198 research outputs found
Interactions among intermediate redshift galaxies. The case of SDSSJ134420.86+663717.8
We present the properties of the central supermassive black holes and the
host galaxies of the interacting object SDSSJ134420.86+663717.8. We obtained
optical long slit spectroscopy data from the Large Binocular Telescope (LBT)
using the Multi Object Double Spectrograph (MODS). Analysing the spectra
revealed several strong broad and narrow emission lines of ionised gas in the
nuclear region of one galaxy, whereas only narrow emission lines were visible
for the second galaxy. The optical spectra were used to plot diagnostic
diagrams, deduce rotation curves of the two galaxies, and calculate the masses
of the central supermassive black holes. We find that the galaxy with broad
emission line features has Seyfert~1 properties, while the galaxy with only
narrow emission line features seems to be star-forming in nature. Furthermore,
we find that the masses of the central supermassive black holes are almost
equal at a few times 10^7 solar mass. Additionally, we present a simple N-body
simulation to shed some light on the initial conditions of the progenitor
galaxies. We find that for an almost orthogonal approach of the two interacting
galaxies, the model resembles the optical image of the system
Das Konzept fĂŒr ein FDM-Kompetenznetzwerk an der UniversitĂ€t zu Köln
Forschungsdatenmanagement (FDM) hat sich innerhalb der letzten Jahre zunehmend als integraler Bestandteil von Forschungsprozessen etabliert. Durch diesen Umstand stellt es eine gemeinschaftliche Herausforderung in einem komplexen sozio-technologischen Umfeld dar.
Das 2018 an der UniversitĂ€t zu Köln (UzK) gegrĂŒndete Cologne Competence Center for Research Data Management (C3RDM) legt u. a. einen Fokus auf die stĂ€rkere Vernetzung der FDM-Akteur*innen auf dem Campus. Diese erscheint notwendig, da FDM an vielen Stellen der UniversitĂ€t in einer nur sehr lose gekoppelten Art und Weise stattfindet, bspw. in Forschungsprojekten, in Instituten, an FakultĂ€ten usw. Der hier vorgestellte Ansatz geht von den zentralen Infrastruktureinrichtungen (UniversitĂ€ts- und Stadtbibliothek, Regionales Rechenzentrum, Forschungsmanagement) aus, die im C3RDM kooperieren und ein strukturelles Modell fĂŒr ein universitĂ€tsweites FDM konzipieren sollen, das sowohl Policies, Entwicklungskonzepte, als auch ein Service-Portfolio zum FDM umfasst. Die bereits vorhandenen und noch aufzubauenden Services auf Seiten des C3RDM sollen möglichst generisch sein und in die Breite wirken. FĂŒr den weiteren Aufbau ist es auĂerdem wichtig, eine gezielte Vernetzung zwischen allen Stakeholdern voranzutreiben, um Fachspezifika und lokale Strukturen zu berĂŒcksichtigen. Zur systematischen Förderung des fakultĂ€tsĂŒbergreifenden Erfahrungsaustausches zwischen den FDM-Akteur*innen gibt das C3RDM zukĂŒnftig Impulse, um Synergien zu identifizieren und nachhaltige FDM-Strukturen aufzubauen.
Ausgehend von einem generischen FDM-Service-Portfolio prĂ€sentieren wir ein initiales Konzept fĂŒr die Vernetzung an der UzK und erste Erfahrungen bei deren Umsetzung. Bei der GröĂe des Standortes und der KomplexitĂ€t der Aufgabe ist eine wichtige Charakteristik in diesem Zusammenhang der experimentelle Charakter, d. h., die iterative Erprobung und Anpassung an spezifische Bedingungen (lokal oder fachspezifisch)
Epidemiology and Risk Factors for Cryptosporidiosis in Children from 8 Low-income Sites : Results from the MAL-ED Study
Funding Information: The MAL-ED study is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the National Institutes of Health (NIH), and the NIH Fogarty International Center. This work was also supported by the National Institute of Allergy and Infectious Diseases of the NIH (grant numbers K23 AI087910 to P. K. and K23 AI087910 to W. A. P.) and by the Sherrilyn and Ken Fisher Center for Environmental Infectious Diseases Discovery Program (to P. D.).Peer reviewedPublisher PD
Aberrant crossed corticospinal facilitation in muscles distant from a spinal cord injury.
