93 research outputs found
Critical behaviour of the Rouse model for gelling polymers
- Author
- Adam M
- Adolf D
- Alexander S
- Bird R B
- Broderix K
- Broderix K
- Broderix K
- Bunde A
- Cates M E
- Cates M E
- Colby R H
- Daoud M
- de Gennes P-G
- de Gennes P-G
- de Gennes P-G
- Devreux F
- Doi M
- Durand D
- Ferry J D
- Haan S W
- Martin J E
- Martin J E
- Peter Müller
- Rouse P E
- Rubinstein M
- Rubinstein M
- Sommer J-U
- Sommer J-U
- Stauffer D
- Stauffer D
- Stauffer D
- Vernon D
- Winter H H
- Zilman A G
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2003
- Field of study
It is shown that the traditionally accepted "Rouse values" for the critical
exponents at the gelation transition do not arise from the Rouse model for
gelling polymers. The true critical behaviour of the Rouse model for gelling
polymers is obtained from spectral properties of the connectivity matrix of the
fractal clusters that are formed by the molecules. The required spectral
properties are related to the return probability of a "blind ant"-random walk
on the critical percolating cluster. The resulting scaling relations express
the critical exponents of the shear-stress-relaxation function, and hence those
of the shear viscosity and of the first normal stress coefficient, in terms of
the spectral dimension ds of the critical percolating cluster and the
exponents σ and τ of the cluster-size distribution.Comment: 9 pages, slightly extended version, to appear in J. Phys.
Rtt107 Phosphorylation Promotes Localisation to DNA Double-Stranded Breaks (DSBs) and Recombinational Repair between Sister Chromatids
- Author
- Adam Jarmuz
- AM Mozlin
- Arthur J. Lustig
- C Michaelis
- DC Zappulla
- DM Sheedy
- E Unal
- F Paques
- Felipe Vilella-Mitjana
- G De Piccoli
- HB Lindroos
- HM Verkade
- IA Manke
- J Rouse
- J Rouse
- J Torres-Rosell
- J Torres-Rosell
- JA Melo
- JD Nelson
- JE Haber
- JK Chin
- JM Daley
- JN Strathern
- K Herzberg
- L Strom
- LC Kadyk
- Luis Aragón
- M Bermudez-Lopez
- M Lisby
- P Bork
- PR Potts
- Pranav Ullal
- PY Ohouo
- R Jensen
- SE Lee
- ST Kim
- TM Roberts
- TM Roberts
- V Guacci
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
Efficient repair of DNA double-stranded breaks (DSB) requires a coordinated response at the site of lesion. Nucleolytic resection commits repair towards homologous recombination, which preferentially occurs between sister chromatids. DSB resection promotes recruitment of the Mec1 checkpoint kinase to the break. Rtt107 is a target of Mec1 and serves as a scaffold during repair. Rtt107 plays an important role during rescue of damaged replication forks, however whether Rtt107 contributes to the repair of DSBs is unknown. Here we show that Rtt107 is recruited to DSBs induced by the HO endonuclease. Rtt107 phosphorylation by Mec1 and its interaction with the Smc5–Smc6 complex are both required for Rtt107 loading to breaks, while Rtt107 regulators Slx4 and Rtt101 are not. We demonstrate that Rtt107 has an effect on the efficiency of sister chromatid recombination (SCR) and propose that its recruitment to DSBs, together with the Smc5–Smc6 complex is important for repair through the SCR pathway
Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis
- Author
- Aahlin Eirik Kjus
- Aamer Ahmed
- Aaniana Kenneth
- Ababneh Ali
- Abaliksta Tomas
- Abantanga Francis
- Abbas Athar
- Abbasy Jibran
- Abbo Olivier
- Abbott Tom
- Abbouch Meryem
- Abd El-Latif Nadia Khalid
- Abd Elkhalek Esraa
- Abd-Elmawla Manar
- Abdallah Emad
- Abdel-Aty Abdulrahman
- Abdel-Hameed Noran
- Abdel-Kader Sara Mahmoud
- Abdelaal Abdelaziz
- Abdelaty Mohamed
- Abdelazeam Anan Rady
- Abdelazim Galaleldin
- Abdelaziz Mohamed A.
- Abdelbadeai Kholoud
- Abdelfatah Afnan
- Abdelhady Samar
- Abdelhamed Rasha
- Abdelhamid Amina
- Abdelhaq Aram
- Abdelkader Mostafa
- Abdelkader Omar
- Abdelkhalek Mohamed
- Abdelmageed Eman
- Abdelmotaleb Ibrahem
- Abdelraouf Ahmed Mahmoud
- Abdelrouf Doaa Maher
- Abdelshakour Mahmoud
- Abdrabou Abdulshafi Khaled
- Abdul-Latif Saiba
- Abdulaziz Hager
- Abdulaziz Mustafa
- Abdulbagi Omar
- Abdulhakeem Eman Mahmoud
- Abdullah Mohamed Abozed
- Abdullah Nik Azim Nik
- Abdullah Noha
- Abdullahi Lawal
- Abdurrazzaaq Abdussemiu
- Abem Owusu Emmanuel
- Abiola Olajide
- Aboelella Majed
- Aboelmagd Omnia
- Aboelsoud Moustafa R.
- Aboul-Naga Mariam Saad
- Abouzaid Arwa
- Abu Qumbos Amjad
- Abu-toyour Maram
- Abubakr Marwan
- Abuowda Yousef
- Abuqwaider Eman
- Abusalem Lana
- Abushamleh Soha
- Ackom Eric
- Acquah Emmanuel
- Adam Ali
- Adam Nourhan
- Adamu Ahmed
- Adawi Ihdaa
- Adawi Mohammad
- Adebanjo Ademola
- Adebola Oluwaseyi
- Adedeji Adesina
- Adel Badr Eldin
- Adel Israa
- Adella Fidelis Jacklyn
- Adelshone Abdelrahman
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O.
