18 research outputs found
Programación I
- Author
- Publication venue
- 'Facultad De Ingenieria Universidad Del Zulia'
- Publication date
- 01/01/2016
- Field of study
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019 : a comprehensive demographic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir H.
- Abolhassani Hassan
- Abosetugn Akine E.
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas G.
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz K.
- Abu-Gharbieh Eman
- Abu-Raddad Laith J.
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac A.
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun M.
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed M.
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar B.
- Aji Budi
- Akalu Temesgen Y.
- Akinyemi Rufus O.
- Akinyemiju Tomi
- Akombi Blessing J.
- Akunna Chisom J.
- Al-Aly Ziyad
- Al-Mekhlaf Hesham M.
- Al-Raddadi Rajaa
- Alahdab Fares
- Alam Khurshid
- Alam Noore
- Alam Samiah
- Alam Tahiya
- Alanezi Fahad M.
- Alanzi Turki M.
- Albertson Samuel B.
- Alcalde-Rabanal Jacqueline E.
- Alema Niguse M.
- Alemu Biresaw W.
- Alemu Yihun M.
- Alhabib Khalid F.
- Alhassan Robert K.
- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
- Aljunid Syed M.
- Alla François
- Allebeck Peter
- Almadi Majid A.
- Almasi Ali
- Almasi-Hashiani Amir
- Almasri Nihad A.
- Almulhim Abdulaziz M.
- Alonso Jordi
- Altirkawi Khalid A.
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- Alvis-Guzman Nelson
- Alvis-Zakzuk Nelson J.
- Amare Azmeraw T.
- Amare Bekalu
- Amini Saeed
- Amini-Rarani Mostafa
- Aminorroaya Arya
- Amiri Fatemeh
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- et al .
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- Pourjafar Hadi
- Pourmalek Farshad
- Pourmirza Kalhori Reza
- Pourshams Akram
- Poznanska Anna
- Prada Sergio I.
- Prakash Sanjay
- Prakash V.
- Prasad Narayan
- Preotescu Liliana
- Pribadi Dimas R.
- Pupillo Elisabetta
- Quazi Syed Zahiruddin
- Rabiee Mohammad
- Rabiee Navid
- Radfar Amir
- Rafiee Ata
- Rafiei Alireza
- Raggi Alberto
- Rahim Fakher
- Rahimi-Movaghar Afarin
- Rahman Mohammad H.
- Rahman Muhammad A.
- Rajabpour-Sanati Ali
- Rajati Fatemeh
- Rakovac Ivo
- Ram Pradhum
- Ramezanzadeh Kiana
- Rana Saleem M.
- Ranabhat Chhabi L.
- Ranta Annemarei
- Rao Puja C.
- Rao Sowmya J.
- Rasella Davide
- Rashedi Vahid
- Rastogi Prateek
- Rath Goura K.
- Rathi Priya
- Rawaf David L.
- Rawaf Salman
- Rawal Lal
- Rawassizadeh Reza
- Rawat Ramu
- Razo Christian
- Redford Sofia B.
- Regassa Lemma D.
- Reiner Robert C.
- Reinig Nickolas
- Reitsma Marissa B.
- Remuzzi Giuseppe
- Renjith Vishnu
- Renzaho Andre M. N. (R17978)
- Ärnlöv Johan
- Øverland Simon
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019.
Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2·72 (95% uncertainty interval [UI] 2·66–2·79) in 2000 to 2·31 (2·17–2·46) in 2019. Global annual livebirths increased from 134·5 million (131·5–137·8) in 2000 to a peak of 139·6 million (133·0–146·9) in 2016. Global livebirths then declined to 135·3 million (127·2–144·1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2·1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27·1% (95% UI 26·4–27·8) of global livebirths. Global life expectancy at birth increased from 67·2 years (95% UI 66·8–67·6) in 2000 to 73·5 years (72·8–74·3) in 2019. The total number of deaths increased from 50·7 million (49·5–51·9) in 2000 to 56·5 million (53·7–59·2) in 2019. Under-5 deaths declined from 9·6 million (9·1–10·3) in 2000 to 5·0 million (4·3–6·0) in 2019. Global population increased by 25·7%, from 6·2 billion (6·0–6·3) in 2000 to 7·7 billion (7·5–8·0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58·6 years (56·1–60·8) in 2000 to 63·5 years (60·8–66·1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
- Author
- Abbafati Cristiana
- Abbas Kaja M.
- Abbasi Mohammad
- Abbasi-Kangevari Mohsen
- Abbasifard Mitra
- Abbastabar Hedayat
- Abd El Razek Hassan Magdy
- Abd El Razek Muhammed Magdy
- Abd-Allah Foad
- Abdelalim Ahmed
- Abdollahi Mohammad
- Abdollahpour Ibrahim
- Abdulkader Rizwan Suliankatchi
- Abdullah Kanaan Hamagharib
- Abedi Aidin
- Abedi Parisa
- Abegaz Kedir Hussein
- Abolhassani Hassan
- Abosetugn Akine Eshete
- Aboyans Victor
- Abrams Elissa M.
