200 research outputs found
A new approach for potential drug target discovery through in silico metabolic pathway analysis using Trypanosoma cruzi genome information
- Author
- Acosta H
- Adroher FJ
- Affranchino JL
- Ana Carolina Ramos GuimarĂŁes
- Atwood JA 3rd
- Barrett MP
- Beach DH
- Berriman M
- Beswick TC
- Bilate AM
- Brak K
- Bringaud F
- Bringaud F
- Buhaescu I
- Canepa GE
- Cannata JJ
- Cavazzuti A
- Cazzulo JJ
- Cazzulo JJ
- Chambers JW
- ConcepciĂłn JL
- Cordeiro AT
- Coura JR
- Croft SL
- CĂĄceres AJ
- de Boiso JF
- de Souza W
- de Souza W
- de Souza W
- Dias JC
- Dixon H
- Dixon H
- Docampo R
- Docampo R
- Doyle PS
- Duschak VG
- El-Sayed NM
- Espinosa A
- Freitas RF
- Fricker SP
- Galarreta BC
- Galperin MY
- GuimarĂŁes AC
- Haemers T
- Hannaert V
- Heby O
- Hudock MP
- Hurtado-Guerrrero R
- Igoillo-Esteve M
- Jiménez-Jiménez J
- Juan SM
- Jurado LA
- Kanehisa M
- Karp PD
- Korn ED
- Korn ED
- Krauth-Siegel RL
- Laurent E Dardenne
- Lee SH
- Liendo A
- Liñares GE
- Lorente SO
- Magaraci F
- Marcelo Alves-Ferreira
- Marin-Neto JA
- Martyn DC
- Maugeri DA
- Maya JD
- Michels PA
- Mielniczki-Pereira AA
- Montalvetti A
- Moyersoen J
- Olivares-Illana V
- Olivares-Illana V
- Otto TD
- Paulino M
- Pereira CA
- Perez-Pineiro R
- Peña-DĂaz J
- Pourshafie M
- Priscila Vanessa da Silva Zabala Capriles
- PĂ©rez-Montfort R
- Racagni GE
- Reyes-Vivas H
- Roberts CW
- Rocha MO
- RodrĂguez-Romero A
- Rogerson GW
- Sanz-Rodriguez CE
- Schmunis GA
- Sgraja T
- Silber AM
- Silber AM
- Stephens JL
- Stern AL
- Sylvester D
- Tarleton RL
- Taylor MB
- Tetaud E
- Tielens AG
- Trapani S
- Urbina JA
- Urbina JA
- Urbina JA
- Urbina JA
- Urbina JA
- van Hellemond JJ
- van Hellemond JJ
- van Weelden SW
- Von Brand T
- Wiemer EA
- Wiesner J
- Wim M Degrave
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
AFLP analysis reveals high genetic diversity but low population structure in Coccidioides posadasiiisolates from Mexico and Argentina
- Author
- A Burt
- A Burt
- B Haubold
- BFJ Manly
- C CalderĂłn
- CE Canteros
- CE Canteros
- CE Canteros
- Cristina Canteros
- D Pappagianis
- DE Neafsey
- E Duarte-Escalante
- Esperanza Duarte-Escalante
- FJ Rohlf
- FS Fisher
- Gerardo ZĂșñiga
- HJ Bandelt
- J Maynard-Smith
- JA Fraser
- K Jewell
- KN Kolivras
- KN Kolivras
- L Excoffier
- LA Zhivotovsky
- Laura Rosio Castañón-Olivares
- M Nei
- MA Mandel
- MarĂa Guadalupe FrĂas-De-LeĂłn
- MarĂa RocĂo del Reyes-Montes
- MC Fisher
- MC Fisher
- MC Fisher
- P Vos
- PM SchlĂŒter
- R Bialek
- R Laniado-LaborĂn
- R Laniado-LaborĂn
- R Laniado-LaborĂn
- R Laniado-LaborĂn
- RA Cordeiro
- RC Baptista Rosas
- RF Hector
- RF Hector
- RH Williams
- S Altschul
- T Polzin
- TJ Sharpton
- TR Allnut
- V Koufopanou
- V Koufopanou
- Publication venue
- Springer Nature
- Publication date
- 01/01/2013
- Field of study
BACKGROUND: Coccidioides immitis and C. posadasii cause coccidioidomycosis, a disease that is endemic to North and South America, but for Central America, the incidence of coccidioidomycosis has not been clearly established. Several studies suggest genetic variability in these fungi; however, little definitive information has been discovered about the variability of Coccidioides fungi in Mexico (MX) and Argentina (AR). Thus, the goals for this work were to study 32 Coccidioides spp. isolates from MX and AR, identify the species of these Coccidioides spp. isolates, analyse their phenotypic variability, examine their genetic variability and investigate the Coccidioides reproductive system and its level of genetic differentiation. METHODS: Coccidioides spp. isolates from MX and AR were taxonomically identified