229 research outputs found
Associations between tooth loss and prognostic biomarkers and the risk for cardiovascular events in patients with stable coronary heart disease
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2017
- Field of study
Background: Underlying mechanisms behind the hypothesized relationship between periodontal disease (PD) and coronary heart disease (CHD) have been insufficiently explored. We evaluated associations between self-reported tooth loss- a marker of PD- and prognostic biomarkers in 15,456 (97%) patients with stable CHD in the global STABILITY trial. Methods and results: Baseline blood samples were obtained and patients reported their number of teeth according to the following tooth loss levels: â26â32 (All)â [lowest level], â20â25â, â15â19â, â1â14â, and âNo Teethâ [highest level]. Linear and Cox regression models assessed associations between tooth loss levels and biomarker levels, and the relationship between tooth loss levels and outcomes, respectively. After multivariable adjustment, the relative biomarker increase between the highest and the lowest tooth loss level was: high-sensitivity C-reactive protein 1.21 (95% confidence interval, 1.14â1.29), interleukin 6 1.14 (1.10â1.18), lipoprotein-associated phospholipase A2 activity 1.05 (1.03â1.06), growth differentiation factor 15 1.11 (1.08â1.14), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) 1.18 (1.11â1.25). No association was detected for high-sensitivity troponin T 1.02 (0.98â1.05). Some attenuation of the relationship between tooth loss and outcomes resulted from the addition of biomarkers to the multivariable analysis, of which NT-proBNP had the biggest impact. Conclusions: A graded and independent association between tooth loss and several prognostic biomarkers was observed, suggesting that tooth loss and its underlying mechanisms may be involved in multiple pathophysiological pathways also implicated in the development and prognosis of CHD. The association between tooth loss and cardiovascular death and stroke persisted despite comprehensive adjustment including prognostic biomarkers
Complex effects of inhibiting hepatic apolipoprotein B100 synthesis in humans
- Author
- Publication venue
- 'Columbia University Libraries/Information Services'
- Publication date
- 01/01/2016
- Field of study
Mipomersen (KynamroÂź) is an antisense oligonucleotide (ASO) that inhibits apolipoprotein B (apoB) synthesis; its LDL lowering effects should, therefore, result from reduced secretion of VLDL. We enrolled 17 healthy volunteers who received placebo injections weekly for 3-wks followed by mipomersen weekly for 7-9 wks. Stable isotopes were used after each treatment to determine fractional catabolic rates (FCRs) and production rates (PRs) of apoB in VLDL, IDL, and LDL, and of TG in VLDL. Mipomersen significantly reduced apoB in VLDL, IDL, and LDL associated with increases in FCRs of VLDL and LDL apoB and reductions in PRs of IDL and LDL apoB. Unexpectedly, the PRs of VLDL apoB and VLDL TG were unaffected. siRNA knockdown of apoB expression in HepG2 cells demonstrated preservation of apoB secretion across a range of apoB synthesis. Titrated ASO knockdown of apoB mRNA in chow-fed mice showed preservation of both apoB and TG secretion. In contrast, titrated ASO knockdown of apoB mRNA in high fat fed mice resulted in stepwise reductions of both apoB and TG secretion. Mipomersen lowered all apoB-lipoproteins without reducing the PR of either VLDL apoB or TG. Our first-in-human data are consistent with longstanding models of post-transcriptional and post-translational regulation of apoB secretion, and are supported by experiments with siRNA in HepG2 cells and ASO in mice. These results indicate that targeting apoB synthesis can lower levels of apoB-lipoproteins without necessarily reducing VLDL secretion, thereby reducing the risk of steatosis associated with this therapeutic strategy
TOOTH LOSS IS INDEPENDENTLY ASSOCIATED WITH ADVERSE OUTCOME BUT NOT MYOCARDIAL INFARCTION IN PATIENTS WITH CHRONIC CORONARY HEART DISEASE
- Author
- Publication venue
- American College of Cardiology Foundation. Published by Elsevier Inc.
