Monitoring Asthma in Childhood: Still a Challenge

Asthma monitoring should be focused on patient outcomes and goals. Using clinical practice tools allows the clinicians to detect problems such as bad adherence to maintenance therapy, comorbidities, or other external reason for a poorly controlled asthma. To succeed in the process of asthma control, doctors need the participation of the family. Because such educational task requires good agreement between patient environment and doctor, it might be difficult to achieve. However, it is worth to implement because the benefit is a life without symptoms of asthma with a minimum medication

The written production of argumentative and dissertation text: a didactic project based on Bakhtin's philosophy

This article is characterized as a theoretical and practical research related to a project developed during the year 2015 in two schools - one public, the other private- , in the city of Birigui, State of São Paulo, Brazil. The main goal of the study was to analyze: the pedagogical project and the teachers’ activities oriented towards teaching and learning of argumentative and dissertation texts. The methodology used in this research comprised: (i) visiting both schools, (ii) producing a description of ongoing school practices, with focus on the teaching of argumentative and dissertation texts, (iii) suggesting a teacher’s activity to improve this apprenticeship, (iv) putting this activity into practice and (v) analyzing obtained results. The theoretical framework used for this study was the Bakhtinian philosophy (BAKHTIN, 2013; 2006a; 2006b; 2006c; 2006d; 2010; 2013; VOLOSHINOV, 1986). This theoretical approach was chosen due to the importance of comprehension of the text not just as an amalgamated set of words, phrases and paragraphs; other than that, we understand it as a structure of meaning, in which we encounter linguistic forms, ideologies and discursive stance. At last, we can say the results show that the argumentative texts render assistance to the development of the students’ argumentative competence and skill, that is, in their ability to argue and organize ideas in a communicative situation

Tratamiento del agua residual de un matadero: Eficiencia del proceso de coagulación - floculación

El objetivo del presente trabajo fue evaluar los beneficios y eficacia del tratamiento de coagulación y floculación de las aguas residuales provenientes de un matadero. Para ello se analizaron muestras de 500 ml y se utilizó sulfato de aluminio (1%) y cloruro férrico (1%) como agentes coagulantes, polímero catiónico (1%) como agente floculante y gradientes de velocidad alta (150 – 300 r.p.m) y velocidad baja (37 – 75 r.p.m).  Las concentraciones iniciales de contaminantes en el efluente fueron: pH (6,98 – 6,97), turbiedad (436 - 537 NTU), SST (430,6 – 228,8 ppm), oxígeno disuelto (1,17 – 2,11mg/L), nitratos (0 – 7,5 mg/L). Los mejores resultados se obtuvieron con la adición de 6 ml de sulfato de aluminio; 1 ml de polímero catiónico, una velocidad de mezcla de 200 r.p.m y un tiempo de sedimentación de 25 minutos, que disminuyeron las concentraciones de turbiedad 4,85 NTU, oxígeno disuelto 9,16 mg/L y STD 333,6 ppm. Asimismo, la adición de 2 mL cloruro férrico, 0,75 mL de polímero catiónico, una velocidad en mezcla rápida de 300 r.p.m y tiempo de sedimentación de 35 minutos, permitieron obtener como resultado 15,46 NTU, oxígeno disuelto 9,45 mg/L, STD 224,7 ppm, nitratos 6 mg/L

From local knowledge to decision making in climate change adaptation at basin scale. Application to the Jucar River Basin, Spain

[EN] Climate change is challenging the conventional approaches for water systems planning. Two main approaches are commonly implemented in the design of climate change adaptation plans: impact-oriented top-down approaches and vulnerability-oriented bottom-up approaches. In order to overcome the shortcomings of both approaches and take advantage of their strengths, we propose an integrative methodology to define adaptation strategies at basin scale, identifying and combining potential changes in water demand and water supply infrastructure along with climate variability and change. The impact of climate change on future local water availability is assessed applying a top-down approach. Local knowledge is used through a participatory bottom-up approach to foresee future scenarios of evolution of the agricultural sector and agricultural water demand, and to identify locally relevant adaptation strategies. A hydroeconomic model integrates the information from both approaches to identify a socially acceptable and cost-effective program of measures for each climate scenario. This method was applied to the Jucar basin, a highly regulated basin with a tight equilibrium between water resources and demands. The results show an important variability of climate change impacts across the basin, with main inflow reductions in the headwaters. The stakeholders prioritized the adaptation options of change to drip irrigation, use of non-conventional resources, and changes in water governance. The results obtained from the hydroeconomic model show that the portfolio of selected adaptation measures could significantly reduce the system's average annual deficit and costOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study has received funding from the European Union's Horizon 2020 research and innovation programme under the GoNEXUS project (GA no. 101003722), as well from ADAPTAMED (RTI2018-101483-B-I00) and the former IMPADAPT project (CGL2013-48424-C2-1-R) with Spanish MINECO (Ministerio de Economia y Competitividad) and European FEDER funds at the early stages. PM-G has been also supported by a FPI grant from the PhD Training Program (BES-2014-070490) of the former MINECO.Marcos-García, P.; Pulido-Velazquez, M.; Sanchis Ibor, C.; García Molla, M.; Ortega-Reig, M.; Garcia-Prats, A.; Girard-Martin, CDP. (2023). From local knowledge to decision making in climate change adaptation at basin scale. Application to the Jucar River Basin, Spain. Climatic Change. 176(4):1-23. https://doi.org/10.1007/s10584-023-03501-8123176

