Variations in Gonadosomatic Index, Gonadal Development and Spawning Induction of Spotted Scat Scatophagus argus (Linnaeus, 1766)

This study evaluated variations in gonadosomatic index (GSI), gonadal development stages, and hormonal spawning induction of Scatophagus argus in captivity. Male and female fish were cultured separately in net cages in Tam Giang lagoon, Central Vietnam, from January to December 2020. Five fish of each sex were randomly sampled monthly. Gonads were collected, GSI determined, and subsequently prepared for histology. Gamete quality was assessed with a light microscope. Spawning was hormonally induced with different doses of human chorionic gonadotropin (hCG) and luteinizing hormone-release hormone (LHRH-A2). Gonadal development started to increase in March, peaking in July. The peak spawning period of the fish was from June to August, displaying the highest GSI value, sperm motility, and oocyte diameter. Only female GSI fluctuated significantly month-by-month (P<0.05). Histological examination indicated that S. argus is a multiple-spawner. Application of LHRH-A2 (70 µg/kg) stimulated spawning and resulted in better latency periods, fertilization, and hatching rates

Developing a dementia-specific preference-­based quality of life measure (AD-5D) in Australia: a valuation study protocol

Introduction: Generic instruments for assessing health-related quality of life may lack the sensitivity to detect changes in health specific to certain conditions, such as dementia. The QOL-AD is a widely used and well validated condition-specific instrument for assessing health-related quality of life for people living with dementia, but it does not enable the calculation of Quality Adjusted Life Years (QALYs), the basis of cost utility analysis. This study will generate a preference-based scoring algorithm for a health state classification system (the AD-5D) derived from the QOL-AD. Methods and analysis: Discrete choice experiments with duration (DCETTO) and best-worst scaling (BWS) health state valuation tasks will be administered to a representative sample of 2,000 members of the Australian general population via an online survey and to 250 dementia dyads (250 people with dementia and their carers) via face-to-face interview. A multinomial (conditional) logistic framework will be used to analyse responses and produce the utility algorithm for the AD-5D. Ethics and dissemination: The algorithms developed will enable prospective and retrospective economic evaluation of any treatment or intervention targeting people with dementia where the QOL-AD has been administered and will be available online. Results will be disseminated through journals that publish health economics articles and through professional conferences. The study has ethical approval

Characterization of the Cytochrome P450 epoxyeicosanoid pathway in non-alcoholic steatohepatitis

Non-alcoholic steatohepatitis (NASH) is an emerging public health problem without effective therapies. Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid into bioactive epoxyeicosatrienoic acids (EETs), which have potent anti-inflammatory and protective effects. However, the functional relevance of the CYP epoxyeicosanoid metabolism pathway in the pathogenesis of NASH remains poorly understood. Our studies demonstrate that both mice with methionine-choline deficient (MCD) diet-induced NASH and humans with biopsy-confirmed NASH exhibited significantly higher free EET concentrations compared to healthy controls. Targeted disruption of Ephx2 (the gene encoding for soluble epoxide hydrolase) in mice further increased EET levels and significantly attenuated MCD diet-induced hepatic steatosis, inflammation and injury, as well as high fat diet-induced adipose tissue inflammation, systemic glucose intolerance and hepatic steatosis. Collectively, these findings suggest that dysregulation of the CYP epoxyeicosanoid pathway is a key pathological consequence of NASH in vivo, and promoting the anti-inflammatory and protective effects of EETs warrants further investigation as a novel therapeutic strategy for NASH

A novel framework for making dominant point detection methods non-parametric

Most dominant point detection methods require heuristically chosen control parameters. One of the commonly used control parameter is maximum deviation. This paper uses a theoretical bound of the maximum deviation of pixels obtained by digitization of a line segment for constructing a general framework to make most dominant point detection methods non-parametric. The derived analytical bound of the maximum deviation can be used as a natural bench mark for the line fitting algorithms and thus dominant point detection methods can be made parameter-independent and non-heuristic. Most methods can easily incorporate the bound. This is demonstrated using three categorically different dominant point detection methods. Such non-parametric approach retains the characteristics of the digital curve while providing good fitting performance and compression ratio for all the three methods using a variety of digital, non-digital, and noisy curves