- Publication date
- 17/03/2015
- Field of study
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
- Abdinov O
- Abi B
- Abolins M
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- Acharya BS
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- Zhemchugov A
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâ„20 GeV and pseudorapidities {pipe}η{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}η{pipe}<0. 8) for jets with 60â€pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â€{pipe}η{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. © 2013 CERN for the benefit of the ATLAS collaboration
Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector
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- Yao W-M
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- Yorita K
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- Youssef S
- Yu D
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- Yu J
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- Zaets VG
- Zaidan R
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- Zajacova Z
- Zalite YK
- Zanello L
- Zarzhitsky P
- Zaytsev A
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- Zema PF
- Zemla A
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- Zenin AV
- Zenin O
- Zenis T
- Zenonos Z
- Zenz S
- Zerwas D
- Zhan Z
- Zhang D
- Zhang H
- Zhang J
- Zhang X
- Zhang Z
- Zhao L
- Zhao T
- Zhao Z
- Zhemchugov A
- Zheng S
- Zhong J
- Zhou B
- Zhou N
- Zhou Y
- Zhu CG
- Zhu H
- Zhu Y
- Zhuang X
- Zhuravlov V
- Zieminska D
- Zilka B
- Zimmermann R
- Zimmermann S
- Zimmermann S
- Ziolkowski M
- Zitoun R
- Zivkovic L
- Zmouchko VV
- Zobernig G
- Zoccoli A
- Zolnierowski Y
- Zsenei A
- zur Nedden M
- Zutshi V
- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 31/12/2010
- Field of study
The inclusive and dijet production cross-sections have been measured for jets
containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass
energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The
measurements use data corresponding to an integrated luminosity of 34 pb^-1.
The b-jets are identified using either a lifetime-based method, where secondary
decay vertices of b-hadrons in jets are reconstructed using information from
the tracking detectors, or a muon-based method where the presence of a muon is
used to identify semileptonic decays of b-hadrons inside jets. The inclusive
b-jet cross-section is measured as a function of transverse momentum in the
range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet
cross-section is measured as a function of the dijet invariant mass in the
range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets
and the angular variable chi in two dijet mass regions. The results are
compared with next-to-leading-order QCD predictions. Good agreement is observed
between the measured cross-sections and the predictions obtained using POWHEG +
Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet
cross-section. However, it does not reproduce the measured inclusive
cross-section well, particularly for central b-jets with large transverse
momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final
version published in European Physical Journal
Single hadron response measurement and calorimeter jet energy scale uncertainty with the ATLAS detector at the LHC
- Author
- A. A. Abdelalim
- A. A. Carter
- A. A. Grillo
- A. A. Komar
- A. A. Minaenko
- A. A. Nepomuceno
- A. A. Snesarev
- A. A. Solodkov
