Comparativa de Dos Técnicas Basadas en Roles para el Desarrollo de Software desde una Perspectiva Industrial

[EN] Both the degree in Telematic Engineering and the degree in Multimedia Engineering have a subject of Software Engineering. One competence of this subject is to train students as professionals for the real world. For this aim, we have applied two versions of a role-playing game where there are both clients, who ask for a system development project, and developers. In the degree in Telematic Ingineering, the teacher plays the role of client, while students play the role of developers. Regarding the degree of Multimedia Engineering, students play both the role of client and developer at the same time (for different projects). In this paper, we tackle both experiences and we show a comparative of results. For Telematic Engineering, we ensure that the workload is the same for all the students. Moreover, the teacher can control directly the work of the students since he/she knows perfectly the project that needs to be developed. Regarding Multimedia Engineering, we try to enhance the students’ creativity since they must devise themselves a project to develop. Moreover, the students learn how to develop both roles, which can be useful for the real world.[ES] Dentro de los grados de Ingeniería Telemática e Ingeniería Multimedia se imparte la asignatura de Ingeniería del Software. Una de las competencias de esta asignatura es formar a los alumnos como profesionales para el mundo real. Para ello, hemos aplicado dos variantes de un juego de rol donde hay clientes, que solicitan un proyecto informático, y desarrolladores. En el Grado de Ingeniería Telemática (GIT), el rol de usuario final lo tomaba un único profesor, mientras que los usuarios jugaban el rol de desarrolladores. En el Grado de Ingeniería Multimedia (GIM), los estudiantes jugaban a la vez el rol de cliente y de desarrolladores (para proyectos distintos). En este artículo se abordan ambas experiencias y se presenta una comparativa de los resultados obtenidos con ellas. En el caso de GIT se garantiza que la carga de trabajo es para todos los estudiantes la misma. Además, el profesor puede llevar un seguimiento más directo al conocer de primera mano el caso a desarrollar. En el caso de GIM se potencia la creatividad de los alumnos, ya que deben inventarse el proyecto a desarrollar. Además, los alumnos aprenden a desempeñar dos roles que les pueden ser útiles en el mundo real.Este trabajo se ha desarrollado dentro del proyecto de innovación educativa “Desarrollo de Software desde una Perspectiva Industrial” de la Universidad de Valencia.Rueda Pascual, S.; Cabotà, J.; Panach Navarrete, J.; Martínez, J.; Pérez, M.; Casas, S. (2017). Comparativa de Dos Técnicas Basadas en Roles para el Desarrollo de Software desde una Perspectiva Industrial. En In-Red 2017. III Congreso Nacional de innovación educativa y de docencia en red. Editorial Universitat Politècnica de València. 552-563. https://doi.org/10.4995/INRED2017.2017.6858OCS55256

Study of caveolin-1 gene expression in whole adipose tissue and its subfractions and during differentiation of human adipocytes

<p>Abstract</p> <p>Context</p> <p>Caveolins are 21-24 kDa integral membrane proteins that serve as scaffolds to recruit numerous signaling molecules. Specific subclasses of caveolae carry out specific functions in cell metabolism. In particular, triglycerides are synthesized at the site of fatty acid entry in one of these caveolae classes.</p> <p>Objective and Methods</p> <p>We studied the expression of caveolin-1 (<it>CAV-1</it>) gene in association with metabolic variables in 90 visceral and 55 subcutaneous adipose tissue samples from subjects with a wide range of fat mass, in the stromovascular fraction (SVC) and isolated adipocytes, and during differentiation of human adipocytes.</p> <p>Results</p> <p><it>CAV-1 </it>gene expression was significantly decreased in visceral adipose tissue (v-<it>CAV-1</it>) of obese subjects. v-<it>CAV-1 </it>was positively associated with several lipogenic genes such as acetyl-coA carboxylase (<it>ACACA</it>, r = 0.34, p = 0.004) and <it>spot-14 </it>(r = 0.33, p = 0.004). In non-obese subjects v-<it>CAV-1 </it>also correlated with fatty acid synthase (<it>FAS</it>, r = 0.60, p < 0.0001). Subcutaneous (sc) adipose tissue (s<it>c-CAV-1</it>) gene expression was not associated with these lipogenic factors when obese and non-obese subjects were studied together. In obese subjects, however, sc-<it>CAV-1 </it>was associated with fatty acid synthase (<it>FAS</it>, r = 0.36, p = 0.02), sterol regulatory element binding protein-1c (<it>SREBP-1c </it>(r = 0.58, p < 0.0001), <it>ACACA </it>(r = 0.33, p = 0.03), <it>spot-14 </it>(r = 0.36, p = 0.02), <it>PPAR-γ co-activator-1 </it>(<it>PGC-1</it>, r = 0.88, n = 19). In these obese subjects, <it>sc-CAV-1 </it>was also associated with fasting triglycerides (r = -0.50, p < 0.0001).</p> <p><it>CAV-1 </it>expression in mature adipocytes was significantly higher than in stromal vascular cells. <it>CAV-1 </it>gene expression in adipocytes from subcutaneous adipose tissue (but not in adipocytes from visceral adipose tissue) was significatively associated with fasting triglycerides. <it>CAV-1 </it>gene expression did not change significantly during differentiation of human preadipocytes from lean or obese subjects despite significant increase of FAS gene expression.</p> <p>Conclusion</p> <p>Decreased <it>CAV-1 </it>gene expression was simultaneously linked to increased triglycerides and decreased lipogenic gene expression among obese subjects, paralleling the observations of hypertriglyceridemia in <it>CAV-1 </it>knockout mice. However, the regulation of <it>CAV-1 </it>gene expression seems independent of the adipogenic program.</p