by phylogenetic inference analysis using partial sequences of the Ag2/PRA gene and their phenotypic characteristics analysed. The genetic variability, reproductive system and level of differentiation were estimated using AFLP markers. The level of genetic variability was assessed measuring the percentage of polymorphic loci, number of effective allele, expected heterocygosity and Index of Association (I(A)). The degree of genetic differentiation was determined by AMOVA. Genetic similarities among isolates were estimated using Jaccard index. The UPGMA was used to contsruct the corresponding dendrogram. Finally, a network of haplotypes was built to evaluate the genealogical relationships among AFLP haplotypes. RESULTS: All isolates of Coccidioides spp. from MX and AR were identified as C. posadasii. No phenotypic variability was observed among the C. posadasii isolates from MX and AR. Analyses of genetic diversity and population structure were conducted using AFLP markers. Different estimators of genetic variability indicated that the C. posadasii isolates from MX and AR had high genetic variability. Furthermore, AMOVA, dendrogram and haplotype network showed a small genetic differentiation among the C. posadasii populations analysed from MX and AR. Additionally, the I(A) calculated for the isolates suggested that the species has a recombinant reproductive system. CONCLUSIONS: No phenotypic variability was observed among the C. posadasii isolates from MX and AR. The high genetic variability observed in the isolates from MX and AR and the small genetic differentiation observed among the C. posadasii isolates analysed, suggest that this species could be distributed as a single genetic population in Latin America
Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial
- Author
- A Kurata
- BH Jiang
- BH Jones
- BK Cole
- Chantalle C. M. Moors
- D Fliser
- EJ Henriksen
- EL Gillespie
- Ellen E. Blaak
- F Karpe
- F Zandbergen
- GH Goossens
- GH Goossens
- GH Goossens
- GH Goossens
- GH Goossens
- GH Goossens
- GH Goossens
- Gijs H. Goossens
- Giovambattista Pani
- GJ Hausman
- J Janke
- JA Olivares-Reyes
- Jack P. Cleutjens
- JJ McMurray
- Johan W. E. Jocken
- JS Samra
- JS Samra
- JW Jocken
- K Maeda
- Karine Clément
- KY Chu
- M Furuhashi
- M Lundgren
- M Pasarica
- MC Munoz
- Michaela Diamant
- Nicolas Venteclef
- NJ van der Zijl
- NK Edens
- Nynke J. van der Zijl
- PS Leung
- RA DeFronzo
- Rohia Alili
- S Pscherer
- S Taleb
- SE Nissen
- TA Aksnes
- X Yang
- Y Tomono
- Yvonne Essers
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
<div><h3>Background</h3><p>Blockade of the renin-angiotensin system (RAS) reduces the incidence of type 2 diabetes mellitus. In rodents, it has been demonstrated that RAS blockade improved adipose tissue (AT) function and glucose homeostasis. However, the effects of long-term RAS blockade on AT function have not been investigated in humans. Therefore, we examined whether 26-wks treatment with the angiotensin II type 1 receptor blocker valsartan affects AT function in humans with impaired glucose metabolism (IGM).</p> <h3>Methodology/Principal Findings</h3><p>We performed a randomized, double-blind, placebo-controlled parallel-group study, in which 38 subjects with IGM were treated with valsartan (VAL, 320 mg/d) or placebo (PLB) for 26 weeks. Before and after treatment, an abdominal subcutaneous AT biopsy was collected for measurement of adipocyte size and AT gene/protein expression of angiogenesis/capillarization, adipogenesis, lipolytic and inflammatory cell markers. Furthermore, we evaluated fasting and postprandial AT blood flow (ATBF) (<sup>133</sup>Xe