275 research outputs found
Modulation of Tcf7l2 Expression Alters Behavior in Mice
- Author
- A Dasgupta
- A Marschner
- AB Grigsby
- Abraham A. Palmer
- AK Khuwaja
- BT MacDonald
- CA Ponder
- CJ Huang
- D Savic
- Daniel Savic
- DR Hemsley
- DT Balu
- E Fernandez-Egea
- FH Kooy
- FJ Braceland
- Greta Sokoloff
- H Clevers
- H Freeman
- J Kasanin
- L Dixon
- LE Egede
- LM Spelman
- M Subramaniam
- Marcelo A. Nobrega
- Marcelo G. Bonini
- Margaret G. Distler
- MC Ryan
- MM Collins
- Nancy A. Shanahan
- PC Guest
- PI Lin
- RI Holt
- RJ Anderson
- RS Mansbach
- RT Moon
- S Cauchi
- S Mukherjee
- S Mukherjee
- SC Dulawa
- SC Gough
- SF Grant
- ST Pohlack
- Stephanie C. Dulawa
- T Hansen
- TA Cohn
- V Bouwman
- V Lyssenko
- V Medved
- WF Lorenz
- WT Regenold
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2011
- Field of study
The comorbidity of type 2 diabetes (T2D) with several psychiatric diseases is well established. While environmental factors may partially account for these co-occurrences, common genetic susceptibilities could also be implicated in the confluence of these diseases. In support of shared genetic burdens, TCF7L2, the strongest genetic determinant for T2D risk in the human population, has been recently implicated in schizophrenia (SCZ) risk, suggesting that this may be one of many loci that pleiotropically influence both diseases. To investigate whether Tcf7l2 is involved in behavioral phenotypes in addition to its roles in glucose metabolism, we conducted several behavioral tests in mice with null alleles of Tcf7l2 or overexpressing Tcf7l2. We identified a role for Tcf7l2 in anxiety-like behavior and a dose-dependent effect of Tcf7l2 alleles on fear learning. None of the mutant mice showed differences in prepulse inhibition (PPI), which is a well-established endophenotype for SCZ. These results show that Tcf7l2 alters behavior in mice. Importantly, these differences are observed prior to the onset of detectable glucose metabolism abnormalities. Whether these differences are related to human anxiety-disorders or schizophrenia remains to be determined. These animal models have the potential to elucidate the molecular basis of psychiatric comorbidities in diabetes and should therefore be studied further
Deprescribing interventions and their impact on medication adherence in community-dwelling older adults with polypharmacy: a systematic review
- Author
- A O’Cathain
- AG Zermansky
- Ali Ali
- AT Page
- AT Page
- AT Page
- B Guthrie
- BE Messerli
- C Beer
- C Chen
- C Jäger
- C Raae-Hansen
- CH Kua
- CJ Lowe
- D Gnjidic
- DE Patton
- Deborah Harrop
- DK Raynor
- E Hatah
- E Reeve
- E Zelko
- EC Tan
- ECK Tan
- I Sturgess
- IA Basheti
- IA Scott
- IA Scott
- J Cramer
- J George
- J Ritchie
- J Thillainadesan
- JD Haag
- JJ Vlasnik
- Joanna Ulley
- JT Hanlon
- KM Steele
- L Campins
- L Osterberg
- L Wit de
- MC Woodward
- MJ Grant
- MJ Twigg
- MT Roth
- N Masnoon
- P Gallagher
- P Kardas
- R Griffiths
- R Thomas
- RE Grymonpre
- RS Mickelson
- S Rambhade
- Sally Fowler Davis
- Sarah Alton
- SS Mortazavi
- T Fiβ
- THAM Vinks
- U Hedegaard
- U Laufs
- V Pérez-Jover
- VW Lee
- WF Gellad
- ZA Marcum
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background: Polypharmacy, and the associated adverse drug events such as non-adherence to prescriptions, is a
common problem for elderly people living with multiple comorbidities. Deprescribing, i.e. the gradual withdrawal
from medications with supervision by a healthcare professional, is regarded as a means of reducing adverse effects
of multiple medications including non-adherence. This systematic review examines the evidence of deprescribing
as an effective strategy for improving medication adherence amongst older, community dwelling adults.