- A. Abdesselam
- A. Ahmad
- A. Akiyama
- A. Aloisio
- A. Alonso
- A. Amorim
- A. Andreazza
- A. Angerami
- A. Anisenkov
- A. Annovi
- A. Antonaki
- A. Antonov
- A. Artamonov
- A. Astbury
- A. Astvatsatourov
- A. B. Fenyuk
- A. B. Lazarev
- A. Bangert
- A. Barashkou
- A. Barbaro Galtieri
- A. Baroncelli
- A. Battaglia
- A. Beddall
- A. Belloni
- A. Bertin
- A. Bingul
- A. Blondel
- A. Bocci
- A. Bogdanchikov
- A. Bogouch
- A. Borisov
- A. Boveia
- A. Braem
- A. Brandt
- A. Bruni
- A. C. König
- A. C. Martyniuk
- A. C. Schaffer
- A. Canepa
- A. Catinaccio
- A. Cattai
- A. Cerri
- A. Chafaq
- A. Cheplakov
- A. Chilingarov
- A. Christov
- A. Ciocio
- A. Clark
- A. Coccaro
- A. Cortes-Gonzalez
- A. D. Doxiadis
- A. D. Hawkins
- A. D. Hershenhorn
- A. D. Pilkington
- A. De Salvo
- A. De Santo
- A. DellâAcqua
- A. Dewhurst
- A. Di Ciaccio
- A. Di Girolamo
- A. Di Mattia
- A. Di Simone
- A. Do Valle Wemans
- A. Doria
- A. Dos Anjos
- A. Dotti
- A. Dudarev
- A. DâOrazio
- A. E. Barton
- A. E. Kiryunin
- A. Engl
- A. Eppig
- A. Ereditato
- A. F. Saavedra
- A. Farbin
- A. Farilla
- A. Favareto
- A. Ferrari
- A. Ferrer
- A. Ferretto Parodi
- A. Filippas
- A. FilipÄiÄ
- A. Firan
- A. Floderus
- A. Formica
- A. Forti
- A. Foussat
- A. G. Buckley
- A. G. Goussiou
- A. G. Kholodenko
- A. G. Myagkov
- A. G. Olchevski
- A. G. Schamov
- A. Gaponenko
- A. Gemmell
- A. Gershon
- A. Gibson
- A. Glazov
- A. Gomes
- A. Gonidec
- A. GoriĆĄek
- A. Guida
- A. Gupta
- A. Haas
- A. Hamilton
- A. Harvey
- A. Henrichs
- A. Hoecker
- A. Hoummada
- A. Huettmann
- A. I. Etienvre
- A. I. Kononov
- A. I. Mincer
- A. Irles Quiles
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- A. J. Armbruster
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- A. Jeremie
- A. Juste Rozas
- A. K. Ciftci
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- A. Kapliy
- A. Kasmi
- A. Kastanas
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- A. Khodinov
- A. Khomich
- A. Khoroshilov
- A. Kiryunin
- A. Klier
- A. Klimentov
- A. Knue
- A. Kootz
- A. Korn
- A. Korol
- A. Kotwal
- A. Koutsman
- A. Krasznahorkay
- A. Kreisel
- A. Kruth
- A. Kugel
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- A. L. Maslennikov
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- A. La Rosa
- A. Larner
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- A. Leung Fook Cheong
- A. Lewis
- A. Limosani
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- A. Lister
- A. Lleres
- A. Loginov
- A. Lounis
- A. Lucotte
- A. Ludwig
- A. M. Bach
- A. M. Castaneda Hernandez
- A. M. Cooper-Sarkar
- A. M. Henriques Correia
- A. M. Kiver
- A. M. Leyko
- A. M. Litke
- A. M. Moisseev
- A. M. Nairz
- A. M. Rahimi
- A. M. Zaitsev
- A. Macchiolo
- A. Maio
- A. Manabe
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- A. Mapelli
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- A. Mayne
- A. McCarn
- A. Meade
- A. Mehta
- A. Mengarelli
- A. Messina
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- A. N. Karyukhin
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- A. Penson
- A. Perus
- A. Petridis
- A. Phan
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- A. Pranko
- A. Quadt
- A. R. Davison
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- A. Redelbach
- A. Reichold
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- A. Robson
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- A. S. Kozhin
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- A. S. Randle-Conde