Mindfulness, promoção da saúde e semiótica: bases para modelos comunicacionais em saúde online

Objetivo: analizar un curso en línea sobre promoción de la salud basado en la atención plena (mindfulness) a través de la teoría de la semiótica discursiva en uno de sus desarrollos más recientes, el aspecto visual o plástico. El objetivo es identificar cómo el texto verbal-visual del curso produce significados y cómo puede ayudar en el diseño de otros cursos. Método: se llevó a cabo un análisis semiótico de dos prácticas y una impresión de pantalla del curso llamado Programa de autocuidado basado en la atención plena, en educación a distancia, desarrollado por el Centro Brasileño de Mindfulness y Promoción de la Salud (“Mente Abierta”), del Departamento de Medicina Preventivade de la Universidad Federal de São Paulo. Resultados: se evaluaronlos elementos estéticos que contribuyeron a la construcción de un entorno de práctica eufórica (vinculado a la salud) y se establecieron relaciones entre el plan de contenido y el plan de expresión de práctica, responsables de la construcción de relaciones semi-simbólicas. Conclusión: se confirmó la valoración de una estética de simplicidad de colores y formas, que convergió en una afirmación de los valores de calma y bienestar compatibles con las prácticas de mindfulness. Objetictive: to analyze an online course on health promotion based on mindfulness (mindfulness) through the theory of discursive semiotics in one of its most recent developments, the visual or plastic aspect. The objective is to identify how the verbal-visual text of the course producesmeanings and how it can help in the design of other courses. Method: a semiotic analysis of two practices and a screen print of the course called Mindfulness-Based Self-Care Program, in distance learning, developed by the Brazilian Center for Mindfulness and Health Promotion (“Open Mind”), of the Department of Preventive Medicine at the Federal University of São Paulo. Results: the aesthetic elements that contributed to the construction of an euphoric practice environment (linked to health) were evaluated and relationships were established between the content planand the practice expression plan, responsible for the construction of a semi-symbolic system. Conclusion: it was confirmed the appreciation of an aesthetics of simplicity of colors and shapes that was converged to an affirmation of the values of calm and well-being compatible with the practices of mindfulness. From this analysis, we seek to reflect on the bases for the development of communicational models related to health promotion in a digital environment.Objetivo: identificar como o texto verbo-visual do curso produz sentidos e como isso pode auxiliar na  construção do design de outros cursos. Método: foi feita a análise semiótica de duas práticas e de um print de tela do curso denominadoPrograma de Autocuidado Baseado em Mindfulness, na modalidade Educação à Distância, desenvolvido pelo CentroBrasileiro de Mindfulness e Promoção da Saúde (“Mente Aberta”), do Departamento de Medicina Preventiva da Universidade Federal de São Paulo. Foram avaliados os elementos estéticos que contribuiriam para a construção de um ambiente de prática eufórico (ligado à saúde) e estabelecidas relações entre o plano de conteúdo e o plano de expressão das práticas, responsáveis pela construção de um sistema semissimbólico. Resultados: confirmou-se a valorização de uma estética da simplicidade de cores eformas que converge para uma afirmação dos valores calma e bem-estar compatíveis com as práticas de mindfulness. Conclusão: a partir dessa análise, busca-se refletir sobre asbases para o desenvolvimento de modelos comunicacionais relacionados à promoção da saúde em ambiente digital.

Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial

[EN] Microwave (MWA) and radiofrequency ablation (RFA) are main ablative techniques for hepatocellular carcinoma (HCC) and colorectal liver metastasis (MT). This randomized phase 2 clinical trial compares the effectiveness of MWA and RFA as well as morphology of corresponding ablation zones. HCC and MT patients with 1.5-4 cm tumors, suitable for ablation, were randomized into MWA or RFA Groups. The primary endpoint was short-to-long diameter ratio of ablation zone (SLR). Primary technical success (TS) and a cumulative local tumor progression (LTP) after a median 2-year follow-up were compared. Between June 2015 and April 2020, 82 patients were randomly assigned (41 patients per group). For the per-protocol analysis, five patients were excluded. MWA created larger ablation zones than RFA (p = 0.036) although without differences in SLR (0.5 for both groups, p = 0.229). The TS was achieved in 98% (46/47) and 90% (45/50) (p = 0.108), and LTP was observed in 21% (10/47) vs. 12% (6/50) (OR 1.9 [95% CI 0.66-5.3], p = 0.238) of tumors in MWA vs. RFA Group, respectively. Major complications were found in 5 cases (11%) vs. 2 cases (4%), without statistical significance. MWA and RFA show similar SLR, effectiveness and safety in liver tumors between 1.5 and 4 cm.This work was supported by a grant for medical research from Spanish Government (FIS-PI12/00799) and by the Spanish Ministerio de Ciencia, Innovacion y Universidades under "Programa Estatal de I+D+i Orientada a los Retos de la Sociedad", Grant RTI2018-094357-B-C21.Radosevic, A.; Quesada, R.; Serlavos, C.; Sánchez, J.; Zugazaga, A.; Sierra, A.; Coll, S.... (2022). Microwave versus radiofrequency ablation for the treatment of liver malignancies: a randomized controlled phase 2 trial. Scientific Reports. 12(1):1-10. https://doi.org/10.1038/s41598-021-03802-xS11012

Polyclonal antibody production anti Pc_312-324 peptide: Its potential use in electrochemical immunosensors for transgenic soybean detection

A new polyclonal antibody that recognizes the CP4 5-enolpyruvylshikimate-3-phosphate synthase (CP4-EPSPS), which provides resistance to glyphosate in soybean (Roundup Ready®, RR soybean), was produced. New Zealand rabbits were injected with a synthetic peptide (Pc_312-324, (PEP)) present in the soybean CP4-EPSPS protein. The anti-PEP antibodies production was evaluated by electrophoresis (SDS-PAGE) and an enzyme-linked immunosorbent assay (ELISA) was developed in order to study their specificity. The ELISA showed that the polyclonal antibody was specific to PEP. In addition, the anti- PEP was immobilized onto a gold disk electrode and the antigen-antibody interaction was evaluated using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Moreover, the EIS showed that the electron transfer resistance of the modified electrode increased after incubation with solutions containing CP4-EPSPS protein from RR transgenic soybean, while no changes were detected after incubation with no-RR soybean proteins. These results suggest that the CP4-EPSPS was immobilized onto the electrode, due to the specific interaction with the anti-PEP. These results show that this antigen-antibody interaction can be detected by electrochemical techniques, suggesting that the anti-PEP produced can be used in electrochemical immunosensors development to quantify transgenic soybean.Fil: Farias, Marcos Ezequiel. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Marani, Mariela Mirta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: Ramirez, Dario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis. Universidad Nacional de San Luis. Facultad de Ciencias Físico Matemáticas y Naturales. Instituto Multidisciplinario de Investigaciones Biológicas de San Luis; ArgentinaFil: Niebylski, Ana Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Instituto de Biotecnología Ambiental y Salud - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Biotecnología Ambiental y Salud; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Biología Molecular; ArgentinaFil: Correa, Nestor Mariano. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; ArgentinaFil: Molina, Patricia Gabriela. Universidad Nacional de Río Cuarto. Instituto para el Desarrollo Agroindustrial y de la Salud. - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto para el Desarrollo Agroindustrial y de la Salud; Argentina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentin

CCR7 as a novel therapeutic target in t-cell PROLYMPHOCYTIC leukemia

T-cell prolymphocytic leukemia (T-PLL) is a poor prognostic disease with very limited options of efficient therapies. Most patients are refractory to chemotherapies and despite high response rates after alemtuzumab, virtually all patients relapse. Therefore, there is an unmet medical need for novel therapies in T-PLL. As the chemokine receptor CCR7 is a molecule expressed in a wide range of malignancies and relevant in many tumor processes, the present study addressed the biologic role of this receptor in T-PLL. Furthermore, we elucidated the mechanisms of action mediated by an anti-CCR7 monoclonal antibody (mAb) and evaluated whether its anti-tumor activity would warrant development towards clinical applications in T-PLL. Our results demonstrate that CCR7 is a prognostic biomarker for overall survival in T-PLL patients and a functional receptor involved in the migration, invasion, and survival of leukemic cells. Targeting CCR7 with a mAb inhibited ligand-mediated signaling pathways and induced tumor cell killing in primary samples. In addition, directing antibodies against CCR7 was highly effective in T-cell leukemia xenograft models. Together, these findings make CCR7 an attractive molecule for novel mAb-based therapeutic applications in T-PLL, a disease where recent drug screen efforts and studies addressing new compounds have focused on chemotherapy or small molecules.Peer reviewe

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

El huerto escolar de la Facultad de Educación - Centro de Formación del Profesorado: un espacio multidisciplinar para trabajar las competencias profesionales de futuros docentes

El huerto escolar sea el hilo conductor para formar a los estudiantes en las competencias profesionales propias del Grado, haciéndolo extensivo a las competencias básicas que debe alcanzar un escolar