Methods: A mixed methods review was undertaken. Eight bibliographic database and two clinical trials registers
were searched between May and December 2017. Results were double screened in accordance with pre-defined
inclusion/exclusion criteria related to polypharmacy, deprescribing and adherence in older, community dwelling
populations. The Mixed Methods Appraisal Tool (MMAT) was used for quality appraisal and an a priori data collection
instrument was used. For the quantitative studies, a narrative synthesis approach was taken. The qualitative data was
analysed using framework analysis. Findings were integrated using a mixed methods technique. The review was
performed in accordance with the PRISMA reporting statement.
Results: A total of 22 original studies were included, of which 12 were RCTs. Deprescribing with adherence as an
outcome measure was identified in randomised controlled trials (RCTs), observational and cohort studies from 13
countries between 1996 and 2017. There were 17 pharmacy-led interventions; others were led by General Practitioners
(GP) and nurses. Four studies demonstrated an overall reduction in medications of which all studies corresponded with
improved adherence. A total of thirteen studies reported improved adherence of which 5 were RCTs. Adherence was
reported as a secondary outcome in all but one study.
Conclusions: There is insufficient evidence to show that deprescribing improves medication adherence. Only 13
studies (of 22) reported adherence of which only 5 were randomised controlled trials. Older people are particularly
susceptible to non-adherence due to multi-morbidity associated with polypharmacy. Bio-psycho-social factors
including health literacy and multi-disciplinary team interventions influence adherence. The authors recommend
further study into the efficacy and outcomes of medicines management interventions. A consensus on priority
outcome measurements for prescribed medications is indicated
Performance of the CMS Cathode Strip Chambers with Cosmic Rays
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
- Akgun U
- Akimenko S
- Akin IV
- Alagoz E
- Alampi G
- Albajar C
- Albayrak EA
- Alberdi J
- Albergo S
- Albert E
- Albrow M
- Alexander J
- Alidra M
- Aliev T
- Allfrey P
- Almeida N
- Altenhofer G
- Altsybeev I
- Alver B
- Alverson G
- Alves GA
- Amaglobeli N
- Amapane N
- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
- Anastassov A
- Andelin D
- Anderson M
- Andrea J
- Andreev V
- Andreev Y
- Anghel IM
- Anguelov T
- Anh T. Vu
- Anisimov A
- Antillon E
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- Anttila E
- Antunes JR
- Antunovic Z
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- Apollinari G
- Apresyan A
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- Arfaei H
- Argiro S
- Arisaka K
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- Asghar MI
- Ashby S
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- Atramentov O
- Auffray E
- Aurisano A
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- Avery P
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- Bakirci MN
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- Ballin J
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- Bandurin D
- Banerjee S
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- Barashko V
- Barbagli G