wash-out), systemic inflammation and insulin sensitivity (hyperinsulinemic-euglycemic clamp). VAL treatment markedly reduced adipocyte size (<em>P</em><0.001), with a shift toward a higher proportion of small adipocytes. In addition, fasting (<em>P</em>â=â0.043) and postprandial ATBF (<em>P</em>â=â0.049) were increased, whereas gene expression of angiogenesis/capillarization, adipogenesis and macrophage infiltration markers in AT was significantly decreased after VAL compared with PLB treatment. Interestingly, the change in adipocyte size was associated with alterations in insulin sensitivity and reduced AT gene expression of macrophage infiltration markers. VAL did not alter plasma monocyte-chemoattractant protein (MCP)-1, TNF-α, adiponectin and leptin concentrations.</p> <h3>Conclusions/Significance</h3><p>26-wks VAL treatment markedly reduced abdominal subcutaneous adipocyte size and AT macrophage infiltration markers, and increased ATBF in IGM subjects. The VAL-induced decrease in adipocyte size was associated with reduced expression of macrophage infiltration markers in AT. Our findings suggest that interventions targeting the RAS may improve AT function, thereby contributing to a reduced risk of developing cardiovascular disease and type 2 diabetes.</p> <h3>Trial Registration</h3><p>Trialregister.nl NTR721 (ISRCTN Registry: ISRCTN<a href="http://www.controlled-trials.com/isrctn/pf/42786336">42786336</a>)</p> </div
Rate and duration of hospitalisation for acute pulmonary embolism in the real-world clinical practice of different countries : Analysis from the RIETE registry
- Author
- Adarraga MD
- Aibar MA
- Alatri A
- Alfonso M
- Alvarez F
- Antonucci G
- Arcelus J
- Ballaz A
- Banos P
- Barba R
- Barillari G
- Barron M
- Barron-Andres B
- Bascunana J
- Bertoletti L
- Bilora F
- Blanco-Molina A
- Bortoluzzi C
- Bounameaux H
- Braester A
- Brandolin B
- Brenner B
- Bucherini E
- Bura-Riviere A
- Calanca L
- Camerota A
- Camon AM
- Carles Sahuquillo Joan
- Cattabiani C
- Chasco L
- Ciammaichella M
- Cruz AJ
- de Miguel J
- del Toro J
- Dentali F
- Dentali Francesco
- Di Micco P
- di Micco Pierpaolo
- Diaz-Pedroche MC
- Diaz-Peromingo JA
- Duce R
- Ellis M
- Escribano JC
- Falga C
- Falvo N
- Farge-Bancel D
- Fernandez-Aracil C
- Fernandez-Capitan C
- Fidalgo Angeles
- Fidalgo MA
- Font C
- Font L
- Garcia MA
- Garcia-Bragado F
- Garcia-Morillo M
- Garcia-Raso A
- Gavin O
- Gaya I
- Gibietis V
- Giorgi-Pierfranceschi M
- Gomez C
- Gomez V
- Gonzalez J
- Grandone E
- Grau E
- Guijarro R
- Gutierrez J
- Hernandez-Blasco L
- Hernandez-Comes G
- Hernando E
- Hij A
- Hirmerova J
- Imbalzano E
- Jara-Palomares L
- Jaras MJ
- Jimenez D
- Jimenez David
- Jimenez R
- Joya MD
- Lessiani G
- Lima J
- Llamas P
- Lobo JL
- Lopez-Jimenez L
- Lopez-Reyes R
- Lopez-Saez JB
- Lopez-Saez Juan Bosco
- Lorente MA
- Lorenzo A
- Lumbierres M
- Madridano O
- Maestre A
- Maestre Ana
- Mahe I
- Maida R
- Maly R
- Marchena PJ
- Martin M
- Martin-Martos F
- Martin-Romero M
- Martinez C
- Mastroiacovo D
- Mastroiacovo Daniela
- Mazzolai L
- Monreal M
- Monreal Manuel
- Morales M
- Moustafa F
- Nieto JA
- Nieto S
- Nunez A
- Nunez MJ
- Odriozola M
- Olivares MC
- Otalora S
- Otero R
- Pace F
- Pardo V
- Pedrajas JM
- Pellejero G
- Perez-Ductor C
- Peris ML
- Pesavento R
- Pinelli M
- Poggio R
- Pons I
- Porras JA
- Pozo R
- Prandoni P
- Quere I
- Quintavalla R
- Ramirez L
- Reyes R
- Riera-Mestre A
- Riesco D
- Rivas A
- Rocci A
- Rodriguez-Davila MA
- Rosa V
- Ruiz-Artacho P
- Sahuquillo JC
- Sala-Sainz MC
- Salgado E
- Samperiz A
- Sanchez GT
- Sanchez-Martinez R
- Siniscalchi C
- Skride A
- Skride Andris
