To assess the prevalence and factors determining timely initiation of breastfeeding among the mothers in resettlement colony in Delhi

Background: The initiation of breastfeeding within 1 h of birth has various benefits and has been found to reduce neonatal mortality and morbidity. Objective: This study is designed to assess the prevalence and determinants of timely initiation of breastfeeding among mothers in a resettlement colony of Delhi. Materials and Methods: A community-based cross-sectional study was conducted in a resettlement colony of East Delhi among mothers with infants <6 months of age. Mothers were enrolled from Anganwadi Centers using systematic random sampling, and a questionnaire was used to record information on feeding practices. Chi-square test and multiple logistic regression analysis were performed. Results: The prevalence of the initiation of breastfeeding within 1 h of birth was 51.7%. Using multiple logistic regression analysis, the factors which were found to be significantly associated were type of delivery (p<0.005), place of delivery (p<0.005), and advice on the initiation of breastfeeding at the time of delivery or postnatal period (p<0.005). Conclusions: In this study, the prevalence of the initiation of breastfeeding is better than the national average. It was higher in children born in government health institutions. This study suggests that the importance of the early initiation of breastfeeding should be emphasized during antenatal care visits through trained skilled health professionals in public and private health sector

CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

CMB-S4---the next-generation ground-based cosmic microwave background (CMB) experiment---is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the Universe, from the highest energies at the dawn of time through the growth of structure to the present day. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semi-analytic projection tool, targeted explicitly towards optimizing constraints on the tensor-to-scalar ratio, $r$, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2--3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments given a desired scientific goal. To form a closed-loop process, we couple this semi-analytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for $r > 0.003$ at greater than $5\sigma$, or, in the absence of a detection, of reaching an upper limit of $r < 0.001$ at $95\%$ CL.Comment: 24 pages, 8 figures, 9 tables, submitted to ApJ. arXiv admin note: text overlap with arXiv:1907.0447

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

CMB-S4

We describe the stage 4 cosmic microwave background ground-based experiment CMB-S4

CMB-S4: Forecasting Constraints on Primordial Gravitational Waves

Abstract: CMB-S4—the next-generation ground-based cosmic microwave background (CMB) experiment—is set to significantly advance the sensitivity of CMB measurements and enhance our understanding of the origin and evolution of the universe. Among the science cases pursued with CMB-S4, the quest for detecting primordial gravitational waves is a central driver of the experimental design. This work details the development of a forecasting framework that includes a power-spectrum-based semianalytic projection tool, targeted explicitly toward optimizing constraints on the tensor-to-scalar ratio, r, in the presence of Galactic foregrounds and gravitational lensing of the CMB. This framework is unique in its direct use of information from the achieved performance of current Stage 2–3 CMB experiments to robustly forecast the science reach of upcoming CMB-polarization endeavors. The methodology allows for rapid iteration over experimental configurations and offers a flexible way to optimize the design of future experiments, given a desired scientific goal. To form a closed-loop process, we couple this semianalytic tool with map-based validation studies, which allow for the injection of additional complexity and verification of our forecasts with several independent analysis methods. We document multiple rounds of forecasts for CMB-S4 using this process and the resulting establishment of the current reference design of the primordial gravitational-wave component of the Stage-4 experiment, optimized to achieve our science goals of detecting primordial gravitational waves for r > 0.003 at greater than 5σ, or in the absence of a detection, of reaching an upper limit of r < 0.001 at 95% CL

Effect of fruit juices and chloride ions on the corrosion behavior of orthodontic archwire

<p>Electrochemical and surface analytical study on the corrosion behavior of AISI 316L stainless steel orthodontic archwire in different fruit juices was carried out. The electrochemical parameters were measured after immersing the wires for approx. 24 h in artificial saliva (AS) containing different fruit juices and separately in fruit juices with 1% NaCl in AS. All the fruit juices used in this study increased the rate of corrosion process in AS in the presence or absence of salt. Addition of 1% NaCl to the AS, all experiments exhibited pitting. <i>Solanum lycopersicum</i> (Tomato) and <i>Durio zibethinus</i> (Amra) are rated as most detrimental to the surface followed by <i>Prunus domestica Linn</i>. (Plum) juice. SEM Micrographs of the specimens show formation of blisters onto the steel surface which are remnants of passive film.</p

Design, Synthesis, and Pharmacological Evaluation of 5,6-Disubstituted Pyridin-2(1<i>H</i>)‑one Derivatives as Phosphodiesterase 10A (PDE10A) Antagonists

We report the design and synthesis of novel 5,6-diarylated pyridin-2­(1<i>H</i>)-one derivatives as pharmacophoric PDE10A inhibitors. This highly potent molecular scaffold was developed from an inactive diarylpyridine-2-amine derivative <b>3b</b> by extensive and systematic analogue synthesis and SAR analysis. Further optimization of the scaffold resulted in identification of pyridin-2­(1<i>H</i>)-one <b>18b</b> as a lead compound with good potency (IC₅₀ = 1.6 nM) and selectivity (>6000-fold) over other related PDEs but with a poor pharmacokinetic profile. Careful metabolite profiling of <b>18b</b> revealed that poor systemic exposure in rats (<i>C</i>_max = 44 ng/mL; AUC_0–<i>t</i> = 359 ng·h/mL) at 10 mg/kg was due to the formation of <i>O</i>-glucuronide conjugate by phase 2 metabolism. The structure of the glucuronide metabolite was confirmed by retention time and LC–MS/MS fragmentation matching with the synthetic glucuronide <b>26</b>. The problem of low exposure of <b>18b</b> was effectively addressed by its conversion to an acetate prodrug <b>25b</b>, which upon oral dosing resulted in an improved pharmacokinetic profile (<i>C</i>_max = 359 ng.h/mL; AUC_0–<i>t</i> = 2436 ng.h/mL) and a desirable brain to plasma ratio of 1.2. The prodrug <b>25b</b> showed good efficacy in selected rodent models of psychosis

Multiplicity dependence of light (anti-)nuclei production in p–Pb collisions at sNN=5.02 TeV

The measurement of the deuteron and anti-deuteron production in the rapidity range −1 < y < 0 as a function of transverse momentum and event multiplicity in p–Pb collisions at √sNN = 5.02 TeV is presented. (Anti-)deuterons are identified via their specific energy loss dE/dx and via their time-of- flight. Their production in p–Pb collisions is compared to pp and Pb–Pb collisions and is discussed within the context of thermal and coalescence models. The ratio of integrated yields of deuterons to protons (d/p) shows a significant increase as a function of the charged-particle multiplicity of the event starting from values similar to those observed in pp collisions at low multiplicities and approaching those observed in Pb–Pb collisions at high multiplicities. The mean transverse particle momenta are extracted from the deuteron spectra and the values are similar to those obtained for p and particles. Thus, deuteron spectra do not follow mass ordering. This behaviour is in contrast to the trend observed for non-composite particles in p–Pb collisions. In addition, the production of the rare 3He and 3He nuclei has been studied. The spectrum corresponding to all non-single diffractive p-Pb collisions is obtained in the rapidity window −1 < y < 0 and the pT-integrated yield dN/dy is extracted. It is found that the yields of protons, deuterons, and 3He, normalised by the spin degeneracy factor, follow an exponential decrease with mass number