Manipulating the enone moiety of levoglucosenone: 1,3-Transposition reactions including ones leading to isolevoglucosenone

This research was part-funded by Circa Group Pty Ltd

Average Heating Rate of Hot Atmospheres in Distant Clusters by Radio AGN: Evidence for Continuous AGN Heating

We examine atmospheric heating by radio active galactic nuclei (AGN) in distant X-ray clusters by cross correlating clusters selected from the 400 Square Degree (400SD) X-ray Cluster survey with radio sources in the NRAO VLA Sky Survey. Roughly 30% of the clusters show radio emission above a flux threshold of 3 mJy within a projected radius of 250 kpc. The radio emission is presumably associated with the brightest cluster galaxy. The mechanical jet power for each radio source was determined using scaling relations between radio power and cavity (mechanical) power determined for nearby clusters, groups, and galaxies with hot atmospheres containing X-ray cavities. The average jet power of the central radio AGN is approximately $2\times 10^{44}$\ergs. We find no significant correlation between radio power, hence mechanical jet power, and the X-ray luminosities of clusters in the redshift range 0.1 -- 0.6. This implies that the mechanical heating rate per particle is higher in lower mass, lower X-ray luminosity clusters. The jet power averaged over the sample corresponds to an atmospheric heating of approximately 0.2 keV per particle within R$_{500}$. Assuming the current AGN heating rate does not evolve but remains constant to redshifts of 2, the heating rate per particle would rise by a factor of two. We find that the energy injected from radio AGN contribute substantially to the excess entropy in hot atmospheres needed to break self-similarity in cluster scaling relations. The detection frequency of radio AGN is inconsistent with the presence of strong cooling flows in 400SD clusters, but does not exclude weak cooling flows. It is unclear whether central AGN in 400SD clusters are maintained by feedback at the base of a cooling flow. Atmospheric heating by radio AGN may retard the development of strong cooling flows at early epochs.Comment: ApJ in pres

Kinetic power of quasars and statistical excess of MOJAVE superluminal motions

The MOJAVE survey contains 101 quasars with a total of 354 observed radio components that are different from the radio cores, among which 95% move with apparent projected superluminal velocities with respect to the core, and 45% have projected velocities larger than 10c (with a maximum velocity 60c). Doppler boosting effects are analyzed to determine the statistics of the superluminal motions. We integrate over all possible values of the Lorentz factor the values of the kinetic energy corresponding to each component. The calculation of the mass in the ejection is carried out by assuming the minimum energy state. This kinetic energy is multiplied by the frequency at which the portions of the jet fluid identified as "blobs" are produced. Hence, we estimate the average total power released by the quasars in the form of kinetic energy in the long term on pc-scales. RESULTS. A selection effect in which both the core and the blobs of the quasar are affected by huge Doppler-boosting enhancement increases the probability of finding a jet ejected within 10 degrees of the line of sight >~40 times above what one would expect for a random distribution of ejection, which explains the ratios of the very high projected velocities given above. The average total kinetic power of each MOJAVE quasar should be very high to obtain this distribution: ~7E47 erg/s. This amount is much higher than previous estimates of kinetic power on kpc-scales based on the analysis of cavities in X-ray gas or radio lobes in samples of objects of much lower radio luminosity but similar black hole masses. The kinetic power is a significant portion of the Eddington luminosity, on the order of the bolometric luminosity, and proportional on average to square root of the radio luminosity, although this correlation might be induced by Malmquist-like bias.Comment: Published in A&A; v2: minor changes to fit the published versio

Exceptional AGN-driven turbulence inhibits star formation in the 3C 326N radio galaxy

We detect bright [CII]158μm line emission from the radio galaxy 3C 326N at z=0.09, which shows weak star formation (SFR⊙~yr−1) despite having strong H2 line emission and 2×109M⊙ of molecular gas. The [CII] line is twice as strong as the 0-0S(1) 17μm H2 line, and both lines are much in excess what is expected from UV heating. We combine infrared Spitzer and Herschel data with gas and dust modeling to infer the gas physical conditions. The [CII] line traces 30 to 50% of the molecular gas mass, which is warm (70−3. The [CII] line is broad with a blue-shifted wing, and likely to be shaped by a combination of rotation, outflowing gas, and turbulence. It matches the near-infrared H2 and the Na D optical absorption lines. If the wing is interpreted as an outflow, the mass loss rate would be larger than 20M⊙/yr, and the depletion timescale shorter than the orbital timescale (108yr). These outflow rates may be over-estimated because the stochastic injection of turbulence on galactic scales can contribute to the skewness of the line profile and mimic outflowing gas. We argue that the dissipation of turbulence is the main heating process of this gas. Cosmic rays can also contribute to the heating but they require an average gas density larger than the observational constraints. We show that strong turbulent support maintains a high gas vertical scale height (0.3-4kpc) in the disk and can inhibit the formation of gravitationally-bound structures at all scales, offering a natural explanation for the weakness of star formation in 3C 326N. To conclude, the bright [CII] line indicates that strong AGN jet-driven turbulence may play a key role in enhancing the amount of molecular gas (positive feedback) but yet can prevent star formation on galactic scales (negative feedback)