Crossed facilitatory interactions in the corticospinal pathway are impaired in humans with chronic incomplete spinal cord injury (SCI). The extent to which crossed facilitation is affected in muscles above and below the injury remains unknown. To address this question we tested 51 patients with neurological injuries between C2-T12 and 17 age-matched healthy controls. Using transcranial magnetic stimulation we elicited motor evoked potentials (MEPs) in the resting first dorsal interosseous, biceps brachii, and tibialis anterior muscles when the contralateral side remained at rest or performed 70% of maximal voluntary contraction (MVC) into index finger abduction, elbow flexion, and ankle dorsiflexion, respectively. By testing MEPs in muscles with motoneurons located at different spinal cord segments we were able to relate the neurological level of injury to be above, at, or below the location of the motoneurons of the muscle tested. We demonstrate that in patients the size of MEPs was increased to a similar extent as in controls in muscles above the injury during 70% of MVC compared to rest. MEPs remained unchanged in muscles at and within 5 segments below the injury during 70% of MVC compared to rest. However, in muscles beyond 5 segments below the injury the size of MEPs increased similar to controls and was aberrantly high, 2-fold above controls, in muscles distant (>15 segments) from the injury. These aberrantly large MEPs were accompanied by larger F-wave amplitudes compared to controls. Thus, our findings support the view that corticospinal degeneration does not spread rostral to the lesion, and highlights the potential of caudal regions distant from an injury to facilitate residual corticospinal output after SCI
METODOLOGĂA DE SELECCIĂN DE POZOS CANDIDATOS PARA TRATAMIENTOS DE CONFORMANCE QUĂMICO
La canalizaciĂłn generalmente es consecuencia de la heterogeneidad del yacimiento, especialmente por grandes variaciones de permeabilidad, ocasionando reducciĂłn en la eficiencia volumĂ©trica como producto de la recirculaciĂłn del fluido inyectado en procesos de recobro secundario y/o mejorado (EOR). Con el objetivo de mejorar el perfil vertical de inyecciĂłn y reducir la recirculaciĂłn de agua inyectada, en Colombia se han implementado, desde el año 2008 a 2020, 33 tratamientos de control de canalizaciĂłn y conformance quĂmico profundo en nueve campos con el objetivo de aumentar la eficiencia de barrido volumĂ©trico para incrementar el factor de recuperaciĂłn de petrĂłleo. El resultado de los tratamientos reportados es de hasta 3 barriles de petrĂłleo incremental por cada barril de gel rĂgido inyectado. Sin embargo, la cantidad de tratamientos de conformance es baja en comparaciĂłn con el nĂșmero de pozos inyectores en el paĂs de aproximadamente 1400).
Por lo tanto, Ecopetrol adaptĂł una metodologĂa de selecciĂłn de pozos candidatos para tratamientos de conformance quĂmico que tiene en cuenta continuidad de los yacimientos, determinaciĂłn y caracterizaciĂłn de la heterogeneidad, estudio de movimiento de fluidos, determinaciĂłn de conectividad del patrĂłn de inyecciĂłn, distribuciĂłn vertical y areal de los fluidos inyectados y producidos, generaciĂłn de grĂĄficos diagnĂłsticos en software Sahara para finalmente identificar los pozos candidatos y realizar el diseño del tratamiento de conformance.
La generaciĂłn de los grĂĄficos diagnĂłstico base de la metodologĂa tiene como punto de partida la distribuciĂłn vertical de producciĂłn secundaria realizada por el mĂ©todo IWR de alocaciĂłn de producciones de malla ponderando caudales, en el cual la producciĂłn de un pozo es distribuida entre los inyectores que lo afectan, y esta producciĂłn es asociada a cada inyector.
Con respecto a la distribuciĂłn areal se toman elementos de flujo creando mallas dinĂĄmicas centradas en inyector y se pondera utilizando la distribuciĂłn angular. La distribuciĂłn de producciĂłn secundaria tiene en cuenta los ILT/PLT realizados histĂłricamente en los pozos inyectores/ productores, mallado y coeficientes de distribuciĂłn de los patrones de inyecciĂłn en el tiempo.
