514 research outputs found

    Media Manipulation or Economic Decline? Explaining the Rise of Nationalism within Bosnia Herzegovina

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    How in less than ten years does a country go from hosting the Olympics to using the opening ceremony stadium to bury bodies? In this paper, I seek to answer the question of why ethnic nationalism was able to gain such strong support in BiH following the collapse of Yugoslavia. I explore three possible explanations. The first focuses on the role of elite manipulation of the media in spreading nationalist narratives. The second, examines the impact of perceived economic woes along ethnic lines that led to scapegoating of other ethnic groups. The third offers a hybrid approach, proposing that perceived economic woes made the public receptive to elite spread of nationalist narratives. Drawing upon three months of field research conducted in Bosnia Herzegovina, including interviews with individuals on all sides of the conflict, during the summer of 2013, as well as the work of previous scholars, my paper seeks to provide a valuable contribution to the scholarly community on understanding the role the media and economics can play in inciting ethnic animosity and violence

    Kirkwood District

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    This Historic District Information form and all of its supplementary documents were compiled by the Case Studies class in the spring of 2007. It includes information on the district known as Kirkwood, as well as prints of Sanborn maps, early plattings of the properties, as well as historic photographs and newspaper clippings.https://scholarworks.gsu.edu/history_heritagepreservation/1050/thumbnail.jp

    Increasing HIV-1 pretreatment drug resistance among antiretroviral-naïve adults initiating treatment between 2006 and 2014 in Nairobi, Kenya

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    Antiretroviral-naïve adults initiating antiretroviral therapy in Nairobi, Kenya were tested for HIV-1 drug resistance at codons K103N, Y181C, G190A, M184V, and K65R using an oligonucleotide ligation assay. Prevalence of pretreatment drug resistance increased from 3.89% in 2006 to 10.93% in 2014 (P \u3c 0.001), and 95% of those with resistance had at least one nonnucleoside reverse transcriptase inhibitor mutation. Resistance to tenofovir (K65R) was found in 2014 but not in 2006

    Chemerin triggers migration of a CD8 T cell subset with natural killer cell functions

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    The recruitment of cells with effector functions into the tumor microenvironment holds potential for delaying cancer progression. We show that subsets of human CD28-effector CD8 T cells, CCR7- CD45RO+ effector memory, and CCR7- CD45RO- effector memory RA phenotypes, express the chemerin receptor CMKLR1 and bind chemerin via the receptor. CMKLR1-expressing human CD8 effector memory T cells present gene, protein, and cytotoxic features of NK cells. Active chemerin promotes chemotaxis of CMKLR1-expressing CD8 effector memory cells and triggers activation of the α4β1 integrin. In an experimental prostate tumor mouse model, chemerin expression is downregulated in the tumor microenvironment, which is associated with few tumor-infiltrating CD8+ T cells, while forced overexpression of chemerin by mouse prostate cancer cells leads to an accumulation of intra-tumor CD8+ T cells. Furthermore, α4 integrin blockade abrogated the chemerin-dependent recruitment of CD8+ T effector memory cells into implanted prostate tumors in vivo. The results identify a role for chemerin:CMKLR1 in defining a specialized NK-like CD8 T cell, and suggest the use of chemerin-dependent modalities to target effector CMKLR1-expressing T cells to the tumor microenvironment for immunotherapeutic purposes

    A content analysis of media coverage on road safety and road traffic crashes in Colombia

