Principales limitaciones identificadas por auditores de La Contraloría General de la República que impiden el cumplimiento de la implementación de las recomendaciones en los informes de control de las Auditorías de Desempeño emitidos desde enero 2016 al 30 de noviembre 2020

El Estado Peruano viene ejecutando esfuerzos para implementar cuantas acciones sean necesarias a fin de hacer más eficaz y eficiente la generación de bienes y servicios que brinda, para así poder alcanzar resultados positivos en beneficio del bienestar de los ciudadanos y el desarrollo del país; en tal sentido, a través de la Política Nacional de Modernización de Gestión Pública al 20211, el Ejecutivo establece la visión, los principios y los lineamientos para una actuación coherente y eficaz del sector público al servicio de los ciudadanos y del desarrollo del país. (Presidencia de Consejo de Ministros, 2021) Bajo este contexto, La Contraloría General de la República lleva a cabo, a través de la “Auditoría de Desempeño”2, la evaluación de la calidad y el desempeño de entrega de los bienes y servicios que brindan las entidades públicas, con la finalidad de alcanzar resultados que impacten en la calidad de los servicios públicos que se brindan a los ciudadanos. Sin embargo, pese a los numerosos esfuerzos que realiza, verificamos que, el aplicativo web Sigueplan, herramienta informativa que sirve para dar seguimiento a las acciones a implementar por las entidades públicas, se muestra que a noviembre de 2020 se tienen registrados un total de 16 Auditorías de Desempeño realizadas a diferentes servicios que fueron brindados por entidades públicas, cuyos Planes de Acción emitidos incluyeron un total de 522 acciones a implementar, y que pese a haber transcurrido el plazo máximo para la implementación, a la fecha aún existen recomendaciones con implementación baja o nula. En tal sentido, en el presente trabajo de investigación se analiza las principales causas identificadas por el equipo auditor a cargo del seguimiento de los Planes de Acción de la Contraloría General de la República, que limitaron la continuidad en el proceso de seguimiento, asimismo, se realiza un análisis del Sistema de reporte de seguimiento – Sigueplan de acceso público, así como de la Directiva N° 008-2016 CG/GPROD que reguló la auditoría de desempeño durante la vigencia de implementación de los Planes de Acción seleccionados, a fin de proponer alternativas de mejora y formular recomendaciones que contribuyan a la mejora del proceso de seguimiento a los Planes de Acción, producto de las auditorias de desempeño.The Peruvian State has been executing efforts to implement the actions that are necessary in order to make the generation of goods and services it provides more effective and efficient to achieve positive results for the well-being of citizens and the development of the country; In this sense, through the National Policy for the Modernization of Public Management by 2021, the Executive establishes the vision, principles and guidelines for a coherent and effective action of the public sector at the service of citizens and the development of the country. (Presidencia de Consejo de Ministros, 2021) Under this context, the Comptroller General of the Republic carries out, through the "Performance Audit", the evaluation of the quality and performance of the delivery of goods and services provided by public entities, in order to achieve results. that impact on the quality of public services provided to citizens. However, despite the numerous efforts made by the Comptroller General of the Republic, we verified that the web application Sigueplan, an informative tool that serves to monitor the actions to be implemented by public entities, it is shown that as of November 2020 a total of 16 Performance Audits have been registered for different services that were provided by public entities, whose Action Plans issued included a total of 522 actions to be implemented, and that despite After the deadline for implementation has elapsed, to date there are recommendations with little or no implementation. In this sense, this research work analyzes the main causes identified by the audit team in charge of monitoring the Action Plans of the Office of the Comptroller General of the Republic, which limited the continuity in the monitoring process, as well as performs an analysis of the monitoring report system - public access plan, as well as Directive No. 008-2016 CG/GPROD that regulated the performance audit during the implementation period of the selected Action Plans, in order to propose alternatives for improvement and formulate recommendations that contribute to the improvement of the follow-up process for action plans, as a result of performance audits.Trabajo de investigació

Influence of the Ambient Storage of LiNi0.8Mn0.1Co0.1O2 Powder and Electrodes on the Electrochemical Performance in Li-ion Technology

Nickel-rich LiNi0.8Mn0.1Co0.1O2 (NMC811) is one of the most promising Li-ion battery cathode materials and has attracted the interest of the automotive industry. Nevertheless, storage conditions can affect its properties and performance. In this work, both NMC811 powder and electrodes were storage-aged for one year under room conditions. The aged powder was used to prepare electrodes, and the performance of these two aged samples was compared with reference fresh NMC811 electrodes in full Li-ion coin cells using graphite as a negative electrode. The cells were subjected to electrochemical as well as ante- and postmortem characterization. The performance of the electrodes from aged NM811 was beyond expectations: the cycling performance was high, and the power capability was the highest among the samples analyzed. Materials characterization revealed modifications in the crystal structure and the surface layer of the NMC811 during the storage and electrode processing steps. Differences between aged and fresh electrodes were explained by the formation of a resistive layer at the surface of the former. However, the ageing of NMC811 powder was significantly mitigated during the electrode processing step. These novel results are of interest to cell manufacturers for the widespread implementation of NMC811 as a state-of-the-art cathode material in Li-ion batteries.This work was supported by European Union’s Horizon 2020 research and innovation programme [No. 814389 (SPIDER project)]; and the CDTI—Ministerio De Ciencia e Innovación’s ‘CERVERA Centros Tecnológicos’ program [CER-20191006 (ALMAGRID project)]. V.P. and T.R. also wish to thank the funding from Gobierno Vasco/Eusko Jaurlaritza (IT-1226-19)

Report from the American Society of Transplantation on frailty in solid organ transplantation

