43 research outputs found
Use of a colonoscope for distal duodenal stent placement in patients with malignant obstruction
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2009
- Field of study
Background: Stent placement in the distal duodenum or proximal jejunum with a therapeutic gastroscope can be difficult, because of the reach of the endoscope, loop formation in the stomach, and flexibility of the gastroscope. The use of a colonoscope may overcome these problems. Objective: To report our experience with distal duodenal stent placement in 16 patients using a colonoscope. Methods: Multicenter, retrospective series of patients with a malignant obstruction at the level of the distal duodenum and proximal jejunum and treated by stent placement using a colonoscope. Main outcome measurements are technical success, ability to eat, complications, and survival. Results: Stent placement was technically feasible in 93% (15/16) of patients. Food intake improved from a median gastric outlet obstruction scoring system (GOOSS) score of 1 (no oral intake) to 3 (soft solids) (p = 0.001). Severe complications were not observed. One patient had persistent obstructive symptoms presumably due to motility problems. Recurrent obstructive symptoms were caused by tissue/tumor ingrowth through the stent mesh [n = 6 (38%)] and stent occlusion by debris [n = 1 (6%)]. Reinterventions included additional stent placement [n = 5 (31%)], gastrojejunostomy [n = 2 (12%)], and endoscopic stent cleansing [n = 1 (6%)]. Median survival was 153 days. Conclusion: Duodenal stent placement can effectively and safely be performed using a colonoscope in patients with an obstruction at the level of the distal duodenum or proximal jejunum. A colonoscope has the advantage that it is long enough and offers good endoscopic stiffness, which avoids looping in the stomach
Computational Methods for Protein Identification from Mass Spectrometry Data
- Author
- A Frank
- A Ganapathy
- A Keller
- A Keller
- A Keller
- A Taylor
- AI Nesvizhskii
- AJ Liska
- AJ Liska
- AJ Liska
- AJ Mackey
- B Habermann
- B Ma
- BC Searle
- BE Boyes
- C Robertson
- CA Hastings
- D Fenyo
- DA Stead
- DB Weatherly
- DC Chamrad
- DF Hochstrasser
- DJ Pappin
- DL Tabb
- DN Perkins
- ED Salin
- F Levander
- H Wang
- HI Field
- HJ Joshi
- I Beer
- I Rogers
- I Shadforth
- J Arthur
- J Eriksson
- J Eriksson
- J Magnin
- J Peng
- J Razumovskaya
- J Reinders
- J Samuelsson
- JA Bons
- JE Elias
- JG Rohrbough
- JJ Thomson
- JK Eng
- JL Joss
- JM Hogan
- Johanna McEntyre
- Jonathan W Arthur
- JR Yates III
- JWH Wong
- K Biemann
- KA Resing
- KA Resing
- KR Coombes
- L Huang
- Leo McHugh
- M Kempka
- M Mann
- M Tuloup
- MA Baldwin
- MJ Noga
- ML Nielsen
- MR Wilkins
- NL Anderson
- P Hernandez
- R Apweiler
- R Ullmer
- RE Moorea
- RJ Arnold
- RM Day
- S Carr
- S Gay
- S Orchard
- SB Vardeman
- SF Altschul
- SJ Cordwell
- V Bafna
- V Dancik
- W Zhang
- WJ Henzel
- WR Pearson
- Y Chen
- Y Han
- Z Zhang
- Z Zhang
- Publication venue
- Public Library of Science
- Publication date
- 01/02/2008
- Field of study
Protein identification using mass spectrometry is an indispensable computational tool in the life sciences. A dramatic increase in the use of proteomic strategies to understand the biology of living systems generates an ongoing need for more effective, efficient, and accurate computational methods for protein identification. A wide range of computational methods, each with various implementations, are available to complement different proteomic approaches. A solid knowledge of the range of algorithms available and, more critically, the accuracy and effectiveness of these techniques is essential to ensure as many of the proteins as possible, within any particular experiment, are correctly identified. Here, we undertake a systematic review of the currently available methods and algorithms for interpreting, managing, and analyzing biological data associated with protein identification. We summarize the advances in computational solutions as they have responded to corresponding advances in mass spectrometry hardware. The evolution of scoring algorithms and metrics for automated protein identification are also discussed with a focus on the relative performance of different techniques. We also consider the relative advantages and limitations of different techniques in particular biological contexts. Finally, we present our perspective on future developments in the area of computational protein identification by considering the most recent literature on new and promising approaches to the problem as well as identifying areas yet to be explored and the potential application of methods from other areas of computational biology