- Ademuyiwa Adesoji O.
- Adenekan Babajide
- Adeniran James
- Adeniyi Adewale
- Adesanya Opeoluwa
- Adesina Alaba
- Adeyeye Ademola
- Adeyeye Ademola
- Adhitama Novia
- Adil Muhammad
- Adisa Adewale O.
- Adiyaman Can
- Adu-Aryee Niiarmah
- Afana Samah
- Agalianos Christos
- Agarwal Arnav
- Agarwal Arnav
- Agbedinu Kwabena
- Aglan Amro
- Aguado Suarez Nuria
- Aguilera Maria Lorena
- Aguilera Maria Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahlonsou Germain
- Ahlqvist Sandra
- Ahlqvist Sandra
- Ahmed Asdaq
- Ahmed Ataa
- Ahmed Hayam
- Ahmed Hussien
- Ahmed Lopna Ahmed Mohamed
- Ahmed Sara
- Ahmed Saraibrahim
- Ahounou Ernest Yemalin Stephane
- Ajah Jonathan
- Ajai Olalekan
- Ajao Akinlabi
- Ajiboye Anthony
- Akoto Elliot
- Akpenyi Onyinye
- Al Amin Shadid
- Al Attar Samaa Mahmoud
- Al Barraw Fayez Elian
- Al Bastawis Fatema
- Al Meligy Amgad
- Al Rafati Ahmad Abdel Razaq
- Al Raouf Eman Abd
- Al Saied Ghiath
- Al Subaie Norah
- Al-Bahrani Ahmed
- Al-Buhaisi Alaa
- Al-Dakka Emad
- Al-faqawi Maha
- Al-farram Hadeel
- Al-khatib Ahmed
- Al-Marakby Dina
- Al-saqqa Sara
- Al-Saqqa Sara W.
- Al-Slaibi Ibrahim
- Al-taher Taher
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- Alada Muslimat
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- Alaloul Enas
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- Alamoudi Mohammed
- Albiety Adel
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- Alexander Philip
- Alexandre Challine
- Alghamdi Ahmed
- Alghamdi Mohammed Saleh A.
- Alhady Khaled
- Alhammali Tariq
- Alhassan Basmah
- Alhazmi Wedyan
- Alherz Mohammad
- Ali Ahmed
- Ali Citra Dewi Mohd
- Ali Elsayed
- Ali Safia
- Ali Syed Abdul Wahhab Eusoffee Wan
- Ali Tebian Hassanein Ahmed
- Ali Wadah
- Alihonou Thierry
- Alis Halil
- Aliyu Halima
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- Aljboor Khaled
- Aljiffry Murad
- Alkaaki Aroub
- Alkelani Muhammad
- Allam Meran
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- Alnusairat Aseel
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- Alsaggaf Mohammed Ubaid
- Alser Osaid H.
- Alshareef Reham
- Altaf Abdulmalik
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- Altamini Afnan
- Altarayra Marwa
- Altibi Ahmed
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- Altinel Yuksel
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- Ang Yun Lin
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- Anis Echaieb
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- Drake Thomas M.
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- Vicenta Collado Maria
- Vida Lucian Corneliu
- Vilcinskas Mantas
- Villalobos Santiago
- Violi Paola
- Visinskas Petras
- Voulgaris Evangelos
- Wael Noha
- Wakefield Rebecca
- Waledziak Maciej
- Walker Michael
- Walker Nathan
- Walls Luke
- Walsh Michael
- Waqar Muhammad
- Warren Oliver
- Waterman Ade
- Werder Gabriela
- Whitaker John
- White Rebecca
- Whitehurst Katharine
- Wiborg Joachim
- Widiastini T. Ariani
- Widmer Lukas Werner
- Wijayarathna L. S.
- Williams Omolara
- Wilson Ling
- Wilson Michael
- Wilson Michael
- Wimalge P. M. S. N.
- Wogensen Fredrik
- Wolf Bernhard
- Wondoh Paul
- Wondoh Paul
- Wong Chui Yee
- Wong Francisca
- Wong Hong Yee
- Wood Greta
- Worku Mengistu
- Worku Tewodros
- Wright Naomi
- Yahaya Muhammad Taqiyuddin
- Yakubu Musah
- Yam Sir Young
- Yang James
- Yap Suhhuey
- Yau Jih Dar
- Ye Joselyn
- Yeang Li Jing
- Yeung Man Hon Andrew
- Yifieyeh Abiboye
- Yildirim Reyyan
- Yip Chingwan
- Ymeri Shpetim
- Yoganathan Pigeneswaren
- Yolcu Sinem
- Yong Guo Liang
- Younis Abobaker
- Youssef Mohamed
- Yuksek Mahmut Arif
- Yusufali Taha
- Zaa'treh Rula
- Zadoroznas Antanas
- Zahran Diaaaldin
- Zakaria Esraay
- Zakaria Mahmoud
- Zakaria Yehia
- Zaki Ahmed
- Zammit Stefan
- Zampitis Nikolaos
- Zani Augusto
- Zani Augusto
- Zanini Nicola
- Zapata Felipe
- Zarb Ciskje
- Zeta Solis Ludwing Alexander
- Zielinski Martin
- Zilinskas Justas
- Zilinskas Justas
- Zilinskas Justas
- Zilinskiene Reda
- Ziubryte Greta
- Zohair Ahmed
- Zuber Markus
- Zuk Grzegorz
- Zulkifli Athirah
- Zumbuhl Lucius
- Publication venue
- Elsevier
- Publication date
- 01/06/2003
- Field of study
BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London
Food Use and Health Effects of Soybean and Sunflower Oils
- Author
- Abeywardena MY
- Adam O
- Ahrens EH
- Allen RR
- Anonymous
- Armstrong B
- Arntzenius AC
- Aursnes I
- Awad ZAB
- Bang HO
- Baudet MF
- Becker N
- Begin ME