Charm System Tests of CPT and Lorentz Invariance with FOCUS

We have performed a search for CPT violation in neutral charm meson oscillations. While flavor mixing in the charm sector is predicted to be small by the Standard Model, it is still possible to investigate CPT violation through a study of the proper time dependence of a CPT asymmetry in right-sign decay rates for $D^0\to K^-\pi^+$ and \d0b\to K^+\pi^-. This asymmetry is related to the CPT violating complex parameter $\xi$ and the mixing parameters $x$ and $y$: $A_{CPT}\propto{\rm Re} \xi y-{\rm Im} \xi x$ . Our 95% confidence level limit is $-0.0068<{\rm Re} \xi y-{\rm Im} \xi x<0.0234$. Within the framework of the Standard Model Extension incorporating general CPT violation, we also find 95% confidence level limits for the expressions involving coefficients of Lorentz violation of $(-2.8<N(x,y,\delta)(\Delta a_0 + 0.6 \Delta a_Z)<4.8)\times 10^{-16}$ GeV, $(-7.0<N(x,y,\delta)\Delta a_X<3.8)\times 10^{-16}$ GeV, and $(-7.0<N(x,y,\delta)\Delta a_Y<3.8)\times 10^{-16}$ GeV, where $N(x,y,\delta)$ is the factor which incorporates mixing parameters $x$, $y$ and the doubly Cabibbo suppressed to Cabibbo favored relative strong phase $\delta$.Comment: 12 pages 5 figure

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a point-like flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius $A$. Also the events detected simultaneously by the surface and fluorescence detectors (the `hybrid' data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Comment: Matches published versio

Low Q^2 Jet Production at HERA and Virtual Photon Structure

The transition between photoproduction and deep-inelastic scattering is investigated in jet production at the HERA ep collider, using data collected by the H1 experiment. Measurements of the differential inclusive jet cross-sections dsigep/dEt* and dsigmep/deta*, where Et* and eta* are the transverse energy and the pseudorapidity of the jets in the virtual photon-proton centre of mass frame, are presented for 0 < Q2 < 49 GeV2 and 0.3 < y < 0.6. The interpretation of the results in terms of the structure of the virtual photon is discussed. The data are best described by QCD calculations which include a partonic structure of the virtual photon that evolves with Q2.Comment: 20 pages, 5 Figure

Stability evaluation of a grid-tied hybrid wind/PV farm joined with a hybrid energy-storage system

This paper presents the stability-evaluation outcomes of a multimachine power system (MMPS) connected with a large-scale hybrid wind farm (WF) and photovoltaic (PV) farm or hybrid wind/PV farm (HWPF) and a hybrid energy-storage system (HESS) consisting of a vanadium redox flow battery (VRFB) and a supercapacitor (SC). A probability scheme is used to determine the rated power of the proposed HESS, where the capacities of the VRFB-ESS and the SC-ESS are designed to effectively utilize their operating features. The control strategy of the HESS is proposed to reduce the pressure of the VRFB-ESS and smooth the output power fluctuations of the HWPF. The steady-state stability, small-signal stability, dynamic performances, and transient simulations of the studied grid-tied HWPF fed to the MMPS with and without the HESS are achieved. The simulation outcomes show that the proposed HESS can enhance the stability and power-smoothing performance of the HWPF fed to the MMPS

Hadron Production in Diffractive Deep-Inelastic Scattering

Characteristics of hadron production in diffractive deep-inelastic positron-proton scattering are studied using data collected in 1994 by the H1 experiment at HERA. The following distributions are measured in the centre-of-mass frame of the photon dissociation system: the hadronic energy flow, the Feynman-x (x_F) variable for charged particles, the squared transverse momentum of charged particles (p_T^{*2}), and the mean p_T^{*2} as a function of x_F. These distributions are compared with results in the gamma^* p centre-of-mass frame from inclusive deep-inelastic scattering in the fixed-target experiment EMC, and also with the predictions of several Monte Carlo calculations. The data are consistent with a picture in which the partonic structure of the diffractive exchange is dominated at low Q^2 by hard gluons.Comment: 16 pages, 6 figures, submitted to Phys. Lett.

Evidence for a mixed mass composition at the `ankle' in the cosmic-ray spectrum

We report a first measurement for ultra-high energy cosmic rays of the correlation between the depth of shower maximum and the signal in the water Cherenkov stations of air-showers registered simultaneously by the fluorescence and the surface detectors of the Pierre Auger Observatory. Such a correlation measurement is a unique feature of a hybrid air-shower observatory with sensitivity to both the electromagnetic and muonic components. It allows an accurate determination of the spread of primary masses in the cosmic-ray flux. Up till now, constraints on the spread of primary masses have been dominated by systematic uncertainties. The present correlation measurement is not affected by systematics in the measurement of the depth of shower maximum or the signal in the water Cherenkov stations. The analysis relies on general characteristics of air showers and is thus robust also with respect to uncertainties in hadronic event generators. The observed correlation in the energy range around the `ankle' at $\lg(E/{\rm eV})=18.5-19.0$ differs significantly from expectations for pure primary cosmic-ray compositions. A light composition made up of proton and helium only is equally inconsistent with observations. The data are explained well by a mixed composition including nuclei with mass $A > 4$. Scenarios such as the proton dip model, with almost pure compositions, are thus disfavoured as the sole explanation of the ultrahigh-energy cosmic-ray flux at Earth.Comment: Published version. Added journal reference and DOI. Added Report Numbe