application of standard methods is often not fast enough for true complete real-time information on seismic sources. In this paper, we present an alternative approach based on recent advances in deep learning for rapid source-parameter estimation of microseismic earthquakes. The seismic inversion is represented in compact form by two convolutional neural networks, with individual feature extraction, and a fully connected neural network, for feature aggregation, to simultaneously obtain full moment tensor and spatial location of microseismic sources. Specifically, a multibranch neural network algorithm is trained to encapsulate the information about the relationship between seismic waveforms and underlying point-source mechanisms and locations. The learning-based model allows rapid inversion (within a fraction of second) once input data are available. A key advantage of the algorithm is that it can be trained using synthetic seismic data only, so it is directly applicable to scenarios where there are insufficient real data for training. Moreover, we find that the method is robust with respect to perturbations such as observational noise and data incompleteness (missing stations). We apply the new approach on synthesized and example recorded small magnitude (M <= 1.6) earthquakes at the Hellisheioi geothermal field in the Hengill area, Iceland. For the examined events, the model achieves excellent performance and shows very good agreement with the inverted solutions determined through standard methodology. In this study, we seek to demonstrate that this approach is viable for microseismicity real-time estimation of source parameters and can be integrated into advanced decision-support tools for controlling induced seismicity

Induced seismicity risk analysis of the hydraulic stimulation of a geothermal well on Geldinganes, Iceland

The rapid increase in energy demand in the city of Reykjavik has posed the need for an additional supply of deep geothermal energy. The deep-hydraulic (re-)stimulation of well RV-43 on the peninsula of Geldinganes (north of Reykjavik) is an essential component of the plan implemented by Reykjavik Energy to meet this energy target. Hydraulic stimulation is often associated with fluid-induced seismicity, most of which is not felt on the surface but which, in rare cases, can be a nuisance to the population and even damage the nearby building stock. This study presents a first-of-its-kind pre-drilling probabilistic induced seismic hazard and risk analysis for the site of interest. Specifically, we provide probabilistic estimates of peak ground acceleration, European microseismicity intensity, probability of light damage (damage risk), and individual risk. The results of the risk assessment indicate that the individual risk within a radius of 2 km around the injection point is below 0.1 micromorts, and damage risk is below 10−2, for the total duration of the project. However, these results are affected by several orders of magnitude of variability due to the deep uncertainties present at all levels of the analysis, indicating a critical need in updating this risk assessment with in situ data collected during the stimulation. Therefore, it is important to stress that this a priori study represents a baseline model and starting point to be updated and refined after the start of the project

Dietary patterns and risk of inflammatory bowel disease in Europe: Results from the EPIC study

Background: Dairy products may be involved in the etiology of inflammatory bowel disease by modulating gut microbiota and immune responses, but data from epidemiological studies examining this relationship are limited. We investigated the association between prediagnostic intake of these foods and dietary calcium and the subsequent development of Crohn’s disease (CD) and ulcerative colitis (UC). Methods: In total, 401,326 participants were enrolled in the European Prospective Investigation into Cancer and Nutrition cohort. At recruitment, consumption of total and specific dairy products (milk, yogurt, cheese) and dietary calcium was measured using validated food frequency questionnaires. Cases developing incident CD (n=110) or UC (n=244) during followup were matched with four controls. Conditional logistic regression analyses were used to calculate odds ratios (ORs) with 95% confidence intervals (CIs), adjusted for total energy intake and smoking. Results: Compared with the lowest quartile, the ORs for the highest quartile of total dairy products and dietary calcium intake were 0.61 (95% CI 0.32-1.19, p trend=0.19) and 0.63 (95% CI 0.28-1.42, p trend=0.23) for CD and 0.80 (95% CI 0.50-1.30, p trend=0.40) and 0.81 (95% CI 0.49-1.34, p trend=0.60) for UC. Compared with nonconsumers, individuals consuming milk had significantly reduced odds of CD (OR 0.30, 95% CI 0.13-0.65) and nonsignificantly reduced odds of UC (OR 0.85, 95% CI 0.49-1.47). Conclusions: Milk consumption may be associated with a decreased risk of developing CD, although a clear dose-response relationship was not established. Further studies are warranted to confirm this possible protective effect

A Novel Soluble Immune-Type Receptor (SITR) in Teleost Fish: Carp SITR Is Involved in the Nitric Oxide-Mediated Response to a Protozoan Parasite