Search for lepton flavour violating decays of the Higgs boson to eτand eμin proton–proton collisions at √s=8TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akin IV
- Albajar C
- Albrow M
- Alcaraz Maestre J
- Aldaya Martin M
- Alderweireldt S
- Aldá Júnior WL
- Aleksandrov A
- Alexander J
- Alimena J
- Alunni Solestizi L
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Amsler C
- Anagnostou G
- Anderson D
- Anderson I
- Andrea J
- Andreev V
- Andreev Yu
- Andrews MB
- Androsov K
- Anelli C
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Arora S
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
- Asin I
- Askew A
- Ata M
- Attikis A
- Aubin A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Awad A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Baber M
- Bacchetta N
- Bachmair F
- Bachtis M
- Baden A
- Baffioni S
- Bagliesi G
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Ball AH
- Ball F
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Barbagli G
- Barberis E
- Barbieri R
- Bargassa P
- Baringer P
- Barker A
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- Barnett BA
- Barney D
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- Barria P
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- Baskakov A
- Battilana C
- Baty A
- Bauerdick LAT
- Baumgartel D
- Baus C
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Beck L
- Beernaert K
- Behnamian H
- Behnke O
- Behrens U
- Bein S
- Beirão Da Cruz E Silva C
- Belchior Batista Das Chagas E
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- Beliy N
- Belknap DA
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- Bell KW
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- Belyaev A
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- Benaglia A
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- Bencze G
- Bendavid J
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- Benitez JF
- Benucci L
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- Benvenuti AC
- Beranek S
- Beretvas A
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- Berger J
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- Bernardes CA
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- Besancon M
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- Bhardwaj A
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- Bhowmik S
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- Bodek A
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- Evangelou I
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- Heredia-De La Cruz I
- Hernandez JM
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- Höing RS
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- Incandela J
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- Iorio AOM
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- Jung AW
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- Junkes A
- Juodagalvis A
- Kaadze K
- Kachanov V
- Kadastik M
- Kadija K
- Kaestli HC
- Kaisen J
- Kalafut S
- Kalakhety H
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- Kalinowski A
- Kalogeropoulos A
- Kalsi AK
- Kamalieddin R
- Kamon T
- Kangal EE
- Kanishchev K
- Kao SC
- Kaplan S
- Kapoor A
- Karacheban O
- Karancsi J
- Karapinar G
- Karapostoli G
- Karchin PE
- Kargoll B
- Karimäki V
- Karjavin V
- Karmgard DJ
- Karneyeu A
- Kasemann M
- Kasieczka G
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- Kayis Topaksu A
- Kazana M
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- Yang M
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- Yates BR
