Strings from Feynman Graph counting : without large N

A well-known connection between n strings winding around a circle and permutations of n objects plays a fundamental role in the string theory of large N two dimensional Yang Mills theory and elsewhere in topological and physical string theories. Basic questions in the enumeration of Feynman graphs can be expressed elegantly in terms of permutation groups. We show that these permutation techniques for Feynman graph enumeration, along with the Burnside counting lemma, lead to equalities between counting problems of Feynman graphs in scalar field theories and Quantum Electrodynamics with the counting of amplitudes in a string theory with torus or cylinder target space. This string theory arises in the large N expansion of two dimensional Yang Mills and is closely related to lattice gauge theory with S_n gauge group. We collect and extend results on generating functions for Feynman graph counting, which connect directly with the string picture. We propose that the connection between string combinatorics and permutations has implications for QFT-string dualities, beyond the framework of large N gauge theory.Comment: 55 pages + 10 pages Appendices, 23 figures ; version 2 - typos correcte

Resurgent revivals in bosonic quantum gases: a striking signature of many-body quantum interferences

Matter wave revivals depend on a delicate interplay of constructive many-body quantum interferences in the developing dynamics of an ultracold bosonic system in an optical lattice. It is shown that the interplay between weak intersite tunneling and strong onsite interactions can lead to the quantum dynamics of a density wave displaying several features not found in the mean-field limit: occupancy oscillations, resurgent revivals, and a (anti-) synchronization of revival peaks and occupancy oscillation peaks. This implies cooperative interference effects that alternate between constructive and destructive features leading to the peak revival behaviors. These many-body quantum interference phenomena create striking features in various observables, which are accessible in experimental measurements.Comment: 6 pages, 4 figure

Quantification of DNA-associated proteins inside eukaryotic cells using single-molecule localization microscopy

Development of single-molecule localization microscopy techniques has allowed nanometre scale localization accuracy inside cells, permitting the resolution of ultra-fine cell structure and the elucidation of crucial molecular mechanisms. Application of these methodologies to understanding processes underlying DNA replication and repair has been limited to defined in vitro biochemical analysis and prokaryotic cells. In order to expand these techniques to eukaryotic systems, we have further developed a photo-activated localization microscopy-based method to directly visualize DNA-associated proteins in unfixed eukaryotic cells. We demonstrate that motion blurring of fluorescence due to protein diffusivity can be used to selectively image the DNA-bound population of proteins. We designed and tested a simple methodology and show that it can be used to detect changes in DNA binding of a replicative helicase subunit, Mcm4, and the replication sliding clamp, PCNA, between different stages of the cell cycle and between distinct genetic backgrounds

Dynamic Capital Structure with Callable Debt and Debt Renegotiations

We consider a dynamic trade-off model of a firm’s capital structure with debt renegotiation. Debt holders only accept restructuring offers from equity holders backed by threats which are in the equity holders’ own interest to execute. Our model shows that in a complete information model in which taxes and bankruptcy costs are the only frictions, violations of the absolute priority rule (APR) are typically optimal. The size of the bankruptcy costs and the equity holders’ bargaining power affect the size of APR violations, but they have only a minor impact on the choice of capital structure

An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans

none24noneS. BONASSI; A. ZNAOR; M. CEPPI; C. LANDO; W.P. CHANG; N. HOLLAND; M. KIRSCH-VOLDERS; E. ZEIGER; S. BAN; R. BARALE; M.P. BIGATTI; C. BOLOGNESI; A. CEBULSKA-WASILEWSKA; E. FABIANOVA; A. FUCIC; L. HAGMAR; G. JOKSIC; A. MARTELLI; L. MIGLIORE; E. MIRKOVA; M.R. SCARFI; A. ZIJNO; H. NORPPA; M. FENECHS., Bonassi; A., Znaor; M., Ceppi; C., Lando; W. P., Chang; N., Holland; M., KIRSCH VOLDERS; E., Zeiger; S., Ban; R., Barale; M. P., Bigatti; C., Bolognesi; A., CEBULSKA WASILEWSKA; E., Fabianova; A., Fucic; L., Hagmar; G., Joksic; Martelli, ANTONIETTA MARIA; L., Migliore; E., Mirkova; M. R., Scarfi; A., Zijno; H., Norppa; M., Fenec

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling

The human prolyl-4-hydroxylase domain (PHD) proteins 1–3 are known as cellular oxygen sensors, acting via the degradation of hypoxia-inducible factor (HIF) α-subunits. PHD2 and PHD3 genes are inducible by HIFs themselves, suggesting a negative feedback loop that involves PHD abundance. To identify novel regulators of the PHD2 gene, an expression array of 704 transcription factors was screened by a method that allows distinguishing between HIF-dependent and HIF-independent promoter regulation. Among others, the E-twenty six transcription factor ETS translocation variant 4 (ETV4) was found to contribute to PHD2 gene expression particularly under hypoxic conditions. Mechanistically, complex formation between ETV4 and HIF-1/2α was observed by mammalian two-hybrid and fluorescence resonance energy transfer analysis. HIF-1α domain mapping, CITED2 overexpression and factor inhibiting HIF depletion experiments provided evidence for cooperation between HIF-1α and p300/CBP in ETV4 binding. Chromatin immunoprecipitation confirmed ETV4 and HIF-1α corecruitment to the PHD2 promoter. Of 608 hypoxically induced transcripts found by genome-wide expression profiling, 7.7% required ETV4 for efficient hypoxic induction, suggesting a broad role of ETV4 in hypoxic gene regulation. Endogenous ETV4 highly correlated with PHD2, HIF-1/2α and several established markers of tissue hypoxia in 282 human breast cancer tissue samples, corroborating a functional interplay between the ETV4 and HIF pathways

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Corporate bond liquidity before and after the onset of the subprime crisis

We analyze liquidity components of corporate bond spreads during 2005–2009 using a new robust illiquidity measure. The spread contribution from illiquidity increases dramatically with the onset of the subprime crisis. The increase is slow and persistent for investment grade bonds while the effect is stronger but more short-lived for speculative grade bonds. Bonds become less liquid when financial distress hits a lead underwriter and the liquidity of bonds issued by financial firms dries up under crises. During the subprime crisis, flight-to-quality is confined to AAA-rated bonds