Risk assessment of aflatoxins in food

© 2020 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority.Peer reviewedPublisher PD

Workshop Deutsch als Zweitsprache, Migration und Mehrsprachigkeit: Jahresschrift - Band 16

Im November 2021 fand der 16. Workshop für Deutsch als Zweitsprache, Migration und Mehrsprachigkeit an der Pädagogischen Hochschule Freiburg statt. Der Workshop war ursprünglich für das Jahr 2020 geplant und bedingt durch die Pandemie um ein Jahr verschoben worden. Aufgrund der pandemischen Entwicklungen im Jahr 2021 wurde auf ein digitales Format umgestellt. Das thematische und methodische Spektrum der Beiträge war auch im 16. Workshop in Freiburg sehr breit gefächert. Wir freuen uns daher, in diesem Band einen Großteil der Beiträge dokumentieren zu können, da sie einen Ausschnitt aus der vielfältigen nationalen und internationalen Forschung zu Mehrsprachigkeit, Deutsch als Zweitsprache und Migration wiedergeben

Osteochondritis dissecans and Osgood Schlatter disease in a family with Stickler syndrome

<p>Abstract</p> <p>Purpose</p> <p>Stickler syndrome is among the most common autosomal dominant connective tissue disorders but is often unrecognised and therefore not diagnosed by clinicians. Despite much speculation, the cause of osteochondrosis in general and osteochondritis dissecans (OCD) and Osgood Schlatter syndrome (OSS) in particular remain unclear. Etiological understanding is essential. We describe a pair of family subjects presented with OCD and OSS as a symptom complex rather than a diagnosis.</p> <p>Methods</p> <p>Detailed clinical and radiographic examinations were undertaken with emphasis on the role of MRI imaging. Magnetic resonance imaging may allow early prediction of articular lesion healing potential in patients with Stickler syndrome.</p> <p>Results</p> <p>The phenotype of Stickler syndrome can be diverse and therefore misleading. The expectation that the full clinical criteria of any given genetic disorder such as Stickler syndrome will always be present can easily lead to an underestimation of these serious inheritable disorders. We report here two family subjects, a male proband and his aunt (paternal sister), both presented with the major features of Stickler syndrome. Tall stature with marfanoid habitus, astigmatism/congenital vitreous abnormality and submucus cleft palate/cleft uvula, and enlarged painful joints with early onset osteoarthritis. Osteochondritis dissecans (OCD) and Osgood Schlatter syndrome (OSS) were the predominating joint abnormalities.</p> <p>Conclusion</p> <p>We observed that the nature of the articular and physeal abnormalities was consistent with a localised manifestation of a more generalised epiphyseal dysplasia affecting the weight-bearing joints. In these two patients, OCD and OSS appeared to be the predominant pathologic musculoskeletal consequences of an underlying Stickler's syndrome. It is empirical to consider generalised epiphyseal dysplasia as a major underlying causation that might drastically affect the weight-bearing joints.</p

Combining the merits of experiments and numerics in flow stability analysis

Boundary layer transition is a determining factor for drag and convective heat transfer for solid bodies moving through a fluid. The transition zone is known to depend on the level of main stream turbulence. Heat transfer experiments will show the different intermittency profiles. Numerical analysis will show the influence of velocity streaks. Detailed flow experiments are used to determine a possible breakdown mechanism, which, in its turn, will be studied in a model numerical analysis

Translating knowledge on best practice into improving quality of RRT care: a systematic review of implementation strategies

Recent studies showed wide variation in the extent to which guidelines and other types of best practice have been implemented as part of routine health care. This is also true for the delivery of renal replacement therapy (RRT) for ESRD patients. Increasing uptake of best practice within such complex care systems requires an understanding of implementation strategies and specific quality improvement (QI) techniques. Therefore, we systematically reviewed over 5000 titles published since 1990 and included papers describing planned attempts to accelerate uptake of best RRT practice into daily care. This resulted in a list of 93 QI initiatives, categorized in order to expedite shared learning. The majority of the initiatives were executed within the domains of vascular access, nutrition, and anemia management. Strategies oriented at patients were most common and many initiatives pre-defined an improvement target before starting implementation. Of the 93 initiatives, 22 were sufficiently robust methodologically to be analyzed in more detail. Our results tend to support previous findings that multifaceted strategies are more effective than single strategies. Improving our understanding of how to successfully implement best practice can inform system-level change and is the only way to close the gap between knowledge on what works and the actual care delivered to ESRD patients. Research into implementation, using specific QI techniques, should therefore be given priority in future.</p