Altered white matter connectivity associated with visual hallucinations following occipital stroke

Introduction Visual hallucinations that arise following vision loss stem from aberrant functional activity in visual cortices and an imbalance of activity across associated cortical and subcortical networks subsequent to visual pathway damage. We sought to determine if structural changes in white matter connectivity play a role in cases of chronic visual hallucinations associated with visual cortical damage. Methods We performed diffusion tensor imaging (DTI) and probabilistic fiber tractography to assess white matter connectivity in a patient suffering from continuous and disruptive phosphene (simple) visual hallucinations for more than 2 years following right occipital stroke. We compared these data to that of healthy age‐matched controls. Results Probabilistic tractography to reconstruct white matter tracts suggests regeneration of terminal fibers of the ipsilesional optic radiations in the patient. However, arrangement of the converse reconstruction of these tracts, which were seeded from the ipsilesional visual cortex to the intrahemispheric lateral geniculate body, remained disrupted. We further observed compromised structural characteristics, and changes in diffusion (measured using diffusion tensor indices) of white matter tracts in the patient connecting the visual cortex with frontal and temporal regions, and also in interhemispheric connectivity between visual cortices. Conclusions Cortical remapping and the disruption of communication between visual cortices and remote regions are consistent with our previous functional magnetic resonance imaging (fMRI) data showing imbalanced functional activity of the same regions in this patient (Rafique et al, 2016, Neurology, 87, 1493–1500). Long‐term adaptive and disruptive changes in white matter connectivity may account for the rare nature of cases presenting with chronic and continuous visual hallucinations

On the absence of appreciable half-life changes in alpha emitters cooled in metals to 1 Kelvin and below

The recent suggestion that dramatic changes may occur in the lifetime of alpha and beta decay when the activity, in a pure metal host, is cooled to a few Kelvin, is examined in the light of published low temperature nuclear orientation (LTNO) experiments, with emphasis here on alpha decay. In LTNO observations are made of the anisotropy of radioactive emissions with respect to an axis of orientation. Correction of data for decay of metallic samples held at temperatures at and below 1 Kelvin for periods of days and longer has been a routine element of LTNO experiments for many years. No evidence for any change of half life on cooling, with an upper level of less than 1%, has been found, in striking contrast to the predicted changes, for alpha decay, of several orders of magnitude. The proposal that such dramatic changes might alleviate problems of disposal of long-lived radioactive waste is shown to be unrealistic.Comment: 27 pages, 12 figures, accepted for publication in Nucl.Phys.A. Revised version, including quantitative analysis of the sensitivity of nuclear orientation experiments, discussed in this work, to changes of alpha-decay lifetimes in metals at low temperatures. Conclusions remain unchange

Thermal imaging metrology using high dynamic range near-infrared photovoltaic-mode camera

The measurement of a wide temperature range in a scene requires hardware capable of high dynamic range imaging. We describe a novel near-infrared thermal imaging system operating at a wavelength of 940 nm based on a commercial photovoltaic mode high dynamic range camera and analyse its measurement uncertainty. The system is capable of measuring over an unprecedently wide temperature range; however, this comes at the cost of a reduced temperature resolution and increased uncertainty compared to a conventional CMOS camera operating in photodetective mode. Despite this, the photovoltaic mode thermal camera has an acceptable level of uncertainty for most thermal imaging applications with an NETD of 4–12 °C and a combined measurement uncertainty of approximately 1% K if a low pixel clock is used. We discuss the various sources of uncertainty and how they might be minimised to further improve the performance of the thermal camera. The thermal camera is a good choice for imaging low frame rate applications that have a wide inter-scene temperature range

Torque-angle-velocity relationships and muscle performance of professional and youth soccer players

Soccer matches consist of a variety of different activities, including repeated sprints. Time to attain velocity (TTAV), load range (LR) and the torque-angle-velocity relationship (TAV3D) represent an important measurement of muscle performance however there are few studies related. The aim of this study was to compare these outcomes between soccer players of different age category. Seventeen professional (PRO) and seventeen under-17 (U17) soccer players were assessed for concentric knee flexion/extension at 60, 120 and 300 °/s. For the extensor muscles, differences were found in favor of the U17 group for TTAV and LR outcomes at 120 °/s, however, the PRO group maintained higher torques in both movement directions in comparison to the U17 in TAV3D evaluation. These results suggest that muscle performance of the PRO group is more efficient than the U17 group