- Beilin LJ
- Berg KJ
- Berry EM
- Berry EM
- Berry EM
- Bierenbaum ML
- Birt DF
- Bjerve KS
- Black HS
- Boeryd B
- Boeryd B
- Bonaa KH
- Booyens J
- Booyens J
- Booyens J
- Botha JH
- Brenner RR
- Brinton EA
- Burns CP
- Burns CP
- Cameron RG
- Campbell EJ
- Carroll KK
- Carroll KK
- Carroll RK
- Cathcart ES
- Chapman GW
- Ciocca S
- Clinton SK
- Consumer and Food Economics Institute
- Cortese C
- Cowan JC
- Dao TL
- Dayton S
- de Man JM
- DuPlessis LM
- Dupont J
- Dupont J
- Dupont J
- Dutton HJ
- Dyerberg J
- Eid A
- Elliott P
- Endres S
- Erickson KL
- Evans CD
- Everitt JI
- Everitt JI
- Formo MW
- Fritsche KL
- Fujiwara F
- Garg MR
- Ginsberg HN
- Goetzl EL
- Goodnight SH
- Goodnight SH
- Goodnight SH
- Gordon T
- Graef GL
- Graef GL
- Gregori DI
- Groen JJ
- Groot PHE
- Gruchow HW
- Hamazaki T
- Hammond EG
- Harris WS
- Hegsted DM
- Hegsted DM
- Heilbrun LK
- Heiss G
- Hems G
- Hildes JA
- Hislop TG
- Hjermann I
- Hjermann I
- Holm LE
- Hopkins GJ
- Hopkins GJ
- Hopkins GJ
- Hornstra G
- Howell RW
- Hwang D
- Hwang DH
- Iacono JM
- Iacono JM
- Institute of Shortening and Edible Oils Inc
- Itoh T
- Jacobson EA
- Joffres MR
- Johnston PV
- Jung MY
- Kaizer L
- Kelley JP
- Keys A
- Keys A
- Keys AB
- Kohlmeier M
- Kremer JM
- Kromann N
- Kromhout D
- Kupranycz DB
- Kuusi T
- Landers RE
- Leaf A
- Leren P
- Leslie CA
- Lewis B
- Life Science Research Office FASEB
- Lipid Research Clinics Program
- Lohlmeier M
- Lundeen PO
- Margetts BM
- Marshall LA
- McCarty MF
- McDonald BE
- McDonald BE
- McKeown-Eyssen GE
- McLaughlin PJ
- Mensink RP
- Meydani SN
- Meydani SN
- Miettinen TA
- Morrison WH
- Moulton KJ
- Mounts TL
- Mounts TL
- Multiple Risk Factor Intervention Trial Research Group
- National Research Council
- Nelson M
- Nestel PJ
- Nestel PJ
- Neuringer M
- Newman BC
- Nordoy A
- Nordoy A
- Nordoy A
- Oarada M
- Olson LM
- Oster P
- Ota DM
- Payan DG
- Pietienen P
- Pietinen P
- Pryde EH
- Purdy RH
- Puska P
- Reich R
- Renaud S
- Renaud S
- Renaud S
- Riemersma RA
- Riemersma RA
- Robinson DR
- Robinson KW
- Rogers AE
- Rola-Pleszczynski M
- Rose DP
- Rouse IL
- Rouse IL
- Rubba P
- Sacks FM
- Sacks FM
- Sacks FM
- Sacks FM
- Salonen JT
- Salonen JT
- Sanders TAB
- Sanders TAB
- Schaefer EJ
- Shepherd J
- Shepherd J
- Simopoulos AP
- Sims RJ
- Sirtori CR
- Smith DL
- Smith DL
- Snyder JM
- Sonntag NOV
- Stamler J
- Sundram K
- Sylvester PW
- Takenaga M
- Ten Hoor F
- The Expert Panel
- Thomas VA
- Tinoco J
- Tinsley IJ
- Trost VW
- Tuyns AJ
- Verreault R
- Virella G
- Warner K
- Warner K
- Warner KA
- Weihbrauch JL
- Weisweiler P
- Welsch CW
- White PJ
- Wilcox JR
- Wood DA
- Yoshino S
- Publication venue
- Iowa State University Digital Repository
- Publication date
- 01/10/1991
- Field of study
This review provides a scientific assessment of current knowledge of health effects of soybean oil (SBO) and sunflower oil (SFO). SBO and SFO both contain high levels of polyunsaturated fatty acids (PUFA) (60.8 and 69%, respectively), with a PUFA:saturated fat ratio of 4.0 for SBO and 6.4 for SFO. SFO contains 69% C18:2n-6 and less than 0.1% C18:3n-3, while SBO contains 54% C18:2n-6 and 7.2% C18:3n-3. Thus, SFO and SBO each provide adequate amounts of C18:2n-6, but of the two, SBO provides C18:3n-3 with a C18:2n-6:C18:3n-3 ratio of 7.1. Epidemiological evidence has suggested an inverse relationship between the consumption of diets high in vegetable fat and blood pressure, although clinical findings have been inconclusive. Recent dietary guidelines suggest the desirability of decreasing consumption of total and saturated fat and cholesterol, an objective that can be achieved by substituting such oils as SFO and SBO for animal fats. Such changes have consistently resulted in decreased total and low-density-lipoprotein cholesterol, which is thought to be favorable with respect to decreasing risk of cardiovascular disease. Also, decreases in high-density-lipoprotein cholesterol have raised some concern. Use of vegetable oils such as SFO and SBO increases C18:2n-6, decreases C20:4n-6, and slightly elevated C20:5n-3 and C22:6n-3 in platelets, changes that slightly inhibit platelet generation of thromboxane and ex vivo aggregation. Whether chronic use of these oils will effectively block thrombosis at sites of vascular injury, inhibit pathologic platelet vascular interactions associated with atherosclerosis, or reduce the incidence of acute vascular occlusion in the