Satisfação com o atendimento em farmácias comunitárias: um estudo no distrito de Braga

Dissertação de mestrado em Gestão de Unidades de SaúdeA presente dissertação tem como objetivo avaliar a satisfação dos clientes com o atendimento em farmácias comunitárias do distrito de Braga. A satisfação é um resultado do marketing de uma empresa e sendo a farmácia uma empresa é uma área importante a ser estudada. Para a realização desta dissertação, realizamos um inquérito. Baseamo-nos em estudos já realizados em relação à satisfação dos clientes em farmácias comunitárias para o desenvolvimento do questionário, de forma a usar escalas previamente validadas. Este inquérito foi aplicado online via email e redes sociais, tendo obtido no total 102 respostas. Os dados obtidos foram analisados no sistema IBM SPSS Statistics 23. Os resultados obtidos mostram que o maior número de inquiridos são pessoas do género feminino, tem idades compreendidas entre os 26 e os 50 anos, vivem em zona rural e como habilitações literárias possuem licenciatura. De forma geral, os resultados mostram que a satisfação é atingida quando parâmetros da qualidade e literacia são alcançados. Avaliou-se também a correlação existente entre variáveis como qualidade, tempo de espera, atendimento e aconselhamento, literacia e lealdade. As variáveis tempo de espera, atendimento e aconselhamento, serviços disponíveis e literacia afetam a satisfação dos clientes com o atendimento, da mesma forma que a satisfação apresenta uma correlação, ainda que fraca, com a lealdade. Deste modo pode-se concluir que a satisfação dos clientes com o atendimento em farmácias comunitárias do distrito de Braga encontra-se saciada e esta está relacionada com várias variáveis.The goal of this dissertation is to evaluate costumer satisfaction regarding the service provided in community pharmacies in the Braga district. Satisfaction results of a company’s marketing and, since a pharmacy is a company, this is an important field to be studied. To perform this dissertation, we conducted a survey. We based our work in studies that had already been performed, pertaining to the satisfaction of clients in community pharmacies, for the development of the questionnaire in order to use previously validated scales. This survey was done online, by email and social networks, obtaining a total of 102 responses. The obtained data was analyzed by the IBM SPSS Statistics 23 system. The obtained results demonstrate that the largest amount of costumers are female, aged between 26 and 50 years old, living in rural areas and possessing as educational qualifications a graduate degree. In general, the results demonstrate that satisfaction is achieved when given quality and literacy parameters are reached. The correlation between variables such as quality, waiting time, service provided, counseling, literacy and loyalty were also evaluated. The variables waiting time, service provided, counseling, available services and literacy affect customer satisfaction pertaining to the service provided, the same way that there is a correlation, although a weak one, between satisfaction and loyalty. Hence it can be concluded that the satisfaction of clients regarding the service provided in community pharmacies of Braga district is satiated and that (that) it is related to several variables

Endoclip line-assisted traction to control cardial postpolypectomy bleeding

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Effect of PEDOT:PSS with secondary dopants and DBD plasma treatment on the conductive properties of polyester fabrics

[Excerpt] Introduction Smart textiles have the capability to interact with the surrounding environment and react in different ways, namely in electrical conduction. The conductive properties of these materials are useful in medical, healthcare, and protective clothing.This research was funded by FEDER funds through the Operational Competitiveness Program– COMPETE, under the projects POCI-01-0247-FEDER-068924, and by National Funds through Fundação para a Ciência e Tecnologia (FCT), under the project UID/CTM/00264/2020. Ana Isabel Ribeiro and Cátia Alves acknowledge FCT, MCTES, FSE, and UE PhD grant SFRH/BD/145269/2019 and 2022.10454.BD