Background- The innate immune system relies upon a wide range of germ-line encoded receptors including a large number of immunoglobulin superfamily (IgSF) receptors. Different Ig-like immune receptor families have been reported in mammals, birds, amphibians and fish. Most innate immune receptors of the IgSF are type I transmembrane proteins containing one or more extracellular Ig-like domains and their regulation of effector functions is mediated intracellularly by distinct stimulatory or inhibitory pathways. Methodology/Principal Findings - Carp SITR was found in a substracted cDNA repertoire from carp macrophages, enriched for genes up-regulated in response to the protozoan parasite Trypanoplasma borreli. Carp SITR is a type I protein with two extracellular Ig domains in a unique organisation of a N-proximal V/C2 (or I-) type and a C-proximal V-type Ig domain, devoid of a transmembrane domain or any intracytoplasmic signalling motif. The carp SITR C-proximal V-type Ig domain, in particular, has a close sequence similarity and conserved structural characteristics to the mammalian CD300 molecules. By generating an anti-SITR antibody we could show that SITR protein expression was restricted to cells of the myeloid lineage. Carp SITR is abundantly expressed in macrophages and is secreted upon in vitro stimulation with the protozoan parasite T. borreli. Secretion of SITR protein during in vivo T. borreli infection suggests a role for this IgSF receptor in the host response to this protozoan parasite. Overexpression of carp SITR in mouse macrophages and knock-down of SITR protein expression in carp macrophages, using morpholino antisense technology, provided evidence for the involvement of carp SITR in the parasite-induced NO production. Conclusion/Significance - We report the structural and functional characterization of a novel soluble immune-type receptor (SITR) in a teleost fish and propose a role for carp SITR in the NO-mediated response to a protozoan parasite

Risk thresholds for alcohol consumption : combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies

Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease, we studied individual-participant data from 599 912 current drinkers without previous cardiovascular disease. Methods We did a combined analysis of individual-participant data from three large-scale data sources in 19 high-income countries (the Emerging Risk Factors Collaboration, EPIC-CVD, and the UK Biobank). We characterised dose-response associations and calculated hazard ratios (HRs) per 100 g per week of alcohol (12.5 units per week) across 83 prospective studies, adjusting at least for study or centre, age, sex, smoking, and diabetes. To be eligible for the analysis, participants had to have information recorded about their alcohol consumption amount and status (ie, non-drinker vs current drinker), plus age, sex, history of diabetes and smoking status, at least 1 year of follow-up after baseline, and no baseline history of cardiovascular disease. The main analyses focused on current drinkers, whose baseline alcohol consumption was categorised into eight predefined groups according to the amount in grams consumed per week. We assessed alcohol consumption in relation to all-cause mortality, total cardiovascular disease, and several cardiovascular disease subtypes. We corrected HRs for estimated long-term variability in alcohol consumption using 152 640 serial alcohol assessments obtained some years apart (median interval 5.6 years [5th-95th percentile 1.04-13.5]) from 71 011 participants from 37 studies. Findings In the 599 912 current drinkers included in the analysis, we recorded 40 310 deaths and 39 018 incident cardiovascular disease events during 5.4 million person-years of follow-up. For all-cause mortality, we recorded a positive and curvilinear association with the level of alcohol consumption, with the minimum mortality risk around or below 100 g per week. Alcohol consumption was roughly linearly associated with a higher risk of stroke (HR per 100 g per week higher consumption 1.14, 95% CI, 1.10-1.17), coronary disease excluding myocardial infarction (1.06, 1.00-1.11), heart failure (1.09, 1.03-1.15), fatal hypertensive disease (1.24, 1.15-1.33); and fatal aortic aneurysm (1.15, 1.03-1.28). By contrast, increased alcohol consumption was loglinearly associated with a lower risk of myocardial infarction (HR 0.94, 0.91-0.97). In comparison to those who reported drinking >0-100-200-350 g per week had lower life expectancy at age 40 years of approximately 6 months, 1-2 years, or 4-5 years, respectively. Interpretation In current drinkers of alcohol in high-income countries, the threshold for lowest risk of all-cause mortality was about 100 g/week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk thresholds below which lower alcohol consumption stopped being associated with lower disease risk. These data support limits for alcohol consumption that are lower than those recommended in most current guidelines. Copyright (C) The Author(s). Published by Elsevier Ltd.Peer reviewe