coronary or cerebral circulation is uncertain. Linoleic acid is needed for normal immune response, and essential fatty acid (EFA) deficiency impairs B and T cell-mediated responses. SBO and SFO can provide adequate linoleic acid for maintenance of the immune response. Excess linoleic acid has supported tumor growth in animals, an effect not verified by data from diverse human studies of risk, incidence, or progression of cancers of the breast and colon. Areas yet to be investigated include the differential effects of n-6- and n-3-containing oil on tumor development in humans and whether shorter-chain n-3 PUFA of plant origin such as found in SBO will modulate these actions of linoleic acid, as has been shown for the longer-chain n-3 PUFA of marine oil
Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection
- Author
- Alba George A
- Alicic Radica
- Altman Natasha
- Anglin Khamal
- Argueta Urania
- Ashktorab Hassan
- Atchley-Challenner Rachel
- Baslet Gaston
- Bassett Ingrid V
- Bateman Lucinda
- Bedi Brahmchetna
- Bhattacharyya Shamik
- Bind Marie-Abele
- Blomkalns Andra L
- Bonilla Hector
- Brim Hassan
- Bush Patricia A
- Castro Mario
- Chan James
- Charney Alexander W
- Chen Peter
- Chibnik Lori B
- Chu Helen Y
- Clifton Rebecca G
- Costantine Maged M
- Cribbs Sushma K
- Davila Nieves Sylvia I
- Deeks Steven G
- Duven Alexandria
- Emery Ivette F
- Erdmann Nathan
- Erlandson Kristine M
- Ernst Kacey C
- Farah-Abraham Rachael
- Farner Cheryl E
- Feuerriegel Elen M
- Fleurimont Judes
- Fonseca Vivian
- Foulkes Andrea S
- Franko Nicholas
- Gainer Vivian
- Gander Jennifer C
- Gardner Edward M
- Geng Linda N
- Gibson Kelly S
- Go Minjoung
- Goldman Jason D
- Grebe Halle
- Greenway Frank L
- Habli Mounira
- Hafner John
- Han Jenny E
- Hanson Keith A
- Heath James
- Hernandez Carla
- Hess Rachel
- Hodder Sally L
- Hoffman Matthew K
- Hoover Susan E
- Horwitz Leora I
- Huang Beatrice
- Hughes Brenna L
- Jagannathan Prasanna
- John Janice
- Jolley Sarah E
- Jordan Michael R
- Karlson Elizabeth W
- Katz Stuart D
- Kaufman Elizabeth S
- Kelly John D
- Kelly Sara W
- Kemp Megan M
- Kirwan John P
- Klein Jonathan D
- Knox Kenneth S
- Krishnan Jerry A
- Kumar Andre
- Laiyemo Adeyinka O
- Lambert Allison A
- Lanca Margaret
- Lee-Iannotti Joyce K
- Levitan Emily B
- Levy Bruce
- Logarbo Brian P
- Longo Michele T
- Luciano Carlos A
- Lutrick Karen
- Maley Jason H
- Mallett Gail
- Marathe Jai G
- Marconi Vincent
- Marshall Gailen D
- Martin Christopher F
- Matusov Yuri
- McComsey Grace A
- McCorkell Lisa
- Mehari Alem
- Mendez-Figueroa Hector
- Mermelstein Robin
- Metz Torri D
- Morse Richard
- Mosier Jarrod
- Mouchati Christian
- Mullington Janet
- Murphy Shawn N
- Nadkarni Girish N
- Neuman Robert B
- Nikolich Janko Z
- Ofotokun Ighovwerha
- Ojemakinde Elizabeth
- Palatnik Anna
- Palomares Kristy
- Parimon Tanyalak
- Parry Samuel
- Parthasarathy Sairam
- Patterson Jan E
- Patterson Thomas F
- Patzer Rachel E
- Peluso Michael J
- Pemu Priscilla
- Pettker Christian M
- Plunkett Beth A
- Pogreba-Brown Kristen
- Poppas Athena
- Quigley John G
- Reddy Uma
- Reece Rebecca
- Reeder Harrison
- Reeves W B
- Reiman Eric M
- Rischard Franz
- Rosand Jonathan
- Rouse Dwight J
- Ruff Adam
- Saade George
- Sandoval Grecio J
- Santana Jorge L
- Schlater Shannon M
- Schulte Carolin C M
- Sciurba Frank C
- Selvaggi Caitlin A
- Shepherd Fitzgerald
- Sherif Zaki A
- Shinnick Daniel J
- Simhan Hyagriv
- Singer Nora G
- Singh Upinder
- Skupski Daniel W
- Sowles Amber
- Sparks Jeffrey A
- Sukhera Fatima I
- Taylor Barbara S
- Teunis Larissa
- Thaweethai Tanayott
- Thomas Robert J
- Thorp John M
- Thuluvath Paul
- Ticotsky Amberly
- Tita Alan T
- Tuttle Katherine R
- Urdaneta Alfredo E
- Valdivieso Daisy
- VanWagoner Timothy M
- Vasey Andrew
- Verduzco-Gutierrez Monica
- Walker Tiffany A
- Wallace Zachary S
- Ward Honorine D
- Warren David E
- Weiner Steven J
- Welch Shelley
- Whiteheart Sidney W
- Wiley Zanthia
- Wisnivesky Juan P
- Yee Lynn M
- Zisis Sokratis
- Publication venue
- DigitalCommons@TMC
- Publication date
- 13/06/2023
- Field of study
IMPORTANCE: SARS-CoV-2 infection is associated with persistent, relapsing, or new symptoms or other health effects occurring after acute infection, termed postacute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID. Characterizing PASC requires analysis of prospectively and uniformly collected data from diverse uninfected and infected individuals.