Couplings of light I=0 scalar mesons to simple operators in the complex plane

The flavour and glue structure of the light scalar mesons in QCD are probed by studying the couplings of the I=0 mesons $\sigma(600)$ and $f_0(980)$ to the operators $\bar{q}q$, $\alpha_s G^2$ and to two photons. The Roy dispersive representation for the $\pi\pi$ amplitude $t_0^0(s)$ is used to determine the pole positions as well as the residues in the complex plane. On the real axis, $t_0^0$ is constrained to solve the Roy equation together with elastic unitarity up to the K\Kbar threshold leading to an improved description of the $f_0(980)$. The problem of using a two-particle threshold as a matching point is discussed. A simple relation is established between the coupling of a scalar meson to an operator $j_S$ and the value of the related pion form-factor computed at the resonance pole. Pion scalar form-factors as well as two-photon partial-wave amplitudes are expressed as coupled-channel Omn\`es dispersive representations. Subtraction constants are constrained by chiral symmetry and experimental data. Comparison of our results for the $\bar{q}q$ couplings with earlier determinations of the analogous couplings of the lightest I=1 and $I=1/2$ scalar mesons are compatible with an assignment of the $\sigma$, $\kappa$, $a_0(980)$, $f_0(980)$ into a nonet. Concerning the gluonic operator $\alpha_s G^2$ we find a significant coupling to both the $\sigma$ and the $f_0(980)$.Comment: 31 pages, 5 figure

Changes in body composition after thermal injury in the rat.

1. The effects on body composition, measured by direct techniques, of a controlled 25% body-surfacearea thermal injury have been studied in two groups of forty male Wistar rats. 2. The extent of weight loss in the animals was directly related to their energy deficit resulting from a combination of injury, food intake and rate of wound healing. 3. Body fat proved the most labile source of tissue energy, decreasing to a minimum of approximately 30 g/kg body-weight. 4. Relationships between water and fat, and water and protein seen in control animals were not significantly different in the traumatized group

The new IOC and IAAF policies on female eligibility: old Emperor, new clothes?

The Caster Semenya debacle touched off by the 2009 Berlin World Athletics Championships resulted finally in IOC and IAAF abandonment of sex testing, which gave way to procedures that make female competition eligibility dependent upon the level of serum testosterone, which must be below the male range or instrumentally countered by androgen resistance. We argue that the new policy is unsustainable because (i) the testosterone-performance connection it posits is uncompelling; (ii) testosterone-induced female advantage is not ipso facto unfair advantage; (iii) the new policy reflects the gender policing impulses endemic to sport as well as the broader cultural impulses to monstrify women and to doctor women who have nothing wrong with them; (iv) female–male performance disparities are not the only reason for sex-segregated sport, but co-exist with respectable cultural and practical reasons, which (v) provide a powerful case for allowing athletes to compete in the sex category congruent with their gender identity

Linear stability analysis of transverse dunes

Sand-moving winds blowing from a constant direction in an area of high sand availability form transverse dunes, which have a fixed profile in the direction orthogonal to the wind. Here we show, by means of a linear stability analysis, that transverse dunes are intrinsically unstable. Any along-axis perturbation on a transverse dune amplify in the course of dune migration due to the combined effect of two main factors, namely: the lateral transport through avalanches along the dune's slip-face, and the scaling of dune migration velocity with the inverse of the dune height. Our calculations provide a quantitative explanation for recent observations from experiments and numerical simulations, which showed that transverse dunes moving on the bedrock cannot exist in a stable form and decay into a chain of crescent-shaped barchans.Comment: 8 pages, 4 figure

alpha'-exact entropies for BPS and non-BPS extremal dyonic black holes in heterotic string theory from ten-dimensional supersymmetry

We calculate near-horizon solutions for four-dimensional 4-charge and five-dimensional 3-charge black holes in heterotic string theory from the part of the ten-dimensional tree-level effective action which is connected to gravitational Chern-Simons term by supersymmetry. We obtain that the entropies of large black holes exactly match the alpha'-exact statistical entropies obtained from microstate counting (D=4) and AdS/CFT correspondence (D=5). Especially interesting is that we obtain agreement for both BPS and non-BPS black holes, contrary to the case of R^2-truncated (four-derivative) actions (D-dimensional N=2 off-shell supersymmetric or Gauss-Bonnet) were used, which give the entropies agreeing (at best) just for BPS black holes. The key property of the solutions, which enabled us to tackle the action containing infinite number of terms, is vanishing of the Riemann tensor \bar{R}_{MNPQ} obtained from torsional connection defined with \bar{\Gamma} = \Gamma - H/2. Morover, if every monomial of the remaining part of the effective action would contain at least two Riemanns \bar{R}_{MNPQ}, it would trivially follow that our solutions are exact solutions of the full heterotic effective action in D=10. The above conjecture, which appeared (in this or stronger form) from time to time in the literature, has controversial status, but is supported by the most recent calculations of Richards (arXiv:0807.3453 [hep-th]). Agreement of our results for the entropies with the microscopic ones supports the conjecture. As for small black holes, our solutions in D=5 still have singular horizons.Comment: 28 pages; v2: minor changes, references added; v3: extended discussion on small black holes in sec. 5.4, more references added, accepted in JHE