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- Bedoya CF
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- 'IOP Publishing'
- Publication date
- 01/01/2009
- Field of study
The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device
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during a cosmic ray run in fall 2008. Measured noise levels are low, with the
number of noisy channels well below 1%. Coordinate resolution was measured for
all types of chambers, and fall in the range 47 microns to 243 microns. The
efficiencies for local charged track triggers, for hit and for segments
reconstruction were measured, and are above 99%. The timing resolution per
layer is approximately 5 ns
Principles of Hand Fracture Management
- Author
- Abrahamsson SO
- Al-Qattan MM
- Al-Qattan MM
- Al-Qattan MM
- Al-Qattan MM
- Anderson D
- Ashkenaze DM
- Bansal R
- Bansal R
- Bennett EH
- Bernstein ML
- Birndorf MS
- Bora FW
- Braakman M
- Brustein M
- Bulcher U
- Bushell BD
- Byrne AM
- Büchler U
- Carlsen BT
- Charles HT
- Crichlow TP
- D Jordan
- De Kesel R
- Deitch MA
- Derkash RS
- DN Haughton
- Drenth DJ
- El-Shennawy M
- Facca S
- Feehan LM
- Figl M
- Ford DJ
- Foster RJ
- Freeland AE
- Fusetti C
- Gedda KO
- Geissler WB
- Gerber C
- Givissis PK
- Grant I
- Handoll HH
- Hansen PB
- Harding IJ
- Hastings H
- Hatanka W
- Hofmeister EP
- Horton TC
- Hsu JD
- Jahss SA
- Kahler DM
- Kelsch G
- Kjaer-Petersen K
- Konradsen L
- Koul AR
- Kurzen P
- La Stayo PC
- Lahey PJ
- Lee SK
- Li W
- Liporace FA
- Lu WW
- Lucchina S
- Lundeen JM
- Lundeen JM
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- Lutz M
- M Malahias
- Massart P
- McMahon PJ
- McNemar TB
- Meunier MJ
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- Nagaoka M
- Newington DP
- Orhun H
- Ouellette EA
- Ozcelik D
- Ozer K
- Petrie PWR
- Poolman RW
- Prokop A
- Rettig ME
- Rolando S
- Roth JJ
- S Hindocha
- Saetta JP
- Sarris I
- Sawaizumi T
- Schädel-Höpfner M
- Singh J
- Sirota MA
- Smith RJ
- Souer JS
- Soyer AD
- Spangberg O
- Statius Muller MG
- Strickland JW
- Tan JS
- Tan V
- Tavassoli J
- Thurston AJ
- Thurston AJ
- Timmenga EJ
- Tiong WH
- Tuncer S
- Tuttle HG
- W Khan
- Wagner CJ
- Waris E
- Winter M
- Wright TA
- Yan YM
- Publication venue
- Bentham Open
- Publication date
- 01/01/2012
- Field of study
The hand is essential in humans for physical manipulation of their surrounding environment. Allowing the ability to grasp, and differentiated from other animals by an opposing thumb, the main functions include both fine and gross motor skills as well as being a key tool for sensing and understanding the immediate surroundings of their owner
Cardiovascular disease, chronic kidney disease, and diabetes mortality burden of cardiometabolic risk factors from 1980 to 2010: a comparative risk assessment
- Author
- Aamodt G
- Abdeen Z
- Abdella NA
- Addo J
- Aekplakorn W
- Afifi MM
- Agabiti Rosei E
- Agyemang C
- Al Nsour M
- Al Nuaim AR
- Ali MK
- Ali MM
- Ambady R
- Aro P
- Azizi F
- Babu BV
- Bahalim AN
- Barbagallo CM
- Barbieri MA
- Barceló A
- Barreto SM
- Barros H
- Bautista LE
- Benetos A
- Bjerregaard P
- Björkelund C
- Bo S
- Bobak M
- BONORA Enzo
- Botana MA
- Bovet P
- Breckenkamp J
- Breteler MM
- Broda G
- Brown IJ
- Bursztyn M
- Campos H
- Cappuccio FP
- Capuano V
- Carnahan E
- Carvajal RG
- Casiglia E
- Castellano M
- Castetbon K
- Cea L
