Women's experiences and representations of diversity management and organizational restructuring in a multinational forest company

This thesis examines the relationship between worker identity and workplace practices from the perspectives of white and Aboriginal women working in a multinational forest company in the northern prairies. Over the course of three manuscripts I demonstrate the salience of ascribed and constructed identities of women to their experiences and representations of forest employment and corporate discourse. Setting the context for the remainder of the thesis, the first manuscript presents an analysis of employment segregation by gender and Aboriginal identity in Canada’s forest sector in 2001 using segregation indices. Results demonstrate that forest employment was vertically segregated by both gender and Aboriginal ancestry in the forest sector in 2001. Men and women of First Nations ancestry were over represented in less-stable and lower paying occupations in woods based forest industries, and both white and First Nations women were over represented in forest services and clerical occupations. To explore women’s perceptions of company practices of diversity management and restructuring, I then analysed interviews with women working in forest processing using critical discourse analysis. In my second manuscript, I demonstrated how women’s representations of diversity management practices were linked to their social identities in terms of Aboriginal identity and class. Yet, as a whole, these representations prompted a questioning of the meaning of difference within diversity management, and of diversity management’s ability to further the interests of marginalised workers. My third manuscript examining representations of restructuring, argues that there is a two way relationship between women’s identities as workers and their representations of restructuring. Whether women reproduced or resisted restructuring was linked to their presented work identities and restructuring and practices in turn were helping to shape women’s worker subjectivities. Results from this thesis demonstrated that how women represent themselves and workplace practices is related to their different experiences in the specific set of social relations of forestry work in the northern prairies

Client experience of rape victims accessing governmental post-rape services in South Africa

This study aims to better understand the experiences of rape victims accessing governmental post-rape services in South Africa. It was part of a larger intervention to develop an e-governance mobile phone ratings app for reporting user satisfaction with post-rape services, which aimed to improve accountability and responsiveness. Participants highlighted positive, negative and often mixed experiences in accessing post-rape services. Entry to centres was often delayed due to low levels of awareness, indirect referrals and delays at police stations. Positive experiences were characterised as welcoming, friendly, empathetic and non-judgemental. Negative experiences were characterised as threatening, blaming, physiologically taxing and lacking in empathy. Inadequate follow-up, delays in progress of cases, and poor communication and quality of information contributed to dissatisfaction with services. The findings of the study were used to inform the design and content of the app, as well as its technology platform and the content of marketing material. These contributed to its successful piloting and use.DFIDUSAIDSIDAOmidyar Networ

Feasibility and acceptability of a mobile phone intervention to improve post-rape service delivery in South Africa

Mobile health (mHealth) interventions – in which mobile phones are used to advance positive health outcomes – have only recently been applied to addressing broader questions of health governance. This report discusses research on a mobile phone app that was designed to create a coordinated platform through which rape victims could express their views on the quality of services and support offered by police and health-care workers in South Africa, in order to promote greater accountability between service providers and clients.The study, which assessed the feasibility and acceptability of the proposed app, comprised qualitative and quantitative research with rape victims and caregivers accessing follow-up services at four rape care centres in Tshwane district, Pretoria. Of 140 participants enrolled in the study (108 rape victims and 32 caregivers), 86.4% reported owning a mobile phone. However, the results also revealed that mobile phone theft during sexual assault was common, with 34 out of 63 participants (55%) who did not bring their mobile phones to their first visit to the facility reporting that their phone had been stolen during the assault. Nonetheless, the findings confirmed the feasibility of the app, which was subsequently developed and piloted. In addition, high levels of interest in using mobile phones to provide feedback on the quality of service delivery (95%) showed the potential value of such an intervention for improved communication between service users and providers.DFIDUSAIDOmidyar NetworkSID

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Early Life Child Micronutrient Status, Maternal Reasoning, and a Nurturing Household Environment have Persistent Influences on Child Cognitive Development at Age 5 years : Results from MAL-ED

Funding Information: The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project (MAL-ED) is carried out as a collaborative project supported by the Bill & Melinda Gates Foundation, the Foundation for the NIH, and the National Institutes of Health/Fogarty International Center. This work was also supported by the Fogarty International Center, National Institutes of Health (D43-TW009359 to ETR). Author disclosures: BJJM, SAR, LEC, LLP, JCS, BK, RR, RS, ES, LB, ZR, AM, RS, BN, SH, MR, RO, ETR, and LEM-K, no conflicts of interest. Supplemental Tables 1–5 and Supplemental Figures 1–3 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/jn/. Address correspondence to LEM-K (e-mail: [email protected]). Abbreviations used: HOME, Home Observation for Measurement of the Environment inventory; MAL-ED, The Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development Project; TfR, transferrin receptor; WPPSI, Wechsler Preschool Primary Scales of Intelligence.Peer reviewe

Early life child micronutrient status, maternal reasoning, and a nurturing household environment have persistent influences on child cognitive development at age 5 years: Results from MAL-ED

Background: Child cognitive development is influenced by early-life insults and protective factors. To what extent these factors have a long-term legacy on child development and hence fulfillment of cognitive potential is unknown. Objective: The aim of this study was to examine the relation between early-life factors (birth to 2 y) and cognitive development at 5 y. Methods: Observational follow-up visits were made of children at 5 y, previously enrolled in the community-based MAL-ED longitudinal cohort. The burden of enteropathogens, prevalence of illness, complementary diet intake, micronutrient status, and household and maternal factors from birth to 2 y were extensively measured and their relation with the Wechsler Preschool Primary Scales of Intelligence at 5 y was examined through use of linear regression. Results: Cognitive T-scores from 813 of 1198 (68%) children were examined and 5 variables had significant associations in multivariable models: mean child plasma transferrin receptor concentration (β: −1.81, 95% CI: −2.75, −0.86), number of years of maternal education (β: 0.27, 95% CI: 0.08, 0.45), maternal cognitive reasoning score (β: 0.09, 95% CI: 0.03, 0.15), household assets score (β: 0.64, 95% CI: 0.24, 1.04), and HOME child cleanliness factor (β: 0.60, 95% CI: 0.05, 1.15). In multivariable models, the mean rate of enteropathogen detections, burden of illness, and complementary food intakes between birth and 2 y were not significantly related to 5-y cognition. Conclusions: A nurturing home context in terms of a healthy/clean environment and household wealth, provision of adequate micronutrients, maternal education, and cognitive reasoning have a strong and persistent influence on child cognitive development. Efforts addressing aspects of poverty around micronutrient status, nurturing caregiving, and enabling home environments are likely to have lasting positive impacts on child cognitive development.publishedVersio

A communal catalogue reveals Earth's multiscale microbial diversity

Our growing awareness of the microbial world's importance and diversity contrasts starkly with our limited understanding of its fundamental structure. Despite recent advances in DNA sequencing, a lack of standardized protocols and common analytical frameworks impedes comparisons among studies, hindering the development of global inferences about microbial life on Earth. Here we present a meta-analysis of microbial community samples collected by hundreds of researchers for the Earth Microbiome Project. Coordinated protocols and new analytical methods, particularly the use of exact sequences instead of clustered operational taxonomic units, enable bacterial and archaeal ribosomal RNA gene sequences to be followed across multiple studies and allow us to explore patterns of diversity at an unprecedented scale. The result is both a reference database giving global context to DNA sequence data and a framework for incorporating data from future studies, fostering increasingly complete characterization of Earth's microbial diversity.Peer reviewe