Elaboración de plantilla ecológica para calzado casual, sustituyendo los insumos sintéticos por recursos reutilizables ecológicos Piura- 2021

El objetivo principal de la investigación fue elaborar plantillas ecológicas para calzado casual sustituyendo los insumos sintéticos por recursos reutilizables ecológicos Piura-2021. El proyecto está basado en una metodología de tipo de estudio aplicada pues se buscó resolver un problema mediante la sustitución de los insumos sintéticos por recursos reutilizables ecológicos en la línea de producción en la industria del calzado, también presenta un enfoque cuantitativo y fue de tipo descriptivo. La muestra estuvo conformada por 30 empleados de la empresa CITECAL incluidos jefes de departamentos, asistentes y operarios. Los resultados obtenidos de esta investigación revelan la viabilidad del proyecto y el aporte significativo que resulta para la empresa y la industria del calzado. Como principal resultado se obtuvo que el 95.4% de la composición del producto es orgánico, Se llegó a la conclusión que mediante el inventario de emisiones de CO2 del proceso operativo de las plantillas ecológicas, se pudo determinar que la fabricación de un solo para de plantillas emiten 0,24 kg de C02, determinando así que el uso de insumos ecológicos disminuye la emisión de.GEI, se concluye que el tiempo de elaboración de plantillas ecológicas es de 30:34 minutos representando casi el doble del tiempo en comparación con la elaboración de plantillas sintéticas, por lo que podemos decir que el proceso debe mejorar

Correlation between the Altered Gut Microbiome and Lifestyle Interventions in Chronic Widespread Pain Patients: A Systematic Review

: Background: Lifestyle interventions have a direct impact on the gut microbiome, changing its composition and functioning. This opens an innovative way for new therapeutic opportunities for chronic widespread patients. Purpose: The goal of the present study was to evaluate a correlation between lifestyle interventions and the gut microbiome in patients with chronic widespread pain (CWP). Methods: The systematic review was conducted until January 2023. Pain and microbiome were the two keywords selected for this revision. The search was conducted in PubMed, Chochrane, PEDro and ScienceDirect, where 3917 papers were obtained. Clinical trials with lifestyle intervention in CWP patients were selected. Furthermore, these papers had to be related with the gut microbiome, excluding articles related to other types of microbiomes. Results: Only six articles were selected under the eligibility criteria. Lifestyle interventions were exercise, electroacupuncture and ingesting a probiotic. Conclusions: Lifestyle intervention could be a suitable choice to improve the gut microbiome. This fact could be extrapolated into a better quality of life and lesser levels of pain

Advancing the knowledge on immunomodulatory properties of human cardiac stem cells

Transplantation of allogeneic human cardiac/stem progenitor cells (hCSC) is currently being tested in several phase I/II clinical trials as a novel and promising therapy for restauration of myocardial tissue function in acute myocardial infarction (AMI) patients. Previous findings demonstrate that these cells have an immune suppressive profile, interacting with different populations from the immune system, resulting in overall attenuation of myocardium inflammation. However, transplanted hCSCs are still recognized and cleared from the injured site impairing long retention times in the tissue that could be translated into a higher clinical benefit. In this work, different models of allogeneic hCSC/ T-lymphocyte interaction in vitro were explored, using the same hCSCs employed in the allogenous hCSCs transplantation phase I/II clinical trial CARE-MI, NCT02439398. T lymphocytes were cultured either in direct contact with hCSCs, or using transwell inserts or with hCSC conditioned medium. In our results, we show that IFN-γ activation is correlated with an increase in hCSC indoleamine 2,3-dioxygenase (IDO) enzyme expression. We also show a significant inhibition of T lymphocyte inhibition when cultivating human peripheral blood mononuclear cells (hPBMCs) in direct cell-cell contact, using transwells or with activated hCSC conditioned medium, combined with tryptophan depletion and kyurenine (a tryptophan metabolite) accumulation in activated hCSCs conditioned medium. These findings provide evidence, that although playing a role in the process, PDL-1 cell contact dependent T-regulatory cell modulation is not the exclusive neither the central mechanism involved in T-lymphocyte proliferation inhibition. This finding further supports the prominent paracrine-based beneficial CSC activities in the host tissue. Our results demonstrate for the first time that hCSCs exert an immune-suppressive effect on T lymphocyte proliferation through a paracrine mechanism associated with IDO enzyme mediated tryptophan metabolism. The knowledge generated contributes not only to a better understanding on hCSC immunomodulatory mechanisms, but also open new avenues in the development of new hCSC transplantation strategies in allogeneic settings

Forward-central two-particle correlations in p-Pb collisions at root s(NN)=5.02 TeV

Two-particle angular correlations between trigger particles in the forward pseudorapidity range (2.5 2GeV/c. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B. V.Peer reviewe

Event-shape engineering for inclusive spectra and elliptic flow in Pb-Pb collisions at root(NN)-N-S=2.76 TeV

Peer reviewe

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Pseudorapidity and transverse-momentum distributions of charged particles in proton-proton collisions at root s=13 TeV

The pseudorapidity (eta) and transverse-momentum (p(T)) distributions of charged particles produced in proton-proton collisions are measured at the centre-of-mass energy root s = 13 TeV. The pseudorapidity distribution in vertical bar eta vertical bar <1.8 is reported for inelastic events and for events with at least one charged particle in vertical bar eta vertical bar <1. The pseudorapidity density of charged particles produced in the pseudorapidity region vertical bar eta vertical bar <0.5 is 5.31 +/- 0.18 and 6.46 +/- 0.19 for the two event classes, respectively. The transverse-momentum distribution of charged particles is measured in the range 0.15 <p(T) <20 GeV/c and vertical bar eta vertical bar <0.8 for events with at least one charged particle in vertical bar eta vertical bar <1. The evolution of the transverse momentum spectra of charged particles is also investigated as a function of event multiplicity. The results are compared with calculations from PYTHIA and EPOS Monte Carlo generators. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Elliptic flow of muons from heavy-flavour hadron decays at forward rapidity in Pb-Pb collisions at root s(NN)=2.76TeV

The elliptic flow, v(2), of muons from heavy-flavour hadron decays at forward rapidity (2.5 <y <4) is measured in Pb-Pb collisions at root s(NN)= 2.76TeVwith the ALICE detector at the LHC. The scalar product, two- and four-particle Q cumulants and Lee-Yang zeros methods are used. The dependence of the v(2) of muons from heavy-flavour hadron decays on the collision centrality, in the range 0-40%, and on transverse momentum, p(T), is studied in the interval 3 <p(T)<10 GeV/c. A positive v(2) is observed with the scalar product and two-particle Q cumulants in semi-central collisions (10-20% and 20-40% centrality classes) for the p(T) interval from 3 to about 5GeV/c with a significance larger than 3 sigma, based on the combination of statistical and systematic uncertainties. The v(2) magnitude tends to decrease towards more central collisions and with increasing pT. It becomes compatible with zero in the interval 6 <p(T)<10 GeV/c. The results are compared to models describing the interaction of heavy quarks and open heavy-flavour hadrons with the high-density medium formed in high-energy heavy-ion collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V.Peer reviewe

Correlation between the Altered Gut Microbiome and Lifestyle Interventions in Chronic Widespread Pain Patients: A Systematic Review

Background: Lifestyle interventions have a direct impact on the gut microbiome, changing its composition and functioning. This opens an innovative way for new therapeutic opportunities for chronic widespread patients. Purpose: The goal of the present study was to evaluate a correlation between lifestyle interventions and the gut microbiome in patients with chronic widespread pain (CWP). Methods: The systematic review was conducted until January 2023. Pain and microbiome were the two keywords selected for this revision. The search was conducted in PubMed, Chochrane, PEDro and ScienceDirect, where 3917 papers were obtained. Clinical trials with lifestyle intervention in CWP patients were selected. Furthermore, these papers had to be related with the gut microbiome, excluding articles related to other types of microbiomes. Results: Only six articles were selected under the eligibility criteria. Lifestyle interventions were exercise, electroacupuncture and ingesting a probiotic. Conclusions: Lifestyle intervention could be a suitable choice to improve the gut microbiome. This fact could be extrapolated into a better quality of life and lesser levels of pain