Benefits of active middle ear implants over hearing aids in patients with sloping high tone hearing loss: comparison with hearing aids

In questo studio retrospettivo, abbiamo confrontato i benefici oggettivi e soggettivi degli impianti attivi dell’orecchio medio (AMEI) rispetto alle tradizionali protesi acustiche (HA) nei pazienti con perdita dell’udito per le frequenze acute. Trentaquattro pazienti con ipoacusia neurosensoriale sono stati trattati con l’impianto di AMEI. Tra questi, sei avevano un audiogramma “in discesa” con perdita dell’udito per le frequenze acute, ed avevano usato per più di sei mesi HA. È stata quindi eseguita una valutazione oggettiva, tramite l’audiometria tonale e il test di riconoscimento delle parole, una versione coreana del “Hearing in Noise Test” (K-HINT), ed una valutazione soggettiva tramite il seguente questionario: Abbreviated Profile of Hearing Aid Benefit (APHAB). I pazienti sono stati sottoposti ai suddetti test in tre occasioni distinte: 1) prima della chirurgia, senza protesi; 2) prima della chirurgia, con HA; 3) tre mesi dopo l’impianto di AMEI. Il guadagno medio per le alte frequenze (≥ 2 kHz) si è rivelato migliore con AMEI che con HA. Sebbene il risultato non ha raggiunto un livello di significatività statistica, gli impianti attivi dell’orecchio medio hanno mostrato un punteggio di riconoscimento delle parole superiore rispetto a HA. Ad ogni modo, il livello di comoda udibilità al quale il punteggio di riconoscimento delle parole è stato testato si è rivelato significativamente più basso con AMEI rispetto ad HA. Al K-HINT i pazienti con AMEI hanno mostrato un migliore riconoscimento rispetto ai risultati ottenuti con HA, sia in condizione di quiete sia di rumore. Gli score APAHB hanno rivelato che i pazienti erano più soddisfatti con AMEI. L’uso degli impianti attivi dell’orecchio medio in pazienti con perdita dell’udito per le frequenze acute ha permesso di ottenere risultati migliori rispetto all’utilizzo delle protesi tradizionali. Basandoci su questi dati, gli AMEI hanno offerto risultati oggettivi e soggettivi migliori, e pertanto, potrebbero rappresentare una valida alternativa per il trattamento delle ipoacusie con audiogramma in discesa

Velocity Fluctuations in Electrostatically Driven Granular Media

We study experimentally the particle velocity fluctuations in an electrostatically driven dilute granular gas. The experimentally obtained velocity distribution functions have strong deviations from Maxwellian form in a wide range of parameters. We have found that the tails of the distribution functions are consistent with a stretched exponential law with typical exponents of the order 3/2. Molecular dynamic simulations shows qualitative agreement with experimental data. Our results suggest that this non-Gaussian behavior is typical for most inelastic gases with both short and long range interactions.Comment: 4 pages, 4 figure

Actin Cytoskeleton and Golgi Involvement in Barley stripe mosaic virus Movement and Cell Wall Localization of Triple Gene Block Proteins

Barley stripe mosaic virus (BSMV) induces massive actin filament thickening at the infection front of infected Nicotiana benthamiana leaves. To determine the mechanisms leading to actin remodeling, fluorescent protein fusions of the BSMV triple gene block (TGB) proteins were coexpressed in cells with the actin marker DsRed: Talin. TGB ectopic expression experiments revealed that TGB3 is a major elicitor of filament thickening, that TGB2 resulted in formation of intermediate DsRed:Talin filaments, and that TGB1 alone had no obvious effects on actin filament structure. Latrunculin B (LatB) treatments retarded BSMV cell-to-cell movement, disrupted actin filament organization, and dramatically decreased the proportion of paired TGB3 foci appearing at the cell wall (CW). BSMV infection of transgenic plants tagged with GFP-KDEL exhibited membrane proliferation and vesicle formation that were especially evident around the nucleus. Similar membrane proliferation occurred in plants expressing TGB2 and/or TGB3, and DsRed: Talin fluorescence in these plants colocalized with the ER vesicles. TGB3 also associated with the Golgi apparatus and overlapped with cortical vesicles appearing at the cell periphery. Brefeldin A treatments disrupted Golgi and also altered vesicles at the CW, but failed to interfere with TGB CW localization. Our results indicate that actin cytoskeleton interactions are important in BSMV cell-to-cell movement and for CW localization of TGB3

