Homologous Flares and Magnetic Field Topology in Active Region NOAA 10501 on 20 November 2003

We present and interpret observations of two morphologically homologous flares that occurred in active region (AR) NOAA 10501 on 20 November 2003. Both flares displayed four homologous H-alpha ribbons and were both accompanied by coronal mass ejections (CMEs). The central flare ribbons were located at the site of an emerging bipole in the center of the active region. The negative polarity of this bipole fragmented in two main pieces, one rotating around the positive polarity by ~ 110 deg within 32 hours. We model the coronal magnetic field and compute its topology, using as boundary condition the magnetogram closest in time to each flare. In particular, we calculate the location of quasiseparatrix layers (QSLs) in order to understand the connectivity between the flare ribbons. Though several polarities were present in AR 10501, the global magnetic field topology corresponds to a quadrupolar magnetic field distribution without magnetic null points. For both flares, the photospheric traces of QSLs are similar and match well the locations of the four H-alpha ribbons. This globally unchanged topology and the continuous shearing by the rotating bipole are two key factors responsible for the flare homology. However, our analyses also indicate that different magnetic connectivity domains of the quadrupolar configuration become unstable during each flare, so that magnetic reconnection proceeds differently in both events.Comment: 24 pages, 10 figures, Solar Physics (accepted

An Observational Overview of Solar Flares

We present an overview of solar flares and associated phenomena, drawing upon a wide range of observational data primarily from the RHESSI era. Following an introductory discussion and overview of the status of observational capabilities, the article is split into topical sections which deal with different areas of flare phenomena (footpoints and ribbons, coronal sources, relationship to coronal mass ejections) and their interconnections. We also discuss flare soft X-ray spectroscopy and the energetics of the process. The emphasis is to describe the observations from multiple points of view, while bearing in mind the models that link them to each other and to theory. The present theoretical and observational understanding of solar flares is far from complete, so we conclude with a brief discussion of models, and a list of missing but important observations.Comment: This is an article for a monograph on the physics of solar flares, inspired by RHESSI observations. The individual articles are to appear in Space Science Reviews (2011

Associations of autozygosity with a broad range of human phenotypes

In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (F-ROH) for >1.4 million individuals, we show that F-ROH is significantly associated (p <0.0005) with apparently deleterious changes in 32 out of 100 traits analysed. These changes are associated with runs of homozygosity (ROH), but not with common variant homozygosity, suggesting that genetic variants associated with inbreeding depression are predominantly rare. The effect on fertility is striking: F-ROH equivalent to the offspring of first cousins is associated with a 55% decrease [95% CI 44-66%] in the odds of having children. Finally, the effects of F-ROH are confirmed within full-sibling pairs, where the variation in F-ROH is independent of all environmental confounding.Peer reviewe

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-w (IFN-w) (13 patients), against the 13 types of IFN-a (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. The auto-Abs neutralize the ability of the corresponding type I IFNs to block SARS-CoV-2 infection in vitro. These auto-Abs were not found in 663 individuals with asymptomatic or mild SARS-CoV-2 infection and were present in only 4 of 1227 healthy individuals. Patients with auto-Abs were aged 25 to 87 years and 95 of the 101 were men. A B cell autoimmune phenocopy of inborn errors of type I IFN immunity accounts for life-threatening COVID-19 pneumonia in at least 2.6% of women and 12.5% of men

Widespread and progressive seafloor-sediment failure following volcanic debris avalanche emplacement: Landslide dynamics and timing offshore Montserrat, Lesser Antilles

