18 research outputs found
Hydrogen-ion driven molecular motions in Cu2+-complexes of a ditopic phenanthrolinophane ligand
One of the first kinetic evaluations of a metal ion interchange between the two coordination sites of a ditopic macrocycle is presented.Garcia-España Monsonis, Enrique, [email protected] ; Soriano Soto, Concepción, [email protected] ; Verdejo Viu, Begoña, [email protected]
Characterization of a Ferryl Flip in Electronically Tuned Nonheme Complexes. Consequences in Hydrogen Atom Transfer Reactivity
Two oxoiron(IV) isomers (R2a and R2b) of general formula [FeIV(O)(RPyNMe3)(CH3CN)]2+ are obtained by reaction of their iron(II) precursor with NBu4IO4. The two isomers differ in the position of the oxo ligand, cis and trans to the pyridine donor. The mechanism of isomerization between R2a and R2b has been determined by kinetic and computational analyses uncovering an unprecedented path for interconversion of geometrical oxoiron(IV) isomers. The activity of the two oxoiron(IV) isomers in hydrogen atom transfer (HAT) reactions shows that R2a reacts one order of magnitude faster than R2b, which is explained by a repulsive noncovalent interaction between the ligand and the substrate in R2b. Interestingly, the electronic properties of the R substituent in the ligand pyridine ring do not have a significant effect on reaction rates. Overall, the intrinsic structural aspects of each isomer define their relative HAT reactivity, overcoming changes in electronic properties of the ligand
BUILDING BRIDGES FOR INNOVATION IN AGEING : SYNERGIES BETWEEN ACTION GROUPS OF THE EIP ON AHA
The Strategic Implementation Plan of the European Innovation Partnership on Active and Healthy Ageing (EIP on AHA) proposed six Action Groups. After almost three years of activity, many achievements have been obtained through commitments or collaborative work of the Action Groups. However, they have often worked in silos and, consequently, synergies between Action Groups have been proposed to strengthen the triple win of the EIP on AHA. The paper presents the methodology and current status of the Task Force on EIP on AHA synergies. Synergies are in line with the Action Groups' new Renovated Action Plan (2016-2018) to ensure that their future objectives are coherent and fully connected. The outcomes and impact of synergies are using the Monitoring and Assessment Framework for the EIP on AHA (MAFEIP). Eight proposals for synergies have been approved by the Task Force: Five cross-cutting synergies which can be used for all current and future synergies as they consider overarching domains (appropriate polypharmacy, citizen empowerment, teaching and coaching on AHA, deployment of synergies to EU regions, Responsible Research and Innovation), and three cross-cutting synergies focussing on current Action Group activities (falls, frailty, integrated care and chronic respiratory diseases).Peer reviewe
Use of Remote Sensing and GIS in Monitoring Water Quality: application to the Mar Menor
Profundizar sobre la teledetección y los programas de tratamiento de imágenes satélites, aplicándolo a la monitorización de la calidad de las aguas, en concreto las del Mar Menor.Escuela de Ingeniería de Caminos y MinasUniversidad Politécnica de Cartagen
Pneumococcal Serotypes Causing Acute Otitis Media Among Children in Barcelona (1992–2011): Emergence of the Multiresistant Clone ST320 of Serotype 19A
Background: There is scarce information about changes in serotypes
and clonal types of Streptococcus pneumoniae causing acute otitis media
(AOM) in recent years, particularly in European countries.
Methods: Pneumococcal serotypes and clones from S. pneumoniae strains
isolated from children with AOM who were attended at Hospital Sant Joan
de Déu, Barcelona (1992 to 2011), were studied. Heptavalent pneumococ-
cal conjugate vaccine (PCV7) was introduced in June 2001. We defined 3
periods: prevaccine period 1992 to 2001, early vaccine period 2002 to 2006
and late vaccine period 2007 to 2011.
Results: There were 376 pneumococcal strains causing AOM, and 373
(99.2%) of them were serotyped. AOM caused by PCV7 serotypes declined
significantly: 161 of 245 (65.7%) episodes in 1992 to 2001 versus 22 of
67 (32.8%) in 2002 to 2006 versus 8 of 61 (13.1%) in 2007 to 2011 P <
0.001. In the last period (2007 to 2011), the potential serotype coverage for
the PCV10 was 16.4% and for the PCV13 was 68.9% (P < 0.001). Sero-
type 19A increased from 5.7% in 1992 to 2001 to 42.6% in 2007 to 2011
(P < 0.001). Among strains with penicillin minimal inhibitory concentra-
tion ≥0.12 μg/mL (n = 241), serotype 19A rose from 2.3% in the first period
to 57.9 % in the last period (P < 0.001). The clonal-type ST320 was initially
detected in 2005, and in the period 2007 to 2011, the ST320 was found in
72.7% of nonsusceptible serotype 19A isolates.