- Abreu Lucas Guimaraes
- Abrigo Michael R. M.
- Abu Haimed Abdulaziz Khalid
- Abu-Gharbieh Eman
- Abu-Raddad Laith Jamal
- Abualhasan Ahmed
- Abushouk Abdelrahman I.
- Acebedo Alyssa
- Ackerman Ilana N.
- Adabi Maryam
- Adair Tim
- Adamu Abdu A.
- Adebayo Oladimeji M.
- Adedeji Isaac Akinkunmi
- Adekanmbi Victor
- Adelson Jaimie D.
- Adeoye Abiodun Moshood
- Adetokunboh Olatunji O.
- Adham Davoud
- Advani Shailesh M.
- Afarideh Mohsen
- Afshari Mahdi
- Afshin Ashkan
- Agardh Emilie E.
- Agarwal Gina
- Agasthi Pradyumna
- Agesa Kareha M.
- Aghaali Mohammad
- Aghamir Seyed Mohammad Kazem
- Agrawal Anurag
- Ahmad Tauseef
- Ahmadi Alireza
- Ahmadi Keivan
- Ahmadi Mehdi
- Ahmadieh Hamid
- Ahmadpour Ehsan
- Ahmed Muktar Beshir
- Aji Budi
- Akalu Temesgen Yihunie
- Akinyemi Rufus Olusola
- Akinyemiju Tomi
- Akombi Blessing
- Akunna Chisom Joyqueenet
- Al-Aly Ziyad
- Al-Mekhlafi Hesham M.
- Al-Raddadi Rajaa M.
- Alahdab Fares
- Alam Khurshid
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- Alcalde-Rabanal Jacqueline Elizabeth
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- Ali Muhammad
- Ali Saqib
- Alicandro Gianfranco
- Alijanzadeh Mehran
- Alinia Cyrus
- Alipour Vahid
- Alizade Hesam
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- Dereje Nebiyu Dereje
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- Szocska Miklos
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- Tabares-Seisdedos Rafael
- Tabb Karen M.
- Tabuchi Takahiro
- Tadakamadla Santosh Kumar
- Taddele Biruk Wogayehu
- Tadesse Degena Bahrey
- Taherkhani Amir
- Tahir Zarfishan
- Tajdini Masih
- Takahashi Ken
- Takala Jukka S.
- Tamiru Animut Tagele
- Tang Muming
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- Tareque Md Ismail
- Tarigan Ingan Ukur
- Taveira Nuno
- Taylor Heather Jean
- Teagle Whitney L.
- Teame Hirut
- Tediosi Fabrizio
- Tefera Yonas Getaye
- Tehrani-Banihashemi Arash
- Teklehaimanot Berhane Fseha
- Tela Freweini Gebrearegay
- Temsah Mohamad-Hani
- Terrason Sonyah
- Tesema Getayeneh Antehunegn
- Tessema Zemenu Tadesse
- Thakur Bhaskar
- Thankappan Kavumpurathu Raman
- Thapar Rekha
- Thomas Nihal
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- Thrift Amanda G.
- Thurston George D.
- Titova Mariya Vladimirovna
- Tlou Boikhutso
- Tohidinik Hamid Reza
- Tonelli Marcello
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- Torre Anna E.
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Traini Eugenio
- Tran Bach Xuan
- Travillian Ravensara
- Trias-Llimos Sergi
- Troeger Christopher E.
- Truelsen Thomas Clement
- Tsai Alexander C.
- Tsatsakis Aristidis
- Tyrovolas Stefanos
- Uddin Riaz
- Ullah Irfan
- Ullah Saif
- Umeokonkwo Chukwuma David
- Undurraga Eduardo A.
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Uthman Olalekan A.
- Vacante Marco
- Vaicekonyte Regina
- Vakilian Alireza
- Valdez Pascual R.
- Valli Alessandro
- Van Donkelaar Aaron
- Vardavas Constantine
- Varughese Santosh
- Vasankari Tommi Juhani
- Vasconcelos Ana Maria Nogales
- Vasseghian Yasser
- Veisani Yousef
- Velasquez Ilais Moreno
- Venketasubramanian Narayanaswamy
- Vidale Simone
- Violante Francesco S.
- Vlassov Vasily
- Vollset Stein Emil
- Vongpradith Avina
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- Vu Giang Thu
- Vujcic Isidora S.
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- Vukovic Rade
- Waheed Yasir
- Wallin Mitchell Taylor
- Walters Magdalene K.