OBJECTIVE: To develop a definition of PASC using self-reported symptoms and describe PASC frequencies across cohorts, vaccination status, and number of infections.
DESIGN, SETTING, AND PARTICIPANTS: Prospective observational cohort study of adults with and without SARS-CoV-2 infection at 85 enrolling sites (hospitals, health centers, community organizations) located in 33 states plus Washington, DC, and Puerto Rico. Participants who were enrolled in the RECOVER adult cohort before April 10, 2023, completed a symptom survey 6 months or more after acute symptom onset or test date. Selection included population-based, volunteer, and convenience sampling.
EXPOSURE: SARS-CoV-2 infection.
MAIN OUTCOMES AND MEASURES: PASC and 44 participant-reported symptoms (with severity thresholds).
RESULTS: A total of 9764 participants (89% SARS-CoV-2 infected; 71% female; 16% Hispanic/Latino; 15% non-Hispanic Black; median age, 47 years [IQR, 35-60]) met selection criteria. Adjusted odds ratios were 1.5 or greater (infected vs uninfected participants) for 37 symptoms. Symptoms contributing to PASC score included postexertional malaise, fatigue, brain fog, dizziness, gastrointestinal symptoms, palpitations, changes in sexual desire or capacity, loss of or change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements. Among 2231 participants first infected on or after December 1, 2021, and enrolled within 30 days of infection, 224 (10% [95% CI, 8.8%-11%]) were PASC positive at 6 months.
CONCLUSIONS AND RELEVANCE: A definition of PASC was developed based on symptoms in a prospective cohort study. As a first step to providing a framework for other investigations, iterative refinement that further incorporates other clinical features is needed to support actionable definitions of PASC
Researching COVID to Enhance Recovery (RECOVER) Adult Study Protocol: Rationale, Objectives, and Design
- Author
- Ahmed Shifa
- Algren Heather A
- Anglin Khamal
- Aponte-Soto Lisa
- Ashktorab Hassan
- Bassett Ingrid V
- Bedi Brahmchetna
- Bhadelia Nahid
- Bime Christian
- Bind Marie-Abele C
- Black Lora J
- Blomkalns Andra L
- Brim Hassan
- Brosnahan Shari B
- Castro Mario
- Chan James
- Charney Alexander W
- Chen Benjamin K
- Chen Li Qing
- Chen Peter
- Chestek David
- Chibnik Lori B
- Chow Dominic C
- Chu Helen Y
- Cicek Mine S
- Clifton Rebecca G
- Collins Shelby
- Costantine Maged M
- Cribbs Sushma K
- Deeks Steven G
- Dickinson John D
- Donohue Sarah E
- Durstenfeld Matthew S
- Emery Ivette F
- Erlandson Kristine M
- Facelli Julio C
- Farah-Abraham Rachael
- Finn Aloke V
- Fischer Melinda S
- Fitzgerald Megan L
- Flaherman Valerie J
- Fleurimont Judes
- Fonseca Vivian
- Foulkes Andrea S
- Gallagher Emily J
- Gander Jennifer C
- Gennaro Maria Laura
- Gibson Kelly S
- Go Minjoung
- Goldman Jason D
- Goodman Steven N
- Granger Joey P
- Greenway Frank L
- Hafner John W
- Han Jenny E
- Harkins Michelle S
- Hauser Kristine S P
- Heath James R
- Hernandez Carla R
- Hess Rachel
- Ho On
- Hodder S L
- Hoffman Matthew K
- Hoover Susan E
- Horowitz Carol R
- Horwitz Leora I
- Hsu Harvey
- Hsue Priscilla Y
- Hughes Brenna L
- Jacoby Vanessa L
- Jagannathan Prasanna
- James Judith A
- John Janice
- Jolley Sarah
- Jordan Michael R
- Judd S E
- Juskowich Joy J
- Kanjilal Diane G
- Karlson Elizabeth W
- Katz Stuart D
- Kelly J Daniel
- Kelly Sara W
- Kim Arthur Y
- Kirwan John P
- Knox Kenneth S
- Krishnan Jerry A
- Kumar Andre
- Laiyemo Adeyinka O
- Lamendola-Essel Michelle F
- Lanca Margaret
- Lee-Lannotti Joyce K
- Lefebvre R Craig
- Levy Bruce D
- Lin Janet Y
- Logarbo Brian P
- Logue Jennifer K
- Longo Michele T
- Luciano Carlos A
- Lutrick Karen
- Malakooti Shahdi K
- Mallett Gail
- Maranga Gabrielle
- Marathe Jai G
- Marconi Vincent C
- Marshall Gailen D
- Martin Christopher F
- Martin Jeffrey N
- May Heidi T
- McComsey Grace A
- McDonald Dylan
- Mendez-Figueroa Hector
- Metz Torri D
- Miele Lucio
- Mittleman Murray A
- Mohandas Sindhu
- Mouchati Christian
- Mullington Janet M
- Nadkarni Girish N
- Nahin Erica R
- Neuman Robert B
- Newman Lisa T
- Nguyen Amber
- Nichols Lauren
- Nikolich Janko Z
- Ofotokun Igho
- Ogbogu Princess U
- Palatnik Anna
- Palomares Kristy T S
- Parimon Tanyalak
- Parry Samuel
- Parthasarathy Sairam
- Patterson Thomas F
- Patzer Rachel E
- Pearman Ann
- Peluso Michael J
- Pemu Priscilla
- Pettker Christian M
- Plunkett Beth A
- Pogreba-Brown Kristen
- Poppas Athena
- Porterfield J Zachary
- Quigley John G
- Quinn Davin K
- Raissy Hengameh
- Rebello Candida J