En el presente trabajo se hace una descripciĂłn y aplicaciĂłn de la metodologĂa integrada que permite identificar la producciĂłn de petrĂłleo y agua por yacimiento en cada patrĂłn de inyecciĂłn, asĂ como la eficiencia del agua inyectada para mapear acciones de mejoramiento de la producciĂłn de petrĂłleo y disminuciĂłn de la producciĂłn de agua, con el objetivo de identificar los sectores con menor desempeño y que requieren optimizaciĂłn del proceso secundario y/o mejorado. La metodologĂa se validĂł y complementĂł con informaciĂłn de trazadores interwell (IWTT) y simulaciĂłn numĂ©rica en lĂneas de flujo (streamline). En ese sentido, se vienen aplicando tratamientos de conformance desde el año 2021 en 23 nuevos pozos con resultados prometedores de producciĂłn incremental de petrĂłleo. La selecciĂłn de pozos candidatos para tratamientos de conformance quĂmico amplĂan las expectativas de masificaciĂłn de estas tecnologĂas en diferentes campos del paĂs y se convierten en pieza fundamental para apalancar la consecuciĂłn de reservas y una disminuciĂłn de la huella de carbono debido principalmente a que con el mismo caudal de fluido inyectado se incrementa la producciĂłn de petrĂłleo y en algunos tratamientos puede disminuir la producciĂłn de agua, asegurando menor consumo de energĂa (CO2) por cada barril de petrĂłleo extraĂdo
A Fine-Structure Map of Spontaneous Mitotic Crossovers in the Yeast Saccharomyces cerevisiae
Homologous recombination is an important mechanism for the repair of DNA damage in mitotically dividing cells. Mitotic crossovers between homologues with heterozygous alleles can produce two homozygous daughter cells (loss of heterozygosity), whereas crossovers between repeated genes on non-homologous chromosomes can result in translocations. Using a genetic system that allows selection of daughter cells that contain the reciprocal products of mitotic crossing over, we mapped crossovers and gene conversion events at a resolution of about 4 kb in a 120-kb region of chromosome V of Saccharomyces cerevisiae. The gene conversion tracts associated with mitotic crossovers are much longer (averaging about 12 kb) than the conversion tracts associated with meiotic recombination and are non-randomly distributed along the chromosome. In addition, about 40% of the conversion events have patterns of marker segregation that are most simply explained as reflecting the repair of a chromosome that was broken in G1 of the cell cycle
REVIEW OF PARTICLE PHYSICS
The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,324 new measurements from 878 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and baryons. We summarize searches for hypothetical particles such as supersymmetric particles, heavy bosons, axions, dark photons, etc. Particle properties and search limits are listed in Summary Tables. We give numerous tables, figures, formulae, and reviews of topics such as Higgs Boson Physics, Supersymmetry, Grand Unified Theories, Neutrino Mixing, Dark Energy, Dark Matter, Cosmology, Particle Detectors, Colliders, Probability and Statistics. Among the 120 reviews are many that are new or heavily revised, including a new review on High Energy Soft QCD and Diffraction and one on the Determination of CKM Angles from B Hadrons. The Review is divided into two volumes. Volume 1 includes the Summary Tables and 98 review articles. Volume 2 consists of the Particle Listings and contains also 22 reviews that address specific aspects of the data presented in the Listings. The complete Review (both volumes) is published online on the website of the Particle Data Group (pdg.lbl.gov) and in a journal. Volume 1 is available in print as the PDG Book. A Particle Physics Booklet with the Summary Tables and essential tables, figures, and equations from selected review articles is available in print and as a web version optimized for use on phones as well as an Android app.Peer reviewe
Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study
Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised
GA4GH: International policies and standards for data sharing across genomic research and healthcare.
The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical and genomic data through both harmonized data aggregation and federated approaches. The decreasing cost of genomic sequencing (along with other genome-wide molecular assays) and increasing evidence of its clinical utility will soon drive the generation of sequence data from tens of millions of humans, with increasing levels of diversity. In this perspective, we present the GA4GH strategies for addressing the major challenges of this data revolution. We describe the GA4GH organization, which is fueled by the development efforts of eight Work Streams and informed by the needs of 24 Driver Projects and other key stakeholders. We present the GA4GH suite of secure, interoperable technical standards and policy frameworks and review the current status of standards, their relevance to key domains of research and clinical care, and future plans of GA4GH. Broad international participation in building, adopting, and deploying GA4GH standards and frameworks will catalyze an unprecedented effort in data sharing that will be critical to advancing genomic medicine and ensuring that all populations can access its benefits
- âŠ