Effect of motivation on the In-depth study processes among student teachers

El objetivo de la investigación es analizar la asociación entre la motivación y sus perfiles con los enfoques de aprendizaje (superficial y profundo) y variables sociodemográficas. Participaron 201 estudiantes de una universidad pública, pertenecientes a cuatro carreras de formación en Pedagogía que cumplimentaron las escalas de Motivación Académica (EMA), de Procesos de Estudio (R-CPE-2F); y una encuesta ad doc. Se utilizó una estrategia asociativa-comparativa transversal. Los resultados indicaron la existencia de relaciones positivas entre la Amotivación con los procesos de estudio superficiales. Se encontraron diferencias en función del sexo en la Amotivación, Regulación Externa e Identificada, y en el Enfoque y Estrategia Superficial, siendo las medias más altas en los hombres. Se determinaron dos perfiles motivacionales, uno con puntuaciones bajas en motivación intrínseca y extrínseca, y el segundo con puntuaciones altas en Motivación al Logro y Regulación Introyectada. También, diferencias en el Enfoque de Aprendizaje Profundo, siendo las medias más altas en el Clúster 2. Los análisis de regresión múltiple mostraron que la Motivación Intrínseca (MI), las Experiencias Estimulantes y el Logro predicen el 41% de la variabilidad en el Enfoque Profundo; y la Amotivación y MI al Conocimiento predicen el 28% para el Enfoque SuperficialThe objective of the research is to analyze the association between motivation and motivation’s profiles with the learning approaches (superficial and deep) and some sociodemographic variables. Participated 201 students from a public university, belonging to four studies in Pedagogy that completed the Scale of Academic Motivation (EMA), Study Processes (R-CPE-2F); and a sociodemographic survey ad doc. A cross-sectional associative-comparative strategy was used. The results indicated the existence of positive relations between the Amotivation and the superficial study processes. Differences were found according to sex in the Amotivation, External and Identified Regulation, and in the Approach and Superficial Strategy, being the highest means in men. Two motivational profiles were determined, one with low scores on intrinsic and extrinsic motivation, and the second with high scores on Achievement Motivation and Introjected Regulation. Differences were found in the Deep Learning Approach, the highest means being in the Cluster 2. Multiple regression analyzes showed that Intrinsic Motivation (MI) to Stimulating Experiences and Achievement, predict 41% of the variability in the Deep Approach; and Amotivation and MI to Knowledge predict 28% for Superficial Approac

A New Kind of Quinonic-Antibiotic Useful Against Multidrug-Resistant S. aureus and E. faecium Infections

Indexación: Scopus.A rapid emergence of resistant bacteria is occurring worldwide, endangering the efficacy of antibiotics and reducing the therapeutic arsenal available for treatment of infectious diseases. In the present study, we developed a new class of compounds with antibacterial activity obtained by a simple, two step synthesis and screened the products for in vitro antibacterial activity against ATCC® strains using the broth microdilution method. The compounds exhibited minimum inhibitory concentrations (MIC) of 1⁻32 μg/mL against Gram-positive ATCC® strains. The structure⁻activity relationship indicated that the thiophenol ring is essential for antibacterial activity and the substituents on the thiophenol ring module, for antibacterial activity. The most promising compounds detected by screening were tested against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VREF) clinical isolates. We found remarkable activity against VREF for compounds 7 and 16, were the MIC50/90 were 2/4 µg/mL and 4/4 µg/mL, respectively, while for vancomycin the MIC50/90 was 256/512 µg/mL. Neither compound affected cell viability in any of the mammalian cell lines at any of the concentrations tested. These in vitro data show that compounds 7 and 16 have an interesting potential to be developed as new antibacterial drugs against infections caused by VREF.https://www.mdpi.com/1420-3049/23/7/177

Generalizing post-stroke prognoses from research data to clinical data

Around a third of stroke survivors suffer from acquired language disorders (aphasia), but current medicine cannot predict whether or when they might recover. Prognostic research in this area increasingly draws on datasets associating structural brain imaging data with outcome scores for ever-larger samples of stroke patients. The aim is to learn brain-behaviour trends from these data, and generalize those trends to predict outcomes for new patients. The practical significance of this work depends on the expected breadth of that generalization. Here, we show that these models can generalize across countries and native languages (from British patients tested in English to Chilean patients tested in Spanish), across neuroimaging technology (from MRI to CT), and from scans collected months or years after stroke for research purposes, to scans collected days or weeks after stroke for clinical purposes

Influence of ligand structure and molecular geometry on the properties of d6 polypyridinic transition metal complexes

Different strategies to improve the excited state properties of polypyridinic complexes by varying ligand structure and molecular geometry are described. Bidentate and tetradentate ligands based on fragments as dipyrido[3,2-a:2′,3′-c]phenazine, dppz, and pyrazino[2,3-f][1,10]-phenanthroline, ppl, have been used. Quinonic residues were fused to these basic units to improve acceptor properties. Photophysical studies were performed in order to test theoretical predictions