- Wamai Richard G.
- Wang Fang
- Wang Haidong
- Wang Hongbo
- Wang Jiayu
- Wang Yafeng
- Wang Yanzhong
- Wang Yuan-Pang
- Ward Joseph L.
- Watson Alexandrea
- Watson Stefanie
- Wei Jingkai
- Wei Melissa Y. Wei
- Weintraub Robert G.
- Weiss Daniel J.
- Weiss Jordan
- Welay Fissaha Tekulu
- Weldesamuel Girmay Teklay
- Werdecker Andrea
- West J. Jason
- Westerman Ronny
- Whisnant Joanna L.
- Whiteford Harvey A.
- Wiangkham Taweewat
- Wickramasinghe Nuwan Darshana
- Wiens Kirsten E.
- Wijeratne Tissa
- Wilner Lauren B.
- Wilson Shadrach
- Wiysonge Charles Shey
- Wojtyniak Bogdan
- Woldu Gebremariam
- Wolfe Charles D. A.
- Wondmeneh Temesgen Gebeyehu
- Wondmieneh Adam Belay
- Wool Eve E.
- Wozniak Sarah S.
- Wu Ai-Min
- Wu Chenkai
- Wu Junjie
- Wunrow Han Yong
- Xie Yang
- Xu Gelin
- Xu Rixing
- Yadgir Simon
- Yamada Tomohide
- Yamagishi Kazumasa
- Yaminfirooz Mousa
- Yano Yuichiro
- Yaya Sanni
- Yazdi-Feyzabadi Vahid
- Yearwood Jamal A.
- Yeheyis Tomas Y.
- Yeshitila Yordanos Gizachew
- Yilgwan Christopher Sabo
- Yilma Mekdes Tigistu
- Yip Paul
- Yonemoto Naohiro
- Yoon Seok-Jun
- York Hunter W.
- Younis Mustafa Z.
- Younker Theodore Patrick
- Yousefi Bahman
- Yousefi Zabihollah
- Yousefifard Mahmoud
- Yousefinezhadi Taraneh
- Yousuf Abdilahi Yousuf
- Yu Chuanhua
- Yu Yong
- Yuan Chun-Wei
- Yuce Deniz
- Yusefzadeh Hasan
- Zadey Siddhesh
- Zahabi Saleh Salehi
- Zaidi Syed Saoud
- Zaki Leila
- Zaki Maysaa El Sayed
- Zakzuk Josefina
- Zamani Mohammad
- Zamanian Maryam
- Zandian Hamed
- Zangeneh Alireza
- Zarafshan Hadi
- Zastrozhin Mikhail Sergeevich
- Zewdie Kaleab Alemayehu
- Zhang Jianrong
- Zhang Yunquan
- Zhang Zhi-Jiang
- Zhao Jeff T.
- Zhao Xiu-Ju George
- Zhao Yingxi
- Zheleva Bistra
- Zheng Peng
- Zhou Maigeng
- Zhu Cong
- Ziapour Arash
- Zimsen Stephanie R. M.
- Zlavog Bianca S.
- Zodpey Sanjay
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and developm nt investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
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- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
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- Bastiani Patrizia
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- Belezhanska Diyana
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- Ben-Shlomo Yoav
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- Craig David
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- Dalmasso Maria Carolina
- Damotte Vincent
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- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
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- Debette Stéphanie
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- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
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- Deramecourt Vincent
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- Diego S.
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- Dionigi Rossi Paolo
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- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
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- Düzel Emrah
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- Etchepareborda Ignacio
- Eugenia Sáez María
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- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
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- Fin Bertrand
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- Ghidoni Roberta
- Giedraitis Vilmantas
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- Giegling Ina
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- Gill Michael
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- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
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- Grande Giulia
- Green Emma
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- Grünblatt Edna
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- Gu Wei
- Guerreiro Rita
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- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
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- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
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- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
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- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
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- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
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- Kuulasmaa Teemu
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- Kölsch Heike
- Küçükali Fahri
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- Lacidogna Giordano
- Lacour ndré
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- Lafuente A.
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- Love Seth
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- Lovestone Simon
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- Parveen Kayenat
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- Powell John
- Powell John F.
- Prakash Kumar-M.
- Preckler S.
- Preckler Silvia
- Priller Josef
- Proitsi Petra
- Proitsi Petra
- Prokic Ivana
- Puerta R.
- Puerta Raquel
- Puerta Raquel
- Péerez Tur J.
- Pérez-Cordon A.
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
- Rainero Innocenzo
- Ramakers Inez
- Ramakers Inez
- Ramirez Alfredo
- Ramirez Alfredo
- Ramirez Alfredo
- Real de Asúa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rong Zhang Bao
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Ross Owen A.