3DCOMET: 3D compression methods test dataset

The use of 3D data in mobile robotics applications provides valuable information about the robot’s environment. However usually the huge amount of 3D information is difficult to manage due to the fact that the robot storage system and computing capabilities are insufficient. Therefore, a data compression method is necessary to store and process this information while preserving as much information as possible. A few methods have been proposed to compress 3D information. Nevertheless, there does not exist a consistent public benchmark for comparing the results (compression level, distance reconstructed error, etc.) obtained with different methods. In this paper, we propose a dataset composed of a set of 3D point clouds with different structure and texture variability to evaluate the results obtained from 3D data compression methods. We also provide useful tools for comparing compression methods, using as a baseline the results obtained by existing relevant compression methods.This work was partially supported by grant DPI2013-40534-R of the Ministerio of Economia y Competitividad of the Spanish Government, supported with Feder funds, and Valencian’s Government project GV/2014/097

Nanocrystalline silicon substituted hydroxyapatite effects on osteoclast differentiation and resorptive activity

In the present study, the effects of nanocrystalline hydroxyapatite (nano-HA) and nanocrystalline Si-substituted hydroxyapatite (nano-SiHA) on osteoclast differentiation and resorptive activity have been evaluated in vitro using osteoclast-like cells. The action of these materials on proinflammatory and reparative macrophage populations was also studied. Nano-SiHA disks delayed the osteoclast differentiation and decreased the resorptive activity of these cells on their surface, as compared to nano-HA samples, without affecting cell viability. Powdered nano-SiHA also induced an increase of the reparative macrophage population. These results along with the beneficial effects on osteoblasts previously observed with powdered nano-SiHA suggest the potential of this biomaterial for modulating the fundamental processes of bone formation and turnover, preventing bone resorption and enhancing bone formation at implantation sites in treatment of osteoporotic bone and in bone repair and regeneration

THE “VALLE DEL SABATO” AND THE SULPHUR MINES OF TUFO AND ALTAVILLAIRPINA

Two the mining companies, two the properties, two the related factories: the Di Marzo and the SocietàAnonimaIndustrieMinerarie (SAIM); two the families, of noble origins, who contributed to the mid-1800s to radical changes in the Valley, including through a direct and personal relationship with social initiatives in favour of the working society. The phenomenon began a new era of development resulting in significant transformations in the social-economic structures and in the organization of the inhabitants. Along with tanning pole, sulphur mines soon became the flagship reality of entrepreneurship irpina, attracting the interest of other businessman and banking groups. The thriving mining went on until the early 1970 's when the international competition and of the oil companies made cheaper sulfur extraction for other routes. At present the Administration and municipalities concerned intended to start an enhancement of industrial archaeology, preparing a feasibility study for the use of such mines by large sections of the people. It is an immense historical, cultural, industrial and natural and anthropological heritage, that should not be lost; therefore the project of a geomining park of the sulphur mines of Tufo and AltavillaIrpina(Italy) can offer to local populations another opportunity for development. Pending its establishment, the production of DOCG wines with the presence of the Greco di Tufo, a white wine produced in the municipalities of the province of Avellino, including Tufo and AltavillaIrpina, continues to enhance the Irpinia territory

CD32 Expression is not Associated to HIV-DNA content in CD4 cell subsets of individuals with Different Levels of HIV Control

A recent study has pointed out to CD32a as a potential biomarker of HIV-persistent CD4 cells. We have characterized the level and phenotype of CD32+ cells contained in different subsets of CD4 T-cells and its potential correlation with level of total HIV-DNA in thirty HIV patients (10 typical progressors naive for cART, 10 cART-suppressed patients, and 10 elite controllers). Total HIV-DNA was quantified in different subsets of CD4 T-cells: Trm and pTfh cells. Level and immunephenotype of CD32+ cells were analyzed in these same subsets by flow cytometry. CD32 expression in Trm and pTfh subsets was similar in the different groups, and there was no significant correlation between the level of total HIV-DNA and the level of CD32 expression in these subsets. However, total HIV-DNA level was correlated with expression of CD127 (rho = -0.46, p = 0.043) and of CCR6 (rho = -0.418, p = 0.027) on CD32+ cells. Our results do not support CD32 as a biomarker of total HIV-DNA content. However, analyzing the expression of certain markers by CD32+ cells could improve the utility of this marker in the clinical setting, prompting the necessity of further studies to both validate our results and to explore the potential utility of certain markers expressed by CD32+ cells.We would like to thank all patients and healthy donors who participated in the study. This study has been funded by projects CP14/00198, PI16/01769, and RD16/0025/0013 integrated in the State Plan for Scientific and Technical Research and Innovation and co-funded by ISCIII-Sub-Directorate General for Research Assessment and Promotion and European Regional Development Fund (ERDF). N Rallon is a Miguel Servet investigator from the Spanish Carlos III Institute of Health (ISCIII), grant CP14/00198, Madrid, Spain. Maria Angeles Navarrete-Munoz was funded by RD16/0025/0013 and the Intramural Research Scholarship from IIS-FJD. Clara Restrepo was funded by project RD16/0025/0013. M Garcia is a predoctoral student co-funded by CP14/00198 project and the Intramural Research Scholarship from IIS-FJD.S

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.&lt;p&gt;&lt;/p&gt; Methods: Sixty-six non-HLA SNPs showing a P value &#60;10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.&lt;p&gt;&lt;/p&gt; Conclusion: Our results suggest a role of PPARG gene in the development of SSc

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe