Self-optimization of pilot power in enterprise femtocells using multi objective heuristic

Deployment of a large number of femtocells to jointly provide coverage in an enterprise environment raises critical challenges especially in future self-organizing networks which rely on plug-and-play techniques for configuration. This paper proposes a multi-objective heuristic based on a genetic algorithm for a centralized self-optimizing network containing a group of UMTS femtocells. In order to optimize the network coverage in terms of handled load, coverage gaps, and overlaps, the algorithm provides a dynamic update of the downlink pilot powers of the deployed femtocells. The results demonstrate that the algorithm can effectively optimize the coverage based on the current statistics of the global traffic distribution and the levels of interference between neighboring femtocells. The algorithm was also compared with the fixed pilot power scheme. The results show over fifty percent reduction in pilot power pollution and a significant enhancement in network performance. Finally, for a given traffic distribution, the solution quality and the efficiency of the described algorithm were evaluated by comparing the results generated by an exhaustive search with the same pilot power configuration

Analysis of shared heritability in common disorders of the brain

ience, this issue p. eaap8757 Structured Abstract INTRODUCTION Brain disorders may exhibit shared symptoms and substantial epidemiological comorbidity, inciting debate about their etiologic overlap. However, detailed study of phenotypes with different ages of onset, severity, and presentation poses a considerable challenge. Recently developed heritability methods allow us to accurately measure correlation of genome-wide common variant risk between two phenotypes from pools of different individuals and assess how connected they, or at least their genetic risks, are on the genomic level. We used genome-wide association data for 265,218 patients and 784,643 control participants, as well as 17 phenotypes from a total of 1,191,588 individuals, to quantify the degree of overlap for genetic risk factors of 25 common brain disorders. RATIONALE Over the past century, the classification of brain disorders has evolved to reflect the medical and scientific communities' assessments of the presumed root causes of clinical phenomena such as behavioral change, loss of motor function, or alterations of consciousness. Directly observable phenomena (such as the presence of emboli, protein tangles, or unusual electrical activity patterns) generally define and separate neurological disorders from psychiatric disorders. Understanding the genetic underpinnings and categorical distinctions for brain disorders and related phenotypes may inform the search for their biological mechanisms. RESULTS Common variant risk for psychiatric disorders was shown to correlate significantly, especially among attention deficit hyperactivity disorder (ADHD), bipolar disorder, major depressive disorder (MDD), and schizophrenia. By contrast, neurological disorders appear more distinct from one another and from the psychiatric disorders, except for migraine, which was significantly correlated to ADHD, MDD, and Tourette syndrome. We demonstrate that, in the general population, the personality trait neuroticism is significantly correlated with almost every psychiatric disorder and migraine. We also identify significant genetic sharing between disorders and early life cognitive measures (e.g., years of education and college attainment) in the general population, demonstrating positive correlation with several psychiatric disorders (e.g., anorexia nervosa and bipolar disorder) and negative correlation with several neurological phenotypes (e.g., Alzheimer's disease and ischemic stroke), even though the latter are considered to result from specific processes that occur later in life. Extensive simulations were also performed to inform how statistical power, diagnostic misclassification, and phenotypic heterogeneity influence genetic correlations. CONCLUSION The high degree of genetic correlation among many of the psychiatric disorders adds further evidence that their current clinical boundaries do not reflect distinct underlying pathogenic processes, at least on the genetic level. This suggests a deeply interconnected nature for psychiatric disorders, in contrast to neurological disorders, and underscores the need to refine psychiatric diagnostics. Genetically informed analyses may provide important "scaffolding" to support such restructuring of psychiatric nosology, which likely requires incorporating many levels of information. By contrast, we find limited evidence for widespread common genetic risk sharing among neurological disorders or across neurological and psychiatric disorders. We show that both psychiatric and neurological disorders have robust correlations with cognitive and personality measures. Further study is needed to evaluate whether overlapping genetic contributions to psychiatric pathology may influence treatment choices. Ultimately, such developments may pave the way toward reduced heterogeneity and improved diagnosis and treatment of psychiatric disorders

Self-Optimization of Pilot Power in Enterprise Femtocells Using Multi objective Heuristic

Deployment of a large number of femtocells to jointly provide coverage in an enterprise environment raises critical challenges especially in future self-organizing networks which rely on plug-and-play techniques for configuration. This paper proposes a multi-objective heuristic based on a genetic algorithm for a centralized self-optimizing network containing a group of UMTS femtocells. In order to optimize the network coverage in terms of handled load, coverage gaps, and overlaps, the algorithm provides a dynamic update of the downlink pilot powers of the deployed femtocells. The results demonstrate that the algorithm can effectively optimize the coverage based on the current statistics of the global traffic distribution and the levels of interference between neighboring femtocells. The algorithm was also compared with the fixed pilot power scheme. The results show over fifty percent reduction in pilot power pollution and a significant enhancement in network performance. Finally, for a given traffic distribution, the solution quality and the efficiency of the described algorithm were evaluated by comparing the results generated by an exhaustive search with the same pilot power configuration

An extensive study on the boron junctions formed by optimized pre-spike∕multiple-pulse flash lamp annealing schemes : junction formation, stability and leakage

In this work, the electrical activation of Boron in Germanium pre‐amorphized silicon substrate upon flash lamp annealing (FLA) is investigated. We demonstrate that FLA helps in the reduction of the EOR defects, resulting in minimal transient enhanced diffusion and dopant deactivation effect. It has also been observed that the junction stability improves with the increasing number of flash pulses, which is clearly reflected by the dopant deactivation level upon post‐thermal treatment. In another FLA scheme, the spike rapid thermal annealing (RTA) performed prior to the flash further enhances the junction stability. However, this pre‐spike RTA step induces extensive dopant diffusion and an overall degradation in sheet resistance. The above observations are concluded to be due to the different extent of silicon interstitial supersaturation that can be explained by the interactions between the extended defects and dopants. Lastly, leakage current for the junctions formed under different FLA schemes are compared. Typical single pulse FLA junction shows high leakage current and it can be reduced through the additional pulses of FLA or effectively suppressed by the pre‐spike RTA flash scheme. In addition, it is also found that the junction leakage can be correlated to the FLA residual defects.Published versio