Physiotherapy for Parkinson's disease: a comparison of techniques (Review)

Background: Despite medical therapies and surgical interventions for Parkinson's disease (PD), patients develop progressive disability. The role of physiotherapy is to maximise functional ability and minimise secondary complications through movement rehabilitation within a context of education and support for the whole person. The overall aim is to optimise independence, safety and wellbeing, thereby enhancing quality of life. Trials have shown that physiotherapy has short-term benefits in PD. However, which physiotherapy intervention is most effective remains unclear. Objectives: To assess the effectiveness of one physiotherapy intervention compared with a second approach in patients with PD. Search methods: Relevant trials were identified by electronic searches of numerous literature databases (for example MEDLINE, EMBASE) and trial registers, plus handsearching of major journals, abstract books, conference proceedings and reference lists of retrieved publications. The literature search included trials published up to the end of January 2012. Selection criteria: Randomised controlled trials of one physiotherapy intervention versus another physiotherapy intervention in patients with PD. Data collection and analysis: Data were abstracted independently from each paper by two authors. Trials were classified into the following intervention comparisons: general physiotherapy, exercise, treadmill training, cueing, dance and martial arts. Main results: A total of 43 trials were identified with 1673 participants. All trials used small patient numbers (average trial size of 39 participants); the methods of randomisation and concealment of allocation were poor or not stated in most trials. Blinded assessors were used in just over half of the trials and only 10 stated that they used intention-to-treat analysis.A wide variety of validated and customised outcome measures were used to assess the effectiveness of physiotherapy interventions. The most frequently reported physiotherapy outcomes were gait speed and timed up and go, in 19 and 15 trials respectively. Only five of the 43 trials reported data on falls (12%). The motor subscales of the Unified Parkinson?s Disease Rating Scale and Parkinson?s Disease Questionnaire-39 were the most commonly reported clinician-rated disability and patient-rated quality of life outcome measures, used in 22 and 13 trials respectively. The content and delivery of the physiotherapy interventions varied widely in the trials included within this review, so no quantitative meta-analysis could be performed. Authors' conclusions: Considering the small number of participants examined, the methodological flaws in many of the studies, the possibility of publication bias, and the variety of interventions, formal comparison of the different physiotherapy techniques could not be performed. There is insufficient evidence to support or refute the effectiveness of one physiotherapy intervention over another in PD.This review shows that a wide range of physiotherapy interventions to treat PD have been tested . There is a need for more specific trials with improved treatment strategies to underpin the most appropriate choice of physiotherapy intervention and the outcomes measured

Lean manufacturing, culture and their role on sustainability: A case study in the Chinese automotive industry

This paper focuses on lean manufacturing and culture and how they influence the sustainability initiatives of an Automotive company in China. The principle of lean manufacturing is widely applied in the automotive industry worldwide. The last few decades have witnessed the accelerating pace of China’s continued emergence as a major industrial power. With the globalisation of multinational corporations and the development of domestic automotive enterprises, there is an increasing number of cross-cultural motor manufacturing companies starting their business in China. In these companies, cultural diversity is an important factor that affects the management strategies. Using a case study approach, this paper shows the relevant themes on the role of lean manufacturing and culture on the sustainability initiatives taken by the company

