185 research outputs found
Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline
Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers
The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for “microdosing.”National Science Foundation (U.S.). Graduate Research FellowshipNational Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32CA159496-02)Burroughs Wellcome Fund (Career Award at the Scientific Interface)National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)David H. Koch Institute for Integrative Cancer Research at MIT (Frontier Research Program
CHIME/FRB Detection of Eight New Repeating Fast Radio Burst Sources
We report on the discovery of eight repeating fast radio burst (FRB) sources
found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME)
telescope. These sources span a dispersion measure (DM) range of 103.5 to 1281
pc cm. They display varying degrees of activity: six sources were
detected twice, another three times, and one ten times. These eight repeating
FRBs likely represent the bright and/or high-rate end of a distribution of
infrequently repeating sources. For all sources, we determine sky coordinates
with uncertainties of 10. FRB 180916.J0158+65 has a
burst-averaged DM = pc cm and a low DM excess over the
modelled Galactic maximum (as low as 20 pc cm); this source also
has a Faraday rotation measure (RM) of rad m, much
lower than the RM measured for FRB 121102. FRB 181030.J1054+73 has the lowest
DM for a repeater, pc cm, with a DM excess of 70
pc cm. Both sources are interesting targets for multi-wavelength
follow-up due to their apparent proximity. The DM distribution of our repeater
sample is statistically indistinguishable from that of the first 12 CHIME/FRB
sources that have not repeated. We find, with 4 significance, that
repeater bursts are generally wider than those of CHIME/FRB bursts that have
not repeated, suggesting different emission mechanisms. Our repeater events
show complex morphologies that are reminiscent of the first two discovered
repeating FRBs. The repetitive behavior of these sources will enable
interferometric localizations and subsequent host galaxy identifications.Comment: 40 pages, 11 figures; accepted by ApJL on 28 September 2019; added
analysis of correlation between width and max. flux densit
Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products
Elucidating the sites and mechanisms of sRAGE action in the healthy state is vital to better understand the biological importance of the receptor for advanced glycation end products (RAGE). Previous studies in animal models of disease have demonstrated that exogenous sRAGE has an anti-inflammatory effect, which has been reasoned to arise from sequestration of pro-inflammatory ligands away from membrane-bound RAGE isoforms. We show here that sRAGE exhibits in vitro binding with high affinity and reversibly to extracellular matrix components collagen I, collagen IV, and laminin. Soluble RAGE administered intratracheally, intravenously, or intraperitoneally, does not distribute in a specific fashion to any healthy mouse tissue, suggesting against the existence of accessible sRAGE sinks and receptors in the healthy mouse. Intratracheal administration is the only effective means of delivering exogenous sRAGE to the lung, the organ in which RAGE is most highly expressed; clearance of sRAGE from lung does not differ appreciably from that of albumin. Copyright: © 2014 Milutinovic et al
Periodic activity from a fast radio burst source
Fast radio bursts (FRBs) are bright, millisecond-duration radio transients
originating from extragalactic distances. Their origin is unknown. Some FRB
sources emit repeat bursts, ruling out cataclysmic origins for those events.
Despite searches for periodicity in repeat burst arrival times on time scales
from milliseconds to many days, these bursts have hitherto been observed to
appear sporadically, and though clustered, without a regular pattern. Here we
report the detection of a day periodicity (or possibly a
higher-frequency alias of that periodicity) from a repeating FRB
180916.J0158+65 detected by the Canadian Hydrogen Intensity Mapping Experiment
Fast Radio Burst Project (CHIME/FRB). In 38 bursts recorded from September
16th, 2018 through February 4th, 2020, we find that all bursts arrive in a
5-day phase window, and 50% of the bursts arrive in a 0.6-day phase window. Our
results suggest a mechanism for periodic modulation either of the burst
emission itself, or through external amplification or absorption, and disfavour
models invoking purely sporadic processes
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