Statistics of the Energy Dissipation Rate and Local Enstrophy in Turbulent Channel Flow

Using high-resolution direct numerical simulations, the height and Reynolds number dependence of higher-order statistics of the energy dissipation rate and local enstrophy are examined in incompressible, fully-developed turbulent channel flow. The statistics are studied over a range of wall distances, spanning the viscous sublayer to the channel flow centerline, for friction Reynolds numbers $Re_\tau = 180$ and $Re_\tau = 381$. The high resolution of the simulations allows dissipation and enstrophy moments up to fourth order to be calculated. These moments show a dependence on wall distance, and Reynolds number effects are observed at the edge of the logarithmic layer. Conditional analyses based on locations of intense rotation are also carried out in order to determine the contribution of vortical structures to the dissipation and enstrophy moments. Our analysis shows that, for the simulation at the larger Reynolds number, small-scale fluctuations of both dissipation and enstrophy become relatively constant for $z^+ \gtrsim 100$.Comment: Accepted by Physica

Pseudogap and Conduction Dimensionalities in High-T_c Superconductors

The nature of normal state charge-carriers' dynamics and the transition in conduction and gap dimensionalities between 2D and 3D for YBa_2 Cu_3 O_{7-delta} and Bi_2 Sr_2 Ca_{1-x} Y_x Cu_2 O_8 high-T_c superconductors were described by computing and fitting the resistivity curves, rho(T,delta,x). These were carried out by utilizing the 2D and 3D Fermi liquid (FL) and ionization energy (E_I) based resistivity models coupled with charge-spin (CS) separation based t-J model [Phys. Rev. B 64, 104516 (2001)]. rho(T,delta,x) curves of Y123 and Bi2212 samples indicate the beginning of the transition of conduction and gap from 2D to 3D with reduction in oxygen content (7-delta) and Ca^{2+} (1-x) as such, c-axis pseudogap could be a different phenomenon from superconductor and spin gaps. These models also indicate that the recent MgB_2 superconductor is at least not Y123 or Bi2212 type.Comment: To be published in Physica

Omega-3 canola oil effectively replaces fish oil as a new safe dietary source of docosahexaenoic acid (DHA) in feed for juvenile Atlantic salmon

Limited availability of fish oils (FO), rich in n-3 long-chain (≥C20) PUFA, is a major constraint for further growth of the aquaculture industry. Long-chain n-3 rich oils from crops GM with algal genes are promising new sources for the industry. This project studied the use of a newly developed n-3 canola oil (DHA-CA) in diets of Atlantic salmon fingerlings in freshwater. The DHA-CA oil has high proportions of the n-3 fatty acids (FA) 18 : 3n-3 and DHA and lower proportions of n-6 FA than conventional plant oils. Levels of phytosterols, vitamin E and minerals in the DHA-CA were within the natural variation of commercial canola oils. Pesticides, mycotoxins, polyaromatic hydrocarbons and heavy metals were below lowest qualifiable concentration. Two feeding trials were conducted to evaluate effects of two dietary levels of DHA-CA compared with two dietary levels of FO at two water temperatures. Fish increased their weight approximately 20-fold at 16°C and 12-fold at 12°C during the experimental periods, with equal growth in salmon fed the FO diets compared with DHA-CA diets. Salmon fed DHA-CA diets had approximately the same EPA+DHA content in whole body as salmon fed FO diets. Gene expression, lipid composition and oxidative stress-related enzyme activities showed only minor differences between the dietary groups, and the effects were mostly a result of dietary oil level, rather than the oil source. The results demonstrated that DHA-CA is a safe and effective replacement for FO in diets of Atlantic salmon during the sensitive fingerling life-stage.acceptedVersio

A global database for metacommunity ecology, integrating species, traits, environment and space

The use of functional information in the form of species traits plays an important role in explaining biodiversity patterns and responses to environmental changes. Although relationships between species composition, their traits, and the environment have been extensively studied on a case-by-case basis, results are variable, and it remains unclear how generalizable these relationships are across ecosystems, taxa and spatial scales. To address this gap, we collated 80 datasets from trait-based studies into a global database for metaCommunity Ecology: Species, Traits, Environment and Space; “CESTES”. Each dataset includes four matrices: species community abundances or presences/absences across multiple sites, species trait information, environmental variables and spatial coordinates of the sampling sites. The CESTES database is a live database: it will be maintained and expanded in the future as new datasets become available. By its harmonized structure, and the diversity of ecosystem types, taxonomic groups, and spatial scales it covers, the CESTES database provides an important opportunity for synthetic trait-based research in community ecology

Neuronal nitric oxide synthase contributes to the regulation of hematopoiesis

Nitric oxide (NO) signaling is important for the regulation of hematopoiesis. However, the role of individual NO synthase (NOS) isoforms is unclear. Our results indicate that the neuronal NOS isoform (nNOS) regulates hematopolesis in vitro and in vivo. nNOS is expressed in adult bone marrow and fetal liver and is enriched in stromal cells. There is a strong correlation between expression of nNOS in a panel of stromal cell lines established from bone marrow and fetal liver and the ability of these cell lines to support hematopoietic stem cells; furthermore, NO donor can further increase this ability. The number of colonies generated in vitro from the bone marrow and spleen of nNOS-null mutants is increased relative to wild-type or inducible- or endothelial NOS knockout mice. These results describe a new role for nNOS beyond its action in the brain and muscle and suggest a model where nNOS, expressed in stromal cells, produces NO which acts as a paracrine regulator of hematopoietic stem cells

Prevention and Mitigation of Acute Radiation Syndrome in Mice by Synthetic Lipopeptide Agonists of Toll-Like Receptor 2 (TLR2)

Bacterial lipoproteins (BLP) induce innate immune responses in mammals by activating heterodimeric receptor complexes containing Toll-like receptor 2 (TLR2). TLR2 signaling results in nuclear factor-kappaB (NF-κB)-dependent upregulation of anti-apoptotic factors, anti-oxidants and cytokines, all of which have been implicated in radiation protection. Here we demonstrate that synthetic lipopeptides (sLP) that mimic the structure of naturally occurring mycoplasmal BLP significantly increase mouse survival following lethal total body irradiation (TBI) when administered between 48 hours before and 24 hours after irradiation. The TBI dose ranges against which sLP are effective indicate that sLP primarily impact the hematopoietic (HP) component of acute radiation syndrome. Indeed, sLP treatment accelerated recovery of bone marrow (BM) and spleen cellularity and ameliorated thrombocytopenia of irradiated mice. sLP did not improve survival of irradiated TLR2-knockout mice, confirming that sLP-mediated radioprotection requires TLR2. However, sLP was radioprotective in chimeric mice containing TLR2-null BM on a wild type background, indicating that radioprotection of the HP system by sLP is, at least in part, indirect and initiated in non-BM cells. sLP injection resulted in strong transient induction of multiple cytokines with known roles in hematopoiesis, including granulocyte colony-stimulating factor (G-CSF), keratinocyte chemoattractant (KC) and interleukin-6 (IL-6). sLP-induced cytokines, particularly G-CSF, are likely mediators of the radioprotective/mitigative activity of sLP. This study illustrates the strong potential of LP-based TLR2 agonists for anti-radiation prophylaxis and therapy in defense and medical scenarios