- Chang CJ
- Chaouki N
- Chatterji S
- Chen CJ
- Chen Z
- Choi JS
- Chua L
- Cobiac LJ
- Cooper RS
- Corsi AM
- Costanza MC
- Cowan MJ
- Craig CL
- Cífková R
- Danaei G
- Dankner RS
- Dastgiri S
- de León AC
- Delgado E
- Di Angelantonio E
- Dinc G
- Doi Y
- Dong GH
- Dorsi E
- Dragano N
- Drewnowski A
- Eggertsen R
- Elliott P
- Engeland A
- Erem C
- Esteghamati A
- Ezzati M
- Fall CH
- Fan JG
- Farzadfar F
- Ferreccio C
- Fezeu L
- Finucane MM
- Firmo JO
- Florez HJ
- Fornés NS
- Fowkes FG
- Franceschini G
- Frisk F
- Frisman GH
- Fuchs FD
- Fuller EL
- Getz L
- Giampaoli S
- Gomez Zumaquero JM
- Graff Iversen S
- Grant JF
- Gulliford MC
- Gupta PC
- Gupta R
- Gureje O
- Gutierrez HR
- Gómez LF
- Hansen TW
- Hata J
- He J
- Heim N
- Heinrich J
- Hemmingsson T
- Hennis A
- Herman WH
- Herrera VM
- Ho S
- Holdsworth M
- Hoorn SV
- Hopman WM
- Hussain A
- Husseini A
- Ibrahim MM
- Ikeda N
- Jacobsen BK
- Jaddou HY
- Jafar TH
- Janghorbani M
- Jasienska G
- Joffres MR
- Jonas JB
- Kadiki OA
- Kalter Leibovici O
- Kamadjeu RM
- Kaptoge S
- Karalis I
- Kastarinen MJ
- Katz J
- Keinan Boker L
- Kelly P
- Khalilzadeh O
- Khang YH
- Kiechl S
- Kim KW
- Kiyohara Y
- Kobayashi J
- Krause MP
- Kubínová R
- Kurjata P
- Kusuma YS
- Lam TH
- Langhammer A
- Lawes CM
- Le C
- Lee J
- Lewington S
- Li Y
- Li Y
- Lim SS
- Lim TO
- Lin CC
- Lin HH
- Lin JK
- Lin X
- Lind L
- Lissner L
- Liu X
- Lopez Jaramillo P
- Lorbeer R
- Lu Y
- Lévy Marchal C
- Ma G
- Ma S
- Macià F
- MacLean DR
- Maggi S
- Magliano DJ
- Makdisse M
- Mancia G
- Mannami T
- Marques Vidal P
- Mbanya JC
- McFarlane Anderson N
- Miccoli R
- Miettola J
- Minh HV
- Miquel JF
- Miranda JJ
- Mohamed MK
- Mohan V
- Mohanna S
- Mokdad A
- Mollentze WF
- Morales DD
- Morgan K
- Mozaffarian D
- Muiesan LM
- Muntoni S
- Nabipour I
- Nakagami T
- Nangia V
- Nemesure B
- Neovius M
- Nerhus KA
- Nervi F
- Neuhauser H
- Nguyen M
- Ninomiya T
- Noale M
- Oh SW
- Ohkubo T
- OLIVIERI Oliviero
- Onat A
- Oróstegui M
- Ouedraogo H
- Pan WH
- Panagiotakos DB
- Panza F
- Park Y
- Passos VM
- Pednekar MS
- Pelizzari PM
- Peres MA
- Phua HP
- Pichardo R
- Pistelli F
- Plans P
- Polakowska M
- Poulter N
- Prabhakaran D
- Pérez C
- Pérez Fernández R
- Qiao Q
- Rafiei M
- Rahim HF
- Raitakari OT
- Ramos LR
- Rampal L
- Rampal S
- Rao M
- Rasmussen F
- Reddy KK
- Redon J
- Revilla L
- Reyes García V
- Riley LM
- Roaeid RB
- Robinson CA
- Rodriguez Artalejo F
- Rojas Martinez R
- Ronkainen K
- Rosero Bixby L
- Roth GA
- Sachdev HS
- Salinas CA
- Sanisoglu SY
- Sans S
- Sarraf Zadegan N
- Scazufca M
- Schaan BD
- Schapochnik N
- Schelleman H
- Schneider IJ
- Schooling CM
- Schwarz B
- Sekuri C
- Sereday MS
- Serra Majem L
- Shaw J
- Shera AS
- Shi Z
- Shiri R
- Shu XO
- Silva DA
- Silva E
- Simons LA
- Singh GM
- Smith M
- Soebardi S
- Solfrizzi V
- Sonestedt E
- Soysal A
- Stattin P
- Stein AD
- Stergiou GS
- Stessman J
- Stevens GA
- Sudo A
- Suka M
- Sundh V
- Sundquist K
- Sundström J
- Swai AB
- Sánchez JR
- Söderberg S
- Tai ES
- Tambs K
- Tesfaye F
- Thomas GN
- Thorogood M
- Tilvis RS
- Tobias M
- Torheim LE
- Trenkwalder P
- Tuomilehto JO
- Tur JA
- Tzourio C
- Uhernik AI
- Ukoli FA
- Unwin N
- Vanderpump MP
- Varo JJ
- Veierød MB
- Velásquez Meléndez G
- Verschuren M
- Viet L
- Villalpando S
- Vioque J
- Vollenweider P
- Volpato S
- Wang N
- Wang YX
- Ward M
- Ward M.