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- A. Salamon
- A. Salnikov
- A. Salvucci
- A. Salzburger
- A. Sanchez
- A. Sansoni
- A. Sbrizzi
- A. Schwartzman
- A. Schöning
- A. Seiden
- A. Sfyrla
- A. Shibata
- A. Shmeleva
- A. Sidoti
- A. Sircar
- A. Soffer
- A. Soukharev
- A. Staude
- A. Straessner
- A. Strandlie
- A. Succurro
- A. T. Doyle
- A. T. H. Arce
- A. T. Watson
- A. T. Waugh
- A. Taffard
- A. Talyshev
- A. Tonoyan
- A. Tricoli
- A. Trivedi
- A. Trzupek
- A. Tua
- A. Tudorache
- A. Tykhonov
- A. Undrus
- A. V. Akimov
- A. V. Ivashin
- A. V. Larionov
- A. V. Pleskach
- A. Vaniachine
- A. Vartapetian
- A. Ventura
- A. Vest
- A. Vogel
- A. Warburton
- A. White
- A. Wildauer
- A. Wilson
- A. Yamamoto
- A. Yurkewicz
- A. Zaytsev
- A. Zemla
- A. Zhemchugov
- A. Zoccoli
- A. Zsenei
- A.-E. Nuncio-Quiroz
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- ATLAS Collaboration
- B. A. Dolgoshein
- B. A. Petersen
- B. A. Schumm
- B. Abbott
- B. Abi
- B. Alvarez Gonzalez
- B. Aubert
- B. Brau
- B. Brelier
- B. Budick
- B. Butler
- B. C. LeGeyt
- B. C. Smith
- B. Caron
- B. Chapleau
- B. Clement
- B. D. Cooper
- B. De Lotto
- B. Demirkoz
- B. DeWilde
- B. Di Girolamo
- B. Di Micco
- B. Dowler
- B. E. Cox
- B. Epp
- B. Esposito
- B. Fatholahzadeh
- B. G. Pope
- B. Gaur
- B. Giacobbe
- B. Gibbard
- B. Gorini
- B. Gosdzik
- B. Guo
- B. H. Samset
- B. H. Smart
- B. Heinemann
- B. J. Gallop
- B. J. OâBrien
- B. Jackson
- B. K. Gjelsten
- B. K. Wosiek
- B. Kaplan
- B. Laforge
- B. Lemmer
- B. Lenzi
- B. Li
- B. Liberti
- B. Lund-Jensen
- B. Lundberg
- B. M. Barnett
- B. M. Hawes
- B. M. M. Allbrooke
- B. M. Salvachua Ferrando
- B. M. Waugh
- B. M. Wynne
- B. Malaescu
- B. Mansoulie
- B. Martin
- B. Martin
- B. Martin dit Latour
- B. MaÄek
- B. Meirose
- B. Mindur
- B. Nicquevert
- B. Nordkvist
- B. Osculati
- B. P. KerĆĄevan
- B. Panes
- B. Penning
- B. Pinto
- B. R. Ko
- B. R. Mellado Garcia
- B. Radics
- B. Resende
- B. Ruckert
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- B. Sellden
- B. Simmons
- B. Sopko
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- B. Stugu
- B. Szeless
- B. T. King
- B. Toczek
- B. Toggerson
- B. Trocmé
- B. Vachon
- B. Wrona
- B. Yabsley
- B. Zabinski
- B. Zhou
- B. Ă sman
- C. A. Chavez Barajas
- C. A. Edwards
- C. A. Jung
- C. A. Solans
- C. Alexa
- C. Amelung
- C. Anastopoulos
- C. Arnault
- C. Ay
- C. B. Gwilliam
- C. Bacci
- C. Belanger-Champagne
- C. Benchouk
- C. Bernius
- C. Bertella
- C. Bini
- C. Biscarat
- C. Blocker
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- C. Bromberg
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- C. Caramarcu
- C. Caso
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- C. Issever
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- C. J. Kenney
- C. J. Oram
- C. J. Potter
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- C. Kourkoumelis
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- C. L. Lampen
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- C. Lange
- C. Lapoire
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- C. Leggett
- C. Leroy
- C. Limbach
- C. Liu
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- C. Malone
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- C. N. Booth
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- C. Omachi
- C. Oropeza Barrera
- C. Osuna
- C. P. Bee
- C. P. Buszello
