242 research outputs found
Large excess of heavy nitrogen in both hydrogen cyanide and cyanogen from comet 17P/Holmes
From millimeter and optical observations of the Jupiter-family comet
17P/Holmes performed soon after its huge outburst of October 24, 2007, we
derive 14 N/15N = 139 +/- 26 in HCN, and 14N/15N = 165 +/- 40 in CN,
establishing that HCN has the same non-terrestrial isotopic composition as CN.
The same conclusion is obtained for the long-period comet C/1995 O1 (Hale-Bopp)
after a reanalysis of previously published measurements. These results are
compatible with HCN being the prime parent of CN in cometary atmospheres. The
15N excess relative to the Earth atmospheric value indicates that N-bearing
volatiles in the solar nebula underwent important N isotopic fractionation at
some stage of Solar System formation. HCN molecules never isotopically
equilibrated with the main nitrogen reservoir in the solar nebula before being
incorporated in Oort-cloud and Kuiper-belt comets. The 12C/13C ratios in HCN
and CN are measured to be consistent with the terrestrial value.Comment: Accepted for publication in the Astrophysical Journal (Letters) 4
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Observation of associated near-side and away-side long-range correlations in √sNN=5.02 TeV proton-lead collisions with the ATLAS detector
Two-particle correlations in relative azimuthal angle (Δϕ) and pseudorapidity (Δη) are measured in √sNN=5.02 TeV p+Pb collisions using the ATLAS detector at the LHC. The measurements are performed using approximately 1 μb-1 of data as a function of transverse momentum (pT) and the transverse energy (ΣETPb) summed over 3.1<η<4.9 in the direction of the Pb beam. The correlation function, constructed from charged particles, exhibits a long-range (2<|Δη|<5) “near-side” (Δϕ∼0) correlation that grows rapidly with increasing ΣETPb. A long-range “away-side” (Δϕ∼π) correlation, obtained by subtracting the expected contributions from recoiling dijets and other sources estimated using events with small ΣETPb, is found to match the near-side correlation in magnitude, shape (in Δη and Δϕ) and ΣETPb dependence. The resultant Δϕ correlation is approximately symmetric about π/2, and is consistent with a dominant cos2Δϕ modulation for all ΣETPb ranges and particle pT
Defending the genome from the enemy within:mechanisms of retrotransposon suppression in the mouse germline
The viability of any species requires that the genome is kept stable as it is transmitted from generation to generation by the germ cells. One of the challenges to transgenerational genome stability is the potential mutagenic activity of transposable genetic elements, particularly retrotransposons. There are many different types of retrotransposon in mammalian genomes, and these target different points in germline development to amplify and integrate into new genomic locations. Germ cells, and their pluripotent developmental precursors, have evolved a variety of genome defence mechanisms that suppress retrotransposon activity and maintain genome stability across the generations. Here, we review recent advances in understanding how retrotransposon activity is suppressed in the mammalian germline, how genes involved in germline genome defence mechanisms are regulated, and the consequences of mutating these genome defence genes for the developing germline
CHIME/FRB Detection of Eight New Repeating Fast Radio Burst Sources
We report on the discovery of eight repeating fast radio burst (FRB) sources
found using the Canadian Hydrogen Intensity Mapping Experiment (CHIME)
telescope. These sources span a dispersion measure (DM) range of 103.5 to 1281
pc cm. They display varying degrees of activity: six sources were
detected twice, another three times, and one ten times. These eight repeating
FRBs likely represent the bright and/or high-rate end of a distribution of
infrequently repeating sources. For all sources, we determine sky coordinates
with uncertainties of 10. FRB 180916.J0158+65 has a
burst-averaged DM = pc cm and a low DM excess over the
modelled Galactic maximum (as low as 20 pc cm); this source also
has a Faraday rotation measure (RM) of rad m, much
lower than the RM measured for FRB 121102. FRB 181030.J1054+73 has the lowest
DM for a repeater, pc cm, with a DM excess of 70
pc cm. Both sources are interesting targets for multi-wavelength
follow-up due to their apparent proximity. The DM distribution of our repeater
sample is statistically indistinguishable from that of the first 12 CHIME/FRB
sources that have not repeated. We find, with 4 significance, that
repeater bursts are generally wider than those of CHIME/FRB bursts that have
not repeated, suggesting different emission mechanisms. Our repeater events
show complex morphologies that are reminiscent of the first two discovered
repeating FRBs. The repetitive behavior of these sources will enable
interferometric localizations and subsequent host galaxy identifications.Comment: 40 pages, 11 figures; accepted by ApJL on 28 September 2019; added
analysis of correlation between width and max. flux densit
A fast radio burst localized at detection to a galactic disk using very long baseline interferometry
Fast radio bursts (FRBs) are millisecond-duration, luminous radio transients
of extragalactic origin. These events have been used to trace the baryonic
structure of the Universe using their dispersion measure (DM) assuming that the
contribution from host galaxies can be reliably estimated. However,
contributions from the immediate environment of an FRB may dominate the
observed DM, thus making redshift estimates challenging without a robust host
galaxy association. Furthermore, while at least one Galactic burst has been
associated with a magnetar, other localized FRBs argue against magnetars as the
sole progenitor model. Precise localization within the host galaxy can
discriminate between progenitor models, a major goal of the field. Until now,
localizations on this spatial scale have only been carried out in follow-up
observations of repeating sources. Here we demonstrate the localization of FRB
20210603A with very long baseline interferometry (VLBI) on two baselines, using
data collected only at the time of detection. We localize the burst to SDSS
J004105.82+211331.9, an edge-on galaxy at , and detect recent
star formation in the kiloparsec-scale vicinity of the burst. The edge-on
inclination of the host galaxy allows for a unique comparison between the line
of sight towards the FRB and lines of sight towards known Galactic pulsars. The
DM, Faraday rotation measure (RM), and scattering suggest a progenitor
coincident with the host galactic plane, strengthening the link between the
environment of FRB 20210603A and the disk of its host galaxy. Single-pulse VLBI
localizations of FRBs to within their host galaxies, following the one
presented here, will further constrain the origins and host environments of
one-off FRBs.Comment: 40 pages, 13 figures, submitted. Fixed typo in abstrac
Disease Detection by Ultrasensitive Quantification of Microdosed Synthetic Urinary Biomarkers
The delivery of exogenous agents can enable noninvasive disease monitoring, but existing low-dose approaches require complex infrastructure. In this paper, we describe a microdose-scale injectable formulation of nanoparticles that interrogate the activity of thrombin, a key regulator of clotting, and produce urinary reporters of disease state. We establish a customized single molecule detection assay that enables urinary discrimination of thromboembolic disease in mice using doses of the nanoparticulate diagnostic agents that fall under regulatory guidelines for “microdosing.”National Science Foundation (U.S.). Graduate Research FellowshipNational Institutes of Health (U.S.) (Ruth L. Kirschstein National Research Service Award F32CA159496-02)Burroughs Wellcome Fund (Career Award at the Scientific Interface)National Cancer Institute (U.S.) (Koch Institute Support (Core) Grant P30-CA14051)David H. Koch Institute for Integrative Cancer Research at MIT (Frontier Research Program
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