Square to stripe transition and superlattice patterns in vertically oscillated granular layers

We investigated the physical mechanism for the pattern transition from square lattice to stripes, which appears in vertically oscillating granular layers. We present a continuum model to show that the transition depends on the competition between inertial force and local saturation of transport. By introducing multiple free-flight times, this model further enables us to analyze the formation of superlattices as well as hexagonal lattice

Recovery and concentration of ammonia from return liquor to promote enhanced CO2 absorption and simultaneous ammonium bicarbonate crystallisation during biogas upgrading in a hollow fibre membrane contactor

In this study, thermal desorption was developed to separate and concentrate ammonia from return liquor, for use as a chemical absorbent in biogas upgrading, providing process intensification and the production of crystalline ammonium bicarbonate as the final reaction product. Applying modest temperature (50°C) in thermal desorption suppressed water vapour pressure and increased selective transport for ammonia from return liquor (0.11MNH3) yielding a concentrated condensate (up to 1.7MNH3). Rectification was modelled through second-stage thermal processing, where higher initial ammonia concentration from the first stage increased mass transfer and delivered a saturated ammonia solution (6.4MNH3), which was sufficient to provide chemically enhanced CO2 separation and the simultaneous initiation of ammonium bicarbonate crystallisation, in a hollow fibre membrane contactor. Condensate recovered from return liquor exhibited a reduction in surface tension. We propose this is due to the stratification of surface active agents at the air-liquid interface during primary-stage thermal desorption which carried over into the condensate, ‘salting’ out CO2 and lowering the kinetic trajectory of absorption. However, crystal induction (the onset of nucleation) was comparable in both synthetic and thermally recovered condensates, indicating the thermodynamics of crystallisation to be unaffected by the recovered condensate. The membrane was evidenced to promote heterogeneous primary nucleation, and the reduction in the recovered condensate surface tension was shown to exacerbate nucleation rate, due to the reduction in activation energy. X-ray diffraction of the crystals formed, showed the product to be ammonium bicarbonate, demonstrating that thermal desorption eliminates cation competition (e.g. Ca2+) to guarantee the formation of the preferred crystalline reaction product. This study identifies an important synergy between thermal desorption and membrane contactor technology that delivers biogas upgrading, ammonia removal from wastewater and resource recovery in a complimentary process

Low-temperature nonequilibrium transport in a Luttinger liquid

The temperature-dependent nonlinear conductance for transport of a Luttinger liquid through a barrier is calculated in the nonperturbative regime for $g=1/2-\epsilon$, where $g$ is the dimensionless interaction constant. To describe the low-energy behavior, we perform a leading-log summation of all diagrams contributing to the conductance which is valid for $|\epsilon| << 1$. With increasing external voltage, the asymptotic low-temperature behavior displays a turnover from the $T^{2/g-2}$ to a universal $T^2$ law.Comment: 13 pages RevTeX 3.0, accepted by Physical Review

Cascades of subharmonic stationary states in strongly non-linear driven planar systems

The dynamics of a one-degree of freedom oscillator with arbitrary polynomial non-linearity subjected to an external periodic excitation is studied. The sequences (cascades) of harmonic and subharmonic stationary solutions to the equation of motion are obtained by using the harmonic balance approximation adapted for arbitrary truncation numbers, powers of non-linearity, and orders of subharmonics. A scheme for investigating the stability of the harmonic balance stationary solutions of such a general form is developed on the basis of the Floquet theorem. Besides establishing the stable/unstable nature of a stationary solution, its stability analysis allows obtaining the regions of parameters, where symmetry-breaking and period-doubling bifurcations occur. Thus, for period-doubling cascades, each unstable stationary solution is used as a base solution for finding a subsequent stationary state in a cascade. The procedure is repeated until this stationary state becomes stable provided that a stable solution can finally be achieved. The proposed technique is applied to calculate the sequences of subharmonic stationary states in driven hardening Duffing's oscillator. The existence of stable subharmonic motions found is confirmed by solving the differential equation of motion numerically by means of a time-difference method, with initial conditions being supplied by the harmonic balance approximation.Comment: 37 pages, 11 figures, revised material on chaotic motio