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- C. Petridou
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- C. Wiglesworth
- C. Wright
- C. Xu
- C. Young
- C. Zeitnitz
- C. Zendler
- C.-M. Cuciuc
- Ch. Geich-Gimbel
- CMS Collaboration
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- D. A. Forbush
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- D. A. Scannicchio
- D. A. Soh
- D. Arutinov
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- E. A. Ouellette
- E. A. Starchenko
- E. Abat
- E. Acerbi
- E. Arik
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- T. Hayakawa
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- T. Horazdovsky
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- T. J. Brodbeck
- T. J. Jones
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- T. J. Neep
- T. Jovin
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- T. Kobayashi
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- T. Kondo
- T. Kono
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- T. Kubota
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- T. Lagouri
- T. Lari
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- T. Lenz
- T. Loddenkoetter
- T. Lohse
- T. M. Hong
- T. M. Liss
- T. Maeno
- T. Mashimo
- T. Masubuchi
- T. Matsushita
- T. Mclaughlan
- T. Meguro
- T. Moa
- T. Mueller
- T. N. Addy
- T. N. Trinh
- T. Nakamura
- T. Nattermann
- T. Naumann
- T. Niinikoski
- T. Nishiyama
- T. Nunnemann
- T. Ohshima
- T. Ohsugi
- T. Okuyama
- T. P. A. Ă kesson
- T. Pauly
- T. Perez Cavalcanti
- T. Poghosyan
- T. Rador
- T. Sandoval
- T. Sandoval
- T. Sarangi
- T. Sasaki
- T. Schwindt
- T. Shin
- T. Sjostrand
- T. Slavicek
- T. Spreitzer
- T. Sugimoto
- T. Sumida
- T. Sykora
- T. T. Voss
- T. Takeshita
- T. Theveneaux-Pelzer
- T. Tic
- T. Todorov
- T. Trefzger
- T. Vickey
- T. Vu Anh
- T. W. Jones
- T. Wenaus
- T. Wengler
- T. Yamamura
- T. Yamanaka
- T. Yamazaki
- T. Z. Kowalski
- T. Zhao
- T. ĆœeniĆĄ
- Th. D. Papadopoulou
- U. Bitenc
- U. Blumenschein
- U. Bratzler
- U. De Sanctis
- U. Husemann
- U. K. Yang
- U. Klein
- U. Kruchonak
- U. Landgraf
- U. Mallik
- U. Parzefall
- U. SchÀfer
- U. Soldevila
- V. A. Bednyakov
- V. A. Gapienko
- V. A. Kantserov
- V. A. Kazanin
- V. A. Korotkov
- V. A. Kramarenko
- V. A. Mitsou
- V. A. Schegelsky
- V. Andrei
- V. B. Bobrovnikov
- V. B. Vinogradov
- V. Bansal
- V. Bartsch
- V. Boisvert
- V. Boldea
- V. Bortolotto
- V. BĂŒscher
- V. Canale
- V. Castillo Gimenez
- V. Cavasinni
- V. Chavda
- V. Chernyatin
- V. Cindro
- V. Consorti
- V. D. Peshekhonov
- V. Dao
- V. E. Ozcan
- V. F. Chepurnov
- V. Ferrara
- V. G. Bondarenko
- V. G. Zaets
- V. Gallo
- V. Garonne
- V. Giakoumopoulou
- V. Giangiobbe
- V. Gilewsky
- V. Grassi
- V. Gratchev
- V. Hedberg
- V. I. Rud
- V. I. Vassilakopoulos
- V. Ippolito
- V. Izzo
- V. J. Guarino
- V. J. Martin
- V. Jain
- V. Juranek
- V. Kartvelishvili
- V. Kaushik
- V. Khovanskiy
- V. Kolesnikov
- V. Koreshev
- V. Kouskoura
- V. Kral
- V. Kukhtin
- V. Kus
- V. Lavorini
- V. Lendermann
- V. M. Kotov
- V. M. Romanov
- V. Malyshev
- V. Martinez Outschoorn
- V. Moeller
- V. N. Goryachev
- V. N. Gushchin
- V. Nguyen Thi Hong
- V. Nikolaenko
- V. O. Tikhomirov
- V. OâShea
- V. P. Lombardo
- V. P. Maleev
- V. Paolone
- V. Perez Reale
- V. Polychronakos
- V. Pozdnyakov
- V. R. Lacuesta
- V. Radescu
- V. Rojo
- V. Rossetti
- V. Rumiantsev
- V. Ryadovikov
- V. Sanchez Martinez
- V. Savinov
- V. Scharf
- V. Simak
- V. Sipica
- V. Smakhtin
