HÁBITOS ALIMENTARIOS DE LAS MUJERES EN RELACIÓN CON EL NIVEL DE CONOCIMIENTOS SOBRE EL CLIMATERIO

Objectives: Knowing the behaviors related to food and toxic habits of women aged 30-60 years in the health area of Vigo.Determine whether menopausal women have healthier behaviors than non menopausal ones. Identify whether any of the socio-demographic variables has an influence on feeding habits or toxic behaviors.Determine whether women with high-very high knowledge have proper habits.Methods: Comparative, observational cross study made of 425 women between 30 and 60 years of age. We used a booklet with personally answered questionnaires, one about menopause and the other about feeding behaviors during the climacteric stage, which includes socio-demographic variables. Data analysis was carried out using SPSS 14.0.Results: A result of 74.3% of the women in the sample has a high/very high level of knowledge but behaviors that do not correlate with this.Conclusions: Women know what they must do to maintain a healthy life, but the majority does not put this into practice. We think it is necessary to introduce in health centers a program about the climacteric stage, coordinated by nurses and midwives and focused on applying to daily life the knowledge that women already have, with the aim of helping them to achieve a better quality of life.This study is part of a wider research on “Knowledge and behaviors related to climacteric stage in women between 30 and 60 years of age in the health area of Vigo sponsored by the “Fondo de Investigaciones Sanitarias” (Spanish Health Research Fund) in 2007Objetivos: Conocer los comportamientos relacionados con la alimentación y hábitos tóxicos de las mujeres de edad comprendida entre 30-60 años del área sanitaria de Vigo.Averiguar si las mujeres menopáusicas tienen comportamientos más saludables que las no menopáusicas.Identificar si alguna de las variables sociodemográficas influye en los comportamientos sobre la alimentación y hábitos tóxicos. Determinar si las mujeres con conocimientos altos-muy altos tienen comportamientos adecuadosMétodos: Estudio comparativo, observacional, transversal, realizado a 425 mujeres de 30-60 años. Se utilizó un cuadernillo con dos cuestionarios autocumplimentados, uno de conocimientos sobre la menopausia y otro sobre los comportamientos relacionados con la alimentación en la etapa del climaterio, incluidas las variables sociodemográficas. El análisis de los datos se realizó mediante SPSS 14.0.Resultados: Las mujeres de nuestra muestra tienen conocimientos altos-muy altos en un 74,3% y unos comportamientos que no se correlacionan con el nivel de conocimientos.Conclusiones: Las mujeres conocen qué es lo que deben realizar para mantener una vida saludable, pero a la hora de ponerlo en práctica no lo hacen mayoritariamente. Consideramos necesaria la implantación en los Centros de Salud, de un programa coordinado por el equipo deEnfermería Global Nº 20 Octubre 2010 Página 2salud, dirigido a aplicar los conocimientos que han demostrado poseer las mujeres a los comportamientos diarios, con el objetivo de alcanzar una mayor calidad de vida. Este estudio forma parte de una investigación más amplia realizada sobre los “Conocimientos y comportamientos relacionados con el climaterio de las mujeres de 30-60 años del Área Sanitaria de Vigo” becado por el Fondo de Investigaciones Sanitarias (2007)

Extreme-ultraviolet fine structure and variability associated with coronal rain revealed by Solar Orbiter/EUI HRIEUV and SPICE

CONTEXT: Coronal rain is the most dramatic cooling phenomenon of the solar corona. Recent observations in the visible and UV spectrum have shown that coronal rain is a pervasive phenomenon in active regions. Its strong link with coronal heating through the thermal non-equilibrium (TNE) a-thermal instability (TI) scenario makes it an essential diagnostic tool for the heating properties. Another puzzling feature of the solar corona in addition to the heating is its filamentary structure and variability, particularly in the extreme UV (EUV). AIMS: We aim to identify observable features of the TNE-TI scenario underlying coronal rain at small and large spatial scales to understand the role it plays in the solar corona. METHODS: We used EUV datasets at an unprecedented spatial resolution of 240 km from the High Resolution Imager (HRI) in the EUV (HRIEUV) of the Extreme Ultraviolet Imager (EUI) and SPICE on board Solar Orbiter from the perihelion in March and April 2022. RESULTS: EUV absorption features produced by coronal rain are detected at scales as small as 260 km. As the rain falls, heating and compression is produced immediately downstream, leading to a small EUV brightening that accompanies the fall and produces a fireball phenomenon in the solar corona. Just prior to impact, a flash-like EUV brightening downstream of the rain, lasting a few minutes, is observed for the fastest events. For the first time, we detect the atmospheric response to the impact of the rain on the chromosphere, and it consists of upward-propagating rebound shocks and flows that partly reheat the loop. The observed widths of the rain clumps are 500a-±a-200 km. They exhibit a broad velocity distribution of 10a-a-A-150 km sa-1and peak below 50 km sa-1. Coronal strands of similar widths are observed along the same loops. They are co-spatial with cool filamentary structure seen with SPICE, which we interpret as the condensation corona transition region. Prior to the appearance of the rain, sequential loop brightenings are detected in gradually cooler lines from coronal to chromospheric temperatures. This matches the expected cooling. Despite the large rain showers, most cannot be detected in AIA 171 in quadrature, indicating that line-of-sight effects play a major role in the visibility of coronal rain. The AIA 304 and SPICE observations still reveal that only a small fraction of the rain can be captured by HRIEUV. CONCLUSIONS: Coronal rain generates EUV structure and variability over a wide range of scales, from coronal loops to the smallest resolvable scales. This establishes the major role that TNE-TI plays in the observed EUV morphology and variability of the corona

