Does the well-being of individuals with Down syndrome and dementia improve when using life story books and rummage boxes? A randomised single case series experiment

Background: This study investigated whether a personalised life story book and rummage box enhanced well-being and led to changes in behaviour for people with Down syndrome (DS) who have dementia. Materials & Methods: A randomised single-case series design was used with five participants who had Down syndrome and a diagnosis of dementia. Participants were invited to take part in three conditions at random a) life story book, b) rummage box and c) no intervention condition. Results: The two reminiscence conditions were significantly associated with enhanced well-being as compared to the no-intervention condition. However, for one participant, the life story book was associated with significantly higher well-being, while for another participant, the rummage box was associated with significantly higher well-being, suggesting some participants may prefer one method over another. Conclusions: Personalised life story books and rummage boxes are associated with higher levels of well-being for people with DS and dementia

Translation: From bench to brain – Using the visual arts and metaphors to engage and educate

This article examines multidisciplinary public engagement projects that bring together developments in psychiatric research and practice with visual art and its use of metaphor. The article focuses on the art exhibition Translation: From bench to brain, which was the basis for further collaborations, illustrating how the learning from the original event influenced subsequent projects. Combining art exhibitions with online documentation and resources, the projects explored not only medical and scientific themes, but also the wider social, cultural and ethical ramifications, specifically aspects of identity, risk and stigma. The activities demonstrate the value of a developmental approach to public engagement as a process, whereby projects build on previous activities and evolving multidisciplinary perspectives, networks and expertise

The degeneracy between star-formation parameters in dwarf galaxy simulations and the Mstar-Mhalo relation

We present results based on a set of N-Body/SPH simulations of isolated dwarf galaxies. The simulations take into account star formation, stellar feedback, radiative cooling and metal enrichment. The dark matter halo initially has a cusped profile, but, at least in these simulations, starting from idealised, spherically symmetric initial conditions, a natural conversion to a core is observed due to gas dynamics and stellar feedback. A degeneracy between the efficiency with which the interstellar medium absorbs energy feedback from supernovae and stellar winds on the one hand, and the density threshold for star formation on the other, is found. We performed a parameter survey to determine, with the aid of the observed kinematic and photometric scaling relations, which combinations of these two parameters produce simulated galaxies that are in agreement with the observations. With the implemented physics we are unable to reproduce the relation between the stellar mass and the halo mass as determined by Guo et al. (2010), however we do reproduce the slope of this relation.Comment: Accepted for publication in MNRAS | 12 pages, 8 figure

On the onset of galactic winds in quiescent star forming galaxies

We studied the effect of supernovae feedback on a disk galaxy, taking into account the impact of infalling gas on both the star formation history and the corresponding outflow structure, the apparition of a supernovae-driven wind being highly sensitive to the halo mass, the galaxy spin and the star formation efficiency. We model our galaxies as cooling and collapsing NFW spheres. The dark matter component is modelled as a static external potential, while the baryon component is described by the Euler equations using the AMR code RAMSES. Metal-dependent cooling and supernovae-heating are also implemented using state-of-the-art recipes coming from cosmological simulations. We allow for 3 parameters to vary: the halo circular velocity, the spin parameter and the star formation efficiency. We found that the ram pressure of infalling material is the key factor limiting the apparition of galactic winds. We obtain a very low feedback efficiency, with supernovae to wind energy conversion factor around one percent, so that only low cicrular velocity galaxies give rise to strong winds. For massive galaxies, we obtain a galatic fountain, for which we discuss the observational properties. We conclude that for quiescent isolated galaxies, galactic winds appear only in very low mass systems. Although that can quite efficiently enrich the IGM with metals, they don't carry away enough cold material to solve the overcooling problem.Comment: 19 pages, 13 figures, 1 table, submited to A&

The potential for land sparing to offset greenhouse gas emissions from agriculture

Greenhouse gas emissions from global agriculture are increasing at around 1% per annum, yet substantial cuts in emissions are needed across all sectors. The challenge of reducing agricultural emissions is particularly acute, because the reductions achievable by changing farming practices are limited and are hampered by rapidly rising food demand. Here we assess the technical mitigation potential offered by land sparing-increasing agricultural yields, reducing farm land area and actively restoring natural habitats on the land spared. Restored habitats can sequester carbon and can offset emissions from agriculture. Using the United Kingdom as an example, we estimate net emissions in 2050 under a range of future agricultural scenarios. We find that a land-sparing strategy has the technical potential to achieve significant reductions in net emissions from agriculture and land-use change. Coupling land sparing with demand-side strategies to reduce meat consumption and food waste can further increase the technical mitigation potential, however economic and implementation considerations might limit the degree to which this technical potential could be realised in practice.This research was funded by the Cambridge Conservation Initiative Collaborative Fund for Conservation and we thank its major sponsor Arcadia. We thank J. Bruinsma for the provision of demand data, the CEH for the provision of soil data and J. Spencer for invaluable discussions. A.L. was supported by a Gates Cambridge Scholarship.This is the author accepted manuscript. The final version is available from Nature Publishing Group via http://dx.doi.org/10.1038/nclimate291

Treg and CTLA-4: Two intertwining pathways to immune tolerance.

Both the CTLA-4 pathway and regulatory T cells (Treg) are essential for the control of immune homeostasis. Their therapeutic relevance is highlighted by the increasing use of anti-CTLA-4 antibody in tumor therapy and the development of Treg cell transfer strategies for use in autoimmunity and transplantation settings. The CTLA-4 pathway first came to the attention of the immunological community in 1995 with the discovery that mice deficient in Ctla-4 suffered a fatal lymphoproliferative syndrome. Eight years later, mice lacking the critical Treg transcription factor Foxp3 were shown to exhibit a remarkably similar phenotype. Much of the debate since has centered on the question of whether Treg suppressive function requires CTLA-4. The finding that it does in some settings but not in others has provoked controversy and inevitable polarization of opinion. In this article, I suggest that CTLA-4 and Treg represent complementary and largely overlapping mechanisms of immune tolerance. I argue that Treg commonly use CTLA-4 to effect suppression, however CTLA-4 can also function in the non-Treg compartment while Treg can invoke CTLA-4-independent mechanisms of suppression. The notion that Foxp3 and CTLA-4 direct independent programs of immune regulation, which in practice overlap to a significant extent, will hopefully help move us towards a better appreciation of the underlying biology and therapeutic significance of these pathways

Exploring environmental entrepreneurship: identity coupling, venture goals, and stakeholder incentives

On the basis of a qualitative study of 25 renewable energy firms, we theorize why and how individuals engage in environmental entrepreneurship, inductively defined as: the use of both commercial and ecological logics to address environmental degradation through the creation of financially profitable organizations, products, services, and markets. Our findings suggest that environmental entrepreneurs: (1) are motivated by identities based in both commercial and ecological logics,(2) prioritize commercial and/or ecological venture goals dependent on the strength and priority of coupling between these two identity types, and (3) approach stakeholders in a broadly inclusive, exclusive, or co-created manner based on identity coupling and goals. These findings contribute to literature streams on hybrid organizing, entrepreneurial identity, and entrepreneurship’s potential for resolving environmental degradation