- Yazgan E
- Yelton J
- Yetkin EA
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yonamine R
- Yoo HD
- Yoo J
- You C
- Yu I
- Yu SS
- Yumiceva F
- Yusli MN
- Zabel J
- Zabi A
- Zaganidis N
- Zagozdzinska A
- Zakaria M
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zeinali M
- Zenoni F
- Zenz SC
- Zeuner WD
- Zevi Della Porta G
- Zeyrek M
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhokin A
- Zhu RY
- Zhukov V
- Zhukova V
- Zorbilmez C
- Zotto P
- Zou D
- Zsigmond AJ
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- Elsevier
- Publication date
- 01/01/2016
- Field of study
A direct search for lepton flavour violating decays of the Higgs boson (H) in the H →eτand H →eμchannels is described. The data sample used in the search was collected in proton–proton collisions at √s=8TeVwith the CMS detector at the LHC and corresponds to an integrated luminosity of 19.7fb−1. No evidence is found for lepton flavour violating decays in either final state. Upper limits on the branching fractions, B(H →eτ) <0.69%and B(H →eμ) <0.035%, are set at the 95% confidence level. The constraint set on B(H →eτ)is an order of magnitude more stringent than the existing indirect limits. The limits are used to constrain the corresponding flavour violating Yukawa couplings, absent in the standard model
Relative Modification of Prompt psi(2S) and J/psi Yields from pp to PbPb Collisions at root(S)(NN)=5.02 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta MV
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- Yusli MN
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- Publication venue
- Publication date
- 04/11/2016
- Field of study
Peer reviewe
Search for supersymmetry in the multijet and missing transverse momentum final state in pp collisions at 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullah WATW
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Afanasiev S
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Al-bataineh A
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alderweireldt S
- Aleksandrov A
- Alexander J
- Ali MABM
- Alimena J
- Almond J
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Anderson I
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Anelli C
- Angioni GLP
- Antonelli L
- Antropov I
- Antunovic Z
- Apanasevich L
- Apollinari G
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
- Asin I
- Askew A
- Ata M
- Attikis A
- Aubin A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Evidence for collectivity in pp collisions at the LHC
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdelalim AA
- Abdullin S
- Abdulsalam A
- Abercrombie D
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Adair A
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- Wu Z
- Wulsin HW
- Wulz C-E
- Wyslouch B
- Wöhrmann C
- Würthwein F
- Xia F
- Xiao M
- Xie S
- Xie W
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- Xu L
- Xu Q
- Xu Z
- Yagil A
- Yalvac M
- Yang M
- Yang UK
- Yang Y
- Yang YC
- Yates BR
- Yazgan E
- Yelton J
- Yetkin EA
- Yetkin T
- Yi K
- Yilmaz Y
- Yohay R
- Yonamine R
- Yoo HD
- Yoo J
- You C
- Yu GB
- Yu I
- Yu SS
- Yumiceva F
- Yusli MN
- Zabel J
- Zabi A
- Zaganidis N
- Zagozdzinska A
- Zakaria M
- Zalewski P
- Zanetti A
- Zanetti M
- Zarubin A
- Zeinali M
- Zenoni F
- Zenz SC
- Zeuner WD
- Zevi Della Porta G
- Zeyrek M
- Zghiche A
- Zhang F
- Zhang H
- Zhang J
- Zhao J
- Zhokin A
- Zhu RY
- Zhukov V
- Zhukova V
- Zientek M
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zsigmond AJ
- Zucchetta A
- Zumerle G
- Zuranski A
- Publication venue
- Physics Letters, B
- Publication date
- 01/01/2016
- Field of study
