The Pine Needle, December 1946

Libraries and archives collect materials from different cultures and time periods to preserve and make available the historical record. As a result, materials such as those presented here may reflect sexist, misogynistic, abusive, racist, or discriminatory attitudes or actions that some may find disturbing, harmful, or difficult to view.Both a humor and literary magazine, The Pine Needle was a University of Maine periodical that began publication in the fall of 1946, the first post-World War II semester that saw GIs returning to campus. While past student publications at UMaine relied on euphemisms for alcohol and dating on campus, The Needle openly emphasized the sexualization of co-eds, as well as the use of drugs, tobacco, and alcohol by students who experienced the battlefield. The December 1946 cover art by Donald T. Caswell (1923-2014). The happy looking Joe on the cover is the talented witchery that habitually drips from the pen of Don Caswell, who is an artist of long standing and sitting. He also does the work on our profile jobs and sports portraits. Norman Rockwell, move over. Caswell, a native of Limestone, Maine, grew up in Brownsville, and joined the U.S. Navy following high school graduation in 1942. He served as a radio operator aboard ships patrolling the Gulf of Alaska throughout the war. Caswell attended the University of Maine on the G.I. Bill, majoring in Art and History. On campus, he was active in the Officer Training Program and was stationed in Tripoli, North Africa as a U.S. Air Force officer during the Korean War. Caswell served as a Lieutenant Colonel in the Air National Guard

Metabolism within the tumor microenvironment and its implication on cancer progression: an ongoing therapeutic target

Since reprogramming energy metabolism is considered a new hallmark of cancer, tumor metabolism is again in the spotlight of cancer research. Many studies have been carried out and many possible therapies have been developed in the last years. However, tumor cells are not alone. A series of extracellular components and stromal cells, such as endothelial cells, cancer-associated fibroblasts, tumor-associated macrophages and tumor-infiltrating T cells, surround tumor cells in the so-called tumor microenvironment. Metabolic features of these cells are being studied in deep in order to find relationships between metabolism within the tumor microenvironment and tumor progression. Moreover, it cannot be forgotten that tumor growth is able to modulate host metabolism and homeostasis, so that tumor microenvironment is not the whole story. Importantly, the metabolic switch in cancer is just a consequence of the flexibility and adaptability of metabolism and should not be surprising. Treatments of cancer patients with combined therapies including anti-tumor agents with those targeting stromal cell metabolism, anti-angiogenic drugs and/or immunotherapy are being developed as promising therapeutics.Mª Carmen Ocaña is recipient of a predoctoral FPU grant from the Spanish Ministry of Education, Culture and Sport. Supported by grants BIO2014-56092-R (MINECO and FEDER), P12-CTS-1507 (Andalusian Government and FEDER) and funds from group BIO-267 (Andalusian Government). The "CIBER de Enfermedades Raras" is an initiative from the ISCIII (Spain). The funders had no role in the study design, data collection and analysis, decision to publish or preparation of the manuscript

Inferences of mantle viscosity based on ice age data sets: Radial structure

We perform joint nonlinear inversions of glacial isostatic adjustment (GIA) data, including the following: postglacial decay times in Canada and Scandinavia, the Fennoscandian relaxation spectrum (FRS), late-Holocene differential sea level (DSL) highstands (based on recent compilations of Australian sea level histories), and the rate of change of the degree 2 zonal harmonic of the geopotential, $J_2$. Resolving power analyses demonstrate the following: (1) the FRS constrains mean upper mantle viscosity to be ∼3 × 10$^{20}$ Pa s, (2) postglacial decay time data require the average viscosity in the top ∼1500 km of the mantle to be 10$^{21}$ Pa s, and (3) the $J_2$ datum constrains mean lower mantle viscosity to be ∼5 × 10$^{21}$ Pa s. To reconcile (2) and (3), viscosity must increase to 10$^{22}$-10$^{23}$ Pa s in the deep mantle. Our analysis highlights the importance of accurately correcting the $J_2$ observation for modern glacier melting in order to robustly infer deep mantle viscosity. We also perform a large series of forward calculations to investigate the compatibility of the GIA data sets with a viscosity jump within the lower mantle, as suggested by geodynamic and seismic studies, and conclude that the GIA data may accommodate a sharp jump of 1-2 orders of magnitude in viscosity across a boundary placed in a depth range of 1000-1700 km but does not require such a feature. Finally, we find that no 1-D viscosity profile appears capable of simultaneously reconciling the DSL highstand data and suggest that this discord is likely due to laterally heterogeneous mantle viscosity, an issue we explore in a companion study.National Science Foundation Division of Ocean Sciences (Grant ID: OCE-0825293 “PLIOMAX”), Cooperative Studies of The Earth’s Deep Interior (Grant ID: EAR-1464024), Harvard Universit

Accreting Millisecond X-Ray Pulsars

Accreting Millisecond X-Ray Pulsars (AMXPs) are astrophysical laboratories without parallel in the study of extreme physics. In this chapter we review the past fifteen years of discoveries in the field. We summarize the observations of the fifteen known AMXPs, with a particular emphasis on the multi-wavelength observations that have been carried out since the discovery of the first AMXP in 1998. We review accretion torque theory, the pulse formation process, and how AMXP observations have changed our view on the interaction of plasma and magnetic fields in strong gravity. We also explain how the AMXPs have deepened our understanding of the thermonuclear burst process, in particular the phenomenon of burst oscillations. We conclude with a discussion of the open problems that remain to be addressed in the future.Comment: Review to appear in "Timing neutron stars: pulsations, oscillations and explosions", T. Belloni, M. Mendez, C.M. Zhang Eds., ASSL, Springer; [revision with literature updated, several typos removed, 1 new AMXP added

Ethics and images of suffering bodies in humanitarian medicine

Media representations of suffering bodies from medical humanitarian organisations raise ethical questions, which deserve critical attention for at least three reasons. Firstly, there is a normative vacuum at the intersection of medical ethics, humanitarian ethics and the ethics of photojournalism. Secondly, the perpetuation of stereotypes of illness, famine or disasters, and their political derivations are a source of moral criticism, to which humanitarian medicine is not immune. Thirdly, accidental encounters between members of the health professions and members of the press in the humanitarian arena can result in misunderstandings and moral tension. From an ethics perspective the problem can be specified and better understood through two successive stages of reasoning. Firstly, by applying criteria of medical ethics to the concrete example of an advertising poster from a medical humanitarian organisation, I observe that media representations of suffering bodies would generally not meet ethical standards commonly applied in medical practice. Secondly, I try to identify what overriding humanitarian imperatives could outweigh such reservations. The possibility of action and the expression of moral outrage are two relevant humanitarian values which can further be spelt out through a semantic analysis of 'témoignage' (testimony). While the exact balance between the opposing sets of considerations (medical ethics and humanitarian perspectives) is difficult to appraise, awareness of all values at stake is an important initial standpoint for ethical deliberations of media representations of suffering bodies. Future pragmatic approaches to the issue should include: exploring ethical values endorsed by photojournalism, questioning current social norms about the display of suffering, collecting empirical data from past or potential victims of disasters in diverse cultural settings, and developing new canons with more creative or less problematic representations of suffering bodies than the currently accepted stereotypes

1960: Abilene Christian College Lectures - Full Text

Table of Contents: Theme Speeches: Christian Faith in the Modern World Basis of Faith - Leonard Mullens - 9 Authority in Christianity - John T. Smithson, Jr. - 27 Origin and Preservation of the Bible - Neil R. Lightfoot - 44 Alleged Discrepancies of the Bible - David H. Bobo - 62 The Unity of the Bible - Jack Meyer - 91 Faith and Reason - Joe Sanders - 115 The Reasonableness of Supernaturalism - Virgil Trout - 126 The Present Statue of the Doctrine of Organic Evolution - J.D. Thomas - 146 The Nature of Man - Roy F. Osborne, Jr. - 181 Modern Challenges to Christian Morals - Carl Spain - 199 The Christ, Whose Son is He? - Gordon Teel - 232 Special Speeches Teaching the Word of God in Korea - L. Haskell Chessfire - 255 The Influence of Christian Education - Judge Jack Pope - 276 Mission Opportunities in the Far East - Harry Robert Fox - 288 Mission Work in Austria - Robert Skelton - 303 Report from Switzerland - Heinrich Blum - 313 The Work in Nigeria - Rees Byrant - 320 The Training of Evangelists in Foreign Fields - Reiner Kallus - 331 Christian Scholarships - Everett Ferguson - 340 Evangelizing the World - A.R. Holton - 349 Panel Discussions The Significance of the Dead Sea Scrolls The Scrolls and the Text of the Bible - Paul Rotenberry - 357 The Relation between the Religion of the Essenes and that of Early Christians - Jay Smith - 366 Biblical Interpretation Expediency and Pattern Authority - J.W. Roberts - 381 Examples in Pattern Authority - Thomas B. Warren - 392 Mental Health and Sin The Present State of Mental Health Knowledge - Donald R. Sime - 409 The Relationship of Mental Health Problems to Sin - Paul Easley - 421 The Teenager The Problems of Youth - Mack Wayne Craig - 432 Influences for Good - Wyatt Sawyer - 443 The Benefits of Abilene Christian College To the Church - Hulen Jackson - 451 To The Home - Robert S. Bell - 459 \u27To the Community - Louie Welch - 465 Expenses At Abilene Christian College - James C. Kerr - 469 The Graduate School at Abilene Christian College What I Am Getting Now in the ACC Graduate Program - Harold Vanderpool - 475 How the ACC Graduate Program Has Stood Up - Everett Ferguson - 481 What the ACC Graduate Program Ought To Be - Frank Pack - 486 The Importance to the Church of the ACC Graduate Program A.R. Holton - 490 Beware: Large File Size Uploaded by Jackson Hage