- Waspadji S
- Welin LX
- Whitlock G
- Wilhelmsen L
- Willeit J
- Woodward M
- Wormser D
- Xavier AJ
- Xu F
- Xu L
- Yamamoto A
- Yang G
- Yang X
- Yeh LC
- Yoon JS
- You Q
- Yu Z
- Zhang J
- Zhang L
- Zheng W
- Zhou M
- Önal AE
- Publication venue
- 'Lancet XXI STORIChChYa, LLC'
- Publication date
- 01/01/2014
- Field of study
Background High blood pressure, blood glucose, serum cholesterol, and BMI are risk factors for cardiovascular
diseases and some of these factors also increase the risk of chronic kidney disease and diabetes. We estimated mortality from cardiovascular diseases, chronic kidney disease, and diabetes that was attributable to these four
cardiometabolic risk factors for all countries and regions from 1980 to 2010.
Methods We used data for exposure to risk factors by country, age group, and sex from pooled analyses of populationbased health surveys. We obtained relative risks for the eff ects of risk factors on cause-specifi c mortality from metaanalyses
of large prospective studies. We calculated the population attributable fractions for- each risk factor alone,
and for the combination of all risk factors, accounting for multicausality and for mediation of the eff ects of BMI by the other three risks. We calculated attributable deaths by multiplying the cause-specifi c population attributable fractions by the number of disease-specifi c deaths. We obtained cause-specifi c mortality from the Global Burden of Diseases, Injuries, and Risk Factors 2010 Study. We propagated the uncertainties of all the inputs to the fi nal estimates.
Findings In 2010, high blood pressure was the leading risk factor for deaths due to cardiovascular diseases, chronic kidney disease, and diabetes in every region, causing more than 40% of worldwide deaths from these diseases; high BMI and glucose were each responsible for about 15% of deaths, and high cholesterol for more than 10%. After
accounting for multicausality, 63% (10\ub78 million deaths, 95% CI 10\ub71\u201311\ub75) of deaths from these diseases in 2010 were attributable to the combined eff ect of these four metabolic risk factors, compared with 67% (7\ub71 million deaths,
6\ub76\u20137\ub76) in 1980. The mortality burden of high BMI and glucose nearly doubled from 1980 to 2010. At the country
level, age-standardised death rates from these diseases attributable to the combined eff ects of these four risk factors
surpassed 925 deaths per 100 000 for men in Belarus, Kazakhstan, and Mongolia, but were less than 130 deaths per 100 000 for women and less than 200 for men in some high-income countries including Australia, Canada, France,
Japan, the Netherlands, Singapore, South Korea, and Spain.