- V. Sopko
- V. Tsiskaridze
- V. Tsulaia
- V. Tudorache
- V. V. Ammosov
- V. V. Kabachenko
- V. V. Kostyukhin
- V. V. Sulin
- V. V. Zmouchko
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- V. Vorobel
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- W. Bhimji
- W. Blum
- W. Buttinger
- W. C. Wong
- W. Cleland
- W. Dabrowski
- W. Davey
- W. Ehrenfeld
- W. F. Mader
- W. Fedorko
- W. Fernando
- W. G. Scott
- W. H. Bell
- W. Iwanski
- W. J. Dearnaley
- W. J. Mills
- W. J. Murray
- W. Ji
- W. K. Brooks
- W. Kozanecki
- W. L. Ebenstein
- W. Lampl
- W. Lavrijsen
- W. Liebig
- W. Mohr
- W. Park
- W. S. Lockman
- W. T. Meyer
- W. Taylor
- W. Trischuk
- W. Vandelli
- W. Verkerke
- W. Wagner
- W. Walkowiak
- W. Wiedenmann
- W. Willis
- X. Chen
- X. Espinal Curull
- X. Ju
- X. Lei
- X. Li
- X. Lou
- X. Portell Bueso
- X. Prudent
- X. Ruan
- X. S. Anduaga
- X. Sun
- X. Wu
- X. Zhang
- X. Zhuang
- Y. A. Kurochkin
- Y. A. Tikhonov
- Y. Arai
- Y. Azuma
- Y. B. Pan
- Y. Bai
- Y. Benhammou
- Y. Coadou
- Y. Davygora
- Y. Doi
- Y. F. Ryabov
- Y. Fang
- Y. Gusakov
- Y. Hasegawa
- Y. Hernåndez Jiménez
- Y. Homma
- Y. Ikegami
- Y. Ilchenko
- Y. Jiang
- Y. Kataoka
- Y. Komori
- Y. Kulchitsky
- Y. Liu
- Y. Mahalalel
- Y. Makida
- Y. Ming
- Y. Munwes
- Y. Nagasaka
- Y. Nakahama
- Y. Ninomiya
- Y. Okumura
- Y. Oren
- Y. Pylypchenko
- Y. Rozen
- Y. S. Gao
- Y. Silver
- Y. Smirnov
- Y. Sugaya
- Y. Suzuki
- Y. Suzuki
- Y. Takahashi
- Y. Takubo
- Y. Tanaka
- Y. Tayalati
- Y. Unno
- Y. V. Grishkevich
- Y. Wu
- Y. Xie
- Y. Yamazaki
- Y. Yang
- Y. Yang
- Y. Yao
- Y. Yasu
- Y. Zhou
- Y. Zhu
- Y. Zolnierowski
- Yu. M. Sviridov
- Z. Czyczula
- Z. D. Greenwood
- Z. Dolezal
- Z. Drasal
- Z. Hajduk
- Z. Hubacek
- Z. Kohout
- Z. L. Ren
- Z. Liang
- Z. Marshall
- Z. Meng
- Z. Qian
- Z. Qin
- Z. Rurikova
- Z. V. Krumshteyn
- Z. van Kesteren
- Z. Weng
- Z. Yan
- Z. Yang
- Z. Zajacova
- Z. Zenonos
- Z. Zhan
- Z. Zhang
- Z. Zhao
- Z. Zinonos
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 06/03/2012
- Field of study
The uncertainty on the calorimeter energy response to jets of particles is
derived for the ATLAS experiment at the Large Hadron Collider (LHC). First, the
calorimeter response to single isolated charged hadrons is measured and
compared to the Monte Carlo simulation using proton-proton collisions at
centre-of-mass energies of sqrt(s) = 900 GeV and 7 TeV collected during 2009
and 2010. Then, using the decay of K_s and Lambda particles, the calorimeter
response to specific types of particles (positively and negatively charged
pions, protons, and anti-protons) is measured and compared to the Monte Carlo
predictions. Finally, the jet energy scale uncertainty is determined by
propagating the response uncertainty for single charged and neutral particles
to jets. The response uncertainty is 2-5% for central isolated hadrons and 1-3%
for the final calorimeter jet energy scale.Comment: 24 pages plus author list (36 pages total), 23 figures, 1 table,
submitted to European Physical Journal
Measurement of the production cross section for W-bosons in association with jets in pp collisions at s=7 TeV with the ATLAS detector
- Author
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- Zwalinski L
- ÂżeniÂż T
- Ă sman B
- Ăye O
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Effects of CETP inhibition with anacetrapib on metabolism of VLDL-TG and plasma apolipoproteins C-II, C-III, and E
- Author
- Aoujil Soumia
- Baer Amanda L.