A systematic review of high-fibre dietary therapy in diverticular disease

The exact pathogenesis of diverticular disease of the sigmoid colon is not well established. However, the hypothesis that a low-fibre diet may result in diverticulosis and a high-fibre diet will prevent symptoms or complications of diverticular disease is widely accepted. The aim of this review is to assess whether a high-fibre diet can improve symptoms and/or prevent complications of diverticular disease of the sigmoid colon and/or prevent recurrent diverticulitis after a primary episode. Clinical studies were eligible for inclusion if they assessed the treatment of diverticular disease or the prevention of recurrent diverticulitis with a high-fibre diet. The following exclusion criteria were used for study selection: studies without comparison of the patient group with a control group. No studies concerning prevention of recurrent diverticulitis with a high-fibre diet met our inclusion criteria. Three randomised controlled trials (RCT) and one case-control study were included in this systematic review. One RCT of moderate quality showed no difference in the primary endpoints. A second RCT of moderate quality and the case-control study found a significant difference in favour of a high-fibre diet in the treatment of symptomatic diverticular disease. The third RCT of moderate quality found a significant difference in favour of methylcellulose (fibre supplement). This study also showed a placebo effect. High-quality evidence for a high-fibre diet in the treatment of diverticular disease is lacking, and most recommendations are based on inconsistent level 2 and mostly level 3 evidence. Nevertheless, high-fibre diet is still recommended in several guideline

Treatment of acute diverticulitis laparoscopic lavage vs. resection (DILALA): study protocol for a randomised controlled trial

<p>Abstract</p> <p>Background</p> <p>Perforated diverticulitis is a condition associated with substantial morbidity. Recently published reports suggest that laparoscopic lavage has fewer complications and shorter hospital stay. So far no randomised study has published any results.</p> <p>Methods</p> <p>DILALA is a Scandinavian, randomised trial, comparing laparoscopic lavage (LL) to the traditional Hartmann's Procedure (HP). Primary endpoint is the number of re-operations within 12 months. Secondary endpoints consist of mortality, quality of life (QoL), re-admission, health economy assessment and permanent stoma. Patients are included when surgery is required. A laparoscopy is performed and if Hinchey grade III is diagnosed the patient is included and randomised 1:1, to either LL or HP. Patients undergoing LL receive > 3L of saline intraperitoneally, placement of pelvic drain and continued antibiotics. Follow-up is scheduled 6-12 weeks, 6 months and 12 months. A QoL-form is filled out on discharge, 6- and 12 months. Inclusion is set to 80 patients (40+40).</p> <p>Discussion</p> <p>HP is associated with a high rate of complication. Not only does the primary operation entail complications, but also subsequent surgery is associated with a high morbidity. Thus the combined risk of treatment for the patient is high. The aim of the DILALA trial is to evaluate if laparoscopic lavage is a safe, minimally invasive method for patients with perforated diverticulitis Hinchey grade III, resulting in fewer re-operations, decreased morbidity, mortality, costs and increased quality of life.</p> <p>Trial registration</p> <p>British registry (ISRCTN) for clinical trials <a href="http://www.controlled-trials.com/ISRCTN82208287">ISRCTN82208287</a><url>http://www.controlled-trials.com/ISRCTN82208287</url></p

O6-methylguanine-DNA-methyltransferase expression and gene polymorphisms in relation to chemotherapeutic response in metastatic melanoma

In a retrospective study, O6-methylguanine-DNA-methyltransferase (MGMT) expression was analysed by immunohistochemistry using monoclonal human anti-MGMT antibody in melanoma metastases in patients receiving dacarbazine (DTIC) as single-drug therapy or as part of combination chemotherapy with DTIC–vindesine or DTIC–vindesine–cisplatin. The correlation of MGMT expression levels with clinical response to chemotherapy was investigated in 79 patients with metastatic melanoma. There was an inverse relationship between MGMT expression and clinical response to DTIC-based chemotherapy (P=0.05). Polymorphisms in the coding region of the MGMT gene were also investigated in tumours from 52 melanoma patients by PCR/SSCP and nucleotide sequence analyses. Single-nucleotide polymorphisms (SNPs) in exon 3 (L53L and L84F) and in exon 5 (I143V/K178R) were identified. There were no differences in the frequencies of these polymorphisms between these melanoma patients and patients with familial melanoma or healthy Swedish individuals. Functional analysis of variants MGMT-I143V and -I143V/K178R was performed by in vitro mutagenesis in Escherichia coli. There was no evidence that these variants decreased the MGMT DNA repair activity compared to the wild-type protein. All melanoma patients with the MGMT 53/84 polymorphism except one had tumours with high MGMT expression. There was no significant correlation between any of the MGMT polymorphisms and clinical response to chemotherapy, although an indication of a lower response rate in patients with SNPs in exon 5 was obtained. Thus, MGMT expression appears to be more related to response to chemotherapy than MGMT polymorphisms in patients with metastatic melanoma