Senstitivty analysis and optimization of nodal point placement for vibration reduction

A method is developed for sensitivity analysis and optimization of nodal point locations in connection with vibration reduction. A straightforward derivation of the expression for the derivative of nodal locations is given, and the role of the derivative in assessing design trends is demonstrated. An optimization process is developed which uses added lumped masses on the structure as design variables to move the node to a preselected location - for example, where low response amplitude is required or to a point which makes the mode shape nearly orthogonal to the force distribution, thereby minimizing the generalized force. The optimization formulation leads to values for added masses that adjust a nodal location while minimizing the total amount of added mass required to do so. As an example, the node of the second mode of a cantilever box beam is relocated to coincide with the centroid of a prescribed force distribution, thereby reducing the generalized force substantially without adding excessive mass. A comparison with an optimization formulation that directly minimizes the generalized force indicates that nodal placement gives essentially a minimum generalized force when the node is appropriately placed

BRAVO economic study of LANDSAT follow-on

The LANDSAT Follow-On satellite consists of two major systems: the instrument module and the Multi-Mission Modular Spacecraft (MMS). The instrument module contains the thematic mapper and the five-band multispectral scanner instruments. The instrument module also includes the solar array, the tracking and data relay satellite (TDRS) antenna, and the wideband data module. The MMS contains the modularized and standardized power, propulsion, attitude control, and command and data handling subsystems. The Shuttle will be supporting the LANDSAT Follow-On system. The LANDSAT Follow-On Project plans two Delta 3910 launches. The first is scheduled for 1981; the second Delta launch will occur as needed to keep one satellite operational on orbit. The second satellite will be ready six months after the first. It could be launched any time after that. Shuttle support of the system could begin in early 1983 but would be scheduled to start after the second Delta launch

Double-impulse magnetic focusing of launched cold atoms.

We have theoretically investigated three-dimensional focusing of a launched cloud of cold atoms using a pair of magnetic lens pulses (the alternate-gradient method). Individual lenses focus radially and defocus axially or vice versa. The performance of the two possible pulse sequences are compared and found to be ideal for loading both 'pancake' and 'sausage' shaped magnetic/optical microtraps. It is shown that focusing aberrations are considerably smaller for double-impulse magnetic lenses compared to single-impulse magnetic lenses. An analysis of clouds focused by the double-impulse technique is presented

Environmental factors influence both abundance and genetic diversity in a widespread bird species.

Genetic diversity is one of the key evolutionary variables that correlate with population size, being of critical importance for population viability and the persistence of species. Genetic diversity can also have important ecological consequences within populations, and in turn, ecological factors may drive patterns of genetic diversity. However, the relationship between the genetic diversity of a population and how this interacts with ecological processes has so far only been investigated in a few studies. Here, we investigate the link between ecological factors, local population size, and allelic diversity, using a field study of a common bird species, the house sparrow (Passer domesticus). We studied sparrows outside the breeding season in a confined small valley dominated by dispersed farms and small-scale agriculture in southern France. Population surveys at 36 locations revealed that sparrows were more abundant in locations with high food availability. We then captured and genotyped 891 house sparrows at 10 microsatellite loci from a subset of these locations (N = 12). Population genetic analyses revealed weak genetic structure, where each locality represented a distinct substructure within the study area. We found that food availability was the main factor among others tested to influence the genetic structure between locations. These results suggest that ecological factors can have strong impacts on both population size per se and intrapopulation genetic variation even at a small scale. On a more general level, our data indicate that a patchy environment and low dispersal rate can result in fine-scale patterns of genetic diversity. Given the importance of genetic diversity for population viability, combining ecological and genetic data can help to identify factors limiting population size and determine the conservation potential of populations

Stellar black holes at the dawn of the universe

It is well established that between 380000 and 1 billion years after the Big Bang the Inter Galactic Medium (IGM) underwent a "phase transformation" from cold and fully neutral to warm (~10^4 K) and ionized. Whether this phase transformation was fully driven and completed by photoionization by young hot stars is a question of topical interest in cosmology. AIMS. We propose here that besides the ultraviolet radiation from massive stars, feedback from accreting black holes in high-mass X-ray binaries (BH-HMXBs) was an additional, important source of heating and reionization of the IGM in regions of low gas density at large distances from star-forming galaxies. METHODS. We use current theoretical models on the formation and evolution of primitive massive stars of low metallicity, and the observations of compact stellar remnants in the near and distant universe, to infer that a significant fraction of the first generations of massive stars end up as BH-HMXBs. The total number of energetic ionizing photons from an accreting stellar black hole in an HMXB is comparable to the total number of ionizing photons of its progenitor star. However, the X-ray photons emitted by the accreting black hole are capable of producing several secondary ionizations and the ionizing power of the resulting black hole could be greater than that of its progenitor. Feedback by the large populations of BH-HMXBs heats the IGM to temperatures of ~10^4 K and maintains it ionized on large distance scales. BH-HMXBs determine the early thermal history of the universe and mantain it as ionized over large volumes of space in regions of low density. This has a direct impact on the properties of the faintest galaxies at high redshifts, the smallest dwarf galaxies in the local universe, and on the existing and future surveys at radio wavelengths of atomic hydrogen in the early universe.Comment: 7 pages, 2 figures, accepted to be published in Astronomy and Astrophysic