The reflares and outburst evolution in the accreting millisecond pulsar SAX J1808.4-3658: A disk truncated near co-rotation?

© 2016. The American Astronomical Society. All rights reserved. The accreting millisecond X-ray pulsar SAX J1808.43658 shows peculiar low luminosity states known as "reflares" after the end of the main outburst. During this phase the X-ray luminosity of the source varies by up to three orders of magnitude in less than 12 days. The lowest X-ray luminosity observed reaches a value of ~1032 erg s-1, only a factor of a few brighter than its typical quiescent level. We investigate the 2008 and 2005 reflaring state of SAX J1808.43658 to determine whether there is any evidence for a change in the accretion flow with respect to the main outburst. We perform a multiwavelength photometric and spectral study of the 2005 and 2008 reflares with data collected during an observational campaign covering the near-infrared, optical, ultra-violet and X-ray band. We find that the NIR/optical/UV emission, expected to come from the outer accretion disk, shows variations in luminosity over an order of magnitude. The corresponding X-ray luminosity variations are instead much deeper, spanning about 23 orders of magnitude. The X-ray spectral state observed during the reflares does not change substantially with X-ray luminosity, indicating a rather stable configuration of the accretion flow. We investigate the most likely configuration of the innermost regions of the accretion flow and we infer an accretion disk truncated at or near the co-rotation radius. We interpret these findings as due to either a strong outflow (due to a propeller effect) or a trapped disk (with limited/no outflow) in the inner regions of the accretion flow

Sleep, vigilance, and thermosensitivity

The regulation of sleep and wakefulness is well modeled with two underlying processes: a circadian and a homeostatic one. So far, the parameters and mechanisms of additional sleep-permissive and wake-promoting conditions have been largely overlooked. The present overview focuses on one of these conditions: the effect of skin temperature on the onset and maintenance of sleep, and alertness. Skin temperature is quite well suited to provide the brain with information on sleep-permissive and wake-promoting conditions because it changes with most if not all of them. Skin temperature changes with environmental heat and cold, but also with posture, environmental light, danger, nutritional status, pain, and stress. Its effect on the brain may thus moderate the efficacy by which the clock and homeostat manage to initiate or maintain sleep or wakefulness. The review provides a brief overview of the neuroanatomical pathways and physiological mechanisms by which skin temperature can affect the regulation of sleep and vigilance. In addition, current pitfalls and possibilities of practical applications for sleep enhancement are discussed, including the recent finding of impaired thermal comfort perception in insomniacs

Calibration of advanced Virgo and reconstruction of the detector strain h( t) during the observing run O3

The three advanced Virgo and LIGO gravitational wave detectors participated to the third observing run (O3) between 1 April 2019 15:00 UTC and 27 March 2020 17:00 UTC, leading to several gravitational wave detections per month. This paper describes the advanced Virgo detector calibration and the reconstruction of the detector strain h(t) during O3, as well as the estimation of the associated uncertainties. For the first time, the photon calibration technique as been used as reference for Virgo calibration, which allowed to cross-calibrate the strain amplitude of the Virgo and LIGO detectors. The previous reference, so-called free swinging Michelson technique, has still been used but as an independent cross-check. h(t) reconstruction and noise subtraction were processed online, with good enough quality to prevent the need for offline reprocessing, except for the two last weeks of September 2019. The uncertainties for the reconstructed h(t) strain, estimated in this paper in a 20-2000 Hz frequency band, are frequency independent: 5% in amplitude, 35 mrad in phase and 10 μs in timing, with the exception of larger uncertainties around 50 Hz