Interpretation The salient features of the cardiometabolic disease and risk factor epidemic at the beginning of
the 21st century are high blood pressure and an increasing eff ect of obesity and diabetes. The mortality burden
of cardiometabolic risk factors has shifted from high-income to low-income and middle-income countries. Lowering
cardiometabolic risks through dietary, behavioural, and pharmacological interventions should be a part of the globalresponse to non-communicable diseases
Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus
- Author
- A Ahmann
- A Barnett
- A Bellomo Damato
- A Dornhorst
- A Garber
- A Garber
- A Gill
- A Maida
- A Merovci
- A Panelo
- A Ptaszynska
- A Trümper
- AA Tahrani
- AA Tahrani
- AA Tahrani
- AA Tahrani
- AA Tahrani
- AA Tahrani
- Abd A. Tahrani
- AD Hughes
- AG Egan
- AH Barnett
- AH Barnett
- AH Barnett
- AH Barnett
- AH Barnett
- AH Cincotta
- AI Palalau
- AJ Krentz
- AJ Mulherin
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AJ Scheen
- AK Madiraju
- AL Peters
- AM Jacobson
- Anthony H. Barnett
- AV Schwartz
- AW Hitchings
- B Ahrén
- B Ahrén
- B Ahrén
- B Ahrén
- B Charbonnel
- B Charbonnel
- B Elbrønd
- B Gallwitz
- B Jose
- B Marcheva
- B Neal
- B Thorens
- B Viollet
- B Zinman
- B Zinman
- BC Meier
- BD Green
- BM Scirica
- C Bonner
- C Day
- C Eng
- C Filozof
- C Wysham
- C Yu Pan
- CB Burness
- CB Giorda
- CB Juhl
- CF Deacon
- CF Deacon
- CF Deacon
- CF Deacon
- CH Wysham
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CJ Bailey
- CK Lam
- CL Meinert
- Clifford J. Bailey
- CM Edwards
- CS Kovacs
- CS Kovacs
- CS Yang
- D Devineni
- D Raccah
- D Russell-Jones
- D Russell-Jones
- DC Klonoff
- DJ Drucker
- DJ Drucker
- DJ Drucker
- DJ Drucker
- DM Kendall
- DR Matthews
- DR Owens
- DT Eurich
- E Erdmann
- E Ferrannini
- E Ferrannini
- E Ferrannini
- E Jimenez-Solem
- E Klein
- E Mannucci
- E Mannucci
- EM Wright
- EM Wright
- EM Wright
- EO Billington
- ES Mearns
- F Giorgino
- F Sun
- F Sun
- F Sun
- FA van de Laar
- FM Ashcroft
- G Derosa
- G Ferrannini
- G Fulcher
- G Schernthaner
- G Umpierrez
- G Zhou
- GA Herman
- GB Bolli
- GS Meneilly
- H Agersø
- H Elrick
- H Hauner
- H Linnebjerg
- H Mulder
- H Park
- H Storgaard
- H Ueno
- H Yki-Järvinen
- H Zimdahl
- HC Fehmann
- HE Lebovitz
- HU Haering
- HU Häring
- HU Häring
- I Gantz
- I Tikkanen
- IW Campbell
- J Dupre
- J Eng
- J Farngren
- J Heaf
- J Lønborg
- J Reusch
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- J Rosenstock
- JA Dormandy
- JA Udell
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Buse
- JB Green
- JC Arjona Ferreira
- JC Arjona Ferreira
- JC Henquin
- JE Campbell
- JE Foley
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- JJ Meier
- JJ Meier
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- JL Chiasson
- JM Gaziano
- JM Trujillo
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- JR Lindsay
- JR Ussher
- K Copley
- K Esposito
- K Esposito
- K McKeage
- K Winkler
- KB Harris
- KC Ferdinand
- KE Wellen
- KM Dungan
- KM Hurren
- KW Mahaffey
- L Blonde
- L Hansen
- L Li
- L Merker
- L Rui
- L Simonsen
- L van Gaal
- LA Leiter
- LC Groop
- LJ Schmidt
- LL Baggio
- LM Younk
- M Abe
- M Barnea
- M Brownlee
- M Christensen
- M Christensen
- M Chung
- M Davies
- M de Groot
- M Diamant
- M Diamant
- M Katout
- M Marre
- M Nauck
- M Nauck
- M Obermeier
- M Pinget
- M Reaney
- M Rendell
- M Ridderstråle
- M Roden
- M Roden
- M Stumvoll
- MA Nauck
- MA Nauck
- MA Nauck
- MA Nauck
- MA Nauck
- MA Nauck
- MA Pfeffer
- MC Riddle
- MC Riddle
- N Erondu