Double-Layer Systems at Zero Magnetic Field

We investigate theoretically the effects of intralayer and interlayer exchange in biased double-layer electron and hole systems, in the absence of a magnetic field. We use a variational Hartree-Fock-like approximation to analyze the effects of layer separation, layer density, tunneling, and applied gate voltages on the layer densities and on interlayer phase coherence. In agreement with earlier work, we find that for very small layer separations and low layer densities, an interlayer-correlated ground state possessing spontaneous interlayer coherence (SILC) is obtained, even in the absence of interlayer tunneling. In contrast to earlier work, we find that as a function of total density, there exist four, rather than three, distinct noncrystalline phases for balanced double-layer systems without interlayer tunneling. The newly identified phase exists for a narrow range of densities and has three components and slightly unequal layer densities, with one layer being spin polarized, and the other unpolarized. An additional two-component phase is also possible in the presence of sufficiently strong bias or tunneling. The lowest-density SILC phase is the fully spin- and pseudospin-polarized ``one-component'' phase discussed by Zheng {\it et al.} [Phys. Rev. B {\bf 55}, 4506 (1997)]. We argue that this phase will produce a finite interlayer Coulomb drag at zero temperature due to the SILC. We calculate the particle densities in each layer as a function of the gate voltage and total particle density, and find that interlayer exchange can reduce or prevent abrupt transfers of charge between the two layers. We also calculate the effect of interlayer exchange on the interlayer capacitance.Comment: 35 pages, 19 figures included. To appear in PR

Anisotropic flow of charged hadrons, pions and (anti-)protons measured at high transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm NN}}=2.76 TeV

The elliptic, $v_2$, triangular, $v_3$, and quadrangular, $v_4$, azimuthal anisotropic flow coefficients are measured for unidentified charged particles, pions and (anti-)protons in Pb-Pb collisions at $\sqrt{s_{\rm NN}} = 2.76$ TeV with the ALICE detector at the Large Hadron Collider. Results obtained with the event plane and four-particle cumulant methods are reported for the pseudo-rapidity range $|\eta|<0.8$ at different collision centralities and as a function of transverse momentum, $p_{\rm T}$, out to $p_{\rm T}=20$ GeV/$c$. The observed non-zero elliptic and triangular flow depends only weakly on transverse momentum for $p_{\rm T}>8$ GeV/$c$. The small $p_{\rm T}$ dependence of the difference between elliptic flow results obtained from the event plane and four-particle cumulant methods suggests a common origin of flow fluctuations up to $p_{\rm T}=8$ GeV/$c$. The magnitude of the (anti-)proton elliptic and triangular flow is larger than that of pions out to at least $p_{\rm T}=8$ GeV/$c$ indicating that the particle type dependence persists out to high $p_{\rm T}$.Comment: 16 pages, 5 captioned figures, authors from page 11, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/186

Centrality dependence of charged particle production at large transverse momentum in Pb-Pb collisions at sNN=2.76\sqrt{s_{\rm{NN}}} = 2.76 TeV

The inclusive transverse momentum ($p_{\rm T}$) distributions of primary charged particles are measured in the pseudo-rapidity range $|\eta|<0.8$ as a function of event centrality in Pb-Pb collisions at $\sqrt{s_{\rm{NN}}}=2.76$ TeV with ALICE at the LHC. The data are presented in the $p_{\rm T}$ range $0.15<p_{\rm T}<50$ GeV/$c$ for nine centrality intervals from 70-80% to 0-5%. The Pb-Pb spectra are presented in terms of the nuclear modification factor $R_{\rm{AA}}$ using a pp reference spectrum measured at the same collision energy. We observe that the suppression of high-$p_{\rm T}$ particles strongly depends on event centrality. In central collisions (0-5%) the yield is most suppressed with $R_{\rm{AA}}\approx0.13$ at $p_{\rm T}=6$-7 GeV/$c$. Above $p_{\rm T}=7$ GeV/$c$, there is a significant rise in the nuclear modification factor, which reaches $R_{\rm{AA}} \approx0.4$ for $p_{\rm T}>30$ GeV/$c$. In peripheral collisions (70-80%), the suppression is weaker with $R_{\rm{AA}} \approx 0.7$ almost independently of $p_{\rm T}$. The measured nuclear modification factors are compared to other measurements and model calculations.Comment: 17 pages, 4 captioned figures, 2 tables, authors from page 12, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/284