- Reddy Uma M
- Reece Rebecca
- Reeder Harrison T
- Rischard Franz P
- Rosas Johana M
- Rosen Clifford J
- Rouphael Nadine G
- Rouse Dwight J
- Ruff Adam M
- Saint Jean Christina
- Sandoval Grecio J
- Santana Jorge L
- Schlater Shannon M
- Sciurba Frank C
- Sekar Anisha
- Selvaggi Caitlin
- Seshadri Sudha
- Sesso Howard D
- Shah Dimpy P
- Shemesh Eyal
- Sherif Zaki A
- Shinnick Daniel J
- Simhan Hyagriv N
- Singer Nora G
- Singh Upinder
- Sowles Amber
- Stiles Lauren E
- Subbian Vignesh
- Sun Jun
- Suthar Mehul S
- Taylor Barbara S
- Teunis Larissa J
- Thaweethai Tanayott
- Thorp John M
- Ticotsky Amberly
- Tita Alan T N
- Tragus Robin
- Tuttle Katherine R
- Urdaneta Alfredo E
- Utz P J
- VanWagoner Timothy M
- Vasey Andrew
- Vernon Suzanne D
- Vidal Crystal
- Walker Tiffany
- Ward Honorine D
- Warren David E
- Weeks Ryan M
- Weiner Steven J
- Weyer Jordan C
- Wheeler Jennifer L
- Whiteheart Sidney W
- Wiley Zanthia
- Williams Natasha J
- Wisnivesky Juan P
- Wood John C
- Yee Lynn M
- Young Natalie M
- Zisis Sokratis N
- Publication venue
- DigitalCommons@TMC
- Publication date
- 23/06/2023
- Field of study
IMPORTANCE: SARS-CoV-2 infection can result in ongoing, relapsing, or new symptoms or other health effects after the acute phase of infection; termed post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID. The characteristics, prevalence, trajectory and mechanisms of PASC are ill-defined. The objectives of the Researching COVID to Enhance Recovery (RECOVER) Multi-site Observational Study of PASC in Adults (RECOVER-Adult) are to: (1) characterize PASC prevalence; (2) characterize the symptoms, organ dysfunction, natural history, and distinct phenotypes of PASC; (3) identify demographic, social and clinical risk factors for PASC onset and recovery; and (4) define the biological mechanisms underlying PASC pathogenesis.
METHODS: RECOVER-Adult is a combined prospective/retrospective cohort currently planned to enroll 14,880 adults aged ≥18 years. Eligible participants either must meet WHO criteria for suspected, probable, or confirmed infection; or must have evidence of no prior infection. Recruitment occurs at 86 sites in 33 U.S. states, Washington, DC and Puerto Rico, via facility- and community-based outreach. Participants complete quarterly questionnaires about symptoms, social determinants, vaccination status, and interim SARS-CoV-2 infections. In addition, participants contribute biospecimens and undergo physical and laboratory examinations at approximately 0, 90 and 180 days from infection or negative test date, and yearly thereafter. Some participants undergo additional testing based on specific criteria or random sampling. Patient representatives provide input on all study processes. The primary study outcome is onset of PASC, measured by signs and symptoms. A paradigm for identifying PASC cases will be defined and updated using supervised and unsupervised learning approaches with cross-validation. Logistic regression and proportional hazards regression will be conducted to investigate associations between risk factors, onset, and resolution of PASC symptoms.
DISCUSSION: RECOVER-Adult is the first national, prospective, longitudinal cohort of PASC among US adults. Results of this study are intended to inform public health, spur clinical trials, and expand treatment options
Diminishing benefits of urban living for children and adolescents’ growth and development
- Author
- Abarca-Gomez L.
- Abdeen Z. A.
- Abdrakhmanova S.
- Abdul Rahim H. F.
- Abdurrahmonova Z.
- Abril G. L.
- Abu-Rmeileh N. M.
- Acosta-Cazares B.
- Adam I.
- Adamczyk M.
- Adams R. J.
- Adu-Afarwuah S.
- Aekplakorn W.
- Afsana K.
- Afzal S.
- Agbor V. N.
- Agdeppa I. A.
- Aghazadeh-Attari J.
- Aguenaou H.
- Aguilar-Salinas C. A.
- Agyemang C.
- Ahmad M. H.
- Ahmad N. A.
- Ahmadi A.
- Ahmadi N.
- Ahmadi N.
- Ahmed I.
- Ahmed S. H.
- Ahrens W.
- Aitmurzaeva G.
- Ajlouni K.
- Al Hourani H. M.
- Al Qaoud N. M.
- Al-Hazzaa H. M.
- Al-Lahou B.
- Al-Raddadi R.
- Alarouj M.
- AlBuhairan F.
- AlDhukair S.
- Aldwairji M. A.
- Alexius S.
- Ali M. M.
- Alkandari A.
- Alkerwi A.
- Alkhatib B. M.
- Allin K.
- Alvarez-Pedrerol M.
- Aly E.
- Amarapurkar D. N.
- Amoah J.
- Amougou N.
- Amouyel P.
- Andersen L. B.
- Anderssen S. A.
- Androutsos O.
- Angquist L.
- Anjana R. M.
- Ansari-Moghaddam A.
- Anufrieva E.
- Aounallah-Skhiri H.
- Araujo J.
- Ariansen I.
- Aris T.
- Arku R. E.
- Arlappa N.
- Aryal K. K.
- Aseffa N.
- Aspelund T.
- Assah F. K.
- Assembekov B.