Measurements of two- and multi-particle angular correlations in pp collisions at s=5,7, and 13TeV are presented as a function of charged-particle multiplicity. The data, corresponding to integrated luminosities of 1.0pb−1 (5 TeV), 6.2pb−1 (7 TeV), and 0.7pb−1 (13 TeV), were collected using the CMS detector at the LHC. The second-order (v2) and third-order (v3) azimuthal anisotropy harmonics of unidentified charged particles, as well as v2 of KS0 and Λ/Λ‾ particles, are extracted from long-range two-particle correlations as functions of particle multiplicity and transverse momentum. For high-multiplicity pp events, a mass ordering is observed for the v2 values of charged hadrons (mostly pions), KS0, and Λ/Λ‾, with lighter particle species exhibiting a stronger azimuthal anisotropy signal below pT≈2GeV/c. For 13 TeV data, the v2 signals are also extracted from four- and six-particle correlations for the first time in pp collisions, with comparable magnitude to those from two-particle correlations. These observations are similar to those seen in pPb and PbPb collisions, and support the interpretation of a collective origin for the observed long-range correlations in high-multiplicity pp collisions.BMWFW and FWF (Austria); FNRS and FWO (Belgium); CNPq, CAPES, FAPERJ, and FAPESP (Brazil); MES (Bulgaria); CERN; CAS, MOST, and NSFC (China); COLCIEN-CIAS (Colombia); MSES and CSF (Croatia); RPF (Cyprus); SENESCYT (Ecuador); MoER, ERC IUT and ERDF (Estonia); Academy of Fin-land, MEC, and HIP (Finland); CEA and CNRS/IN2P3 (France); BMBF, DFG, and HGF (Germany); GSRT (Greece); OTKA and NIH (Hun-gary); DAE and DST (India); IPM (Iran); SFI (Ireland); INFN (Italy); MSIP and NRF (Republic of Korea); LAS (Lithuania); MOE and UM (Malaysia); BUAP, CINVESTAV, CONACYT, LNS, SEP, and UASLP-FAI (Mexico); MBIE (New Zealand); PAEC (Pakistan); MSHE and NSC (Poland); FCT (Portugal); JINR (Dubna); MON, RosAtom, RAS and RFBR (Russia); MESTD (Serbia); SEIDI and CPAN (Spain); Swiss Funding Agencies (Switzerland); MST (Taipei); ThEPCenter, IPST, STAR and NSTDA (Thailand); TUBITAK and TAEK (Turkey); NASU and SFFR (Ukraine); STFC (United Kingdom); DOE and NSF (USA)
Search for neutral resonances decaying into a Z boson and a pair of b jets or tau leptons
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WAT Wan
- Abdullin S
- Abdulsalam A
- Abu Zeid S
- Ackert A
- Acosta D
- Acosta JG
- Acosta M Vazquez
- Adair A
- Adam W
- Adams JR
- Adams MR
- Adams T
- Adiguzel A
- Adzic P
- Agapitos A
- Aggleton R
- Agram J-L
- Ahmad A
- Ahmad M
- Ahmad M
- Ahmed I
- Ahuja S
- Akchurin N
- Akgun B
- Akin IV
- Albajar C
- Albrow M
- Alda Junior WL
- Alderweireldt S
- Aleksandrov A
- Alexander J
- Ali MAB Md
- Alimena J
- Alverson G
- Alves FL
- Alves GA
- Alyari M
- Amapane N
- Amsler C
- Anagnostou G
- Anderson D
- Anderson I
- Andrea J
- Andreev V
- Andreev Yu
- Andrews MB
- Androsov K
- Anelli C
- Angioni GL Pinna
- Antonelli L
- Antropov I
- Antunes J Rodrigues
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Arora S
- Asavapibhop B
- Asawatangtrakuldee C
- Asilar E
- Asin I
- Askew A
- Ata M
- Attikis A
- Aubin A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Baber M
- Bacchetta N
- Bachmair F
- Bachtis M
- Baden A
- Baffioni S
- Bagliesi G
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Ball AH
- Ball F
- Ban Y
- Banerjee S
- Banerjee S
- Bani L
- Bansal S
- Barbagli G
- Barberis E
- Barbieri R
- Bargassa P
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Baron O
- Barone L
- Barria P
- Bartek R
- Barth C
- Bartok M
- Bartosik N
- Basegmez S
- Baskakov A
- Battilana C
- Baty A
- Bauerdick LAT
- Baumgartel D
- Baus C
- Bayshev I
- Bean A
- Beauceron S
- Beaudette F
- Beck L
- Bedoya C Fernandez
- Beernaert K
- Behnamian H
- Behnke O
- Behrens U
- Bein S
- Belchior Batista Das Chagas E
- Belforte S
- Beliy N
- Belknap DA
- Bell AJ
- Bell KW
- Bellan R
- Bellato M
- Belloni A
- Beluffi C
- Belyaev A
- Belyaev A
- Benaglia A
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- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
- Benhabib L
- Beni N
- Benitez JF
- Benucci L
- Benussi L
- Benvenuti AC
- Beranek S
- Beretvas A
- Bergauer T
- Berger J
- Beri SB
- Bernardes CA
- Bernardini J
- Bernet C
- Berruti GM
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Besancon M
- Betchart B
- Betts RR
- Bhardwaj A
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhawandeep U
- Bhopatkar V
- Bhowmik S
- Bialkowska H
- Bian JG
- Bianchini L
- Bianco S
- Bierwagen K
- Biino C
- Bilei GM
- Bilin B
- Bilki B
- Bilmis S
- Bisello D
- Bitioukov S