- Soler S
- Soler Silvia
- Surinach JM
- Tiraferri E
- Tolosa C
- Tonello D
- Torres M
- Trujillo-Santos J
- Tzoran I
- Uresandi F
- Usandizaga E
- Valero B
- Valle R
- Vanassche T
- Vandenbriele C
- Vela J
- Verhamme P
- Verhamme Peter
- Vicente MP
- Vilar C
- Villalobos A
- Visona A
- Vitola B
- Wells P
- Yoo HHB
- Zdraveska M
- Publication venue
- 'European Respiratory Society (ERS)'
- Publication date
- 01/01/2019
- Field of study
publishersversionPeer reviewe
Abdominal obesity and low physical activity are associated with insulin resistance in overweight adolescents: a cross-sectional study
- Author
- A Bremer
- A Friend
- A Moran
- AL Rosenbloom
- American College of Sports Medicine
- AR ArgĂŒeso
- B Gutin
- BE Ainsworth
- BM Popkin
- C Giannini
- C Levy-Marchal
- C Maffeis
- CB Anderson
- CJ Nolan
- Claudia-MarĂa VelĂĄsquez-RodrĂguez
- Colombia. Ministerio de la ProtecciĂłn Social
- Colombian Family Welfare Institute
- D Stupar
- D Yeste
- E Acosta GarcĂa
- E Kassi
- E RodrĂguez-RodrĂguez
- E Saito
- FA Patiño Villada
- Food and Nutrition Board Institute of Medicine
- G Agudelo
- G Valerio
- GL Ambrosini
- GL Myers
- GM Ochoa Agudelo
- GR Hajer
- I Abete
- Instituto Colombiano de Bienestar Familiar Profamilia, Instituto Nacional De Salud, Escuela de Nutrición y Dietética Universidad de Antioquia, Organización Panamericana de la Salud
- J Yin
- JA Olivares Reyes
- JM Lee
- JR FernĂĄndez
- Juliana BermĂșdez-Cardona
- K Kotlyarevska
- L Nasreddine
- Leidy GĂłmez-Ocampo
- LM Manjarrés
- LM Manjarrés
- LS Alvarez
- M Bolet Astoviza
- M De Onis
- M Dowda
- M Lafontan
- M Prentki
- M Simarro Rueda
- MA Sesé
- Marcela VelĂĄsquez-Villa
- MD De Boer
- ML Garmendia
- MV Fedewa
- N Mirza
- National Cholesterol Education Program National Heart, Lung, and Blood Institute, National Institutes of Health. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on
- National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents
- NS Rizzo
- O Androutsos
- Profamilia Instituto Nacional De Salud, Bienestar Familiar, Ministerio de la Proteccion Social, Prosperidad para todos
- R Meshkani
- R Weiss
- RM Uscåtegui Peñuela
- RR Pate
- S Cook
- S Suh
- S Zanuso
- SH Chu
- SR Colberg
- SR Daniels
- T Celik
- T Koike
- TG Lohman
- WA Marshall
- WA Marshall
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
ABSTRACT: Background: Previous studies have assessed the metabolic changes and lifestyles associated with overweight adolescents. However, these associations are unclear amongst overweight adolescents who have already developed insulin resistance. This study assessed the associations between insulin resistance and anthropometric, metabolic, inflammatory, food consumption, and physical activity variables amongst overweight adolescents. Methods: This cross-sectional study divided adolescents (n = 120) between 10 and 18 years old into 3 groups: an overweight group with insulin resistance (O + IR), an overweight group without insulin resistance (O-IR), and a normal-weight control group (NW). Adolescents were matched across groups based on age, sex, pubertal maturation, and socioeconomic strata. Anthropometric, biochemical, physical activity, and food consumption variables were assessed. Insulin resistance was assessed using homeostatic model assessment (HOMA Calculator Version 2.2.2 from ©Diabetes Trials Unit, University of Oxford), and overweight status was assessed using body mass index according to World Health Organization (2007) references. A chi-square test was used to compare categorical variables. ANOVAs or Kruskal-Wallis tests were used for continuous variables. Multiple linear regression