Landslides associated with flank collapse are volumetrically the most significant sediment transport process around volcanic islands. Around Montserrat, in the Lesser Antilles, individual landslide deposits have volumes (1 to 20 km3) that are up to two orders of magnitude larger than recent volcanic dome collapses (up to 0.2 km3). The largest landslide deposits were emplaced in at least two stages, initiated by the emplacement of volcanic debris avalanches which then triggered larger-scale failure of seafloor sediment, with deformation propagating progressively downslope for up to 30 km on gradients of <1°. An unusually detailed seismic, side-scan sonar and bathymetric dataset shows that the largest landslide off Montserrat (forming Deposit 8) incorporated ~ 70 m of in-situ sediment stratigraphy, and comprises ~ 80% seafloor sediment by volume. Well-preserved internal bedding and a lack of shortening at the frontally-confined toe of the landslide, shows that sediment failure involved only limited downslope transport. We discuss a range of models for progressively-driven failure of in-situ bedded seafloor sediment. For Deposit 8 and for comparable deposits elsewhere in the Lesser Antilles, we suggest that failure was driven by an over-running surface load that generated excess pore pressures in a weak and deforming undrained package of underlying stratigraphy. A propagating basal shear rupture may have also enhanced the downslope extent of sediment failure. Extensive seafloor-sediment failure may commonly follow debris avalanche emplacement around volcanic islands if the avalanche is emplaced onto a fine-grained parallel-bedded substrate. The timing of landslides off Montserrat is clustered, and associated with the deposition of thick submarine pyroclastic fans. These episodes of enhanced marine volcaniclastic input are separated by relatively quiescent periods of several 100 ka, and correspond to periods of volcanic edifice maturity when destructive processes dominate over constructive processes

High-resolution seismic imaging of a Younger Dryas and Holocene mass movement complex in glacial lake Windermere, UK

The stratigraphy and sedimentological processes operating over the last 15,000 years within glacial lake Windermere (UK), at the mouth of Cunsey Beck, were imaged by a decimetre-resolution seismic reflection survey. A complex of fifteen mass movement deposits was identified as contemporaneous with the Younger Dryas, and two within the overlying Holocene drape. The high vertical resolution and dense grid of profiles allowed pseudo three-dimensional mapping of individual events, along with the determination of their relative temporal relationships. The size of the mass wasting deposits has been estimated to range between 2100 and &gt; 100,000 m3. The geometry, structure and relationship to the existing stratigraphy suggest a rapid emplacement of the Younger Dryas mass movement deposits, facilitated by climatic changes making subaqueous slopes unstable, with possible triggering by seismic activity. Morphometric parameters, such as volume and planar surface area, indicate a greater mobility of the Younger Dryas mass movement deposits compared to the Holocene events. The sediments of all imaged mass movement deposits are believed to originate from the slope deposits of the lake. The age of two Holocene mass movement deposits, triggered by flooding or terrestrial debris flows, is estimated to be 2400 and 4400 years BP

Combinations of volcanic-flank and seafloor-sediment failure offshore Montserrat, and their implications for tsunami generation

Recent seafloor mapping around volcanic islands shows that submarine landslide deposits are common and widespread. Such landslides may cause devastating tsunamis, but accurate assessment of tsunami hazard relies on understanding failure processes and sources. Here we use high-resolution geophysical data offshore from Montserrat, in the Lesser Antilles, to show that landslides around volcanic islands may involve two fundamentally different sources of sediment (island-flank and larger seafloor-sediment failures), and can occur in multiple stages. A combination of these processes produces elongate deposits, with a blocky centre (associated with island-flank collapse), surrounded by a smoother-surfaced deposit that is dominated by failed seafloor sediment. The failure of seafloor sediment is associated with little marginal accumulation, and involves only limited downslope motion. Submarine landslide deposits with similar blocky and smoothsurfaced associations are observed in several locations worldwide, but the complex emplacement processes implied by this morphological relationship can only be revealed by high-resolution geophysical data. Such complexity shows that the volume of landslide deposits offshore of volcanic islands cannot simply be used in tsunami models to reflect a single-stage collapse of primary volcanic material. By applying predictive equations for tsunami amplitude to investigate general scenarios of volcanic island landslide generation, we show that the tsunami hazard associated with volcanic island collapse remains highly significant. Volcanic flank failures, even if relatively small, may generate large local tsunamis, but associated seafloor sediment failures, even if they have a much greater volume, have a substantially lower potential for tsunami generation