Conclusions: Among children with AOM, a rapid expansion of the mul-
tiresistant clone ST320 expressing serotype 19A has been observed in Bar-
celona. The implementation of PCV13, which includes this serotype, may
decrease the prevalence of AOM and reduce antimicrobial resistance
High invasiveness of pneumococcal serotypes included in the new generation of conjugate vaccines
The implementation of the seven-valent pneumococcal conjugate vaccine, PCV7, has resulted in significant changes in the pneumococcal
population being carried and causing disease. We aimed to determine the invasive disease potential of serotypes causing invasive paediatric
disease in the era of conjugate vaccines in Catalonia, Spain, and their potential coverage by the 13-valent pneumococcal conjugate vaccine,
PCV13. As a secondary objective, we evaluated whether implementation of PCV7 had resulted in significant changes in the invasive disease
potential of the most frequent serotypes circulating in the area. Two pneumococcal collections obtained from children admitted to the
University Hospital Sant Joan de Deu (Barcelona, Spain) between 2007 and 2011 were compared: a first set of 159 invasive disease isolates,
and a second set of 209 nasopharyngeal isolates recovered from healthy children admitted for minor surgery. The most common invasive
serotypes were 1 (24.5%, n = 39), 19A (21.2%, n = 34), 5 (8.8%, n = 14), 7F (8.8%, n = 14) and 3 (5%, n = 8). The most common serotypes
in carriage were 19A (10%, n = 21), 6C (9%, n = 19), 23B (8.1%, n = 17), 6A (7.6%, n = 16) and 19F (6.2%, n = 13). A significantly higher
propensity to cause invasive disease was observed for serotypes 1, 3, 5, 7F and 19A, all of which are included in PCV13. After
false-discovery-rate correction, the results were robust for serotypes 1, 5, 7F and 19A. Non-PCV13 serotypes had a low invasive disease
potential. Our data reinforce the need for continuous surveillance and should encourage efforts to introduce universal vaccination with
PCV13 in children in our region
Uso de ésteres derivados de pirazol protón-ionizables y sus correspondientes sales para el tratamiento de la enfermedad de Chagas y la leishmaniasis
Número de publicación: ES2566228 B1 . Número de solicitud: 201431309. Solicitud internacional: PCT/ES2015/070658Uso de ésteres derivados de pirazol, preferiblemente derivados protón-ionizables en forma neutra o en forma de sales (pirazolatos), como medicamentos y más particularmente para la prevención y/o el tratamiento de enfermedades de origen parasitario tales como la enfermedad de Chagas o la leishmaniasisUniversidad de GranadaConsejo Superior de Investigaciones Científicas (CSIC)Universidad de Valenci
Correction: Detection of Streptococcus pneumoniae and Haemophilus influenzae Type B by Real-Time PCR from Dried Blood Spot Samples among Children with Pneumonia: A Useful Approach for Developing Countries
Pediatric Chagas disease in Europe: 45 cases from Spain and Switzerland
Chagas disease, a potentially fatal parasitic infection, is emerging in Europe in the context of international migration but there is little public health attention and frequent lack of clinicians' awareness. To date, there is no published information about clinical characteristics in children
Detection of Streptococcus pneumoniae and Haemophilus influenzae type B by real-time PCR from dried blood spot samples among children with pneumonia: a useful approach for developing countries
Correction https://doi.org/10.1371/journal.pone.0147678Background: Dried blood spot (DBS) is a reliable blood collection method for storing samples at room temperature and easily transporting them. We have previously validated a Real-Time PCR for detection of Streptococcus pneumoniae in DBS. The objective of this study was to apply this methodology for the diagnosis of S. pneumoniae and Haemophilus influenzae b (Hib) in DBS samples of children with pneumonia admitted to two hospitals in Mozambique and Morocco. Methods: Ply and wzg genes of S. pneumoniae and bexA gene of Hib, were used as targets of Real-Time PCR. 329 DBS samples of children hospitalized with clinical diagnosis of pneumonia were tested. Results: Real-Time PCR in DBS allowed for a significant increase in microbiological diagnosis of S. pneumoniae and Hib. When performing blood bacterial culture, only ten isolates of S. pneumoniae and none of Hib were detected (3·0% positivity rate, IC95% 1·4-5·5%). Real-Time PCR from DBS samples increased the detection yield by 4x fold, as 30 S. pneumoniae and 11 Hib cases were detected (12·4% positivity rate, IC95% 9·0-16·5%; P<0·001). Conclusion: Real-Time PCR applied in DBS may be a valuable tool for improving diagnosis and surveillance of pneumonia caused by S. pneumoniae or Hib in developing countries