Energiesprong - Betrachtung des ganzheitlichen Konzepts für serielles Sanieren unter den Rahmenbedingungen von Mehrfamilienhäusern

Energiesprong (niederländisch für Energiesprung) ist ein innovatives Konzept für die energetische Sanierung von Wohngebäuden, das schnelle Umsetzung, Kostenreduktion, Nachhaltigkeit und Mieterfreundlichkeit verspricht. Energiesprong setzt auf industrielle Vorfertigung von Fassaden- und Dachelementen (serielle Sanierung) und den Einsatz von regenerativen Energien, um den sogenannten NetZero-Standard (entspricht dem Nullenergiehaus) zu erreichen. Ziel ist es, eine für alle Beteiligten attraktive Sanierung zu ermöglichen. Dies wird unter anderem über erheblich verkürzte Montagezeiten und warmmietenneutrale Refinanzierung angestrebt. Die dafür erforderlichen Kostensenkungen werden beim seriellen Sanieren durch die Automatisierung in der Produktion und Skaleneffekte in der Massenfertigung erreicht. Im Rahmen dieser Arbeit soll das Konzept Energiesprong hinsichtlich der Anwendung auf Mehrfamilienhäuser betrachtet und kritisch hinterfragt werden. Dazu werden zuvorderst die politischen und praktischen Gründe umrissen, die die Notwendigkeit und das Potenzial von innovativen Ansätzen darstellen. Im zweiten Kapitel wird das Energiesprong-Konzept detailliert erläutert; neben den Innovationen im Plan und Bauverfahren werden die Besonderheiten der Gebäudehülle, der Anlagentechnik und des Energiekonzepts beschrieben. Darüber hinaus werden wirtschaftliche Aspekte und die Rolle der verschiedenen Akteure umrissen. Aus der Beschreibung gehen eine Vielzahl an Vorteilen hervor, die Energiesprong gegenüber konventionellen Sanierungsverfahren verspricht. Anschließend werden einige Punkte dieser zentralen Versprechen diskutiert und eine Grundlage für die Entwicklung von Kriterien zukünftiger Evaluationen entwickelt

Exophiala angulospora infection in hatchery reared lumpfish (Cyclopterus lumpus) broodstock

Funding Information Biotechnology and Biological Sciences Research Council. Grant Numbers: BB/M026566/1, BB/P020224/1 Natural Environment Research Council. Grant Number: NE/P007570/1 University of AberdeenPeer reviewedPublisher PD

Clinical Relevance of Transjugular Liver Biopsy in Comparison with Percutaneous and Laparoscopic Liver Biopsy

Background. Transjugular liver biopsy (TJLB) is frequently used to obtain liver specimens in high-risk patients. However, TJLB sample size possibly limits their clinical relevance. Methods. 102 patients that underwent TJLB were included. Clinical parameters and outcome of TJLB were analyzed. Control samples consisted of 112 minilaparoscopic liver biopsies (mLLBs) and 100 percutaneous liver biopsies (PLBs). Results. Fewer portal tracts were detected in TJLB (4.3 ± 0.3) in comparison with PLB (11.7 ± 0.5) and mLLB (11.0 ± 0.6). No difference regarding the specification of indeterminate liver disease and staging/grading of chronic hepatitis was observed. In acute liver failure (n = 32), a proportion of hepatocellular necrosis beyond 25% was associated with a higher rate of death or liver transplantation. Conclusions. Despite smaller biopsy samples the impact on the clinical decision process was found to be comparable to PLB and mLLB. TJLB represents a helpful tool to determine hepatocellular necrosis rates in patients with acute liver failure

Economic Transition and Natural Resource Management in East-and Southeast Asia

Abstract: For several decades the effective and efficient dissemination of new agricultural knowledge among farmers in developing countries has been problematic. Two major programs were implemented in Indonesia, namely The Training and Visit (T&V) Extension Program or The Massive Guidance (BIMAS) Program, from the mid 1960s until the end of the1980s, and the Farmer Field School (FFS) Program, during the 1990s. The main difference between these two programs is that, where the T&V was concerned, farmers were instructed what to do, while the FFS program encouraged and stimulated farmers to make their own decisions. This paper aims to discuss and compare the effectiveness of these two programs with reference to rice production in Indonesia. This paper would like to argue that, for regions where the level of development is still very low, implementing a T&V program instructing farmers what to do is probably more appropriate than an FFS. As for regions where agriculture is relatively developed, an effective FFS program is more appropriate

Frequency, prognostic impact, and subtype association of 8p12, 8q24, 11q13, 12p13, 17q12, and 20q13 amplifications in breast cancers