Doing marine spatial zoning in coastal marine tropics: Palawan’s Environmental Critical Areas Network (ECAN)

This is the final version. Available from Elsevier via the DOI in this record. Zoning is an important tool in marine spatial planning (MSP) for balancing the multi-uses of the marine environment. Whilst mainly developed conceptually and implemented in Europe and North America, marine zoning is becoming a popular tool for addressing diverse coastal marine issues in the tropics. However, we know little about how it is being implemented in practice in that context. In this study, we analysed the factors and strategies that enable and hinder the establishment of marine zoning in the low-income tropics through a case study of the 26-year history of the development of the Environmental Critical Areas Network (ECAN) in Palawan, Philippines. We employed two participatory methods: Innovation Histories to investigate how implementation barriers and opportunities change over time, and the Net-Map method to reveal the social relations and power distributions that enabled, blocked, and stalled its implementation. We found that MSP can be durable in these contexts when institutionalised in national law and adopted by local co-coordinative bodies, yet it remains an externally-driven agenda. Our study shows that the scaling up of zoning does not necessarily help resolve conflicts around marine and coastal space, and highlights the importance and influence of the political economy on MSP implementation and outcomes. We conclude that MSP's insensitivity to contextual power relations and politics raises concerns over social inclusivity, equity and justice. Moving forward, MSP implemented in the tropics needs to make conflicts, trade-offs and power distributions explicit at the outset through participatory decision-making that involves and empowers all stakeholders from the early stages of initiatives.United Kingdom Research and InnovationGlobal Challenges Research Fun

A hypoperfusion context may aid to interpret hyperlactatemia in sepsis-3 septic shock patients: a proof-of-concept study

__Background:__ Persistent hyperlactatemia is particularly difficult to interpret in septic shock. Besides hypoperfusion, adrenergic-driven lactate production and impaired lactate clearance are important contributors. However, clinical recognition of different sources of hyperlactatemia is unfortunately not a common practice and patients are treated with the same strategy despite the risk of over-resuscitation in some. Indeed, pursuing additional resuscitation in non-hypoperfusion-related cases might lead to the toxicity of fluid overload and vasoactive drugs. We hypothesized that two different clinical patterns can be recognized in septic shock patients through a multimodal perfusion monitoring. Hyperlactatemic patients with a hypoperfusion context probably represent a more severe acute circulatory dysfunction, and the absence of a hypoperfusion context is eventually associated with a good outcome. We performed a retrospective analysis of a database of septic shock patients with persistent hyperlactatemia after initial resuscitation. __Results:__ We defined hypoperfusion context by the presence of a ScvO2 < 70%, or a P(cv-a)CO2 ≥6 mmHg, or a CRT ≥4 s together with hyperlactatemia. Ninety patients were included, of whom seventy exhibited a hypoperfusion-related pattern and 20 did not. Although lactate values were comparable at baseline (4.8 ± 2.8 vs. 4.7 ± 3.7 mmol/L), patients with a hypoperfusion context exhibited a more severe circulatory dysfunction with higher vasopressor requirements, and a trend to longer mechanical ventilation days, ICU stay, and more rescue therapies. Only one of the 20 hyperlactatemic patients without a hypoperfusion context died (5%) compared to 11 of the 70 with hypoperfusion-related hyperlactatemia (16%). __Conclusions:__ Two different clinical patterns among hyperlactatemic septic shock patients may be identified according to hypoperfusion context. Patients with hyperlactatemia plus low ScvO2, or high P(cv-a)CO2, or high CRT values exhibited a more severe circulatory dysfunction. This provides a starting point to launch further prospective studies to confirm if this approach can lead to a more selective resuscitation strategy

Search for chargino-neutralino production with mass splittings near the electroweak scale in three-lepton final states in √s=13 TeV pp collisions with the ATLAS detector

A search for supersymmetry through the pair production of electroweakinos with mass splittings near the electroweak scale and decaying via on-shell W and Z bosons is presented for a three-lepton final state. The analyzed proton-proton collision data taken at a center-of-mass energy of √s=13  TeV were collected between 2015 and 2018 by the ATLAS experiment at the Large Hadron Collider, corresponding to an integrated luminosity of 139  fb−1. A search, emulating the recursive jigsaw reconstruction technique with easily reproducible laboratory-frame variables, is performed. The two excesses observed in the 2015–2016 data recursive jigsaw analysis in the low-mass three-lepton phase space are reproduced. Results with the full data set are in agreement with the Standard Model expectations. They are interpreted to set exclusion limits at the 95% confidence level on simplified models of chargino-neutralino pair production for masses up to 345 GeV