- N Inagaki
- NB Amin
- NB Amin
- NB Watts
- NE Straznicky
- NM Maruthur
- OG Kolterman
- P Arnouts
- P Barrington
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- P Marchetti
- P Nyirjesy
- P Stein
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- R Wilcox
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- RA DeFronzo
- RA Hayward
- RE Pratley
- RE Ratner
- RF Carlson
- RG Yip
- RI Holt
- RM Bergenstal
- RR Henry
- RR Henry
- RR Henry
- RR Holman
- RR Holman
- RS Weinstock
- S Del Prato
- S Grandy
- S Hu
- S Kalra
- S Madsbad
- S Malmgren
- S Sha
- SC Gough
- SC Gough
- SC Hung
- SE Inzucchi
- SE Kahn
- SE Kahn
- SE Nissen
- SE Nissen
- SH Tella
- SL Schwarz
- SR Joshi
- SR Salpeter
- SS Lund
- T Biftu
- T Blevins
- T Dujic
- T Hach
- T Heise
- T Karagiannis
- T Karagiannis
- T Marbury
- T Mazzone
- T Seck
- T Vilsbøll
- T Wang
- V Jahagirdar
- VA Fonseca
- VA Fonseca
- VR Aroda
- VT Samuel
- W Duckworth
- W Kothny
- W Liang
- W Meng
- W Yang
- WB White
- XP Yang
- Y Huang
- Y Ohkubo
- Y Seino
- Y Wang
- Y Zhang
- YG Kim
- YG Kim
- YK Loke
- YL He
- YM Cho
- YN Sun
- Z Punthakee
- Z Skrivanek
- Ö Ljunggren
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 24/06/2016
- Field of study
Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-care systems. Improving metabolic control to approach normal glycaemia (where practical) greatly benefits long-term prognoses and justifies early, effective, sustained and safety-conscious intervention. Improvements in the understanding of the complex pathogenesis of T2DM have underpinned the development of glucose-lowering therapies with complementary mechanisms of action, which have expanded treatment options and facilitated individualized management strategies. Over the past decade, several new classes of glucose-lowering agents have been licensed, including glucagon-like peptide 1 receptor (GLP-1R) agonists, dipeptidyl peptidase 4 (DPP-4) inhibitors and sodium/glucose cotransporter 2 (SGLT2) inhibitors. These agents can be used individually or in combination with well-established treatments such as biguanides, sulfonylureas and thiazolidinediones. Although novel agents have potential advantages including low risk of hypoglycaemia and help with weight control, long-term safety has yet to be established. In this Review, we assess the pharmacokinetics, pharmacodynamics and safety profiles, including cardiovascular safety, of currently available therapies for management of hyperglycaemia in patients with T2DM within the context of disease pathogenesis and natural history. In addition, we briefly describe treatment algorithms for patients with T2DM and lessons from present therapies to inform the development of future therapies
Social networks and life satisfaction: The interplay of network density and regulatory focus
- Author
- A Mehra
- A Tellegen
- AL Kristof-Brown
- BJ Hoffman
- BW Headey
- C Ostroff
- CA O’Reilly
- CM Brendl
- D Diener
- D Krackhardt
- D Watson
- DC Funder
- DC Molden
- DJ Brass
- DJ Brass
- DL Ferris
- DM Webster
- E Diener
- E Diener
- E Diener
- E Diener
- E Diener
- E Diener
- E. Tory Higgins
- EB Smith
- ET Higgins
- ET Higgins
- ET Higgins
- F Flynn
- G Cumming
- H Grant
- HH Kelley
- HT Reis
- J Shah
- J Shah
- J Stokes
- JC Brodscholl
- JF Helliwell
- JH Fowler
- JM Podolny
- JM Pollack
- JS Coleman
- JS House
- JS Hurlbert
- JT Cacioppo
- JT Cacioppo
- K Lanaj
- K Lewin
- KJ Preacher
- KM DeNeve
- LC Idson
- LF Bergmann
- LR Goldberg
- LS Aiken
- M Granovetter
- M Granovetter
- M Kilduff
- M Snyder
- M Snyder
- MA Busseri