models were used to calculate the probability of the occurrence of insulin resistance based on the independent variables. Results: The risk of insulin resistance amongst overweight adolescents increases significantly when they reach a waist circumference > p95 (OR = 1.9, CIs = 1.3-2.7, p = 0.013) and watch 3 or more hours/day of television (OR = 1.7, CIs = 0.98-2.8, p = 0.033). Overweight status and insulin resistance were associated with higher levels of inflammation (hsCRP â„1 mg/L) and cardiovascular risk according to arterial indices. With each cm increase in waist circumference, the HOMA index increased by 0.082; with each metabolic equivalent (MET) unit increase in physical activity, the HOMA index decreased by 0.026. Conclusions: Sedentary behaviour and a waist circumference > p90 amongst overweight adolescents were associated with insulin resistance, lipid profile alterations, and higher inflammatory states. A screening that includes body mass index, in waist circumference, and physical activity evaluations of adolescents might enable the early detection of these alterations
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
- Andrade AH
- Andrade G
- Andreis DT
- Andreis DT
- Annane D
- Antonelli M
- Antoniadou A
- Antonio C
- Antonucci E
- AntĂłn DG
- Anzueto A
- Appiani F
- Aquevedo A
- Aragon C
- Araujo NJ
- Araujo VF
- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
- Arias N
- Arias-Verdu MD
- Arias-Verdu MD
- Arias-Verdu MD
- Armaganidis A
- Arora MK
- Arora N
- Arrigo M
- Arslantas MK
- Artiguenave M
- Aslanian P
- Aspide R
- Asyralyyeva G
- Ataman S
- Ataman S
- Atchade E
- Atchade E
- Atchasiri S
- Athapattu P
- Atkins G
- Aublanc M
- Aublanc M
- Augustin P
- Augustin P
- Auquier P
- Avilés-Jurado FX
- Avramidis V
- Ayala LY
- Aydin M
- Azevedo JC
- Azevedo JR
- Aznar GP
- Babalis D
- Babini G
- Bachli EB
- Bader A
- Bader A
- Baena J
- Baidya DK
- Baikova VN
- Bakker J
- BalcĂĄzar LC
- BalcĂĄzar LC
- Baldassarri R
- Baldwin CE
- Balik M
- Ball I
- Ballin A
- Balsera B
- Banderas-Bravo ME
- Banderas-Bravo ME
- Bandert A
- Bangstad IL
- Baptista N
- Baquero JD
- Barbadillo S
- Barberet G
- Barberet G
- Barberet G
- Barbier J
- Barcenilla F
- Barea-Mendoza JA
- Barinas OD
- Baron AV
- Barrachina LG
- Barral M
- Basile-Filho A
- Bassi GL
- Bates D
- Battistini M
- Bauer M
- Bauer PR
- Baumstarck K
- Baumstarck K
- Bawin M
- Bazan N
- Bañeras J
- Beane A
- Beduneau G
- Beduneau G
- Beduneau G
- Beeharry SD
- Beerepoot M
- Begzjav T
- Beishuizen A
- Bell C
- Belletti A
- Bellissimo-Rodrigues F
- Belloli A
- Bellomo R
- Bellver BQ
- Belmonte R
- Ben-Hamouda N
- Bendel S
- Bendel S
- Benyamina M
- Beretta S
- Berg R
- Bergantino B
- Berghmans J
- Bernal FF
- Berric A
- Berrutti D
- Berthelsen RE
- Bertini P
- Bertini P
- Berto MB
- Besevli SG
- Bestle MH
- Bettex D
- Bettex DA
- Beunders R
- Bhasin D
- Bhattal MK
- Bhide S
- Bianchi I
- Bianchi I
- Bianzina S
- Bianzina S
- Bianzina S
- Bishop J
- Bissenova N
- Bisso MC
- Blans MJ
- Blobner M
- Bloomer MJ
- Blot K
- Blot S
- Blot S
- Boa F
- Bobi Q
- Bodingbauer M
- BodĂ M
- Boer C
- Bogossian E
- Bonet S
- Bonn M
- Bonnet M
- Borges FK
- Bouadma L
- Boucekine M
- Bougouin W
- Bourenne J
- Boyd JG
- Boyd JG
- Bozbay S
- Bozza F
- Bradac O
- Brandon RA
- Brandon RB
- Braschi A
- Braschi A
- Braschi A
- Brasseur A
- Brasseur A
- Brasseur A
- Braune S
- Brazzi L
- Breitkreutz R
- Brianti R
- Brioni M
- Brochard L
- Brochard L
- Brochard L
- Brock N
- Brody DL
- Brook R
- Brousseau C
- Brown K
- Brugger SC
- Brugger SC
- Bruno F
- Bruno K
- Brusasco C
- Brusasco C
- Brusasco C
- Bruyere O
- Bucknall T
- Buddi S
- Buise M
