Santiago de Chile: comprehension and configuration of a modern city since the visit of Karl Brunner, 1932

En su primera visita a Chile (1929 a 1932), el urbanista Karl Brunner elabora las bases de un estudio para el futuro ensanche de la ciudad capital. Los estudios propuestos en este viaje se compilan en el libro Santiago de Chile: Su estado actual y futura formación (1932). El texto es un análisis descriptivo del Santiago que encuentra y cómo, desde esa misma realidad debe transitar hacia la ciudad moderna que proclama. Allí se manifiesta el corpus teórico y práctico que trae desde Europa central, donde su argumento de modernidad se confronta inteligentemente con la realidad observada. Una ciudad real que se aborda a través de visiones en simultaneidad de distintas escalas de comprensión e intervención, y que se codifica en imágenes y descripciones, hasta llegar a una propuesta de normativas. A través de un análisis cuidadoso de representaciones, proyectos y el discurso que contiene, se intenta develar cuál es la propuesta para Santiago que encarna Brunner, cómo determina las distintas visiones para una misma ciudad y descifrar cómo pudo concebir su tránsito desde la ciudad encontrada hacia una configuración y una expresión moderna como capital, relevando el hecho de que lo moderno estará dado fundamentalmente por el cambio de escala inevitable de la ciudad del futuro próximo.In his first visit to Chile (1929-1932), the urbanist Karl Brunner elaborates the bases of a study for the future expansion of the capital city. The studies proposed on this trip are compiled in the book “Santiago de Chile: Su estado actual y futura formación” (1932). The text is a descriptive analysis of city that he finds and how it should move towards the modern city that proclaims. There the theoretical and practical corpus that brings from central Europe manifests, where his argument of modernity intelligently confronts with the reality observed. A city that is approached through simultaneous visions in different scales of understanding and intervention, and that is coded in images and descriptions until the regulations proposal. Through the analysis of representation, projects and the containing discourse, it tries to reveal what is the embodied proposal for Santiago, determine the different visions for a same city and fi gure out how he could conceive their transit from the found city towards a configuration and a modern expression as capital.Dossier: Ciudades, Territorios, DibujosFacultad de Arquitectura y Urbanism

Santiago de Chile: comprehension and configuration of a modern city since the visit of Karl Brunner, 1932

En su primera visita a Chile (1929 a 1932), el urbanista Karl Brunner elabora las bases de un estudio para el futuro ensanche de la ciudad capital. Los estudios propuestos en este viaje se compilan en el libro Santiago de Chile: Su estado actual y futura formación (1932). El texto es un análisis descriptivo del Santiago que encuentra y cómo, desde esa misma realidad debe transitar hacia la ciudad moderna que proclama. Allí se manifiesta el corpus teórico y práctico que trae desde Europa central, donde su argumento de modernidad se confronta inteligentemente con la realidad observada. Una ciudad real que se aborda a través de visiones en simultaneidad de distintas escalas de comprensión e intervención, y que se codifica en imágenes y descripciones, hasta llegar a una propuesta de normativas. A través de un análisis cuidadoso de representaciones, proyectos y el discurso que contiene, se intenta develar cuál es la propuesta para Santiago que encarna Brunner, cómo determina las distintas visiones para una misma ciudad y descifrar cómo pudo concebir su tránsito desde la ciudad encontrada hacia una configuración y una expresión moderna como capital, relevando el hecho de que lo moderno estará dado fundamentalmente por el cambio de escala inevitable de la ciudad del futuro próximo.In his first visit to Chile (1929-1932), the urbanist Karl Brunner elaborates the bases of a study for the future expansion of the capital city. The studies proposed on this trip are compiled in the book “Santiago de Chile: Su estado actual y futura formación” (1932). The text is a descriptive analysis of city that he finds and how it should move towards the modern city that proclaims. There the theoretical and practical corpus that brings from central Europe manifests, where his argument of modernity intelligently confronts with the reality observed. A city that is approached through simultaneous visions in different scales of understanding and intervention, and that is coded in images and descriptions until the regulations proposal. Through the analysis of representation, projects and the containing discourse, it tries to reveal what is the embodied proposal for Santiago, determine the different visions for a same city and fi gure out how he could conceive their transit from the found city towards a configuration and a modern expression as capital.Dossier: Ciudades, Territorios, DibujosFacultad de Arquitectura y Urbanism

Santiago de Chile: comprehension and configuration of a modern city since the visit of Karl Brunner, 1932

En su primera visita a Chile (1929 a 1932), el urbanista Karl Brunner elabora las bases de un estudio para el futuro ensanche de la ciudad capital. Los estudios propuestos en este viaje se compilan en el libro Santiago de Chile: Su estado actual y futura formación (1932). El texto es un análisis descriptivo del Santiago que encuentra y cómo, desde esa misma realidad debe transitar hacia la ciudad moderna que proclama. Allí se manifiesta el corpus teórico y práctico que trae desde Europa central, donde su argumento de modernidad se confronta inteligentemente con la realidad observada. Una ciudad real que se aborda a través de visiones en simultaneidad de distintas escalas de comprensión e intervención, y que se codifica en imágenes y descripciones, hasta llegar a una propuesta de normativas. A través de un análisis cuidadoso de representaciones, proyectos y el discurso que contiene, se intenta develar cuál es la propuesta para Santiago que encarna Brunner, cómo determina las distintas visiones para una misma ciudad y descifrar cómo pudo concebir su tránsito desde la ciudad encontrada hacia una configuración y una expresión moderna como capital, relevando el hecho de que lo moderno estará dado fundamentalmente por el cambio de escala inevitable de la ciudad del futuro próximo.In his first visit to Chile (1929-1932), the urbanist Karl Brunner elaborates the bases of a study for the future expansion of the capital city. The studies proposed on this trip are compiled in the book “Santiago de Chile: Su estado actual y futura formación” (1932). The text is a descriptive analysis of city that he finds and how it should move towards the modern city that proclaims. There the theoretical and practical corpus that brings from central Europe manifests, where his argument of modernity intelligently confronts with the reality observed. A city that is approached through simultaneous visions in different scales of understanding and intervention, and that is coded in images and descriptions until the regulations proposal. Through the analysis of representation, projects and the containing discourse, it tries to reveal what is the embodied proposal for Santiago, determine the different visions for a same city and fi gure out how he could conceive their transit from the found city towards a configuration and a modern expression as capital.Dossier: Ciudades, Territorios, DibujosFacultad de Arquitectura y Urbanism

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at root s=13 TeV

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An embedding technique to determine ττ backgrounds in proton-proton collision data

An embedding technique is presented to estimate standard model tau tau backgrounds from data with minimal simulation input. In the data, the muons are removed from reconstructed mu mu events and replaced with simulated tau leptons with the same kinematic properties. In this way, a set of hybrid events is obtained that does not rely on simulation except for the decay of the tau leptons. The challenges in describing the underlying event or the production of associated jets in the simulation are avoided. The technique described in this paper was developed for CMS. Its validation and the inherent uncertainties are also discussed. The demonstration of the performance of the technique is based on a sample of proton-proton collisions collected by CMS in 2017 at root s = 13 TeV corresponding to an integrated luminosity of 41.5 fb(-1).Peer reviewe

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

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