- deGoma Emil M.
- Donovan Daniel S.
- Dunbar Richard L.
- Ginsberg Henry N.
- Gutstein David E.
- Holleran Stephen
- Jumes Patricia
- Karmally Wahida
- Lassman Michael E.
- Liu Yang
- Millar John S.
- Obunike Joseph
- Rader Daniel J.
- Rafeek Hashmi
- Ramakrishnan Rajasekhar
- Reyes-Soffer Gissette
- Standiford Taylor
- Thomas Tiffany
- Wagner John A.
- Publication venue
- CUNY Academic Works
- Publication date
- 17/03/2017
- Field of study
Cholesteryl ester transfer protein (CETP) mediates the transfer of HDL cholesteryl esters for triglyceride (TG) in VLDL/LDL. CETP inhibition, with anacetrapib, increases HDL-cholesterol, reduces LDL-cholesterol, and lowers TG levels. This study describes the mechanisms responsible for TG lowering by examining the kinetics of VLDL-TG, apoC-II, apoC-III, and apoE. Mildly hypercholesterolemic subjects were randomized to either placebo (N = 10) or atorvastatin 20 mg/qd (N = 29) for 4 weeks (period 1) followed by 8 weeks of anacetrapib, 100 mg/qd (period 2). Following each period, subjects underwent stable isotope metabolic studies to determine the fractional catabolic rates (FCRs) and production rates (PRs) of VLDL-TG and plasma apoC-II, apoC-III, and apoE. Anacetrapib reduced the VLDL-TG pool on a statin background due to an increased VLDL-TG FCR (29%; P = 0.002). Despite an increased VLDL-TG FCR following anacetrapib monotherapy (41%; P = 0.11), the VLDL-TG pool was unchanged due to an increase in the VLDL-TG PR (39%; P = 0.014). apoC-II, apoC-III, and apoE pool sizes increased following anacetrapib; however, the mechanisms responsible for these changes differed by treatment group. Anacetrapib increased the VLDL-TG FCR by enhancing the lipolytic potential of VLDL, which lowered the VLDL-TG pool on atorvastatin background. There was no change in the VLDL-TG pool in subjects treated with anacetrapib monotherapy due to an accompanying increase in the VLDL-TG PR
Effects of PCSK9 Inhibition With Alirocumab on Lipoprotein Metabolism in Healthy Humans
- Author
- Becue Frederic
- Cowan Lisa
- Fontanez Nelson
- Ginsberg Henry N.
- Holleran Stephen F.
- Karmally Wahida
- Lichtenstein Alice H.
- Marcovina Santica M.
- Maroccia Magali
- Matta James
- Matthan Nirupa R.
- Nandakumar Renu
- Ngai Colleen I.
- Obunike Joseph
- Pavlyha Marianna
- Poitiers Franck
- Ramakrishnan Rajasekhar
- Sasiela William J.
- Soffer Gissette
- Surks Howard K.
- Swanson Brian
- Thomas Tiffany
- Publication venue
- 'Columbia University Libraries/Information Services'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND: Alirocumab, a monoclonal antibody to proprotein convertase subtilisin/kexin type 9 (PCSK9), lowers plasma low-density lipoprotein (LDL) cholesterol and apolipoprotein B100 (apoB). Although studies in mice and cells have identified increased hepatic LDL receptors as the basis for LDL lowering by PCSK9 inhibitors, there have been no human studies characterizing the effects of PCSK9 inhibitors on lipoprotein metabolism. In particular, it is not known whether inhibition of PCSK9 has any effects on very low-density lipoprotein or intermediate-density lipoprotein (IDL) metabolism. Inhibition of PCSK9 also results in reductions of plasma lipoprotein (a) levels. The regulation of plasma Lp(a) levels, including the role of LDL receptors in the clearance of Lp(a), is poorly defined, and no mechanistic studies of the Lp(a) lowering by alirocumab in humans have been published to date.