- Buitinck SH
- Buranavanich P
- Bureau C
- Burle JF
- Burtin P
- Busico M
- Butler MB
- Butrov AV
- Caballero CH
- Caballero J
- Cabello JT
- Cabello JT
- Cabrera AR
- Cabrera JL
- Cabrera JL
- Cabrini L
- Cairus C
- Cakin O
- Caliskan K
- Calpe P
- Calvo CP
- Calvo SA
- Camargo M
- Cambronero JA
- Cameron C
- Campbell R
- Campelo FA
- Campelo FA
- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
- Carmona SA
- Carmona SA
- Carmona SA
- Carone M
- Carpio D
- CarratalĂĄ A
- Carreira MM
- Carrero-GĂłmez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
- Casals XN
- Cassina T
- Castañeda DP
- Castellana D
- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
- CatalĂĄn RM
- Catena E
- Catena E
- Cauwenberghs H
- Cavalcanti D
- Cavalheiro AM
- Cavalier E
- Cavicchi FZ
- Cavicchi FZ
- Cengiz M
- Ceriani R
- Cermelli S
- CeroviÄ O
- Cha YS
- Chabanne R
- Chacon-Alves S
- Champigneulle B
- Champigneulle B
- Chan KC
- Chan KK
- Chan WS
- Chang CH
- Chang WY
- Chao A
- Chao A
- Chao AS
- Chao HC
- Chaouat M
- Charitidou E
- Charpentier C
- Charpentier J
- Charron C
- Chatelon J
- Chaudhari HK
- Chaussard M
- Chavanon O
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- Chernyshuk S
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- WIND study group
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- Yamaguchi Y
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- Yamazaki A
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- Yan WW
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- Yeh YC
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- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
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- Yonis H
- Yoon SZ
- Yoruk F
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- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
- You KM
- Youn AM
- Young A
- Yu KM
- Yumoto T
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- Yuzawa J
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- Zabini D
- Zahorec M
- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
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- Zayas B
- Zepeda EM
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- ZĂœkovĂĄ I
- Ălvarez JT
- Ălvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Effect of sitagliptin on cardiovascular outcomes in type 2 diabetes
- Author
- Abdulhakim E
- Abraham P
- Abramov G
- Abu Hassan MR
- Adamson K
- Adawi F
- Adkins K
- Adler A
- Adler A
- Agarwal P
- Ahn KJ
- Akpunonu B
- Albota A
- Albu J
- Alexander K
- Alexandru C
- Alfonsi F
- Alt I
- Alvarisqueta AF
- Alvarsson M
- Alversson M
- Ambos A
- Ambos A
- Ambrosio G
- Ambulkar S
- Anagnostis G
- Anastasi L
- Andersone I
- Arambam P
- Aravind S
- Araz M
- Arciszewska M
- Argoud G
- Arias P
- Armaganijan L
- Armstrong PW
- Armstrong PW
- Aroda V
- Artemiuk E
- Aschner Montoya P
- Aschner P
- Athwal R
- Aziz NA
- Azizad M
- Babenko A
- Badat A
- Badenhoop K
- Bahit M
- Baker J
- Bakiner O
- Balaji V
- Balode A
- Baltramonaitiene K
- Banerji MA
- Barbarash O
- Barros P
- Barsiene L
- Bartkowiak A Jr
- Bashkin A
- Batch B
- Bays H
- Beaven A
- Behn P
- Behnke T
- Beijerbacht H
- Benatar J
- Bender G
- Berdan L
- Bergenstal R
- Bernardez S
- Bernecki G
- Bester F
- Bethel A
- Bethel MA
- Bhargava A
- Bias D
- Binnekamp M
- Birkeland K
- Blach E
- Blagden M
- Blicharski T
- Bobeva R
- Bolster E
- Bondar I
- Borges JL
- Bostandzhieva R
- Botella M
- Botero Lopez R
- Brabec T
- Braun M
- Breedveld R
- Brieger D
- Brito F
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- ĆmiaĆowski A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2015
- Field of study
BACKGROUND: Data are lacking on the long-term effect on cardiovascular events of adding sitagliptin, a dipeptidyl peptidase 4 inhibitor, to usual care in patients with type 2 diabetes and cardiovascular disease. METHODS: In this randomized, double-blind study, we assigned 14,671 patients to add either sitagliptin or placebo to their existing therapy. Open-label use of antihyperglycemic therapy was encouraged as required, aimed at reaching individually appropriate glycemic targets in all patients. To determine whether sitagliptin was noninferior to placebo, we used a relative risk of 1.3 as the marginal upper boundary. The primary cardiovascular outcome was a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina. RESULTS: During a median follow-up of 3.0 years, there was a small difference in glycated hemoglobin levels (least-squares mean difference for sitagliptin vs. placebo, -0.29 percentage points; 95% confidence interval [CI], -0.32 to -0.27). Overall, the primary outcome occurred in 839 patients in the sitagliptin group (11.4%; 4.06 per 100 person-years) and 851 patients in the placebo group (11.6%; 4.17 per 100 person-years). Sitagliptin was noninferior to placebo for the primary composite cardiovascular outcome (hazard ratio, 0.98; 95% CI, 0.88 to 1.09; P<0.001). Rates of hospitalization for heart failure did not differ between the two groups (hazard ratio, 1.00; 95% CI, 0.83 to 1.20; P = 0.98). There were no significant between-group differences in rates of acute pancreatitis (P = 0.07) or pancreatic cancer (P = 0.32). CONCLUSIONS: Among patients with type 2 diabetes and established cardiovascular disease, adding sitagliptin to usual care did not appear to increase the risk of major adverse cardiovascular events, hospitalization for heart failure, or other adverse events
Measurement and interpretation of same-sign W boson pair production in association with two jets in pp collisions at s = 13 TeV with the ATLAS detector
- Author
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- Zhemchugov A
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- Zimine NI
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- Zorbas TG
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- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 01/04/2024
- Field of study
This paper presents the measurement of fducial and diferential cross sections for both the inclusive and electroweak production of a same-sign W-boson pair in association with two jets (W±W±jj) using 139 fbâ1 of proton-proton collision data recorded at a centre-of-mass energy of âs = 13 TeV by the ATLAS detector at the Large Hadron Collider. The analysis is performed by selecting two same-charge leptons, electron or muon, and at least two jets with large invariant mass and a large rapidity diference. The measured fducial cross sections for electroweak and inclusive W±W±jj production are 2.92 ± 0.22 (stat.) ± 0.19 (syst.)fb and 3.38±0.22 (stat.)±0.19 (syst.)fb, respectively, in agreement with Standard Model predictions. The measurements are used to constrain anomalous quartic gauge couplings by extracting 95% confdence level intervals on dimension-8 operators. A search for doubly charged Higgs bosons H±± that are produced in vector-boson fusion processes and decay into a same-sign W boson pair is performed. The largest deviation from the Standard Model occurs for an H±± mass near 450 GeV, with a global signifcance of 2.5 standard deviations
Localization and broadband follow-up of the gravitational-wave transient GW150914
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- Zimmer S