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    Introduction: In Colombia, road traffic crashes are the eighth leading cause of death. In 2017, as part of the Bloomberg Philanthropies Initiative for Global Road Safety (BIGRS), Vital Strategies supported government-led journalist trainings in Colombia to shift media discourse of road safety as a public health and development issue with known risk factors and achievable solutions, to ultimately catalyze public and policymaker concern and action. This study evaluates the effects these trainings had on road safety reporting.Methods: Articles about BIGRS road safety work published between 1 May 2017 and Aug. 30, 2021 were collected from a database maintained by communication officers. The sample included 870 articles, which were systematically analyzed for year-wise frequency by independent coders. Inter-reliability (Cohen’s Kapp K > 0.94) was established using a codebook developed to identify examples of best practices shared during trainings.Results: From 2017 to 2021, there was a 27% increase in articles that situated road traffic collisions (RTCs) as due to systemic issues (thematic framing) rather than isolated events (episodic framing). Almost all observed articles used at least one WHO-recommended story angle (96%) and key element (95%). Reporting angles focused on the human story were largely underutilized (2%–5%). Government representatives (81%), mostly from the Secretary of Mobility (67%), were the most cited sources and road safety advocates were the least (3%). Use of terms “crash” and “collision” increased across the study period (crash: 47% in 2017 to 59% in 2021; collision: 0.4% in 2019 to 5% in 2020). However, RTCs continued to be widely called “accidents” (46%). More than half of articles referenced either “victims” or “vulnerable road users” (55%); use of “person” to refer to victims/vulnerable road users increased from 33% in 2017 to 56% in 2020.Conclusion: Over the course of the BIGRS journalist training program, reporting in Colombia increasingly used best practices to frame road safety as a public health issue. This highlights how media engagement is important to comprehensive road safety strategies and should be more widely adopted. Future training efforts should focus on finding the human story, and on changing overreliance on terms like “accident” that make RTCs seem inevitable

    Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk

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    Correction to: Nature Geneticshttps://doi.org/10.1038/s41588-023-01314-0, published online 13 March 2023. In the version of the article initially published, the sample sizes in the main text and Supplementary Tables 1 and 2 were incorrect. In the abstract, the last paragraph of the Introduction, the first paragraph of the Results, the top box in Figure 1a and the Supplementary Information, the total sample size has been corrected from 580,869 to 588,452 participants and the size of the European cohort from 468,062 to 475,645. Some of the effect sizes in Supplementary Table 14 (columns W, Z, AC, AF) had the wrong sign. There was also an error in Supplementary Table 3 where the sample size instead of the variant count was shown for EXCEED. The errors do not affect the conclusions of the study. Additionally, two acknowledgments for use of INTERVAL pQTL and Lung eQTL consortium data were omitted from the Supplementary Information. These errors have been corrected in the Supplementary Information and HTML and PDF versions of the article

    Optimasi Portofolio Resiko Menggunakan Model Markowitz MVO Dikaitkan dengan Keterbatasan Manusia dalam Memprediksi Masa Depan dalam Perspektif Al-Qur`an

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    Risk portfolio on modern finance has become increasingly technical, requiring the use of sophisticated mathematical tools in both research and practice. Since companies cannot insure themselves completely against risk, as human incompetence in predicting the future precisely that written in Al-Quran surah Luqman verse 34, they have to manage it to yield an optimal portfolio. The objective here is to minimize the variance among all portfolios, or alternatively, to maximize expected return among all portfolios that has at least a certain expected return. Furthermore, this study focuses on optimizing risk portfolio so called Markowitz MVO (Mean-Variance Optimization). Some theoretical frameworks for analysis are arithmetic mean, geometric mean, variance, covariance, linear programming, and quadratic programming. Moreover, finding a minimum variance portfolio produces a convex quadratic programming, that is minimizing the objective function ðð¥with constraintsð ð 𥠥 ðandð´ð¥ = ð. The outcome of this research is the solution of optimal risk portofolio in some investments that could be finished smoothly using MATLAB R2007b software together with its graphic analysis

    Search for heavy resonances decaying to two Higgs bosons in final states containing four b quarks

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    A search is presented for narrow heavy resonances X decaying into pairs of Higgs bosons (H) in proton-proton collisions collected by the CMS experiment at the LHC at root s = 8 TeV. The data correspond to an integrated luminosity of 19.7 fb(-1). The search considers HH resonances with masses between 1 and 3 TeV, having final states of two b quark pairs. Each Higgs boson is produced with large momentum, and the hadronization products of the pair of b quarks can usually be reconstructed as single large jets. The background from multijet and t (t) over bar events is significantly reduced by applying requirements related to the flavor of the jet, its mass, and its substructure. The signal would be identified as a peak on top of the dijet invariant mass spectrum of the remaining background events. No evidence is observed for such a signal. Upper limits obtained at 95 confidence level for the product of the production cross section and branching fraction sigma(gg -> X) B(X -> HH -> b (b) over barb (b) over bar) range from 10 to 1.5 fb for the mass of X from 1.15 to 2.0 TeV, significantly extending previous searches. For a warped extra dimension theory with amass scale Lambda(R) = 1 TeV, the data exclude radion scalar masses between 1.15 and 1.55 TeV

    Robust estimation of bacterial cell count from optical density

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    Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
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