- Blekman F
- Blobel V
- Bloch D
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Boccali T
- Bocci A
- Bochenek J
- Bodek A
- Bodlak M
- Boimska B
- Boletti A
- Bolla G
- Bonacorsi D
- Bonato A
- Bondu O
- Boos E
- Bornheim A
- Borras K
- Bortignon P
- Bortoletto D
- Borzou A
- Bose S
- Bose T
- Boser C
- Botta C
- Boudoul G
- Bouhali O
- Bourilkov D
- Bouvier E
- Bradmiller-Feld J
- Braghieri A
- Braibant-Giacomelli S
- Brandstetter J
- Brandt S
- Branson JG
- Breedon R
- Breto G
- Breuker H
- Brew C
- Brianza L
- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Brinson J
- Brito L
- Brochet S
- Brodski M
- Brom J-M
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- Brooke JJ
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- Bunn J
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- Byszuk A
- Caballero I Gonzalez
- Cabrera A
- Cabrillo IJ
- Cadamuro L
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- Cali IA
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- Campagnari C
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- Candelise V
- Canelli MF
- Cankocak K
- Capiluppi P
- Cappello G
- Caputo C
- Cardaci M
- Carlin R
- Carlsmith D
- Carlson B
- Carnes A
- Carrillo Montoya CA
- Carrillo Moreno S
- Cartiglia N
- Carvalho W
- Carver M
- Casal B
- Casarsa M
- Casasso S
- Castaldi R
- Castello R
- Castilla-Valdez H
- Castro A
- Caudron A
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceard L
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- Publication venue
- Publication date
- 01/01/2016
- Field of study
Peer reviewe
Which types of stent, uncovered or covered, should be used in gastric outlet obstructions?
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Stability in the metamemory realism of eyewitness confidence judgments
- Author
- A Koriat
- A Koriat
- A Koriat
- A Schlottmann
- A-C Jonsson
- AS Benjamin
- BH Bornstein
- BL Cutler
- C Mengelkamp
- Carl Martin Allwood
- CM Allwood
- CM Allwood
- CM Allwood
- CM Allwood
- CM Kelley
- D Kuhn
- EJ Marsh
- F Gabbert
- G Odinot
- G Schraw
- GL Wells
- GL Wells
- GL Wells
- GL Wells
- H Quené
- HL Roediger III
- HL Roediger III
- HM Paterson
- J Knutsson
- J Tisak
- JB Asendorpf
- JF Yates
- JF Yates
- K Sijtsma
- L Stankov
- M Boyce
- Marcus Johansson
- MR Leippe
- N Brewer
- O Kwok
- P Howie
- P Juslin
- R Hertwig
- RCL Lindsay
- RJ Leonesio
- S Kleitman
- S Kleitman
- S Lichtenstein
- S Lichtenstein
- Sandra Buratti
- SL Sporer
- SM Lane
- SW Raudenbush
- TE Duncan
- TJ Perfect
- TO Nelson
- TO Nelson
- W Schneider
- W Schneider
- WB Thompson
- WL Kelemen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genomics and proteomics using computational biology
- Author
- A Shevchenko
- AI Nesvizhskii
- AI Nesvizhskii
- AL McCormack
- Alexey I Nesvizhskii
- AM Frank
- BA Parks
- CH Wu
- DA Wolters
- David N. Perkins
- DL Tabb
- E Birney
- E Pennisi
- E Pitzer
- F Crick
- F Desiere
- F Desiere
- GS Omenn
- J-M Claverie
- JA Taylor
- JK Eng
- JR Yates III
- JS Choudhary
- JS Choudhary
- JV Olsen
- K Biemann
- Konstantinos Liolios
- L Stein
- LJ Foster
- LM Godoy de
- M Clamp
- M Mann
- MJ Roth
- MR Brent
- R Aebersold
- R Craig
- RJ Simpson
- S Kim
- S Tanner
- S Washietl
- SD Patterson
- SF Altschul
- X Han
- Publication venue
- Springer Cham
- Publication date
- 01/05/2018
- Field of study
Current functional genomics relies on known and characterised genes, but despite significant efforts in the field of genome annotation, accurate identification and elucidation of protein coding gene structures remains challenging. Methods are limited to computational predictions and transcript-level experimental evidence; hence translation cannot be verified. Proteomic mass spectrometry is a method that enables sequencing of gene product fragments, enabling the validation and refinement of existing gene annotation as well as the elucidation of novel protein coding regions. However, the application of proteomics data to genome annotation is hindered by the lack of suitable tools and methods to achieve automatic data processing and genome mapping at high accuracy and throughput