Techno-economic evaluation of a grid-connected hybrid PV-wind power generation system in San Luis Potosi, Mexico

This paper presents a study of the installation of a hybrid PV-Wind power generation system for social interest houses in the city of San Luis Potosi, Mexico. To assess the benefits of the implementation of this type of systems, a technological, economic and environmental evaluation is carried out based on the available renewable energy resources and considering a typical load profile of consumers. The obtained results show the feasibility of installation of small capacity hybrid generation systems in the city, however governmental incentives must be implemented to make more attractive and affordable the proposed systems for medium/low income users

Alteraciones morfológicas de las médulas óseas en pacientes con covid-19. revision sistemática y meta-análisis

Introduction: Despite the fact that hematological alterations at the peripheral level are widely known, little is known about the alterations caused by COVID-19 at the bone marrow level. Objective: To determine the morphological alterations of the bone marrow caused by COVID-19. Material and methods: Systematic review and meta-analysis. Observational studies and reports and case series were included and editorials, reviews, letters to the editor were excluded. A search was performed in Pubmed, ScienceDirect and Scielo. The risk of bias was assessed using the NewCatell-Ottawa and Hassan Murad scales for case reports and series. The outcomes were the morphological parameters of the bone marrow. For the quantitative synthesis of the information, a proportion meta-analysis was performed using random effects in RStudio. Results: Hypercellularity occurred in 65% (95% CI: 51%-78%), maturation arrest of the myeloid series occurred in 57% (95% CI: 29%-83%). and the alteration of the M/E ratio occurred in 60% (95% CI: 46%-74%). Conclusion: The most frequent morphological alterations in the bone marrow were hypercellularity, arrest in myeloid maturation and alteration of the M/E ratio in patients with COVID-19.Introducción: Pese a conocerse ampliamente las alteraciones hematológicas a nivel periférico, aún es poco lo que se conoce acerca de las alteraciones originadas por la COVID-19 a nivel de la médula ósea. Objetivo: Determinar las alteraciones morfológicas de la médula ósea causadas por la COVID-19. Material y Métodos: Revisión sistemática y meta-análisis. Se incluyeron estudios observacionales y reportes y series de caso y se excluyeron a editoriales, revisiones y cartas al editor. Se realizó una búsqueda estructurada en Pubmed, ScienceDirect y Scielo. El riesgo de sesgo se evaluó mediante la escala NewCatell-Otawa y de Hassan Murad para los reportes y series de caso. Los desenlaces fueron los parámetros morfológicos de la médula ósea. Para la síntesis cuantitativa de la información se realizó un meta-análisis de proporción mediante efectos aleatorios en RStudio. Resultados: La hipercelularidad se presentó en el 65% (IC-95%: 51%-78%), la detención de la maduración de la serie mieloide se presentó en el 57% (IC-95%: 29%-83%) y la alteración de la relación M/E se presentó en el 60% (IC-95%: 46%-74%). Conclusión: Las alteraciones morfológicas en la médula ósea más frecuentes fueron la hipercelularidad, detención en la maduración mieloide y alteración de la relación M/E en los pacientes con COVID-19

Mental impact of Covid-19 among Spanish healthcare workers. A large longitudinal survey

Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); Ministerio de Ciencia e Innovación; Gerencia Regional de Salud de Castilla y León (SACYL, GRS COVID 32/A/20).Aims Longitudinal data on the mental health impact of the coronavirus disease 2019 (Covid-19) pandemic in healthcare workers is limited. We estimated prevalence, incidence and persistence of probable mental disorders in a cohort of Spanish healthcare workers (Covid-19 waves 1 and 2) -and identified associated risk factors. Methods 8996 healthcare workers evaluated on 5 May-7 September 2020 (baseline) were invited to a second web-based survey (October-December 2020). Major depressive disorder (PHQ-8 ≥ 10), generalised anxiety disorder (GAD-7 ≥ 10), panic attacks, post-traumatic stress disorder (PCL-5 ≥ 7), and alcohol use disorder (CAGE-AID ≥ 2) were assessed. Distal (pre-pandemic) and proximal (pandemic) risk factors were included. We estimated the incidence of probable mental disorders (among those without disorders at baseline) and persistence (among those with disorders at baseline). Logistic regression of individual-level [odds ratios (OR)] and population-level (population attributable risk proportions) associations were estimated, adjusting by all distal risk factors, health care centre and time of baseline interview. Results 4809 healthcare workers participated at four months follow-up (cooperation rate = 65.7%; mean = 120 days s.d. = 22 days from baseline assessment). Follow-up prevalence of any disorder was 41.5%, (v. 45.4% at baseline, p < 0.001); incidence, 19.7% (s.e. = 1.6) and persistence, 67.7% (s.e. = 2.3). Proximal factors showing significant bivariate-adjusted associations with incidence included: work-related factors [prioritising Covid-19 patients (OR = 1.62)], stress factors [personal health-related stress (OR = 1.61)], interpersonal stress (OR = 1.53) and financial factors [significant income loss (OR = 1.37)]. Risk factors associated with persistence were largely similar. Conclusions Our study indicates that the prevalence of probable mental disorders among Spanish healthcare workers during the second wave of the Covid-19 pandemic was similarly high to that after the first wave. This was in good part due to the persistence of mental disorders detected at the baseline, but with a relevant incidence of about 1 in 5 of HCWs without mental disorders during the first wave of the Covid-19 pandemic. Health-related factors, work-related factors and interpersonal stress are important risks of persistence of mental disorders and of incidence of mental disorders. Adequately addressing these factors might have prevented a considerable amount of mental health impact of the pandemic among this vulnerable population. Addressing health-related stress, work-related factors and interpersonal stress might reduce the prevalence of these disorders substantially. Study registration number: NCT0455656

Zoonosis, cambio climático y sociedad

La sociedad contemporánea se enfrenta a uno de los retos más grandes de la historia humana, el calentamiento global, mismo que acarrea enormes consecuencias, tales como los disturbios climáticos, así como los patrones de las enfermedades de origen animal transmisibles al hombre. Precisamente ante este escenario las instituciones educativas de nivel superior deben dar cumplimiento a su responsabilidad y ser las generadoras de alternativas de solución mediante el trabajo especializado de investigación; y para ello, la pesquisa científica es la mejor de las alternativas a nuestro alcance para comprender y encarar estos desafíos.Universidad Autónoma del Estado de México y Ediciones y Gráficos Eón, S.A. de C.V

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

The global abundance of tree palms

Aim Palms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree palm relative abundance to help improve understanding of tropical forests and reduce uncertainty about these ecosystems under climate change. Location Tropical and subtropical moist forests. Time period Current. Major taxa studied Palms (Arecaceae). Methods We assembled a pantropical dataset of 2,548 forest plots (covering 1,191 ha) and quantified tree palm (i.e., ≥10 cm diameter at breast height) abundance relative to co‐occurring non‐palm trees. We compared the relative abundance of tree palms across biogeographical realms and tested for associations with palaeoclimate stability, current climate, edaphic conditions and metrics of forest structure. Results On average, the relative abundance of tree palms was more than five times larger between Neotropical locations and other biogeographical realms. Tree palms were absent in most locations outside the Neotropics but present in >80% of Neotropical locations. The relative abundance of tree palms was more strongly associated with local conditions (e.g., higher mean annual precipitation, lower soil fertility, shallower water table and lower plot mean wood density) than metrics of long‐term climate stability. Life‐form diversity also influenced the patterns; palm assemblages outside the Neotropics comprise many non‐tree (e.g., climbing) palms. Finally, we show that tree palms can influence estimates of above‐ground biomass, but the magnitude and direction of the effect require additional work. Conclusions Tree palms are not only quintessentially tropical, but they are also overwhelmingly Neotropical. Future work to understand the contributions of tree palms to biomass estimates and carbon cycling will be particularly crucial in Neotropical forests