HOXA9 promotes glioblastoma initiation, aggressiveness and resistance to therapy

Glioblastoma is the most common and malignant subtype of glioma, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 may render glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and prognosis. Expression microarrays were used to identify HOXA9 target genes. Stable glioblastoma cell lines with ectopic HOXA9 overexpression or shRNA-­mediated knockdown of HOXA9 were established to evaluate the roles of HOXA9 in cell viability, death, invasion, and response to temozolomide. Subcutaneous and orthotopic intracranial xenograft models of glioblastoma were established to evaluate the oncogenic potential of HOXA9 in vivo, and its role in response to temozolomide and overall survival. Transcriptomic analyses identified novel HOXA9-­target genes that have key roles in critical cancer processes, including cell proliferation, adhesion, DNA metabolism and repair, and stem cell maintenance. Functional assays with a variety of glioblastoma cells revealed that HOXA9 promotes cell viability, stemness, and invasion; conversely, HOXA9 displayed anti-­apoptotic functions. Additionally, ectopic expression of HOXA9 promoted the malignant transformation of human immortalized astrocytes in an intracranial orthotopic mouse model of glioblastoma, and caused tumor-­associated death. HOXA9 also mediated resistance to temozolomide treatment both in vitro and in vivo. Mechanistically, BCL2 was identified as a novel HOXA9 target that may be therapeutically targeted. Indeed, the pharmacological inhibition of BCL2 with ABT-­737 specifically reverted temozolomide resistance in HOXA9-­positive cells. These data establish HOXA9 as a critical driver of glioma initiation, aggressiveness and resistance to therapy

SARS-CoV-2 introductions and early dynamics of the epidemic in Portugal

Genomic surveillance of SARS-CoV-2 in Portugal was rapidly implemented by the National Institute of Health in the early stages of the COVID-19 epidemic, in collaboration with more than 50 laboratories distributed nationwide. Methods By applying recent phylodynamic models that allow integration of individual-based travel history, we reconstructed and characterized the spatio-temporal dynamics of SARSCoV-2 introductions and early dissemination in Portugal. Results We detected at least 277 independent SARS-CoV-2 introductions, mostly from European countries (namely the United Kingdom, Spain, France, Italy, and Switzerland), which were consistent with the countries with the highest connectivity with Portugal. Although most introductions were estimated to have occurred during early March 2020, it is likely that SARS-CoV-2 was silently circulating in Portugal throughout February, before the first cases were confirmed. Conclusions Here we conclude that the earlier implementation of measures could have minimized the number of introductions and subsequent virus expansion in Portugal. This study lays the foundation for genomic epidemiology of SARS-CoV-2 in Portugal, and highlights the need for systematic and geographically-representative genomic surveillance.We gratefully acknowledge to Sara Hill and Nuno Faria (University of Oxford) and Joshua Quick and Nick Loman (University of Birmingham) for kindly providing us with the initial sets of Artic Network primers for NGS; Rafael Mamede (MRamirez team, IMM, Lisbon) for developing and sharing a bioinformatics script for sequence curation (https://github.com/rfm-targa/BioinfUtils); Philippe Lemey (KU Leuven) for providing guidance on the implementation of the phylodynamic models; Joshua L. Cherry (National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health) for providing guidance with the subsampling strategies; and all authors, originating and submitting laboratories who have contributed genome data on GISAID (https://www.gisaid.org/) on which part of this research is based. The opinions expressed in this article are those of the authors and do not reflect the view of the National Institutes of Health, the Department of Health and Human Services, or the United States government. This study is co-funded by Fundação para a Ciência e Tecnologia and Agência de Investigação Clínica e Inovação Biomédica (234_596874175) on behalf of the Research 4 COVID-19 call. Some infrastructural resources used in this study come from the GenomePT project (POCI-01-0145-FEDER-022184), supported by COMPETE 2020 - Operational Programme for Competitiveness and Internationalisation (POCI), Lisboa Portugal Regional Operational Programme (Lisboa2020), Algarve Portugal Regional Operational Programme (CRESC Algarve2020), under the PORTUGAL 2020 Partnership Agreement, through the European Regional Development Fund (ERDF), and by Fundação para a Ciência e a Tecnologia (FCT).info:eu-repo/semantics/publishedVersio

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Successfull endoscopic closure of gastrocutaneous fistula with an over-the-scope clip

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Endoscopic Removal of Two Esophageal Over-The-Scope Clips with Cold Saline Solution Technique

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Characterisation of microbial attack on archaeological bone

As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved