50 research outputs found
Pharaonic Egypt and the Ancient Near East in American cinema at the beginning of the Cold War (1945-1960)
Acabada la Segunda Guerra Mundial en 1945, Estados Unidos y la UniĂłn SoviĂ©tica iniciaron un periodo de tensiĂłn y enfrentamientos conocido como la Guerra FrĂa, que durĂł hasta los años noventa. El cine estadounidense aprovechĂł para transmitir las ideologĂas y mensajes polĂticos que interesaban al poder en pelĂculas ambientadas en la AntigĂŒedad como SansĂłn y Dalila, Los diez mandamientos o SalomĂłn y la reina de Saba. En este artĂculo se realiza un anĂĄlisis del patrimonio cinematogrĂĄfico de esta Ă©poca como vehĂculo transmisor de ideologĂas del momento que fueron trasladadas a las Ă©pocas mĂĄs remotas de nuestro pasado.When World War II concluded in 1945 the United States and Soviet Union began a period of tension and confrontation known as the Cold War, which lasted until the 1990s. American cinema took advantage of this historical period to convey ideological messages dictated by the political elite through films set in the Antiquity,
such as Samson and Delilah, The Ten Commandments and Solomon and the Queen of Sheba. This article aims to analyse the cinematographic heritage in order to understand its function as a vehicle for the transmission of contemporary ideologies to the historical periods in which those movies were set
Anti-glomerular Basement Membrane Glomerulonephritis: A Study in Real Life
Glomerulonephritis; Kidney survival; Plasma exchangeGlomerulonefritis; SupervivĂšncia renal; Intercanvi de plasmaGlomerulonefritis; Supervivencia renal; Intercambio de plasmaIntroduction: Anti-glomerular basement membrane (anti-GBM) disease is a severe entity with few therapeutic options including plasma exchange and immunosuppressive agents. The aim of this study was to analyze the clinical and pathological features that predict the evolution of end-stage kidney disease (ESKD) and the kidney survival in a cohort of patients with anti-GBM disease with renal involvement in real life.
Methods: A retrospective multicentre observational study including 72 patients from 18 nephrology departments with biopsy-proven anti-GBM disease from 1999 to 2019 was performed. Progression to ESKD in relation to clinical and histological variables was evaluated.
Results: Creatinine at admission was 8.6 (± 4) mg/dL and 61 patients (84.7%) required dialysis. Sixty-five patients (90.3%) underwent plasma exchange. Twenty-two patients (30.6%) presented pulmonary hemorrhage. Kidney survival was worse in patients with creatinine levels > 4.7 mg/dL (3 vs. 44% p 50% crescents (6 vs. 49%; p = 0.03). Dialysis dependence at admission and creatinine levels > 4.7 mg/dL remained independent significant predictors of ESKD in the multivariable analysis [HR (hazard ratio) 3.13 (1.25â7.84); HR 3 (1.01â9.14); p 4.7 mg/dL and 50.5% crescents had an area under the curve (AUC) of 0.9 (95% CI 0.82â0.97; p < 0.001) and 0.77 (95% CI 0.56â0.98; p = 0.008), respectively. Kidney survival at 1 and 2 years was 13.5 and 11%, respectively. Patient survival at 5 years was 81%.
Conclusion: In real life, patients with severe anti-GBM disease (creatinine > 4.7 mg/dL and > 50% crescents) remained with devastating renal prognosis despite plasma exchange and immunosuppressive treatment. New therapies for the treatment of this rare renal disease are urgently needed
Influence of Multiple Conformations and Paths on Rate Constants and Product Branching Ratios. Thermal Decomposition of 1-Propanol Radicals
The potential energy surface involved in the thermal decomposition of 1-propanol radicals was investigated in detail using automated codes (tsscds2018 and Q2DTor). From the predicted elementary reactions, a relevant reaction network was constructed to study the decomposition at temperatures in the range 1000â2000 K. Specifically, this relevant network comprises 18 conformational reaction channels (CRCs), which in general exhibit a large wealth of conformers of reactants and transition states. Rate constants for all the CRCs were calculated using two approaches within the formulation of variational transition-state theory (VTST), as incorporated in the TheRa program. The simplest, one-well (1W) approach considers only the most stable conformer of the reactant and that of the transition state. In the second, more accurate approach, contributions from all the reactant and transition-state conformers are taken into account using the multipath (MP) formulation of VTST. In addition, kinetic Monte Carlo (KMC) simulations were performed to compute product branching ratios. The results show significant differences between the values of the rate constants calculated with the two VTST approaches. In addition, the KMC simulations carried out with the two sets of rate constants indicate that, depending on the radical considered as reactant, the 1W and the MP approaches may display different qualitative pictures of the whole decomposition processThis work was partially supported by the ConsellerĂa de Cultura, EducaciĂłn e OrdenaciĂłn Universitaria e da ConsellerĂa de EconomĂa, Emprego e Industria (Axuda para ConsolidaciĂłn e EstructuraciĂłn de unidades de investigaciĂłn competitivas do Sistema Universitario de Galicia, Xunta de Galicia ED431C 2017/17 & Centro singular de investigaciĂłn de Galicia acreditaciĂłn 2016-2019, ED431G/09), the Ministerio de EconomĂa y Competitividad of Spain (Research Grant No CTQ2014-58617-R), and the European Regional Development Fund (ERDF). D.F.-C. also thanks Xunta de Galicia for financial support through a postdoctoral grant. The authors thank âCentro de SupercomputaciĂłn de Galicia (CESGA)â for the use of their computational facilitiesS
Corrigendum to: Venomics of the poorly studied hognosed pitvipers Porthidium arcosae and Porthidium volcanicum
2 pĂĄginas y 1 figura. Corrigendum del registro: http://hdl.handle.net/10261/256298We report the first proteomics analyses of the venoms of two poorly studied snakes, the Manabi hognosed pitviper Porthidium arcosae endemic to the western coastal province of ManabĂ (Ecuador), and the Costa Rican hognosed pitviper P. volcanicum with distribution restricted to South Pacific Costa Rica and western PanamĂĄ. These venom proteomes share a conserved compositional pattern reported in four other congeneric species within the clade of South American Porthidium species, P. nasutum, P. lansbergii, P. ophryomegas, and P. porrasi. The paraspecific immunorecognition profile of antivenoms produced in Costa Rica (ICP polyvalent), PerĂș (Instituto Nacional de Salud) and Brazil (soro antibotrĂłpico pentavalente, SAB, from Instituto Butantan) against the venom of P. arcosae was investigated through a third-generation antivenomics approach. The maximal venom-binding capacities of the investigated antivenoms were 97.1 mg, 21.8 mg, and 25.7 mg of P. arcosae venom proteins per gram of SAB, ICP, and INS-PERU antibody molecules, respectively, which translate into 28.4 mg, 13.1 mg, and 15.2 mg of total venom proteins bound per vial of SAB, ICP, and INS-PERU AV. The antivenomics results suggest that 21.8%, 7.8% and 6.1% of the SAB, ICP, and INS-PERU antibody molecules recognized P. arcosae venom toxins. The SAB antivenom neutralized P. arcosae venom's lethality in mice with an ED50 of 31.3 mgV/g SAB AV. This preclinical neutralization paraspecificity points to Brazilian SAB as a promising candidate for the treatment of envenomings by Ecuadorian P. arcosae. BIOLOGICAL SIGNIFICANCE: Assessing the preclinical efficacy profile of antivenoms against homologous and heterologous medically relevant snake venoms represents an important goal towards defining the biogeographic range of their clinical utility. This is particularly relevant in regions, such as Mesoamerica, where a small number of pharmaceutical companies produce antivenoms against the venoms of a small number of species of maximum medical relevance among the local rich herpetofauna, leaving a wide range of snakes of secondary medical relevance, but also causing life-threatening human envenomings without nominal clinical coverage. This work is part of a larger project aiming at mapping the immunological characteristics of antivenoms generated in Latin American countries towards venoms of such poorly studied snakes of the local and neighboring countries' herpetofauna. Here we report the proteomics characterization of the Manabi hognosed pitviper Porthidium arcosae endemic to the western coastal province of ManabĂ (Ecuador), and the Costa Rican hognosed pitviper P. volcanicum with distribution restricted to southwestern Costa Rica, the antivenomics assessment of three bothropoid commercial antivenoms produced in Costa Rica, PerĂș, and Brazil against the venom components of P. arcosae, and the in vivo capacity of the Brazilian soro antibotrĂłpico pentavalente (SAB) from Instituto Butantan to neutralize the murine lethality of P. arcosae venom. The preclinical paraspecific ED50 of 31.3 mg of P. arcosae venom per gram of antivenom points to Brazilian SAB as a promising candidate for the treatment of envenomings by the Manabi hognosed pitviper P. arcosae.This study was partly supported by grant EFP-00021744 financed by
Fundaç Ìao RondËonia de Amparo ao Desenvolvimento das Aç Ìoes Cien-
tĂficas e Tecnol Ìogicas (FAPERO, RondËonia, Brazil). Research performed
at IBV-CSIC was partially funded by grant BFU2017-89103-P from the
Ministerio de Ciencia e Innovaci Ìon, Madrid, Spain. Work performed at
Instituto Clodomiro Picado was supported by VicerrectorĂa de Inves-
tigaci Ìon (741-C0-071) and VicerrectorĂa de Acci Ìon Social (Proyecto ED-
3248) of Universidad de Costa Rica. The excellent bench work assistance
of Sarai Quesada-Bernat with antivenomics, and Yania RodrĂguez
Jim Ìenez with determination of the murine LD50 for P. arcosae venom
and neutralization of its lethal effect by the Brazilian pentavalent
bothropic antivenom, are gratefully acknowledgedPeer reviewe
The miniJPAS & J-NEP surveys: Identification and characterization of the Ly Emitter population and the Ly Luminosity Function
We present the Lyman- (Lya) Luminosity Function (LF) at ,
estimated from a sample of 67 Lya-emitter (LAE) candidates in the J-PAS
Pathfinder surveys: miniJPAS and J-NEP. These two surveys cover a total
effective area of deg with 54 Narrow Band (NB) filters across
the optical range, with typical limiting magnitudes of . This set of
NBs allows to probe Lya emission in a wide and continuous range of redshifts.
We develop a method for detecting Lya emission for the estimation of the Lya LF
using the whole J-PAS filter set. We test this method by applying it to the
miniJPAS and J-NEP data. In order to compute the corrections needed to estimate
the Lya LF and to test the performance of the candidates selection method, we
build mock catalogs. These include representative populations of Lya Emitters
at as well as their expected contaminants, namely low- galaxies
and QSOs. We show that our method is able to provide the Lya LF at the
intermediate-bright range of luminosity (). The photometric information provided
by these surveys suggests that our samples are dominated by bright,
Lya-emitting Active Galactic Nuclei. At
erg\,s, we fit our Lya LF to a power-law with slope . We
also fit a Schechter function to our data, obtaining: Log(\Phi^* /
\text{Mpc^{-3}})=-6.30^{+0.48}_{-0.70}, Log, . Overall, our
results confirm the presence of an AGN component at the bright-end of the Lya
LF. In particular, we find no significant contribution of star-forming LAEs to
the Lya LF at Log / erg\,s)>43.5. This work serves as a
proof-of-concept for the results that can be obtained with the upcoming data
releases of the J-PAS survey.Comment: 25 pages, 15 figures, submitted to A&
InnovaciĂłn, InclusiĂłn Social y Prospectiva en la GestiĂłn Gerencial: Tomo 1
PublishedLa presente publicaciĂłn recoge resultados preliminares y finales de algunas de las investigaciones que vienen desarrollando los profesores y estudiantes vinculados a los grupos de investigaciĂłn del Centro de Estudios e Investigaciones en Desarrollo Regional CEIDER, de la Facultad de Ciencias EconĂłmicas y Empresariales de la Universidad Santiago de Cali, en trabajo colaborativo con investigadores nacionales e internacionales, cofinanciados con recursos de la Universidad y de otras instituciones mediante convocatorias de investigaciĂłn.
La diversidad y riqueza de las temĂĄticas en ciencias econĂłmicas y empresariales lleva a tĂłpicos como: el sector de la salud, las nuevas formas de empleabilidad, la innovaciĂłn social, los impactos medioambientales, la inmersiĂłn en los mercados globalizados y la vivienda de interĂ©s social; los cuales se abordan en cada uno de los capĂtulos de este libro
La comunicación de la ciencia en América Latina: esfuerzos de evaluación en la diversidad
Este libro presenta una compilaciĂłn de 11 artĂculos que se inscriben en diferentes lĂneas temĂĄticas dentro de la ComunicaciĂłn de la ciencia, pero que tienen como hilo comĂșn la presentaciĂłn de resultados de evaluaciĂłn, en diferentes enfoques y niveles, y que son una breve muestra del quehacer en el campo.UCR::VicerrectorĂa de InvestigaciĂłn::Unidades de InvestigaciĂłn::Ciencias Sociales::Centro de InvestigaciĂłn en ComunicaciĂłn (CICOM
Altimetry for the future: Building on 25 years of progress
In 2018 we celebrated 25 years of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology. The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the ââGreenâ Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instrumentsâ development and satellite missionsâ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion
Altimetry for the future: building on 25 years of progress
In 2018 we celebrated 25âŻyears of development of radar altimetry, and the progress achieved by this methodology in the fields of global and coastal oceanography, hydrology, geodesy and cryospheric sciences. Many symbolic major events have celebrated these developments, e.g., in Venice, Italy, the 15th (2006) and 20th (2012) years of progress and more recently, in 2018, in Ponta Delgada, Portugal, 25 Years of Progress in Radar Altimetry. On this latter occasion it was decided to collect contributions of scientists, engineers and managers involved in the worldwide altimetry community to depict the state of altimetry and propose recommendations for the altimetry of the future. This paper summarizes contributions and recommendations that were collected and provides guidance for future mission design, research activities, and sustainable operational radar altimetry data exploitation. Recommendations provided are fundamental for optimizing further scientific and operational advances of oceanographic observations by altimetry, including requirements for spatial and temporal resolution of altimetric measurements, their accuracy and continuity. There are also new challenges and new openings mentioned in the paper that are particularly crucial for observations at higher latitudes, for coastal oceanography, for cryospheric studies and for hydrology.
The paper starts with a general introduction followed by a section on Earth System Science including Ocean Dynamics, Sea Level, the Coastal Ocean, Hydrology, the Cryosphere and Polar Oceans and the âGreenâ Ocean, extending the frontier from biogeochemistry to marine ecology. Applications are described in a subsequent section, which covers Operational Oceanography, Weather, Hurricane Wave and Wind Forecasting, Climate projection. Instrumentsâ development and satellite missionsâ evolutions are described in a fourth section. A fifth section covers the key observations that altimeters provide and their potential complements, from other Earth observation measurements to in situ data. Section 6 identifies the data and methods and provides some accuracy and resolution requirements for the wet tropospheric correction, the orbit and other geodetic requirements, the Mean Sea Surface, Geoid and Mean Dynamic Topography, Calibration and Validation, data accuracy, data access and handling (including the DUACS system). Section 7 brings a transversal view on scales, integration, artificial intelligence, and capacity building (education and training). Section 8 reviews the programmatic issues followed by a conclusion