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/148387/1/ajt15198_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/148387/2/ajt15198.pd

Evolutionary analysis and molecular dissection of caveola biogenesis

Caveolae are an abundant feature of mammalian cells. Integral membrane proteins called caveolins drive the formation of caveolae but the precise mechanisms underlying caveola formation, and the origin of caveolae and caveolins during evolution, are unknown

Preserving Virtual Worlds Final Report

The Preserving Virtual Worlds project is a collaborative research venture of the Rochester Institute of Technology, Stanford University, the University of Maryland, the University of Illinois at Urbana-Champaign and Linden Lab, conducted as part of Preserving Creative America, an initiative of the National Digital Information Infrastructure and Preservation Program at the Library of Congress. The primary goals of our project have been to investigate issues surrounding the preservation of video games and interactive fiction through a series of case studies of games and literature from various periods in computing history, and to develop basic standards for metadata and content representation of these digital artifacts for long-term archival storage

MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes

Polymerase I and transcript release factor (PTRF)/Cavin is a cytoplasmic protein whose expression is obligatory for caveola formation. Using biochemistry and fluorescence resonance energy transfer–based approaches, we now show that a family of related proteins, PTRF/Cavin-1, serum deprivation response (SDR)/Cavin-2, SDR-related gene product that binds to C kinase (SRBC)/Cavin-3, and muscle-restricted coiled-coil protein (MURC)/Cavin-4, forms a multiprotein complex that associates with caveolae. This complex can constitutively assemble in the cytosol and associate with caveolin at plasma membrane caveolae. Cavin-1, but not other cavins, can induce caveola formation in a heterologous system and is required for the recruitment of the cavin complex to caveolae. The tissue-restricted expression of cavins suggests that caveolae may perform tissue-specific functions regulated by the composition of the cavin complex. Cavin-4 is expressed predominantly in muscle, and its distribution is perturbed in human muscle disease associated with Caveolin-3 dysfunction, identifying Cavin-4 as a novel muscle disease candidate caveolar protein

The international EAACI/GA(2)LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

Publisher Copyright: © 2021 GA²LEN. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA(2)LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria.Peer reviewe

The international EAACI/GA²LEN/EuroGuiDerm/APAAACI guideline for the definition, classification, diagnosis, and management of urticaria

This update and revision of the international guideline for urticaria was developed following the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is a joint initiative of the Dermatology Section of the European Academy of Allergology and Clinical Immunology (EAACI), the Global Allergy and Asthma European Network (GA(2)LEN) and its Urticaria and Angioedema Centers of Reference and Excellence (UCAREs and ACAREs), the European Dermatology Forum (EDF; EuroGuiDerm), and the Asia Pacific Association of Allergy, Asthma and Clinical Immunology with the participation of 64 delegates of 50 national and international societies and from 31 countries. The consensus conference was held on 3 December 2020. This guideline was acknowledged and accepted by the European Union of Medical Specialists (UEMS). Urticaria is a frequent, mast cell-driven disease that presents with wheals, angioedema, or both. The lifetime prevalence for acute urticaria is approximately 20%. Chronic spontaneous or inducible urticaria is disabling, impairs quality of life, and affects performance at work and school. This updated version of the international guideline for urticaria covers the definition and classification of urticaria and outlines expert-guided and evidence-based diagnostic and therapeutic approaches for the different subtypes of urticaria

Pitfalls in assessing stromal tumor infiltrating lymphocytes (sTILs) in breast cancer

Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.Stromal tumor-infiltrating lymphocytes (sTILs) are important prognostic and predictive biomarkers in triple-negative (TNBC) and HER2-positive breast cancer. Incorporating sTILs into clinical practice necessitates reproducible assessment. Previously developed standardized scoring guidelines have been widely embraced by the clinical and research communities. We evaluated sources of variability in sTIL assessment by pathologists in three previous sTIL ring studies. We identify common challenges and evaluate impact of discrepancies on outcome estimates in early TNBC using a newly-developed prognostic tool. Discordant sTIL assessment is driven by heterogeneity in lymphocyte distribution. Additional factors include: technical slide-related issues; scoring outside the tumor boundary; tumors with minimal assessable stroma; including lymphocytes associated with other structures; and including other inflammatory cells. Small variations in sTIL assessment modestly alter risk estimation in early TNBC but have the potential to affect treatment selection if cutpoints are employed. Scoring and averaging multiple areas, as well as use of reference images, improve consistency of sTIL evaluation. Moreover, to assist in avoiding the pitfalls identified in this analysis, we developed an educational resource available at www.tilsinbreastcancer.org/pitfalls.Peer reviewe

The Human Phenotype Ontology in 2024: phenotypes around the world.

The Human Phenotype Ontology (HPO) is a widely used resource that comprehensively organizes and defines the phenotypic features of human disease, enabling computational inference and supporting genomic and phenotypic analyses through semantic similarity and machine learning algorithms. The HPO has widespread applications in clinical diagnostics and translational research, including genomic diagnostics, gene-disease discovery, and cohort analytics. In recent years, groups around the world have developed translations of the HPO from English to other languages, and the HPO browser has been internationalized, allowing users to view HPO term labels and in many cases synonyms and definitions in ten languages in addition to English. Since our last report, a total of 2239 new HPO terms and 49235 new HPO annotations were developed, many in collaboration with external groups in the fields of psychiatry, arthrogryposis, immunology and cardiology. The Medical Action Ontology (MAxO) is a new effort to model treatments and other measures taken for clinical management. Finally, the HPO consortium is contributing to efforts to integrate the HPO and the GA4GH Phenopacket Schema into electronic health records (EHRs) with the goal of more standardized and computable integration of rare disease data in EHRs