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73 research outputs found

DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity

Author: Akagawa M Ito S, Toyoda K, et al.
Al-Shobaili HA Al Robaee AA,Alzolibani AA,et al
Albright CD Klem E, Shah AA, et al.
Awasthi SS Singhal YC, Awasthi B, et al.
Awasthi YC Yang Y, Tiwari NK, et al.
Barrera G Muraca R, Pizzimenti S, et al.
Barrera G Pizzimenti S, Dianzani MU
Bauer G Zarkovic N
Benedetti A Comporti M, Esterbauer H
Brambilla G Sciaba L, Faggin P, et al.
Cajelli E Ferraris A, Brambilla G
Canuto RA Muzio G, Maggiora M, et al.
Casares C Ramírez-Camacho R, Trinidad A, et al.
Casciola-Rosen LA Anhalt G, Rosen A
Cerbone A Toaldo C, Laurora S, et al.
Chalasani N Deeg MA, Crabb DW
Chaudhary P Sharma R, Sahu M, et al.
Chen HJ Gonzalez FJ, Shou M, et al.
Chen HJC Chung FL
Cho YJ Kim HY, Huang H, et al.
Cho YJ Wang H, Kozekov ID, et al.
Cho YJ Wang H, Kozekov ID, et al.
Chou MY Fogelstrand L, Hartvigsen K, et al.
Chung FL Chen HJ, Nath RG
Chung FL Nath RG, Nagao M, et al.
Chung FL Pan J, Choudhury S, et al.
Cipak A Jaganjac M, Tehlivets O, et al.
Cohen G Riahi Y, Sasson S
Csala M Kardon T, Legeza B, et al.
Dasari S Tchounwou PB
de los Santos C Zaliznyak T, Johnson F
Dianzani MU
Doorn JA Petersen DR
Douki T Odin F, Caillat S, et al.
Eckl PM Ortner A, Esterbauer H
Espinosa A Zhou W, Ek M, et al.
Esterbauer H Schaur RJ, Zollner H
Esterbauer H Zollner H
Feng Z Hu W, Hu Y, et al.
Fink SP Reddy GR, Marnett LJ
Forman HJ
Forman HJ Fukuto JM, Miller T, et al.
Frijhoff J Winyard PG, Zarkovic N, et al.
Fruehauf JP Meyskens FL Jr.
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Huang H Wang H, Qi N, et al.
Huang H Wang H, Stephen Lloyd R, et al.
Hussain SP Raja K, Amstad PA, et al.
Kadlubar FF Anderson KE, Haussermann S, et al.
Karihtala P Kauppila S, Puistola U, et al.
Karlhuber GM Bauer HC, Eckl PM
Kawai Y Takeda S, Terao J
Khan F Moinuddin, Mir AR, et al.
Khatoon F Moinuddin, Alam K, et al.
Kowalczyk P Cieśla JM, Komisarski M, et al.
Kozekov ID Nechev LV, Moseley MS, et al.
Kozekov ID Nechev LV, Sanchez A, et al.
Kumar B Koul S, Khandrika L, et al.
Kurien BT Hensley K, Bachmann M, et al.
Kurien BT Scofield RH
Kurien T Porter A, Dorri Y, et al.
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Leonarduzzi G Chiarpotto E, Biasi F, et al.
Licht R Dieker JWC, Jacobs CWM, et al.
Mao H Reddy GR, Manett LJ, et al.
Mao H Schnetz-Boutaud NC, Weisenseel JP, et al.
Marnett LJ
Marnett LJ
Marnett LJ Hurd HK, Hollstein MC, et al.
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Miranda-Carús M-E Askanase AD, Clancy RM, et al.
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Nair U Bartsch H, Nair J
Nickel T Schmauss D, Hanssen H, et al.
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Oberley TD Toyokuni S, Szweda LI
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Patel BP Rawal UM, Dave TK, et al.
Pelicano H Carney D, Huang P
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Pettazzoni P Pizzimenti S, Toaldo C, et al.
Pizzimenti S Barrera G, Dianzani MU, et al.
Pizzimenti S Briatore F, Laurora S, et al.
Poli G Dianzani MU, Cheeseman KH, et al.
Pollack M Oe T, Lee SH, et al.
Ranjan D Chen C, Johnston TD, et al.
Ren Y Tang J, Mok MY, et al.
Rindgen D Lee SH, Nakajima M, et al.
Sanchez AM Minko IG, Kurtz AJ, et al.
Savill J Dransfield I, Gregory C, et al.
Scofield RH Kurien BT, Ganick S, et al.
Seki S Kitada T, Yamada T, et al.
Singh M Kapoor A, Bhatnagar A
Skrzydlewska E Stankiewicz A, Sulkowska M, et al
Stone MP Huang H, Brown KL, et al.
Sunjic SB Cipak A, Rabuzin F, et al.
Tang MS Wang HT, Hu Y, et al.
Thorn CF Oshiro C, Marsh S, et al.
Tjalkens RB Cook LW, Petersen DR
Trachootham D Alexandre J, Huang P
Trachootham D Zhang H, Zhang W, et al.
Trachootham D Zhou Y, Zhang H, et al.
Tsao SM Yin MC, Liu WH
Turk PW Laayoun A, Smith SS, et al.
Uchida K
Uchida K Kanematsu M, Sakai K, et al.
Uchida K Szweda LI, Chae HZ, et al.
Voulgaridou GP Anestopoulos I, Franco R, et al.
Wacker M Wanek P, Eder E
Wang H Kozekov ID, Harris TM, et al.
Wei X Yin H
Weismann D Binder CJ
White MF
Winczura A Czubaty A, Winczura K, et al.
Wuttge DM Bruzelius M, Stemme S
Yang IY Hossain M, Miller H, et al.
Yang IY Johnson F, Grollman AP, et al.
Yara S Lavoie JC, Beaulieu JF, et al.
Zaliznyak T Boonala R, Attaluri S, et al.
Zanetti D Poli G, Vizio B, et al.
Zarkovic N Ilic Z, Jurin M, et al.
Zeher M Szodoray P, Gyimesi E, et al.
Zhang H Trachootham D, Lu W, et al.
Zhang S Villalta PW, Wang M, et al.
Publication venue: 'American Institute of Mathematical Sciences (AIMS)'
Publication date: 01/01/2017
Field of study

Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein, crotonaldehyde and 4-hydroxy-2-nonenal, react with DNA bases, generating promutagenic exocyclic DNA adducts, which likely contribute to the mutagenic and carcinogenic effects associated with oxidative stress-induced LPO. However, reactive aldehydes, when added to tumor cells, can exert an anticancerous effect. They act, analogously to other chemotherapeutic drugs, by forming DNA adducts and, in this way, they drive the tumor cells toward apoptosis. The aldehyde-DNA adducts, which can be observed during inflammation, play an important role by inducing epigenetic changes which, in turn, can modulate the inflammatory process. The pathogenic role of the adducts formed by the products of LPO with biological macromolecules in the breaking of immunological tolerance to self antigens and in the development of autoimmunity has been supported by a wealth of evidence. The instrumental role of the adducts of reactive LPO products with self protein antigens in the sensitization of autoreactive cells to the respective unmodified proteins and in the intermolecular spreading of the autoimmune responses to aldehyde-modified and native DNA is well documented. In contrast, further investigation is required in order to establish whether the formation of adducts of LPO products with DNA might incite substantial immune responsivity and might be instrumental for the spreading of the immunological responses from aldehyde-modified DNA to native DNA and similarly modified, unmodified and/or structurally analogous self protein antigens, thus leading to autoimmunity

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Repositório da Universidade Nova de Lisboa

