158 research outputs found
Polarization aberrations in next-generation giant segmented mirror telescopes (GSMTs) I. Effect on the coronagraphic performance
Next-generation large segmented mirror telescopes are expected to perform
direct imaging and characterization of Earth-like rocky planets, which requires
contrast limits of to at wavelengths from I to J band. One
critical aspect affecting the raw on-sky contrast are polarization aberrations
arising from the reflection from the telescope's mirror surfaces and instrument
optics. We simulate the polarization aberrations and estimate their effect on
the achievable contrast for three next-generation ground-based large segmented
mirror telescopes. We performed ray-tracing in Zemax and computed the
polarization aberrations and Jones pupil maps using the polarization
ray-tracing algorithm. The impact of these aberrations on the contrast is
estimated by propagating the Jones pupil maps through a set of idealized
coronagraphs using hcipy, a physical optics-based simulation framework. The
optical modeling of the giant segmented mirror telescopes (GSMTs) shows that
polarization aberrations create significant leakage through a coronagraphic
system. The dominant aberration is retardance defocus, which originates from
the steep angles on the primary and secondary mirrors. The retardance defocus
limits the contrast to to at 1 at visible
wavelengths, and to at infrared wavelengths. The
simulations also show that the coating plays a major role in determining the
strength of the aberrations. Polarization aberrations will need to be
considered during the design of high-contrast imaging instruments for the next
generation of extremely large telescopes. This can be achieved either through
compensation optics, robust coronagraphs, specialized coatings, calibration,
and data analysis approaches or by incorporating polarimetry with high-contrast
imaging to measure these effects.Comment: 18 pages, 12 figures, Accepted in Astronomy & Astrophysics manuscript
no. aa45651-2
Your Trash Is Someone's Treasure The Politics of Value at a Michigan Landfill
This article discusses scavenging and dumping as alternative approaches to deriving value from rubbish at a large Michigan landfill. Both practices are attuned to the indeterminacy and power of abandoned things, but in different ways. Whereas scavenging relies on acquiring familiarity with an object by getting to know its particular qualities, landfilling and other forms of mass disposal make discards fungible and manipulable by stripping them of their former identities. By way of examining the different ways in which people become invested in the politics of value at the landfill, whether as part of expressions of gender and class or for personal enjoyment, different comportments toward materiality are revealed to have underlying social and moral implications. In particular, it is argued that different approaches to the evaluation of rubbish involve competing understandings of human and material potential
Roles for H2A.Z and Its Acetylation in GAL1 Transcription and Gene Induction, but Not GAL1-Transcriptional Memory
H2A.Z does not appear to have a role in GAL1 transcriptional memory, but it does have both acetylation-dependent and acetylation-independent roles in GAL1 induction and expression
Grain Surface Models and Data for Astrochemistry
AbstractThe cross-disciplinary field of astrochemistry exists to understand the formation, destruction, and survival of molecules in astrophysical environments. Molecules in space are synthesized via a large variety of gas-phase reactions, and reactions on dust-grain surfaces, where the surface acts as a catalyst. A broad consensus has been reached in the astrochemistry community on how to suitably treat gas-phase processes in models, and also on how to present the necessary reaction data in databases; however, no such consensus has yet been reached for grain-surface processes. A team of ∼25 experts covering observational, laboratory and theoretical (astro)chemistry met in summer of 2014 at the Lorentz Center in Leiden with the aim to provide solutions for this problem and to review the current state-of-the-art of grain surface models, both in terms of technical implementation into models as well as the most up-to-date information available from experiments and chemical computations. This review builds on the results of this workshop and gives an outlook for future directions
Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms.
Due to their similarities in anatomy, physiology, and pharmacology to humans, mice are a valuable model system to study the generation and mechanisms modulating conventional outflow resistance and thus intraocular pressure. In addition, mouse models are critical for understanding the complex nature of conventional outflow homeostasis and dysfunction that results in ocular hypertension. In this review, we describe a set of minimum acceptable standards for developing, characterizing, and utilizing mouse models of open-angle ocular hypertension. We expect that this set of standard practices will increase scientific rigor when using mouse models and will better enable researchers to replicate and build upon previous findings
Whole-genome sequencing reveals host factors underlying critical COVID-19
Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease
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