- ML Verquer
- MT Hansen
- N Liberman
- N Liberman
- P Steel
- P Totterdell
- Paul Ingram
- PT Costa
- PV Marsden
- RA Emmons
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- RE Lucas
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- RF Baumeister
- RS Burt
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- S Cohen
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- TJ Strauman
- U Schimmack
- U Schimmack
- U Schimmack
- W Mischel
- W Pavot
- X Zou
- Xi Zou
- Y Berson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
CMS Data Processing Workflows during an Extended Cosmic Ray Run
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- Publication venue
- INSTITUTE OF PHYSICS PUBLISHING
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Aligning the CMS Muon Chambers with the Muon Alignment System during an Extended Cosmic Ray Run
- Author
- Abadjiev K
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abelev B
- Acosta D
- Acosta JG
- Acosta MV
- Actis O
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- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adolphi R
- Adzic P
- Afaq MA
- Agostino L
- Agram JL
- Aguilar Benitez M
- Ahmad M
- Ahmad WH
- Ahmed I
- Ahmed W
- Ahuja S
- Aisa D
- Aisa S
- Akchurin N
- Akgun B
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- Akin IV
- Alagoz E
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- Albayrak EA
- Alberdi J
- Albergo S
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- Alidra M
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- Altenhofer G
- Altsybeev I
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- Alves GA
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- Ambroglini F
- Amsler C
- Anagnostou G
- Ananthan B
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- Andelin D
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- Andreev Y
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- Publication venue
- Publication date
- 01/01/2009
- Field of study
Peer reviewe
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
- Aad G
- Abbott B
- Abeling K
- Abicht NJ
- Abidi SH
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- Yamauchi H
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- Yamazaki Y
- Yan J
- Yan S
- Yan Z
- Yang HJ
- Yang HT
- Yang S
- Yang T
- Yang X
- Yang X
- Yang Y
- Yang Y
- Yang Z
- Yao W-M
- Yap YC
- Ye H
- Ye H
- Ye J
- Ye S
- Ye X
- Yeh Y
- Yeletskikh I
- Yeo BK
- Yexley MR
- Yin P
- Yorita K
- Younas S
- Young C
- Young CJS
- Yu C
- Yu Y
- Yuan M
- Yuan R
- Yue L
- Zaazoua M
- Zabinski B
- Zaid E
- Zakareishvili T
- Zakharchuk N
- Zambito S
- Zamora Saa JA
- Zang J
- Zanzi D
- Zaplatilek O
- Zeitnitz C
- Zeng H
- Zeng JC
- Zenger DT
- Zenin O
- Zenz S
- Zerradi S
- Zerwas D
- Zhai M
- Zhang B
- Zhang DF
- Zhang J
- Zhang J
- Zhang K
- Zhang L
- Zhang P
- Zhang R
- Zhang S
- Zhang T
- Zhang X
- Zhang X
- Zhang Y
- Zhang Y
- Zhang Z
- Zhang Z
- Zhao H
- Zhao P
- Zhao T
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zheng J
- Zheng K
- Zheng X
- Zheng Z
- Zhong D
- Zhou B
- Zhou H
- Zhou N
- Zhou Y
- Zhu CG
- Zhu J
- Zhu Y
- Zhu Y
- Zhuang X
- Zhukov K
- Zhulanov V
- Zimine NI
- Zinsser J
- Ziolkowski M
- Zoccoli A
- Zoch K
- Zorbas TG
- Zormpa O
- Zou W
- Zwalinski L
- Åkesson TPA
- Öncel ÖO
- Ženiš T
- Živković L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fb−1 of proton-proton collision data recorded at a centre-of-mass energy of √s = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
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