- Rossi Giacomina
- Rossi Giacomina
- Rossor Martin
- Rossor Martin
- Roveta Fausto
- Royo J.L.
- Rubino Elisa
- Rubinsztein David C.
- Rubinsztein David C.
- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Ruiz Agustín
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Ryan Natalie S.
- Ryan Nathalie
- Ráabano A.
- Rábano Alberto
- Sachdev Perminder
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Saltvedt Ingvild
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ángela
- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sando Sigrid B.
- Sastre Merlín Isabel
- Sastre I.
- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- Schürmann Britta
- Selbæk Geir
- Selbæk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Sánchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Desigualdades de classe e gênero e saúde mental nas cidades Class and gender inequalities and mental health in the cities
- Author
- ALMEIDA-FILHO N.
- Ana Bernarda Ludermir
- ARAYA R.
- BARTLEY M.
- BARTLEY M.
- BEBBINGTON P.
- BLUE I.
- BROWN G.W.
- BROWN George W.
- COKER A. L.
- COKER A. L.
- DOHRENWEND B.P.
- DRESSLER W.W.
- ELLSBERG M.
- ELLSBERG Mary Carol
- EZZY D.
- FERRIE J.E.
- GARCIA-MORENO C. G.
- GIFFIN K.
- GOLDBERG David
- GRAETZ B.
- GRAETZ B.
- HAMMARSTRÖM A.
- HARPHAM T.
- HEISE L.
- HEISE L.
- HELLER Agnes
- INKELES A.
- JENKINS R.
- JENKINS Rachel
- KHAN R.S.
- KUMAR S.
- LAHELMA E.
- LEWIS G.
- LIMA M.S.
- LUDERMIR A.B.
- LUDERMIR A.B.
- LUDERMIR A.B.
- LUDERMIR A.B.
- LUDERMIR A.B.
- MACRAN Susan
- MARMOT M.G.
- MCCAULEY J.
- MORRELL S.
- MOSER Caroline O. N.
- MURPHY J.M.
- NICOLAIDIS C.
- NICOLAIDIS C.
- PATEL V.
- POSSAS Cristina
- POWER C.
- POWER Chris
- RODGERS B.
- ROJAS G.
- ROSENFIELD S.
- ROUDINESCO Elizabeth
- RUIZ-PEREZ I.
- RUTTER Michael
- SANTANA V.S.
- SANTOS Milton
- SCHRAIBER Lilia Blima
- SCIENCE Chico
- SINGER Paul
- STANSFELD S.
- URANI A.
- VENTURI Gustavo
- VIRTANEN P.
- WARR P.
- WARR Peter
- WATTS C.
- WEICH S.
- WILKINSON Richard G.
- WILKINSON Richard G.
- WOHLFARTH T.
- Publication venue
- Universidade do Estado do Rio de Janeiro
- Publication date
- 01/09/2008
- Field of study
O caráter social da doença mental se expressa objetivamente na sua distribuição desigual entre homens e mulheres e entre diferentes classes sociais. Essas desigualdades representam um persistente achado na literatura. Diversos autores têm encontrado alta prevalência dos Transtornos Mentais Comuns (TMC) em mulheres, nos excluídos do mercado formal de trabalho, nos indivíduos de baixa renda e nos de baixa escolaridade. Alguns estudos fundamentais para a visão contemporânea sobre as desigualdades de classe e gênero dos TMC são tratados neste artigo. As reflexões a respeito dos determinantes sociais da doença mental apontam desafios para a formulação de políticas públicas de saúde.<br>The social nature of mental disorders is objectively apparent from its unequal distribution between men and women and between social classes. These inequalities are recurrent in the literature. Several authors have found high prevalence of Common Mental Disorders (CMD) among women, among the unemployed and informal workers, the low income and the low educated individuals. Some studies, fundamental for the contemporary view on the inequalities between class and gender of the CMD, are here presented. Considerations about the social determinants of mental illness point to some challenges for mental health planners
A second update on mapping the human genetic architecture of COVID-19
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- Wyllie DH
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- Yagi K
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- Yaspan B
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- Yasui Y
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- Yermakovich D
- Yeung RSM
- Yi X
- Yonekawa A
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- Yoshihara T
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- Yue F
- Yun N
- Yáñez CE
- Yáñez Z
- Zainulabid UA
- Zainy T
- Zak A
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- Zamudio IPM
- Zanella A
- Zapata-Contreras D
- Zapatamartinez M
- Zarate R
- Zarei N
- Zavaleta DAF
- Zawadzki P
- Zawati MH
- Zborowski AC
- Zeberg H
- Zechner M
- Zhang Q
- Zhao X
- Zheng C
- Zheng T
- Zhlawi HJ
- Zhlawi MWJ
- Zholdybayeva E
- Zhou W
- Zhu W
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- Zuñiga-Pacheco P
- Zárate RN
- Zúñiga-Ramos J
- Álvarez BG
- Ávila-Arcos MA
- Ávila-Arcos MC
- Özer O
- Überla K
- Þorsteinsdóttir U
- Publication venue
- Nature Research
- Publication date
- 21/06/2023
- Field of study
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gómez A. D.
- Aguilera N.
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M. D.
- Alvarez Ignacio
- Amer-Ferrer G.
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera M.
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Assogna Francesca
- Bacha Juan Ignacio
- Bagnoli Silvia
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bastiani Patrizia
- Belezhanska Diyana
- Bellenguez Céline
- Bellou Eftychia
- Benaque A.
- Benaque Alba
- Bennett K.
- Benussi Alberto
- Benussi Luisa
- Bernal Sánchez-Arjona María
- Bernal M.
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Bizzarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Botne Sando Sigrid
- Brayne Carol
- Bresner Catherine
- Brusco Luis Ignacio
- Buendia M.
- Buerger Katharina
- Buiza-Rueda D.
- Buiza-Rueda D.
- Bullido M. J.
- Bullido María J.
- Burguera J. A.
- Burholt Vanessa
- Caffarra Paolo
- Calero M.
- Calero Miguel
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrión-Claro M.
- Casajeros M. J.
- Castaño Eduardo M.
- Cañabate P.
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chillotti Caterina
- Chipi Elena
- Chêne Geneviève
- Ciccone Simona
- Ciullo Valentina
- Clare Linda
- Clarimón Jordi
- Clarimón Jordi
- Clark Christopher
- Conti Elisa
- Corbatón-Anchuelo A.
- Corbatón-Anchuelo Arturo
- Cores Valeria
- Corma-Gómez Anaïs
- Costantini Emanuele
- Craig David
- Cruz-Gamero J. M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daniele Antonio
- Dardiotis Efthimios
- de Mendonça Alexandre
- de Pancorbo M. M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean François
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diego S.
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Escuela R.
- Esiri Margaret
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferrari Camilla
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fließbach Klaus
- Fornage Myriam
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C.
- Franco-Macías E.
- Franco-Macías Emilio
- Frank-García A.
- Frank-García A.
- Frikke-Schmidt Ruth
- Froelich Lutz
- Gailhajenet A.
- Galeano Pablo
- Galimberti Daniela
- Garcia Madrona S.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J. M.
- García-Alberca Jose María
- García-González P.
- García-González Pablo
- García-Madrona Sebastián
- Garrote-Espina L.
- Gelpi Ellen
- Germani Sandra
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil S.
- Gil Silvia
- Goldhardt Oliver
- González-Perez Antonio
- González-Pérez A.
- Graff Caroline
- Grande Giulia
- Greco Antonio
- Grenier-Boley Benjamin
- Grimmer Timo
- Grozeva Detelina
- Grünblatt Edna
- Guitart M.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Harris Jenny
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández I.
- Hernández I.
- Hernández I.
- Herrman Martin J.
- Herrmann Martin J.
- Heun Reinhard
- Hevilla S.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Hägg Sara
- Ibarria M.
- Ikram M. Arfan
- Ingelsson Martin
- Ingino Carlos
- Janowitz Daniel
- Jansen Iris E.
- Jansen Iris E.
- Jessen Frank
- Jesús S.
- Jian Xueqiu
- Joachim Catharine
- Johansson Charlotte
- Johnston Janet
- Jones Matthew
- Jürgen Deckert
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Kochen Silvia
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kosmidis Mary H.
- Koutsouraki Effrosyni
- Kunkle Brian W.
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M. A.
- Lacidogna Giordano
- Laczo Jan
- Lafuente A.
- Lage C.
- Lage Carmen
- Lambert Jean Charles
- Laske Christoph
- Lauria Alessandra
- Lebouvier Thibaud
- Legaz A.
- Lehtisalo Jenni
- Lemstra Afina W.
- Leonenko Ganna
- Lerch Ondrej
- Lindström Jaana
- Lisetti Viviana
- Lisso Julieta
- Lleó A.
- Lleó Alberto
- Lopez de Munain A.
- Lopez de Munain Adolfo
- Love Seth
- Luckuck Lauren
- López-García S.
- López-García Sara
- Löwenmark Malin
- Macias J.
- Macias-García D.
- Macleod C.
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Mangone Carlos
- Mann David M.
- Manzanares S.
- Marianthi Arnaoutoglou
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Martín Montes A.
- Martín Montes Angel
- Martín E.
- Martínez Rodríguez Carmen
- Martínez B.
- Martínez C.
- Martínez Carmen
- Martínez M. T.
- Martínez V.
- Martínez-Lage Álvarez P.
- Martínez-Larrad María Teresa
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masullo Carlo
- Mather Karen A.