METHODS: Eighteen (10 F, 8 mol/L) participants completed a placebo-controlled, 2-period study. They received 2 doses of placebo, 2 weeks apart, followed by 5 doses of 150 mg of alirocumab, 2 weeks apart. At the end of each period, fractional clearance rates (FCRs) and production rates (PRs) of apoB and apo(a) were determined. In 10 participants, postprandial triglycerides and apoB48 levels were measured.
RESULTS: Alirocumab reduced ultracentrifugally isolated LDL-C by 55.1%, LDL-apoB by 56.3%, and plasma Lp(a) by 18.7%. The fall in LDL-apoB was caused by an 80.4% increase in LDL-apoB FCR and a 23.9% reduction in LDL-apoB PR. The latter was due to a 46.1% increase in IDL-apoB FCR coupled with a 27.2% decrease in conversion of IDL to LDL. The FCR of apo(a) tended to increase (24.6%) without any change in apo(a) PR. Alirocumab had no effects on FCRs or PRs of very low-density lipoproteins-apoB and very low-density lipoproteins triglycerides or on postprandial plasma triglycerides or apoB48 concentrations.
CONCLUSIONS: Alirocumab decreased LDL-C and LDL-apoB by increasing IDL- and LDL-apoB FCRs and decreasing LDL-apoB PR. These results are consistent with increases in LDL receptors available to clear IDL and LDL from blood during PCSK9 inhibition. The increase in apo(a) FCR during alirocumab treatment suggests that increased LDL receptors may also play a role in the reduction of plasma Lp(a).
CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01959971
Search for dark matter produced in association with bottom or top quarks in âs = 13 TeV pp collisions with the ATLAS detector
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- Yamanaka Takashi
- Yamane Fumiya
- Yamatani Masahiro
- Yamazaki Tomohiro
- Yamazaki Yuji
- Yan Zhen
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- Yang Hongtao
- Yang Yi
- Yang Zongchang
- Yao Weiming
- Yap Yee
- Yasu Yoshiji
- Yatsenko Elena
- Yau Wong Kaven
- Ye Jingbo
- Ye Shuwei
- Yeletskikh Ivan
- Yigitbasi Efe
- Yildirim Eda
- Yorita Kohei
- Yoshihara Keisuke
- Young Charles
- Young Christopher
- Yu Jaehoon
- Yu Jie
- Yuen Stephanie
- Yusuff Imran
- Zabinski Bartlomiej
- Zacharis Georgios
- Zaidan Remi
- Zaitsev Alexander
- Zakharchuk Nataliia
- Zalieckas Justas
- Zaman Aungshuman
- Zambito Stefano
- Zanzi Daniele
- Zeitnitz Christian
- Zemaityte Gabija
- Zemla Andrzej
- Zeng Jian
- Zeng Qi
- Zenin Oleg
- Zerwas Dirk
- Zhang Dengfeng
- Zhang Dongliang
- Zhang Fangzhou
- Zhang Guangyi
- Zhang Huijun
- Zhang Jinlong
- Zhang Lei
- Zhang Liqing
- Zhang Matt
- Zhang Peng
- Zhang Rui
- Zhang Ruiqi
- Zhang Xueyao
- Zhang Yu
- Zhang Zhiqing
- Zhao Xiandong
- Zhao Yongke
- Zhao Zhengguo
- Zhemchugov Alexey
- Zhou Bing
- Zhou Chen
- Zhou Li
- Zhou Maosen
- Zhou Mingliang
- Zhou Ning
- Zhou You
- Zhu Cheng
- Zhu Hongbo
- Zhu Junjie
- Zhu Yingchun
- Zhuang Xuai
- Zhukov Konstantin
- Zibell Andre
- Zieminska Daria
- Zimine Nikolai
- Zimmermann Christoph
- Zimmermann Stephanie
- Zinonos Zinonas
- Zinser Markus
- Ziolkowski Michael
- Zobernig Georg
- Zoccoli Antonio
- Zou Rui
- zur Nedden Martin
- Zwalinski Lukasz
- Ă kesson Torsten
- Ć filigoj Tina
- ĆœeniĆĄ Tibor
- ĆœivkoviÄ Lidija
- Îlvarez Piqueras DamiĂĄn
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fbâ1 of protonâproton collision data recorded by the ATLAS experiment at âs = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements
- âŠ