Cancer-Associated Thrombosis in Cirrhotic Patients with Hepatocellular Carcinoma.

It is common knowledge that cancer patients are more prone to develop venous thromboembolic complications (VTE). It is therefore not surprising that patients with hepatocellular carcinoma (HCC) present with a significant risk of VTE, with the portal vein being the most frequent site (PVT). However, patients with HCC are peculiar as both cancer and liver cirrhosis are conditions that can perturb the hemostatic balance towards a prothrombotic state. Because HCC-related hypercoagulability is not clarified at all, the aim of the present review is to summarize the currently available knowledge on epidemiology and pathogenesis of non-malignant thrombotic complications in patients with liver cirrhosis and HCC. They are at increased risk to develop both PVT and non-splanchnic VTE, indicating that both local and systemic factors can foster the development of site-specific thrombosis. Recent studies have suggested multiple and often interrelated mechanisms through which HCC can tip the hemostatic balance of liver cirrhosis towards hypercoagulability. Described mechanisms include increased fibrinogen concentration/polymerization, thrombocytosis, and release of tissue factor-expressing extracellular vesicles. Currently, there are no specific guidelines on the use of thromboprophylaxis in this unique population. There is the urgent need of prospective studies assessing which patients have the highest prothrombotic profile and would therefore benefit from early thromboprophylaxis

The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters. X. The radial distribution of stellar populations in NGC 2808

Due to their extreme helium abundance, the multiple stellar populations of the globular cluster NGC 2808 have been widely investigated from a photometric, spectroscopic, and kinematic perspective. The most striking feature of the color-magnitude diagram of NGC 2808 is the triple main sequence (MS), with the red MS corresponding to a stellar population with primordial helium, and the middle and the blue MS being enhanced in helium up to Y$\sim$0.32 and $\sim$0.38, respectively. A recent study has revealed that this massive cluster hosts at least five distinct stellar populations (A, B, C, D, and E). Among them populations A, B, and C correspond to the red MS, while populations C and D are connected to the middle and the blue MS. In this paper we exploit Hubble-Space-Telescope photometry to investigate the radial distribution of the red, the middle and the blue MS from the cluster center out to about 8.5 arcmin. Our analysis shows that the radial distribution of each of the three MSs is different. In particular, as predicted from multiple-population formation models, both the blue MS and the middle MS appears to be more concentrated than the red MS with a significance level for this result wich is above 3{\sigma}.Comment: Accepted for publication in MNRA

The Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters. XIII. ACS/WFC Parallel-Field Catalogues

As part of the Hubble Space Telescope UV Legacy Survey of Galactic Globular Clusters, 110 parallel fields were observed with the Wide Field Channel of the Advanced Camera for Surveys, in the outskirts of 48 globular clusters, plus the open cluster NGC 6791. Totalling about $0.3$ square degrees of observed sky, this is the largest homogeneous Hubble Space Telescope photometric survey of Galalctic globular clusters outskirts to date. In particular, two distinct pointings have been obtained for each target on average, all centred at about $6.5$ arcmin from the cluster centre, thus covering a mean area of about $23\,{\rm arcmin^{2}}$ for each globular cluster. For each field, at least one exposure in both F475W and F814W filters was collected. In this work, we publicly release the astrometric and photometric catalogues and the astrometrised atlases for each of these fields.Comment: 30 pages, 23 figures. Accepted by MNRA

Comparação entre os modos multiplanar e renderizado na avaliação da área das valvas atrioventriculares fetais por meio da ultrassonografia 3D/4D

OBJECTIVE: To compare the agreement of multiplanar and rendering modes in the assessment fetal atrioventricular valves (mitral and tricuspid) areas by three-dimensional (3D) ultrasonography using the software spatio-temporal image correlation (STIC). METHODS: We conducted a prospective cross-sectional study with normal pregnant women, with single fetuses, between 18-33 weeks. To measure the areas, we used the plan of four-chamber view. In the case of multiplanar, the plane was rotated on the axis Z form the heart to position at 9h. For rendering, the green line (region of interest - ROI) was placed from the atria of the heart perpendicular to the crux. The agreement was assessed by a Bland-Altman (limits of agreement) using the relative difference between the measures: ((rendering mode) - (multiplanar mode)) / (average). RESULTS: 328 fetuses were evaluated. We have not identified the occurrence of systematic error between methods: the average relative difference was 1.62% (-2.07% to 5.32%, confidence interval 95%) in the mitral and 1.77% (- 1.08% to 4.62%) in the tricuspid valve. The limits of agreement between methods were -65.26% to 68.51% for the mitral and -49.91% to 53.45% for the tricuspid. CONCLUSIONS: There was no systematic error between modes and thus the observed values for the area of fetal atrioventricular valves can be used for comparisons needs to be corrected. However, relatively large variations may be observed when repeating the measurement area by different modes.OBJETIVO: Avaliar a concordância entre as medidas das áreas das valvas atrioventriculares (mitral e tricúspide) fetais realizadas por ultrassonografia tridimensional (3D) pelo software spatio-temporal image correlation (STIC) usando os modos multiplanar e renderizado. MÉTODOS: Estudo prospectivo de corte transversal avaliando fetos de gestações únicas, consideradas saudáveis, entre 18 a 33 semanas de idade gestacional. Para a medida das áreas, utilizou-se o plano de quatro câmaras cardíacas. No caso do multiplanar, o plano foi rodado no eixo z de forma o coração se dispuser em 9h. Para o renderizado, a linha verde (região de interesse - ROI) foi posicionada a partir dos átrios, perpendicular à cruz do coração. A concordância foi avaliada pelo método de Bland-Altman (limites de concordância) utilizando a diferença relativa entre as medidas: ((modo renderizado) - (modo multiplanar)) / (média).< RESULTADOS: 328 fetos foram avaliados. Não identificamos a ocorrência de erro sistematizado entre os métodos: a diferença relativa média foi de 1,62% (-2,07% a 5,32%, intervalo de confiança de 95%) na mitral e de 1,77% (-1,08% a 4,62%) na tricúspide. Os limites de concordância entre os métodos foram de -65,26% a 68,51% para a mitral e de -49,91% a 53,45% para a tricúspide. CONCLUSÕES: Não foi observado erro sistematizado entre os modos e desta forma os valores observados para a área das valvas atrioventriculares fetais podem ser utilizados para comparações sem necessidades de correções. Entretanto, variações relativamente grandes podem ser observadas ao se repetir a medida da área pelos diferentes modos.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Federal University of São Paulo Department of Obstetrics Division of Fetal CardiologyUniversity of São Paulo Faculty of Medicine of Ribeirão Preto Department of Obstetrics and GynecologySchool of Ultrasound and Medicine of Ribeirão Preto RecyclingNational Institute of Science and Technology (INCT) of Hormones and Women's HealthUNIFESP, Department of Obstetrics Division of Fetal CardiologySciEL

OT FE-Box Test Procedures

The OT FE readout requirements is the precise (~0.5 ns) and efficient drift time measurement at an occupancy of ~4% to ensure single hit resolution. The acquired achievement of such performance on an assembled FE-Box is verify through a final test performed using a special FE-Tester. In this note the test procedures are described

The Combined Quantification and Interpretation of Multiple Quantitative Magnetic Resonance Imaging Metrics Enlightens Longitudinal Changes Compatible with Brain Repair in Relapsing-Remitting Multiple Sclerosis Patients.

Quantitative and semi-quantitative MRI (qMRI) metrics provide complementary specificity and differential sensitivity to pathological brain changes compatible with brain inflammation, degeneration, and repair. Moreover, advanced magnetic resonance imaging (MRI) metrics with overlapping elements amplify the true tissue-related information and limit measurement noise. In this work, we combined multiple advanced MRI parameters to assess focal and diffuse brain changes over 2 years in a group of early-stage relapsing-remitting MS patients. Thirty relapsing-remitting MS patients with less than 5 years disease duration and nine healthy subjects underwent 3T MRI at baseline and after 2 years including T1, T2, T2* relaxometry, and magnetization transfer imaging. To assess longitudinal changes in normal-appearing (NA) tissue and lesions, we used analyses of variance and Bonferroni correction for multiple comparisons. Multivariate linear regression was used to assess the correlation between clinical outcome and multiparametric MRI changes in lesions and NA tissue. In patients, we measured a significant longitudinal decrease of mean T2 relaxation times in NA white matter (p = 0.005) and a decrease of T1 relaxation times in the pallidum (p &lt; 0.05), which are compatible with edema reabsorption and/or iron deposition. No longitudinal changes in qMRI metrics were observed in controls. In MS lesions, we measured a decrease in T1 relaxation time (p-value &lt; 2.2e-16) and a significant increase in MTR (p-value &lt; 1e-6), suggesting repair mechanisms, such as remyelination, increased axonal density, and/or a gliosis. Last, the evolution of advanced MRI metrics-and not changes in lesions or brain volume-were correlated to motor and cognitive tests scores evolution (Adj-R(2) &gt; 0.4, p &lt; 0.05). In summary, the combination of multiple advanced MRI provided evidence of changes compatible with focal and diffuse brain repair at early MS stages as suggested by histopathological studies

Análise de viabilidade econômica de um sistema de produção modal de eucalipto para lenha na região de Itapeva, SP.

bitstream/item/141820/1/Comunicado-Tecnico-365-2015.pd

Measurement of the production of a W boson in association with a charm quark in pp collisions at √s = 7 TeV with the ATLAS detector

The production of a W boson in association with a single charm quark is studied using 4.6 fb−1 of pp collision data at s√ = 7 TeV collected with the ATLAS detector at the Large Hadron Collider. In events in which a W boson decays to an electron or muon, the charm quark is tagged either by its semileptonic decay to a muon or by the presence of a charmed meson. The integrated and differential cross sections as a function of the pseudorapidity of the lepton from the W-boson decay are measured. Results are compared to the predictions of next-to-leading-order QCD calculations obtained from various parton distribution function parameterisations. The ratio of the strange-to-down sea-quark distributions is determined to be 0.96+0.26−0.30 at Q 2 = 1.9 GeV2, which supports the hypothesis of an SU(3)-symmetric composition of the light-quark sea. Additionally, the cross-section ratio σ(W + +c¯¯)/σ(W − + c) is compared to the predictions obtained using parton distribution function parameterisations with different assumptions about the s−s¯¯¯ quark asymmetry

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13