Institutional Research Information System University of Turin

Approaches in biotechnological applications of natural polymers

Author: Abreu FOMS Oliveira EF, Paula HCB, et al.
Albuquerque PBS Barros Júnior W, Santos GRC, et
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Almeida RR Magalhúes HS, Souza JRR, et al.
Alvarez-Lorenzo C Blanco-Fernandez B, Puga AM, e
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Angellier H Molina-Boisseau S, Dufresne A
Antoniou J Liu F, Majeed H, et al.
Antoniou J Liu F, Majeed H, et al.
Arruda IRS Albuquerque PBS, Santos GRC, et al.
Auriemma G Mencherini T, Russo P, et al.
Baier G Baumann D, Siebert JM, et al.
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Bedane AH Eić M, Farmahini-Farahani M, et al.
Benard C Cultrone A, Michel C
Biliuta G Fras L, Drobota M, et al.
Bittencourt CR Farias EAO, Bezerra KC, et al.
Blank CE Hinman NW
Bouaziz F Koubaa M, Neifar M, et al.
Brinchi L Cotana F, Fortunati E, et al.
Brummer Y Cui W, Wang Q
Buriti FCA Freitas SC, Egito AS, et al.
Busilacchi A Gigante A, Mattioli-Belmonte M, et
Campo VL Kawano DF, Silva DB, et al.
Carlmark A Larsson E, Malmström E.
Carneiro-da-Cunha MG Cerqueira MA, Souza BWS, et
Carneiro-da-Cunha MG Cerqueira MA, Souza BWS, et
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Da Cunha PLR De Paula RCM, Feitosa JPA
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Weiner ML
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Zou YF Zhang BZ, Inngjerdingen KT, et al.
Publication venue: 'American Institute of Mathematical Sciences (AIMS)'
Publication date: 01/01/2016
Field of study

Natural polymers, such as gums and mucilage, are biocompatible, cheap, easily available and non-toxic materials of native origin. These polymers are increasingly preferred over synthetic materials for industrial applications due to their intrinsic properties, as well as they are considered alternative sources of raw materials since they present characteristics of sustainability, biodegradability and biosafety. As definition, gums and mucilages are polysaccharides or complex carbohydrates consisting of one or more monosaccharides or their derivatives linked in bewildering variety of linkages and structures. Natural gums are considered polysaccharides naturally occurring in varieties of plant seeds and exudates, tree or shrub exudates, seaweed extracts, fungi, bacteria, and animal sources. Water-soluble gums, also known as hydrocolloids, are considered exudates and are pathological products; therefore, they do not form a part of cell wall. On the other hand, mucilages are part of cell and physiological products. It is important to highlight that gums represent the largest amounts of polymer materials derived from plants. Gums have enormously large and broad applications in both food and non-food industries, being commonly used as thickening, binding, emulsifying, suspending, stabilizing agents and matrices for drug release in pharmaceutical and cosmetic industries. In the food industry, their gelling properties and the ability to mold edible films and coatings are extensively studied. The use of gums depends on the intrinsic properties that they provide, often at costs below those of synthetic polymers. For upgrading the value of gums, they are being processed into various forms, including the most recent nanomaterials, for various biotechnological applications. Thus, the main natural polymers including galactomannans, cellulose, chitin, agar, carrageenan, alginate, cashew gum, pectin and starch, in addition to the current researches about them are reviewed in this article.. }To the Conselho Nacional de Desenvolvimento Cientfíico e Tecnológico (CNPq) for fellowships (LCBBC and MGCC) and the Coordenação de Aperfeiçoamento de Pessoal de Nvíel Superior (CAPES) (PBSA). This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit, the Project RECI/BBB-EBI/0179/2012 (FCOMP-01-0124-FEDER-027462) and COMPETE 2020 (POCI-01-0145-FEDER-006684) (JAT)

Universidade do Minho: RepositoriUM

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The disruption of proteostasis in neurodegenerative diseases

Author: Abravaya K Phillips B, Morimoto RI
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Publication venue: 'American Institute of Mathematical Sciences (AIMS)'
Publication date: 01/01/2015
Field of study

Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. In this context, the proteostasis network (PN) is essential to achieve a stable and functional proteome. Disruption of the PN is associated with aging and can lead to and/or potentiate the occurrence of many neurodegenerative diseases (ND). This not only emphasizes the importance of the PN in health span and aging but also how its modulation can be a potential target for intervention and treatment of human diseases.info:eu-repo/semantics/publishedVersio