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- Zweizig J
- Publication venue
- Astrophysical Journal Letters
- Publication date
- 01/01/2016
- Field of study
A gravitational-wave (GW) transient was identified in data recorded by the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) detectors on 2015 September 14. The event, initially designated G184098 and later given the name GW150914, is described in detail elsewhere. By prior arrangement, preliminary estimates of the time, significance, and sky location of the event were shared with 63 teams of observers covering radio, optical, near-infrared, X-ray, and gamma-ray wavelengths with ground- and space-based facilities. In this Letter we describe the low-latency analysis of the GW data and present the sky localization of the first observed compact binary merger. We summarize the follow-up observations reported by 25 teams via private Gamma-ray Coordinates Network circulars, giving an overview of the participating facilities, the GW sky localization coverage, the timeline, and depth of the observations. As this event turned out to be a binary black hole merger, there is little expectation of a detectable electromagnetic (EM) signature. Nevertheless, this first broadband campaign to search for a counterpart of an Advanced LIGO source represents a milestone and highlights the broad capabilities of the transient astronomy community and the observing strategies that have been developed to pursue neutron star binary merger events. Detailed investigations of the EM data and results of the EM follow-up campaign are being disseminated in papers by the individual teams
Combination of searches for heavy spin-1 resonances using 139 fbâ1 of proton-proton collision data at s = 13 TeV with the ATLAS detector
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- Fitzhugh PM
- Fleck I
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- Flores Sanz De Acedo L
- Flores M
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- Zhemchugov A
- Zheng J
- Zheng K
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- Zhong D
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- Zimine NI
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- Zoccoli A
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- Zwalinski L
- Ă kesson TPA
- Ăncel ĂO
- ĆœeniĆĄ T
- ĆœivkoviÄ L
- Publication venue
- Springer Nature
- Publication date
- 19/04/2024
- Field of study
A combination of searches for new heavy spin-1 resonances decaying into different pairings of W, Z, or Higgs bosons, as well as directly into leptons or quarks, is presented. The data sample used corresponds to 139 fbâ1 of proton-proton collisions at
= 13 TeV collected during 2015â2018 with the ATLAS detector at the CERN Large Hadron Collider. Analyses selecting quark pairs (qq, bb,
, and tb) or third-generation leptons (ÏÎœ and ÏÏ) are included in this kind of combination for the first time. A simplified model predicting a spin-1 heavy vector-boson triplet is used. Cross-section limits are set at the 95% confidence level and are compared with predictions for the benchmark model. These limits are also expressed in terms of constraints on couplings of the heavy vector-boson triplet to quarks, leptons, and the Higgs boson. The complementarity of the various analyses increases the sensitivity to new physics, and the resulting constraints are stronger than those from any individual analysis considered. The data exclude a heavy vector-boson triplet with mass below 5.8 TeV in a weakly coupled scenario, below 4.4 TeV in a strongly coupled scenario, and up to 1.5 TeV in the case of production via vector-boson fusion
- âŠ