Selective information use and perseveration in the search behavior of infants and young children

Two experiments examined the early development of selective information use in search. The first experiment tested 9- and 16-month-olds on a modification of Piaget's Stage IV object permanence task. It examined infants' use of information from previous experiences with an object (prior information) and from the most recent hiding (current information) to locate a hidden object. In the second experiment, 2-, -, and 4-year-old children received these same sources of information along with new forms of prior and current information: information about the typical locations of objects (location specificity) and verbal information. No systematic perseveration was observed at 9 months, although previous findings related to perseveration were replicated. Perseveration was found at 16 months, but there was also evidence of selectivity at that age. When errors occurred, they tended to be to the prior location, but they were infrequent in comparison to correct searches at the current location. The preschoolers, while continuing to show perseveration, were more consistently selective than the infants. They also showed considerable generality in extending their selectivity to new sources of information.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/25209/1/0000649.pd

Does recognition memory improve with age?

In order to test the hypothesis that recognition is a developmentally stable component of the memory system, age differences in recognition of faces were examined while controlling for nonmemory factors that might contribute to differences between the groups. Three groups of children (mean ages: 3 years, 4 months; 4 years, 9 months; and 6 years, 11 months) and a group of college students were tested on a recognition task and a similar matching task. The results indicated no change in recognition across the preschool years but an improvement from the later preschool period to the first grade. Further analyses indicated that this improvement was not due to changes in decision criteria or perceptual skills. These findings call into question the view that recognition is a developmentally invariant component of the memory system.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/24243/1/0000506.pd

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study

Background: Surgical site infection (SSI) is one of the most common infections associated with health care, but its importance as a global health priority is not fully understood. We quantified the burden of SSI after gastrointestinal surgery in countries in all parts of the world. Methods: This international, prospective, multicentre cohort study included consecutive patients undergoing elective or emergency gastrointestinal resection within 2-week time periods at any health-care facility in any country. Countries with participating centres were stratified into high-income, middle-income, and low-income groups according to the UN's Human Development Index (HDI). Data variables from the GlobalSurg 1 study and other studies that have been found to affect the likelihood of SSI were entered into risk adjustment models. The primary outcome measure was the 30-day SSI incidence (defined by US Centers for Disease Control and Prevention criteria for superficial and deep incisional SSI). Relationships with explanatory variables were examined using Bayesian multilevel logistic regression models. This trial is registered with ClinicalTrials.gov, number NCT02662231. Findings: Between Jan 4, 2016, and July 31, 2016, 13 265 records were submitted for analysis. 12 539 patients from 343 hospitals in 66 countries were included. 7339 (58·5%) patient were from high-HDI countries (193 hospitals in 30 countries), 3918 (31·2%) patients were from middle-HDI countries (82 hospitals in 18 countries), and 1282 (10·2%) patients were from low-HDI countries (68 hospitals in 18 countries). In total, 1538 (12·3%) patients had SSI within 30 days of surgery. The incidence of SSI varied between countries with high (691 [9·4%] of 7339 patients), middle (549 [14·0%] of 3918 patients), and low (298 [23·2%] of 1282) HDI (p < 0·001). The highest SSI incidence in each HDI group was after dirty surgery (102 [17·8%] of 574 patients in high-HDI countries; 74 [31·4%] of 236 patients in middle-HDI countries; 72 [39·8%] of 181 patients in low-HDI countries). Following risk factor adjustment, patients in low-HDI countries were at greatest risk of SSI (adjusted odds ratio 1·60, 95% credible interval 1·05–2·37; p=0·030). 132 (21·6%) of 610 patients with an SSI and a microbiology culture result had an infection that was resistant to the prophylactic antibiotic used. Resistant infections were detected in 49 (16·6%) of 295 patients in high-HDI countries, in 37 (19·8%) of 187 patients in middle-HDI countries, and in 46 (35·9%) of 128 patients in low-HDI countries (p < 0·001). Interpretation: Countries with a low HDI carry a disproportionately greater burden of SSI than countries with a middle or high HDI and might have higher rates of antibiotic resistance. In view of WHO recommendations on SSI prevention that highlight the absence of high-quality interventional research, urgent, pragmatic, randomised trials based in LMICs are needed to assess measures aiming to reduce this preventable complication

The Origins of mathematical knowledge in childhood/ Sophian

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The Development of Search Behavior in Infancy and Early Childhood.

The information-processing skills underlying early search behavior were examined in two studies. One study was done with infants 9 and 16 months of age; the other with children 2, 2 1/2, and 4 years of age. The experimental task for both studies was based on Piaget's Stage IV object permanence task. In the infant study, children were given either hiding experience, finding experience, or both hiding and finding experience with a target object at one of three locations. This experience constituted a source of "prior" information about the object's location. Subsequently, the object was hidden at a different one of the three locations. The hiding was done either in full view of the infant or behind a screen. When the hiding was visible it was constituted a source of "current" information. The preschool study included all of the conditions from the infant study. In addition, two new forms of information were introduced that could not be used with infants. On some trials, current information was provided verbally instead of by allowing children to watch the object being hidden at the second location. Also, sometimes prior information was provided by using target objects and locations that were differentially associated with each other (e.g., pillow-bedroom) instead of by providing any specific experience at an initial location. The results of the two studies indicated that even the youngest infants were able to use information derived from watching as the object was hidden as a basis for search, but use of more indirect sources of information emerged only at the older ages. Use of prior information from experience at an initial location was evident by 16 months of age. Verbal information was used to some extent by the 2-year-old, but it was used more consistently by the older two age groups. Only the 4-year-olds showed reliable use of the information provided by using target objects and locations that were differentially associated. Further age differences emerged in the way children responded to conflicts between alternative sources of information. As early as 16 months of age, children showed some selectivity in their use of information, in that they gave precedence to current over prior information when the two were in conflict. However, selectivity continued to increase over the preschool years. There was no evidence of systematic perseveration at 9 months of age, contrary to Piagetian theory. However, perseveration was observed at older ages. This perseveration appeared to be more sophisticated than the Piagetian account implies, and it was necessarily incompatible with selective information use.PhDDevelopmental psychologyUniversity of Michiganhttp://deepblue.lib.umich.edu/bitstream/2027.42/157999/1/8025774.pd

Involuntary memory and the development of retrieval skills in young children

An incidental memory paradigm was used to study involuntary encoding processes and voluntary retrieval strategies in children's memory. Preschool (mean age: 4 years, 4 months) and kindergarten (mean age: 5 years, 10 months) children sorted pictures according to their color or category membership, and then received either a recall test (Experiment 1) or a recognition test (Experiment 2). Better retention of category- than color-sorted items was observed for kindergarten children in free recall, preschool and kindergarten children in cued recall, and neither group in recognition. These results were interpreted in terms of the retrieval strategies used by children in each of the memory tasks. The importance of distinguishing between voluntary and involuntary memory processes, and between acquisition and retrieval, in studies of depth-of-processing was emphasized. Developmental differences in performance appear to derive primarily from the role of voluntary search strategies in retrieval, rather than from age differences in involuntary encoding processes.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/22479/1/0000020.pd