Software para gestión del recurso humano en el Hogar de Parálisis Cerebral Roberto Callejas Montalvo

Diseñar y Construir un software que cumpla con las expectativas y necesidades de información, de la Unidad de Recursos Humanos del Hogar de Parálisis Cerebral Roberto Callejas Montalvo HOPAC de tal manera que facilite la gestión y la toma de decisiones, además que permita tener información oportuna y relevante. El proyecto contemplará únicamente la administración de la información del personal que labora para el Hogar de Parálisis Cerebral “Roberto Callejas Montalvo”, en lo que respecta a las siguientes áreas: información del empleado, marcaciones de reloj, préstamos personales, acciones de personal, evaluaciones del desempeño y capacitaciones de persona

Incorporación y aprehensión de saberes sobre plantas útiles a partir del juego: prácticas de extensión en Botánica Aplicada

A partir de la concepción de que la extensión universitaria constituye un pilar conceptual e ideológico de la Universidad Reformista junto a la enseñanza y la investigación, se desarrollan prácticas que vinculan las investigaciones sobre etnobotánica aplicada con la tarea docente en Botánica Aplicada y su transferencia a la resolución de problemas cotidianos. Se presentan los resultados de una experiencia destinada a niños y jóvenes que están sometidos a internación hospitalaria que, a través del juego, vincula vegetales de uso habitual con los saberes vigentes en distintos ámbitos

Centrality evolution of the charged-particle pseudorapidity density over a broad pseudorapidity range in Pb-Pb collisions at root s(NN)=2.76TeV

Peer reviewe

Incorporación y aprehensión de saberes sobre plantas útiles a partir del juego: prácticas de extensión en Botánica Aplicada

A partir de la concepción de que la extensión universitaria constituye un pilar conceptual e ideológico de la Universidad Reformista junto a la enseñanza y la investigación, se desarrollan prácticas que vinculan las investigaciones sobre etnobotánica aplicada con la tarea docente en Botánica Aplicada y su transferencia a la resolución de problemas cotidianos. Se presentan los resultados de una experiencia destinada a niños y jóvenes que están sometidos a internación hospitalaria que, a través del juego, vincula vegetales de uso habitual con los saberes vigentes en distintos ámbitos.</p

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of OAS1, OAS2, or RNASEL in five unrelated children with MIS-C. The cytosolic double-stranded RNA (dsRNA)-sensing OAS1 and OAS2 generate 2'-5'-linked oligoadenylates (2-5A) that activate the single-stranded RNA-degrading ribonuclease L (RNase L). Monocytic cell lines and primary myeloid cells with OAS1, OAS2, or RNase L deficiencies produce excessive amounts of inflammatory cytokines upon dsRNA or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stimulation. Exogenous 2-5A suppresses cytokine production in OAS1-deficient but not RNase L-deficient cells. Cytokine production in RNase L-deficient cells is impaired by MDA5 or RIG-I deficiency and abolished by mitochondrial antiviral-signaling protein (MAVS) deficiency. Recessive OAS-RNase L deficiencies in these patients unleash the production of SARS-CoV-2-triggered, MAVS-mediated inflammatory cytokines by mononuclear phagocytes, thereby underlying MIS-C

The Detailed Science Case for the Maunakea Spectroscopic Explorer: the Composition and Dynamics of the Faint Universe

210 pages, 91 figures. Exposure draft. Appendices to the Detailed Science Case can be found at http://mse.cfht.hawaii.edu/docs/MSE is an 11.25m aperture observatory with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy. More than 3200 fibres will feed spectrographs operating at low (R ~ 2000 - 3500) and moderate (R ~ 6000) spectral resolution, and approximately 1000 fibers will feed spectrographs operating at high (R ~ 40000) resolution. MSE is designed to enable transformational science in areas as diverse as tomographic mapping of the interstellar and intergalactic media; the in-situ chemical tagging of thick disk and halo stars; connecting galaxies to their large scale structure; measuring the mass functions of cold dark matter sub-halos in galaxy and cluster-scale hosts; reverberation mapping of supermassive black holes in quasars; next generation cosmological surveys using redshift space distortions and peculiar velocities. MSE is an essential follow-up facility to current and next generations of multi-wavelength imaging surveys, including LSST, Gaia, Euclid, WFIRST, PLATO, and the SKA, and is designed to complement and go beyond the science goals of other planned and current spectroscopic capabilities like VISTA/4MOST, WHT/WEAVE, AAT/HERMES and Subaru/PFS. It is an ideal feeder facility for E-ELT, TMT and GMT, and provides the missing link between wide field imaging and small field precision astronomy. MSE is optimized for high throughput, high signal-to-noise observations of the faintest sources in the Universe with high quality calibration and stability being ensured through the dedicated operational mode of the observatory. (abridged

The Detailed Science Case for the Maunakea Spectroscopic Explorer: the Composition and Dynamics of the Faint Universe

210 pages, 91 figures. Exposure draft. Appendices to the Detailed Science Case can be found at http://mse.cfht.hawaii.edu/docs/MSE is an 11.25m aperture observatory with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy. More than 3200 fibres will feed spectrographs operating at low (R ~ 2000 - 3500) and moderate (R ~ 6000) spectral resolution, and approximately 1000 fibers will feed spectrographs operating at high (R ~ 40000) resolution. MSE is designed to enable transformational science in areas as diverse as tomographic mapping of the interstellar and intergalactic media; the in-situ chemical tagging of thick disk and halo stars; connecting galaxies to their large scale structure; measuring the mass functions of cold dark matter sub-halos in galaxy and cluster-scale hosts; reverberation mapping of supermassive black holes in quasars; next generation cosmological surveys using redshift space distortions and peculiar velocities. MSE is an essential follow-up facility to current and next generations of multi-wavelength imaging surveys, including LSST, Gaia, Euclid, WFIRST, PLATO, and the SKA, and is designed to complement and go beyond the science goals of other planned and current spectroscopic capabilities like VISTA/4MOST, WHT/WEAVE, AAT/HERMES and Subaru/PFS. It is an ideal feeder facility for E-ELT, TMT and GMT, and provides the missing link between wide field imaging and small field precision astronomy. MSE is optimized for high throughput, high signal-to-noise observations of the faintest sources in the Universe with high quality calibration and stability being ensured through the dedicated operational mode of the observatory. (abridged

The Detailed Science Case for the Maunakea Spectroscopic Explorer: the Composition and Dynamics of the Faint Universe

210 pages, 91 figures. Exposure draft. Appendices to the Detailed Science Case can be found at http://mse.cfht.hawaii.edu/docs/MSE is an 11.25m aperture observatory with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy. More than 3200 fibres will feed spectrographs operating at low (R ~ 2000 - 3500) and moderate (R ~ 6000) spectral resolution, and approximately 1000 fibers will feed spectrographs operating at high (R ~ 40000) resolution. MSE is designed to enable transformational science in areas as diverse as tomographic mapping of the interstellar and intergalactic media; the in-situ chemical tagging of thick disk and halo stars; connecting galaxies to their large scale structure; measuring the mass functions of cold dark matter sub-halos in galaxy and cluster-scale hosts; reverberation mapping of supermassive black holes in quasars; next generation cosmological surveys using redshift space distortions and peculiar velocities. MSE is an essential follow-up facility to current and next generations of multi-wavelength imaging surveys, including LSST, Gaia, Euclid, WFIRST, PLATO, and the SKA, and is designed to complement and go beyond the science goals of other planned and current spectroscopic capabilities like VISTA/4MOST, WHT/WEAVE, AAT/HERMES and Subaru/PFS. It is an ideal feeder facility for E-ELT, TMT and GMT, and provides the missing link between wide field imaging and small field precision astronomy. MSE is optimized for high throughput, high signal-to-noise observations of the faintest sources in the Universe with high quality calibration and stability being ensured through the dedicated operational mode of the observatory. (abridged

The Detailed Science Case for the Maunakea Spectroscopic Explorer: the Composition and Dynamics of the Faint Universe

210 pages, 91 figures. Exposure draft. Appendices to the Detailed Science Case can be found at http://mse.cfht.hawaii.edu/docs/MSE is an 11.25m aperture observatory with a 1.5 square degree field of view that will be fully dedicated to multi-object spectroscopy. More than 3200 fibres will feed spectrographs operating at low (R ~ 2000 - 3500) and moderate (R ~ 6000) spectral resolution, and approximately 1000 fibers will feed spectrographs operating at high (R ~ 40000) resolution. MSE is designed to enable transformational science in areas as diverse as tomographic mapping of the interstellar and intergalactic media; the in-situ chemical tagging of thick disk and halo stars; connecting galaxies to their large scale structure; measuring the mass functions of cold dark matter sub-halos in galaxy and cluster-scale hosts; reverberation mapping of supermassive black holes in quasars; next generation cosmological surveys using redshift space distortions and peculiar velocities. MSE is an essential follow-up facility to current and next generations of multi-wavelength imaging surveys, including LSST, Gaia, Euclid, WFIRST, PLATO, and the SKA, and is designed to complement and go beyond the science goals of other planned and current spectroscopic capabilities like VISTA/4MOST, WHT/WEAVE, AAT/HERMES and Subaru/PFS. It is an ideal feeder facility for E-ELT, TMT and GMT, and provides the missing link between wide field imaging and small field precision astronomy. MSE is optimized for high throughput, high signal-to-noise observations of the faintest sources in the Universe with high quality calibration and stability being ensured through the dedicated operational mode of the observatory. (abridged