- Matoska Vaclav
- Matthews F.
- Mauleón A.
- Mayeux Richard
- McCracken C.
- McGuinness Bernadette
- Mead Simon
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menzies Georgina
- Menéndez-González M.
- Menéndez-González M.
- Mihova Kalina Yonkova
- Mir P.
- Mir Pablo
- Molina-Porcel Laura
- Molinuevo J. L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno M.
- Moreno-Grau S.
- Moreno-Grau S.
- Morgan Kevin
- Muchnik Carolina
- Muñoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Natunen Teemu
- Neary David
- Ngandu Tiia
- Nicolas Gaël
- Nordestgaard Børge G.
- Novack Gisela
- Nöthen Markus M.
- Olaso Robert
- Olivar Natividad
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Padovani Alessandro
- Palacio Dana Lis
- Pancho A.
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Passmore Peter
- Pastor Ana Belén
- Pastor P.
- Pastor Pau
- Pedersen Nancy L.
- Pelejá E.
- Peltonen Markku
- Pericak-Vance Margaret A.
- Periñán-Tocino T.
- Perneczky Robert
- Peters Oliver
- Phillips Judith
- Piaceri Irene
- Pickering-Brown Stuart
- Pijnenburg Yolande A.L.
- Pineda J. A.
- Pineda Juan A.
- Pineda-Sanchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol-Ripoll G.
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Polvikoski Tuomo M.
- Popp Julius
- Posthuma Danielle
- Preckler S.
- Prestia Federico Ariel
- Priller Josef
- Pérez Tur J.
- Pérez-Cordon A.
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
- Quintela I.
- Rainer Malik
- Rainero Innocenzo
- Ramirez Alfredo
- Real de Asúa D.
- Real Luis M.
- Real Luis M.
- Reyes Toso Carlos
- Reynolds Chandra A.
- Richardson Anna
- Riedel-Heller Steffi
- Riederer Peter
- Rios Mario
- Roberto Natalia
- Rodrigo S.
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Rossi Giacomina
- Roveta Fausto
- Royo J. L.
- Royo Jose Luís
- Rubino Elisa
- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Rujescu Dan
- Rábano A.
- Rábano A.
- Saad Salha
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Salani Francesca
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ángela
- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sastre I.
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M.
- Seidu Nazib M.
- Selbæk Geir
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Serrano-Ríos Manuel
- Seshadri Sudha
- Sevillano Zulma
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Snowden Julie
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Sommerville Ewen W.
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Strandberg Timo
- Stringa Najada
- Sáez M. E.
- Sáez María Eugenia
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Tagliavini Fabrizio
- Takalo Mari
- Tankard Rick M.
- Tegos Thomas
- Teipel Stefan
- Tesi Niccolo
- Thomassen Jesper Qvist
- Thonberg Håkan
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Magda
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Tárraga L.
- Tárraga Lluís
- Ullgren Abbe
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vardy Emma R.L.C.
- Vargas L.
- Vicente M. P.
- Vidal Jean Sebastien
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li San
- Weber Heike
- Weinhold Leonie
- Wilcock Gordon
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Robert
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zoia Chiara Paola
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/06/2021
- Field of study
Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
- Abalos M. S.
- Abdelnour C.
- Abner E.
- Abraham R.
- Ad Adarmes-Gómez
- Adam Boxer
- Adam Ziemann
- Adams H.
- Adams P. M.
- Adarmes-Gómez A.
- Adarmes-Gómez A. D.
- Adriana Gamboa
- Adrienne L Cupples
- Adrienne Tin
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Agustina Legaz
- Ahmad S.
- Aimee Pierce
- Aino Salminen
- Airi Jussila
- Aisha Khaleeq
- Aki Havulinna
- Akinyemi R. O.
- Al-Chalabi A.
- Alan B Stevens
- Alan Lerner
- Alarcón-Martín E.
- Albert M. S.
- Alberto Benussi
- Albin R. L.
- Alcolea D.
- Aldo Saenz
- Alegret M.
- Alessandra Chesi
- Alessandro Vacca
- Alexander Teumer
- Alexis Brice
- Ali M.
- Alisa Manning
- Alison E Fohner
- Allan I Levey
- Allen M.
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- Sandra Weintraub
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- Sara López-García
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- Siirtola H.
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- Silvia Rodrigo
- Silvia Rodrigo-Herrero
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- Suominen L.
- Susan Eaton
- Susan H Slifer
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- Susana Diego
- Susanna Lemmelä
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- Teumer A.
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- Thomas S Wingo
- Thomas T.
- Thomas Wisniewski
- Thomassen J. Q.
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- Tiffany F Kautz
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- Tim Lu
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- Victoria Perez
- Victoriana Martínez
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- Will S Bush
- William Kremen
- William Nash
- William W Seeley
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- Williamson J.
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- Xing Chen
- Xinli Hu
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- Xuan Liu
- Yanbing Wang
- Yanek L.
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- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
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- Zulaica M.
- Zulma Sevillano
- Álvarez V.
- Åsa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u3b2, tau, immunity and lipid processing
- Author
- Abner Erin
- Adams Hieab H.
- Adams Perrie M.
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G.
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bass Nicholas J.
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Beiser Alexa S.
- Bellenguez Celine
- Ben-Shlomo Yoav
- Benito Yolanda A.
- Bennett David
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- Bossu Paola
- Bowen James D.
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A.
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido Maria J.
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Butkiewicz Mariusz
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carracedo Angel
- Carrasquillo Minerva M.
- Cecchetti Roberta
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cupidi Chiara
- Cupples L. Adrienne
- Cushion Thomas D.
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-Francois
- De Deyn Peter Paul
- De Jager Phil L.
- de Rojas Itziar
- Debette Stphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean-Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diez-Fairen Monica
- Dombroski Beth A.
- Doody Rachelle S.
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Fox Nick C.
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Froelich Lutz
- Frosch Matthew P.
- Galasko Douglas R.
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E.
- Garnier Jean-Guillaume
- Garzia Fabienne
- Gearing Marla
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M.
- Graff Caroline
- Graff-Radford Neill R.
- Green Robert C.
- Grenier-Boley Benjamin
- Growdon John H.
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Helisalmi Seppo
- Hernandez Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Honig Lawrence S.
- Hooper Nigel M.
- Huebinger Ryan M.
- Huell Michael
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M. Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Joeckel Karl-Heinz
- Johnston Janet A.
- Jones Lesley
- Jun Gyungah R.
- Kamboh M. Ilyas
- Karamujic-Comic Hata
- Karydas Anna
- Katz Mindy J.
- Kauwe John S. K.
- Kawalia Amit
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koelsch Heike
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- LaFerla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Launer Lenore J.
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B.
- Levey Allan, I
- Li Shuo
- Lieberman Andrew P.
- Lin Honghuang
- Lipton Richard B.
- Livingston Gill
- Lleo Alberto
- Longstreth W. T., Jr.
- Lopez Oscar L.
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E.
- Meslage Stphane
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John
- Morris John C.
- Mosley Thomas H.
- Moutet Marie-Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C.
- Naranjo Maria Candida Deniz
- Nicolas Gael
- Noethen Markus M.
- O'Bryant Sid
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orellana Adelina
- Orfei Maria Donata
- Owen Michael J.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William R.
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John F.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Quintela Ines
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M.
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Roschupkin Gena
- Rosen Howard J.
- Rosenberg Roger N.
- Rossor Martin
- Rotter Jerome, I
- Royall Donald R.
- Rubinsztein David C.
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S.
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A.
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lori S.
- Schott Jonathan M.
- Seeley William W.
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Singleton Andrew B.
- Sleegers Kristel
- Slifer Susan
- Smith A. David
- Smith Albert, V
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A.
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Tang Mitchell
- Tanzi Rudolph E.
- Tarraga Lluis
- Thonberg Hakan
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz JoAnn
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Uitterlinden A. G. Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Lee Sven J.
- van Duijn Cornelia M.
- Van Eldik Linda J.
- Vance Jeffery M.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vellas Bruno
- Vinters Harry V.
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wichmann H-Erich
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S.
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2019
- Field of study
Author Correction: Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (Nature Genetics, (2019), 51, 3, (414-430), 10.1038/s41588-019-0358-2)
- Author
- Abner Erin
- Adams Hieab H.
- Adams Perrie M.
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Ignacio
- Alvarez Victoria
- Amin Najaf
- Amlie-Wolf Alexandre
- Amouyel Phillippe
- Apostolova Liana G.
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Avramidou Despoina
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Bass Nicholas J.
- Bayer Anthony
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Beiser Alexa S.
- Bellenguez Céline
- Ben-Shlomo Yoav
- Benito Yolanda A.
- Bennett David
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Bisceglio Gina
- Blacker Deborah
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paola
- Bossù Paola
- Bowen James D.
- Boxer Adam
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A.
- Brown Kristelle
- Brundin Rose Marie
- Bruni Amalia Cecilia
- Bullido Maria J.
- Burke James R.
- Burns Jeffrey M.
- Bush Will S.
- Butkiewicz Mariusz
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carracedo Ángel
- Carrasquillo Minerva M.
- Cecchetti Roberta
- Chen Yuning
- Choi Seung Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- Clarimon Jordi
- Clarke Robert
- Collinge John
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cuccaro Michael L.
- Cupidi Chiara
- Cupples L. Adrienne
- Cushion Thomas D.
- Damotte Vincent
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean Francois
- De Deyn Peter P.
- De Jager Phil L.