- Assuncao M. C. F.
- Aung M. S.
- Auvinen J.
- Avdicova M.
- Avi S.
- Azevedo A.
- Azimi-Nezhad M.
- Azizi F.
- Azmin M.
- Babu B. V.
- Baharudin A.
- Bahijri S.
- Bakacs M.
- Baker J. L.
- Balakrishna N.
- Balanova Y.
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- Publication venue
- Publication date
- 01/01/2023
- Field of study
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being1–6. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5–19 years on the basis of rural and urban place of residence in 200 countries and territories from 1990 to 2020. In 1990, children and adolescents residing in cities were taller than their rural counterparts in all but a few high-income countries. By 2020, the urban height advantage became smaller in most countries, and in many high-income western countries it reversed into a small urban-based disadvantage. The exception was for boys in most countries in sub-Saharan Africa and in some countries in Oceania, south Asia and the region of central Asia, Middle East and north Africa. In these countries, successive cohorts of boys from rural places either did not gain height or possibly became shorter, and hence fell further behind their urban peers. The difference between the age-standardized mean BMI of children in urban and rural areas was <1.1 kg m–2 in the vast majority of countries. Within this small range, BMI increased slightly more in cities than in rural areas, except in south Asia, sub-Saharan Africa and some countries in central and eastern Europe. Our results show that in much of the world, the growth and developmental advantages of living in cities have diminished in the twenty-first century, whereas in much of sub-Saharan Africa they have amplified
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
- Abbas M.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
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- Aamer A
- Aaniana K
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- Abd El Hamid N
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- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
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- Abdel-Kader SM
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- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
- Al-Saqqa SW
- Al-Saqqa SW
- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
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- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
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- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
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- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
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- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
- Barakat SAE
- Barendegere V
- Barker T
- Barkolias C
- Barmayehvar B
- Barnabas GN
- Barnacle J
- Barneo L
- Barrionuevo Ojeda RR
- Barrios E
- Barrios E
- Barros De Castro Segundo LC
- Barroso de Lima CV
- Barry J
- Basilico S
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- Bassem M
- Bassit KA
- Basso SMM
- Basson S
- Batt J
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- Beasley W
- Beaton C
- Bedada AG
- Bediako-Bowan A
- Behar N
- Beisa V
- Beisa V
- Bekhet AH
- Bekhet NM
- Beleno AEM
- Belkouchi A
- Belli A
- Bello B
- Benammi S
- Benevento A
- Benevento A
- Benger M
- Bennai RM
- Benons N
- Bentounsi Z
- Benyaiche C
- Berti S
- Bertuello I
- Beuran M
- Beuran M
- Beyene R
- Bezerra Morais PA
- Bezzina M
- Bhang A
- Bhangu A
- Bhangu A
- Bhargava A
- Bharj IS
- Bhat S
- Bhatnagar A
- Bhattacharya S
- Bhopal KF
- Bhopal KF
- Bianco F
- Bigaran A
- Billy M
- Bin Adnan A
- Bin Hasnan M
- Bin Ismail MJ
- Bin Mahamood A
- Birindelli A
- Birring A
- Bisset C
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- Bjorklund I
- Blacker S
- Blackwell J
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- Blanco-Colino R
- Blencowe N
- Blencowe N
- Bliksoen M
- Blower E
- Bluelle R
- Blundell R
- Boakye-Yiadom K
- Boal M
- Bocchetti T
- Boddy A
- Bode C
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- Bond-Smith G
- Bondin J
- Bondurri A
- Bondurri A
- Boni S
- Bonnard A
- Bonney W
- Borda Luque G
- Borda-Luque G
- Borda-Luque G
- Borg E
- Borg E
- Borg E
- Borin E
- Bortolasi L
- Bortolasi L
- Boshnaq M
- Botes S
- Bottini C
- Botto N
- Bouali O
- Bougard H
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- Bradulskis S
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- Bratu MR
- Bratu R-M
- Braungart S
- Bray LD
- Breaud J
- Breistrand M
- Breitenstein S
- Breslin R
- Brincat SD
- Broch A
- Brogden T
- Brown D
- Brown E
- Brown J
- Brown J
- Browning DRL
- Brunoni B
- Bsisu I
- Bucci L
- Bugaev N
- Bugeja R
- Buisson P
- Bukari M
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- Burger S
- Burmistrovas A
- Burns H
- Bustangi N
- Butt MT
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- Cabala Chiong JA
- Cacurri A
- Cadogan DD
- Cahill R
- Cakaloglu HC
- Caliman C
- Callan R
- Camacho R
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- Camilleri-Brennan J
- Camilleri-Brennan J
- Camilleri-Brennan JF
- Camilo Correa J
- Campagnaro T
- Canta Calua A
- Capito C
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- Careta MC
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- Carmela Lapitan M
- Carmona JM
- Carpio J
- Carrasco N
- Carreira J-A
- Carreiro De Freitas AV
- Cassar K
- Castro Mollo M
- Catani M
- Cautiero R
- Caydiid H
- Cecilia T
- Celik S
- Cengiz TB
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Cengiz Y
- Ceriani C
- Cevik M
- Chabok A
- Chachulski W
- Chai C-A
- Chai FY
- Chambers A
- Chambers A
- Chan E
- Chan L
- Chan T-YK
- Chan XW
- Chan Z
- Chandrakumar C
- Chang K
- Chang KY-C
- Chapman A
- Chapman SJ
- Charles A
- Cheah AEZ
- Chen CY
- Chen KY
- Chen T-L
- Chenn R
- Cheong YJ
- Chetta N
- Cheung YHE
- Chew LS
- Chhabra S
- Chibuye C
- Chidambaram S
- Chiesa D
- Chilton G
- Chin PX
- Chin YR
- Chiu S
- Chiu S
- Chiu SMY
- Choi J
- Choi P
- Chong BFHK
- Chong CL
- Chong CL
- Chong CL
- Chong CS
- Chong H-Y
- Chong HY
- Choudhry A
- Chow CYN
- Chowdhury A
- Chowdhury D
- Chu K
- Chun A