First perihelion of EUI on the Solar Orbiter mission

CONTEXT: The Extreme Ultraviolet Imager (EUI) on board Solar Orbiter consists of three telescopes: the two High Resolution Imagers, in EUV (HRIEUV) and in Lyman-α (HRILya), and the Full Sun Imager (FSI). Solar Orbiter/EUI started its Nominal Mission Phase on 2021 November 27. AIMS: Our aim is to present the EUI images from the largest scales in the extended corona off-limb down to the smallest features at the base of the corona and chromosphere. EUI is therefore a key instrument for the connection science that is at the heart of the Solar Orbiter mission science goals. METHODS: The highest resolution on the Sun is achieved when Solar Orbiter passes through the perihelion part of its orbit. On 2022 March 26, Solar Orbiter reached, for the first time, a distance to the Sun close to 0.3 au. No other coronal EUV imager has been this close to the Sun. RESULTS: We review the EUI data sets obtained during the period 2022 March–April, when Solar Orbiter quickly moved from alignment with the Earth (2022 March 6), to perihelion (2022 March 26), to quadrature with the Earth (2022 March 29). We highlight the first observational results in these unique data sets and we report on the in-flight instrument performance. CONCLUSIONS: EUI has obtained the highest resolution images ever of the solar corona in the quiet Sun and polar coronal holes. Several active regions were imaged at unprecedented cadences and sequence durations. We identify in this paper a broad range of features that require deeper studies. Both FSI and HRIEUV operated at design specifications, but HRILya suffered from performance issues near perihelion. We conclude by emphasizing the EUI open data policy and encouraging further detailed analysis of the events highlighted in this paper

EUV fine structure and variability associated with coronal rain revealed by Solar Orbiter/EUI HRIEUV and SPICE

Coronal rain is the most dramatic cooling phenomenon of the solar corona and an essential diagnostic tool for the coronal heating properties. A puzzling feature of the solar corona, besides the heating, is its EUV filamentary structure and variability. We aim to identify observable features of the TNE-TI scenario underlying coronal rain at small and large spatial scales, to understand the role it plays in the solar corona. We use EUV datasets at unprecedented spatial resolution of ~240 km from EUI/HRIEUV and SPICE of Solar Orbiter from the spring 2022 perihelion. EUV absorption features produced by coronal rain are detected at scales as small as 260 km. As the rain falls, heating and compression is produced immediately downstream, leading to a small EUV brightening accompanying the fall and producing a "fireball" phenomenon. Just prior to impact, a flash-like EUV brightening downstream of the rain, lasting a few minutes is observed for the fastest events. For the first time, we detect the atmospheric response to the rain's impact on the chromosphere and consists of upward propagating rebound shocks and flows partly reheating the loop. The observed widths of the rain clumps are 500 +- 200 km. They exhibit a broad velocity distribution of 10 - 150 km s^-1, peaking below 50 km s^-1. Coronal strands of similar widths are observed along the same loops co-spatial with cool filamentary structure, which we interpret as the CCTR. Matching with the expected cooling, prior to the rain appearance sequential loop brightenings are detected in gradually cooler lines from corona to chromospheric temperatures. Despite the large rain showers, most cannot be detected in AIA 171 in quadrature, indicating that LOS effects play a major role in coronal rain visibility. Still, AIA 304 and SPICE observations reveal that only a small fraction of the rain can be captured by HRIEUV.Comment: Astronomy & Astrophysics; 32 Pages, 24 Main Figures, Appendi

Eliminación de la hepatitis C. Documento de posicionamiento de la Asociación Española para el Estudio del Hígado (AEEH)