- de Rojas Itziar
- Debette Stéphanie
- DeCarli Charles
- Del Zompo Maria
- Deleuze Jean Francois
- Deloukas Panagiotis
- Denning Nicola
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W.
- Diez-Fairen Monica
- Dombroski Beth A.
- Doody Rachelle S.
- Drichel Dmitriy
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Ertekin-Taner Nilifur
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Feulner Thomas
- Fievet Nathalie
- Fin Bertrand
- Fisher Elizabeth
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Fox Nick C.
- Fratiglioni Laura
- Frisardi Vincenza
- Frizatti Aura
- Frosch Matthew P.
- Frölich Lutz
- Galasko Douglas R.
- Galimberti Daniela
- Gallacher John
- Gallo Maura
- Garcia Melissa E.
- Garnier Jean Guillaume
- Garzia Fabienne
- Gearing Marla
- George-Hyslop Peter St
- Germanou Antonia
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Gkatzima Olymbia
- Goate Alison M.
- Graff Caroline
- Graff-Radford Neill R.
- Green Robert C.
- Grenier-Boley Benjamin
- Growdon John H.
- Grozeva Detelina
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Gwilliam Rhian
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Helisalmi Seppo
- Hernández Isabel
- Heun Reinhard
- Heuser Isabella
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hofer Edith
- Hoffmann Per
- Hollingworth Paul
- Holmans Peter A.
- Holmes Clive
- Honig Lawrence S.
- Hooper Nigel M.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Hüll Michael
- Ikram M. Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee Way
- Johnston Janet A.
- Jones Lesley
- Jun Gyungah R.
- Jöckel Karl Heinz
- Kamboh M. Ilyas
- Karamujić-Čomić Hata
- Karydas Anna
- Katz Mindy J.
- Kauwe John S.K.
- Kawalia Amit
- Kaye Jeffrey A.
- Keene C. Dirk
- Kehoe Patrick G.
- Keller Lina
- Kilander Lena
- Kim Ronald
- Klopp Norman
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Koutroumani Maria
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Kölsch Heike
- LaFerla Frank M.
- Lah James J.
- Lambert Jean Charles
- Lannfelt Lars
- Larson Eric B.
- Launer Lenore J.
- Lawlor Brian
- Leber Markus
- Leonenko Ganna
- Leverenz James B.
- Levey Allan I.
- Li Shuo
- Lieberman Andrew P.
- Lin Honghuang
- Lipton Richard B.
- Livingston Gill
- Lleo Alberto
- Longstreth W. T.
- Lopez Oscar L.
- Lord Jenny
- Love Seth
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Ma Li
- Maier Wolfgang
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Mann David
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mateo Ignacio
- Mayeux Richard
- Mayhaus Manuel
- Mayo Kevin
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- McQuillin Andrew
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Menzies Georgina E.
- Meslage Stéphane
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John C.
- Morris John C.
- Mosley Thomas H.
- Moutet Marie Laure
- Mukherjee Shubhabrata
- Munger Ron
- Munoz-Fernadez Carmen
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C.
- Naranjo Maria Candida Deniz
- Nicolas Gael
- Nöthen Markus M.
- Olaso Robert
- Olichney John M.
- Orellana Adelina
- Orfei Maria Donata
- Owen Michael J.
- O’Bryant Sid
- O’Donovan Michael C.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William R.
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pickering-Brown Stuart
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John F.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Quintela Inés
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Real Luis M.
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rodriguez-Rodriguez Eloy
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Roshchupkin Gennady
- Rossor Martin
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C.
- Ruiz Agustin
- Russo Giancarlo
- Ryan Natalie S.
- Saba Yasaman
- Sacchinelli Eleonora
- Sager Mark A.
- Salani Francesca
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sano Mary
- Sarnowski Chloe
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lori S.
- Schott Jonathan M.
- Seeley William W.
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Singleton Andrew B.
- Sleegers Kristel
- Slifer Susan
- Smith A. David
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Song Yuenjoo
- Sonnen Joshua A.
- Sorbi Sandro
- Sordon Sabrina
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- Tang Mitchell
- Tanzi Rudolph E.
- Tarraga Lluís
- Thonberg Hakan
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Jo Ann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Uitterlinden A. G.Andre
- Uphill James
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- van den Bussche Hendrik
- van der Lee Sven J.
- van Duijn Cornelia M.
- Van Eldik Linda J.
- Vance Jeffery M.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vardy Emma
- Vellas Bruno
- Vinters Harry V.
- Voijnovic Dina
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li San
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wichmann H. Erich
- Wilcock Gordon
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wiltfang Jens
- Wingo Thomas S.
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang En
- Yu Lei
- Zhao Yi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/2019
- Field of study
An amendment to this paper has been published and can be accessed via a link at the top of the paper