Risk in CNS drug discovery: focus on treatment of Alzheimer's Disease

Despite rapid progress in our understanding of disease mechanisms and an exploding list of new targets for therapeutic intervention, drug discovery and development remains a highly risky business. Understanding the risk involved requires appreciation of the differing perspectives of risk held by the various stakeholders involved in drug research. Risk can be reduced by thoughtful management of drug candidate selection, careful planning and program execution by a team of engaged experts, and disciplined decision making. Drug development is particularly challenging for treatments of neurodegenerative diseases such as Alzheimer's disease, in which translation from animal models of efficacy to human success is poor or unknown, the timelines for clinical study are long, and the markers of efficacy are still evolving. Despite this there are several therapies in clinical development that hold the promise of influencing this disease through novel and possibly synergistic mechanisms

Study protocol for a double blind, randomised, placebo-controlled trial of continuous subpectoral local anaesthetic infusion for pain and shoulder function following mastectomy: SUB-pectoral Local anaesthetic Infusion following MastEctomy (SUBLIME) study.

INTRODUCTION: Over 16 000 mastectomies are performed in England and Wales annually. Acute postoperative pain and nausea are common. The most frequently occurring long-term complications are chronic pain (up to 50%) and reduced shoulder function (reported at 35%). Regional techniques that improve acute postoperative pain relief may reduce the incidence of these complications. This study assesses the effectiveness of a 24-hour continuous local anaesthetic in the subpectoral plane in improving postoperative pain and quality of life in patients undergoing mastectomy. METHODS AND ANALYSIS: This is a randomised, double blind, placebo-controlled, two-centre, parallel group trial in women undergoing mastectomy with or without axillary involvement. One hundred and sixty participants will be randomised in a 1:1 ratio to receive either 0.25% levobupivacaine or 0.9% saline by subpectoral infusion postoperatively for 24 h. All participants will be provided with an intravenous morphine patient-controlled analgesia (PCA) system. Participants will be followed-up for 24 h in hospital and at approximately 14 days and 6 months postoperatively. Joint primary outcome measures are total morphine consumption and total pain score (captured via patient-recorded visual analogue scale (VAS) 4 hourly) during the first 24 h postoperatively. Primary statistical analysis of total pain is based on the area under the curve of pain versus time graph. Secondary outcomes include PCA attempts in first 24 h; VAS pain scores and shoulder function by goniometry at 24 h, 14 days (approximately) and 6 months; Verbal Rating Scale pain scores in first 24 h; Brief Pain Inventory and Oxford Shoulder Score at 6 months; duration of hospital stay; incidence of postoperative nausea and vomiting; cost-effectiveness. ETHICS AND DISSEMINATION: The study is approved by the South West England Research Ethics Committee (12/SW/0149). RESULTS: will be published in a peer-reviewed journal and presented at local, national and international scientific meetings. TRIAL REGISTRATION: ISRCTN46621916. EudraCT 2011-005775-16

Photometric monitoring of the doubly imaged quasar UM673: possible evidence for chromatic microlensing

We present the results of two-band CCD photometric monitoring of the gravitationally lensed quasar Q 0142-100 (UM 673).The data, obtained at ESO-La Silla with the 1.54 m Danish telescope in the Gunn i-band (October 1998 - September 1999) and in the Johnson V-band (October 1998 to December 2001), were analyzed using three different photometric methods. The light-curves obtained with all methods show variations, with a peak-to-peak amplitude of 0.14 magnitude in $V$. Although it was not possible to measure the time delay between the two lensed QSO images, the brighter component displays possible evidence for microlensing: it becomes bluer as it gets brighter, as expected under the assumption of differential magnification of a quasar accretion diskComment: Accepted for publication in Astronomy & Astrophysics; 8 pages, 7 figure