La Asociación Española para el Estudio del Hígado (AEEH) está convencida de que la eliminación de la hepatitis C en España es posible siempre y cuando seamos capaces de emplear los recursos y las herramientas necesarias para la misma. Este documento refleja la posición de la AEEH respecto a la eliminación del virus de la hepatitis C (VHC), estableciendo una amplia serie de recomendaciones que se pueden agrupar en cinco categorías: 1) cribado del VHC en función de la edad, de la existencia de factores de riesgo clásicos de adquisición de la infección, búsqueda activa de pacientes diagnosticados con anterioridad y desarrollo de estrategias de microeliminación en poblaciones vulnerables; 2) simplificación del diagnóstico del VHC (diagnóstico en un solo paso y diagnóstico en el punto de atención del paciente); 3) simplificación del tratamiento de los pacientes y mejora de los circuitos asistenciales; 4) medidas de política sanitaria, y, finalmente, 5) establecimiento de indicadores de eliminación del VHC. The Spanish Association for the Study of the Liver (AEEH) is convinced that the elimination of hepatitis C virus (HCV) in Spain is possible as long as we are able to use the resources and tools necessary for it. This document reflects the position of the AEEH regarding the elimination of HCV, establishing a wide range of recommendations that can be grouped into five categories: 1) Screening of HCV according to age, of the existence of classic acquisition risk factors of infection, active search of previously diagnosed patients and development of microelimination strategies in vulnerable populations; 2) Simplification of HCV diagnosis (one-step diagnosis and diagnosis at the point of patient care); 3) Simplification of patient treatment and improvement of care circuits; 4) Health policy measures, and, finally, 5) Establishment of HCV elimination indicators

Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen

The effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca’s large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.Peer reviewe

The SEQC2 epigenomics quality control (EpiQC) study

BACKGROUND: Cytosine modifications in DNA such as 5-methylcytosine (5mC) underlie a broad range of developmental processes, maintain cellular lineage specification, and can define or stratify types of cancer and other diseases. However, the wide variety of approaches available to interrogate these modifications has created a need for harmonized materials, methods, and rigorous benchmarking to improve genome-wide methylome sequencing applications in clinical and basic research. Here, we present a multi-platform assessment and cross-validated resource for epigenetics research from the FDA's Epigenomics Quality Control Group. RESULTS: Each sample is processed in multiple replicates by three whole-genome bisulfite sequencing (WGBS) protocols (TruSeq DNA methylation, Accel-NGS MethylSeq, and SPLAT), oxidative bisulfite sequencing (TrueMethyl), enzymatic deamination method (EMSeq), targeted methylation sequencing (Illumina Methyl Capture EPIC), single-molecule long-read nanopore sequencing from Oxford Nanopore Technologies, and 850k Illumina methylation arrays. After rigorous quality assessment and comparison to Illumina EPIC methylation microarrays and testing on a range of algorithms (Bismark, BitmapperBS, bwa-meth, and BitMapperBS), we find overall high concordance between assays, but also differences in efficiency of read mapping, CpG capture, coverage, and platform performance, and variable performance across 26 microarray normalization algorithms. CONCLUSIONS: The data provided herein can guide the use of these DNA reference materials in epigenomics research, as well as provide best practices for experimental design in future studies. By leveraging seven human cell lines that are designated as publicly available reference materials, these data can be used as a baseline to advance epigenomics research

Penile prosthesis implantation in the covid era. post-surgery follow up and management of complications

Objectives: To provide recommendations regarding surgery, follow-up, and management of possible complications related to penile prostheses implantation, during the COVID-19 pandemic. Material and methods: We designed a critical narrative review of the studies investigating the impact of COVID-19 on urology practice and on penile prosthetic implantology. A comprehensive search in the MEDLINE database was performed. Different combinations of the following keywords were used according to a free-text protocol:: "SARS-CoV-2", "COVID19", "COVID Urology", "COVID19 surgery", "penile prostheses". Papers in English and Spanish language, published until September 2020 were included in the review. Results: Penile prosthesis implantation is an elective surgery which should always be deferred when it cannot be performed in maximum safety conditions. However, it may lead to complications wich must be resolved urgently even within the COVID-19 Era. Conclusions: Currently, it is mandatory to develop shared strategies to avoid potential COVID-19-related complications for surgical patients. Penile prosthesis implantation should be deferred to avoid unnecessary risks and all preventive measures should be taken to minimize the risks in the event of non-detayabte surgery. (C) 2021 Asociacion Espanola de Andrologia, Medicina Sexual y Reproductiva. Published by Elsevier Espana, S.L.U. All rights reserved