BACKGROUND: Oncogene amplification and overexpression occur in tumor cells. Amplification status may provide diagnostic and prognostic information and may lead to new treatment strategies. Chromosomal regions 8p12, 8q24, 11q13, 17q12 and 20q13 are recurrently amplified in breast cancers. METHODS: To assess the frequencies and clinical impact of amplifications, we analyzed 547 invasive breast tumors organized in a tissue microarray (TMA) by fluorescence in situ hybridization (FISH) and calculated correlations with histoclinical features and prognosis. BAC probes were designed for: (i) two 8p12 subregions centered on RAB11FIP1 and FGFR1 loci, respectively; (ii) 11q13 region centered on CCND1; (iii) 12p13 region spanning NOL1; and (iv) three 20q13 subregions centered on MYBL2, ZNF217 and AURKA, respectively. Regions 8q24 and 17q12 were analyzed with MYC and ERBB2 commercial probes, respectively. RESULTS: We observed amplification of 8p12 (amplified at RAB11FIP1 and/or FGFR1) in 22.8%, 8q24 in 6.1%, 11q13 in 19.6%, 12p13 in 4.1%, 17q12 in 9.9%, 20q13(Z )(amplified at ZNF217 only) in 9.9%, and 20q13(Co )(co-amplification of two or three 20q13 loci) in 8.5% of cases. The 8q24, 12p13, and 17q12 amplifications were correlated with high grade. The most frequent single amplifications were 8p12 (9.8%), 8q24 (3.3%) and 12p13 (3.3%), 20q13(Z )and 20q13(Co )(1.6%) regions. The 17q12 and 11q13 regions were never found amplified alone. The most frequent co-amplification was 8p12/11q13. Amplifications of 8p12 and 17q12 were associated with poor outcome. Amplification of 12p13 was associated with basal molecular subtype. CONCLUSION: Our results establish the frequencies, prognostic impacts and subtype associations of various amplifications and co-amplifications in breast cancers

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways

Identification of genetic variants associated with Huntington's disease progression: a genome-wide association study

Background Huntington's disease is caused by a CAG repeat expansion in the huntingtin gene, HTT. Age at onset has been used as a quantitative phenotype in genetic analysis looking for Huntington's disease modifiers, but is hard to define and not always available. Therefore, we aimed to generate a novel measure of disease progression and to identify genetic markers associated with this progression measure. Methods We generated a progression score on the basis of principal component analysis of prospectively acquired longitudinal changes in motor, cognitive, and imaging measures in the 218 indivduals in the TRACK-HD cohort of Huntington's disease gene mutation carriers (data collected 2008–11). We generated a parallel progression score using data from 1773 previously genotyped participants from the European Huntington's Disease Network REGISTRY study of Huntington's disease mutation carriers (data collected 2003–13). We did a genome-wide association analyses in terms of progression for 216 TRACK-HD participants and 1773 REGISTRY participants, then a meta-analysis of these results was undertaken. Findings Longitudinal motor, cognitive, and imaging scores were correlated with each other in TRACK-HD participants, justifying use of a single, cross-domain measure of disease progression in both studies. The TRACK-HD and REGISTRY progression measures were correlated with each other (r=0·674), and with age at onset (TRACK-HD, r=0·315; REGISTRY, r=0·234). The meta-analysis of progression in TRACK-HD and REGISTRY gave a genome-wide significant signal (p=1·12 × 10−10) on chromosome 5 spanning three genes: MSH3, DHFR, and MTRNR2L2. The genes in this locus were associated with progression in TRACK-HD (MSH3 p=2·94 × 10−8 DHFR p=8·37 × 10−7 MTRNR2L2 p=2·15 × 10−9) and to a lesser extent in REGISTRY (MSH3 p=9·36 × 10−4 DHFR p=8·45 × 10−4 MTRNR2L2 p=1·20 × 10−3). The lead single nucleotide polymorphism (SNP) in TRACK-HD (rs557874766) was genome-wide significant in the meta-analysis (p=1·58 × 10−8), and encodes an aminoacid change (Pro67Ala) in MSH3. In TRACK-HD, each copy of the minor allele at this SNP was associated with a 0·4 units per year (95% CI 0·16–0·66) reduction in the rate of change of the Unified Huntington's Disease Rating Scale (UHDRS) Total Motor Score, and a reduction of 0·12 units per year (95% CI 0·06–0·18) in the rate of change of UHDRS Total Functional Capacity score. These associations remained significant after adjusting for age of onset. Interpretation The multidomain progression measure in TRACK-HD was associated with a functional variant that was genome-wide significant in our meta-analysis. The association in only 216 participants implies that the progression measure is a sensitive reflection of disease burden, that the effect size at this locus is large, or both. Knockout of Msh3 reduces somatic expansion in Huntington's disease mouse models, suggesting this mechanism as an area for future therapeutic investigation

Family Picture

"Even life in the circle of Beckmann's family yielded no relief from anxiety. In Family Picture six disparate people are compressed into a small, crowded, low-ceilinged room. The artist himself, clutching a horn and wearing bright yellow shoes, lies on a narrow piano bench. Next to him stands his wife, whose grey face is reflected in an oval mirror and whose state of undress reminds one immediately of the bound woman in The Night. Frau Tude, Beckmann's mother-in-law, is seated at the table, hiding her face in her large hand. A sister-in-law stares out into the room, while a servant reads the newspaper at right. Peter Beckmann, the son, is stretched out on the floor, and a mysterious, small, crowned figure enters the space on the left from behind the piano. This personage- possibly related to the mysterious king in the central panel of Departure, painted some twelve years later- functions into Beckmann's iconography as a symbol of the painter himself...Beckmann was living apart from his family when this was painted." -- From Selz, Peter Howard, 1919- Max Beckmann / New York : Abbeville Press, 1996. p.29full vie

The Mocking of the Prodigal Son

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Die Nacht

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