Synthesis and spectroscopy of benzylamine-substituted BODIPYs for bioimaging

Three new boron dipyrromethene (BODIPY) dyes substituted with a benzylamino group at the 3-position have been synthesized from halogenated BODIPYs by nucleophilic substitution. The spectroscopic and photophysical properties have been explored in different solvents and have been compared with an analogous 8- benzylaminoBODIPY derivative. The position of the benzylamino group has a significant influence on the spectral band positions, fluorescence quantum yields, and fluorescence lifetimes. The 8- benzylaminoBODIPY emits in the blue range, whereas the 3- substituted shows green fluorescence. Additionally, the extension of the conjugation at the 5-position of 3-benzylaminoBODIPY produces a bathochromic shift of the absorption and emission spectra. The solvent effect on their spectroscopic features has been investigated using the generalized Catalán solvent scales. Quantum-chemical calculations have been performed to assess the effect of the position of the substitution on the spectroscopic properties. Finally, the BODIPY dyes have been employed as probes in fluorescence lifetime imaging of living cells, demonstrating their high potential for bioimaging

Bis(haloBODIPYs) with Labile Helicity: Valuable Simple Organic Molecules That Enable Circularly Polarized Luminescence

Simple organic molecules (SOM) based on bis(haloBODIPY) are shown to enable circularly polarized luminescence (CPL), giving rise to a new structural design for technologically valuable CPL-SOMs. The established design comprises together synthetic accessibility, labile helicity, possibility of reversing the handedness of the circularly polarized emission, and reactive functional groups, making it unique and attractive as advantageous platform for the development of smart CPL-SOMs

Les tumeurs desmoplastiques

A travers une présentation de 3 observations de patients suivis au service de chirurgie infantile A et d’oncologie pédiatrique au CHU de Rabat et une revue de la littérature, nous relevons les constations suivantes : La TDPCR est un cancer agressif, cliniquement non spécifique. Le diagnostic orienté par l'échographie et le scanner, est confirmé lors de la laparotomie par l'étude anatomopathologique, immunohistochimique et cytogénétique (la mise en évidence par RT-PCR du transcrit de fusion EWS-WT1). Le traitement repose essentiellement sur la chirurgie, la chimiothérapie et la radiothérapie. Le pronostic reste sombre, d’ où la nécessité de thérapies ciblées

Functionalisation and photophysical properties of highly fluorescent Boradiazaindacene (BODIPY) derivatives

The objective of the work described in this thesis was the synthesis and the functionalisation at the 3,5-positions of highly fluorescent BODIPY (Borondipyrromethene) dyes. For this purpose, research has mainly focused on the synthesis of the 3,5-dichloro-BODIPY as a precursor to develop the extended 3,5-disubstitutedBODIPY derivatives using nucleophilic aromatic substitution, transition metal cross coupling reactions and to study their photophysical properties. In the first chapter, we have developed an effective and efficient synthesis of the novel 3,5-dichloro-BODIPY with different subunits at thestatus: publishe