- Chun T
- Chung KJ
- Chung S
- Ciccioli E
- Cirocchi R
- Ciubotaru C
- Claire R
- Clarissa A
- Clark DJ
- Clark T
- Clegg-Lampety J-N
- Clegg-Lamptey J-N
- Clement KD
- Clements JM
- Clerico G
- Clifford C
- Cloro LM
- Coasaca Huaraya R
- Coccolini F
- Coccolini F
- Coccolini F
- Coccolini F
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- Cocorullo G
- Cohen DM
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- Cole S
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- Coletti M
- Colombani J-F
- Cona C
- Conci S
- Confalonieri G
- Conlon KC
- Connor K
- Connor K
- Contreras Merida SM
- Contreras Urquizu M
- Contreras Vergara AL
- Contreras E
- Coomber R
- Coompson CL
- Corbellini C
- Corbellino M
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- Coronel J
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- Corro-Diaz S
- Costa C
- Costa-Maia J
- Costa-Maia J
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- Costas-Chavarri A
- Courboin E
- Court E
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- Cragg J
- Craus-Miguel A
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- Cucumazzo S
- Cullen F
- Curletti G
- Currow C
- Currow C
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- D'Amours S
- D'amours SK
- D'cruz R
- D'Souza MS
- D'Souza R
- Da Silva LA
- Dabboor M
- Dabbour K
- Dabessa D
- Dablouk M
- Dablouk MO
- Dagoe E
- Dahy A
- Dainius E
- Dakubo J
- Dal Canto M
- Dalli J
- Dally C
- Dambrauskas Z
- Dambrauskas Z
- Dan I
- Danelli P
- Daniels I
- Daniyan M
- Danys D
- Dao W
- Daqeeq A
- Dar M
- Dar W
- Dardenne S
- Darweesh M
- Darwish AKZ
- Das A
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- Datta U
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- De Luca E
- De Marco P
- De Sousa AV
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- Dean R
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- Debrah S
- Deckelbaum DL
- Decker E
- Dedekind B
- Dedey F
- Deichsel F
- Del Basso C
- del Pilar Paucar A
- Delforge X
- Dell A
- Dempster E
- Denakpo M
- Denewar A
- Depalma N
- Deputy M
- Der Y
- Dervenis C
- Despotidis V
- Desta S
- Deutschmann P
- Devadasar GH
- Dharamshi HA
- Dhillon D
- Di Franco F
- Di Martino N
- Di Saverio S
- Di Saverio S
- Diab A
- Diaconescu B
- Diaconescu I-B
- Dias S
- Diaz Vico T
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dione Parreno-Sacdalan M
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani RMNR
- Dorisme A
- dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake TM
- Drake TM
- Drake TM
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy MM
- Ebrahim OS
- Eduard P
- Edwards J
- Edye M
- Eid MM
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- Ekow M
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- El Dahab AA
- El Deen KN
- El Gendy A
- El Gendy NH
- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
- El-Dien KS
- El-Din RA
- El-Din SA
- El-Gizawy E
- El-Hamouly AS
- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
- El-Sawy A
- El-Sehily A
- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem AA
- Elazoul M
- Elbanby E
- Elbanby ES
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy KH
- Eldafrawy M
- Eldamaty L
- Eldeeb AZ
- Eldeen EA
- Eldin MAB
- EldosoukyMohammed A
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
- Elhadary NM
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
- Elhendawy AOA
- Elhoseny G
- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek EA
- Elkholy A
- Elkholy SS
- Elkolaly SS
- Elkorashy AM
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar MA
- Elnemr AE
- Elrazek AA
- Elsabbagh N
- Elsameea AA
- Elsawahly DME
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed NAR
- Elsayed ZM
- Elsebaaye AO
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay AE
- Elshami M
- Elshanwany S
- Elsharkawy AA
- Elsheikh S
- Elsherbiney S
- Elsherbiny AS
- Elsherif FA
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy DEAA
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
- Essam AA
- Essam M
- Essoun S
- Esteban E
- Estee MM
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista CV
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahmy MAB
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat MM
- Faraz A
- Fares M
- Farhad M
- Farhan-Alanie MMH
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fergusson SJ
- Fermani C
- Fermani CG
- Fernandes C
- Fernandez C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald JE
- Fitzgerald JE
- Florez Farfan ES
- Foco M
- Fok CYJ
- Fontana T
- Foo CC
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler AJ
- Fozard T
- Fozard T
- Frade F
- Fraga GP
- Francisco Roxas M
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas AV
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan MM
- Gaafar S
- Gaarder T
- Gad A
- Gad MO
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaignard E
- Gaignard E
- Gaizauskas V
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez CP
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan YY
- Gani MA
- Garaycochea O
- Garcia Bernardo C
- Garcia Florez LJ
- Garcia Septiem J
- Garcia Torres CP
- Garcia-Florez L
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi DG
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy AA
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim MA
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino FR
- Giavarini L
- Giglio MC
- Gilbert R
- Gilbert RW
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo RSR
- Giuliani S
- Giuliani S
- Giuriato TF
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey JC
- GlobalSurg Collaborative
- Glover TE
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh CC
- Goh CC
- Goh W
- Gohar ME-SAM
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzales Montejo MS
- Gonzales Stuva JP
- Gonzalez M
- Goodstein M
- Gosling S
- Gosling SG
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti PP
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella MG
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler DC
- Grosos C
- Grossart C
- Gubeli A
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
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