Data security in cloud storage services

Cloud Computing is considered to be the next-generation architecture for ICT where it moves the application software and databases to the centralized large data centers. It aims to offer elastic IT services where clients can benefit from significant cost savings of the pay-per-use model and can easily scale up or down, and do not have to make large investments in new hardware. However, the management of the data and services in this cloud model is under the control of the provider. Consequently, the cloud clients have less control over their outsourced data and they have to trust cloud service provider to protect their data and infrastructure from both external and internal attacks. This is especially true with cloud storage services. Nowadays, users rely on cloud storage as it offers cheap and unlimited data storage that is available for use by multiple devices (e.g. smart phones, tablets, notebooks, etc.). Besides famous cloud storage providers, such as Amazon, Google, and Microsoft, more and more third-party cloud storage service providers are emerging. These services are dedicated to offering more accessible and user friendly storage services to cloud customers. Examples of these services include Dropbox, Box.net, Sparkleshare, UbuntuOne or JungleDisk. These cloud storage services deliver a very simple interface on top of the cloud storage provided by storage service providers. File and folder synchronization between different machines, sharing files and folders with other users, file versioning as well as automated backups are the key functionalities of these emerging cloud storage services. Cloud storage services have changed the way users manage and interact with data outsourced to public providers. With these services, multiple subscribers can collaboratively work and share data without concerns about their data consistency, availability and reliability. Although these cloud storage services offer attractive features, many customers have not adopted these services. Since data stored in these services is under the control of service providers resulting in confidentiality and security concerns and risks. Therefore, using cloud storage services for storing valuable data depends mainly on whether the service provider can offer sufficient security and assurance to meet client requirements. From the way most cloud storage services are constructed, we can notice that these storage services do not provide users with sufficient levels of security leading to an inherent risk on users\u27 data from external and internal attacks. These attacks take the form of: data exposure (lack of data confidentiality); data tampering (lack of data integrity); and denial of data (lack of data availability) by third parties on the cloud or by the cloud provider himself. Therefore, the cloud storage services should ensure the data confidentiality in the following state: data in motion (while transmitting over networks), data at rest (when stored at provider\u27s disks). To address the above concerns, confidentiality and access controllability of outsourced data with strong cryptographic guarantee should be maintained. To ensure data confidentiality in public cloud storage services, data should be encrypted data before it is outsourced to these services. Although, users can rely on client side cloud storage services or software encryption tools for encrypting user\u27s data; however, many of these services fail to achieve data confidentiality. Box, for example, does not encrypt user files via SSL and within Box servers. Client side cloud storage services can intentionally/unintentionally disclose user decryption keys to its provider. In addition, some cloud storage services support convergent encryption for encrypting users\u27 data exposing it to “confirmation of a file attack. On the other hand, software encryption tools use full-disk encryption (FDE) which is not feasible for cloud-based file sharing services, because it encrypts the data as virtual hard disks. Although encryption can ensure data confidentiality; however, it fails to achieve fine-grained access control over outsourced data. Since, public cloud storage services are managed by un-trusted cloud service provider, secure and efficient fine-grained access control cannot be realized through these services as these policies are managed by storage services that have full control over the sharing process. Therefore, there is not any guarantee that they will provide good means for efficient and secure sharing and they can also deduce confidential information about the outsourced data and users\u27 personal information. In this work, we would like to improve the currently employed security measures for securing data in cloud store services. To achieve better data confidentiality for data stored in the cloud without relying on cloud service providers (CSPs) or putting any burden on users, in this thesis, we designed a secure cloud storage system framework that simultaneously achieves data confidentiality, fine-grained access control on encrypted data and scalable user revocation. This framework is built on a third part trusted (TTP) service that can be employed either locally on users\u27 machine or premises, or remotely on top of cloud storage services. This service shall encrypts users data before uploading it to the cloud and decrypts it after downloading from the cloud; therefore, it remove the burden of storing, managing and maintaining encryption/decryption keys from data owner\u27s. In addition, this service only retains user\u27s secret key(s) not data. Moreover, to ensure high security for these keys, it stores them on hardware device. Furthermore, this service combines multi-authority ciphertext policy attribute-based encryption (CP-ABE) and attribute-based Signature (ABS) for achieving many-read-many-write fine-grained data access control on storage services. Moreover, it efficiently revokes users\u27 privileges without relying on the data owner for re-encrypting massive amounts of data and re-distributing the new keys to the authorized users. It removes the heavy computation of re-encryption from users and delegates this task to the cloud service provider (CSP) proxy servers. These proxy servers achieve flexible and efficient re-encryption without revealing underlying data to the cloud. In our designed architecture, we addressed the problem of ensuring data confidentiality against cloud and against accesses beyond authorized rights. To resolve these issues, we designed a trusted third party (TTP) service that is in charge of storing data in an encrypted format in the cloud. To improve the efficiency of the designed architecture, the service allows the users to choose the level of severity of the data and according to this level different encryption algorithms are employed. To achieve many-read-many-write fine grained access control, we merge two algorithms (multi-authority ciphertext policy attribute-based encryption (MA- CP-ABE) and attribute-based Signature (ABS)). Moreover, we support two levels of revocation: user and attribute revocation so that we can comply with the collaborative environment. Last but not least, we validate the effectiveness of our design by carrying out a detailed security analysis. This analysis shall prove the correctness of our design in terms of data confidentiality each stage of user interaction with the cloud

Evaluation of rapid low-cost colorimetric methods for diagnosis of multidrug-resistant tuberculosis in limited-resource settings

One third of the world\u27s population is currently infected with tuberculosis (TB), a consuming airborne disease whose main causative agent is Mycobacterium tuberculosis. The majority of these patients are found in the world\u27s poorest areas. Treatment of TB is a lengthy and demanding process utilizing a cocktail of powerful drugs; however, multidrug resistant TB (MDR-TB) strains, defined by resistance to both isoniazid (INH) and rifampicin (RIF), are now emerging worldwide and threatening disease control efforts. The major problem facing efforts to combat MDR-TB spread is its early detection. Conventional fairly affordable methods for drug resistance detection are based on solid culture and are highly time consuming (3-6 weeks in addition to initial pathogen culturing). On the other hand, the more rapid liquid culture-based automated systems are costly to set up and maintain while the very rapid molecular assays (hours to few days) are simply too complex and unaffordable and non-sustainable in limited resource settings. The objective of this work was to evaluate the performance of two liquid culture-based colorimetric assays for detection of drug resistance; nitrate reducate assay (NRA) and colorimetric redox indicator (CRI) methods for detection of MDR-TB. The assays were tested on mycobacterial isolates from Egyptian patients and their performance was compared with microscopic observation drug susceptibility assay (MODS) and the commercial automated culture system MGIT 960. Concordance was 96.7% for CRI and 93.3%, at almost one-tenth of the MGIT cost, and close to that of MODS without the need for an inverted microscope. The NRA format used in this study is more convenient and higher in throughput than the initially developed format. Additionally, DNA was extracted from the mycobacterial isolates and16S rDNA was amplified and sequenced to gain insight on the molecular diversity of Egyptian strains. Moreover, the molecular basis of strain resistance was investigated by DNA sequencing of the genes most commonly containing resistance conferring mutations. Analysis of the 16S rDNA sequencing results confirmed the identity of the samples as mycobacterium tuberculosis and suggested possible presence of two different strains. On the other hand, the analysis of the resistance related genes found common resistance conferring mutations in the MDR samples

Role of Histological Investigation in The Protective Evaluation of Ginger

Background: Monosodium glutamate (MSG) usage has been increased in the industry year after year reflecting its crescent use in the food industry. MSG toxicity is specific to the tissue in the body. Herbal drugs provide a managing role for several hepatic disorders so it is critical to find an effective and preventive agent to manage various hepatic insults. Objective: This experimental study aimed to examine the possible protective effect of ginger extract against injury induced by MSG as a therapeutic agent in pharmaceutical therapies. Materials and methods: Four groups of rats were divided and obtained treatment periods, after that they conducted serial histological and histochemical changes in control, MSG- and ginger-treated rats, focusing particularly on liver pathology. Results: MSG exhibited histological and histochemical changes in the liver. Such alterations induced hepatopathology, involving a return to a somewhat normal condition-ginger treatment. Conclusions: Ginger as herbal supplementations speed up the healing progression of hepatotoxicity. This study reports the effect of ginger exerts anti-toxicity and anti-fibrotic potentials

The Etiology of Viral Lower Respiratory Tract Infections at a Tertiary Hospital in Jordan over Five Years

Background Lower respiratory tract infection (LRTI) is the most common condition treated in primary care and is considered the third leading cause of death worldwide. The objective of our study is to determine the etiological agents that cause viral LRTI in Jordan, aiming to help physicians to choose the appropriate treatment strategy. Materials and Methods We conducted a retrospective study on patients who were admitted with the diagnosis of LRTI between January, 2011 and January, 2016. We used Fast-track Diagnostics (FTD)® Respiratory 21 Kit (Fast-track Diagnostics, Luxembourg) real-time PCR to determine the viral etiology of LRTI, and we investigated pandemic H1N1 2009 swine flu virus using rapid test PCR. Results This study involved 495 patients with a mean age of 57.79 ± 18.43 years. The causative agents were identified in 157 patients out of 495 patients (31.7%). FTD real-time PCR was done for 170 patients, and the test was positive for seasonal Influenza A virus in 7.1% of patients, influenza B in 4.1%, RSV in 4.7%, metapneumovirus in 4.1%, adenovirus in 4.1%, corona 229E/NL63 in 4.1%, parainfluenza virus in 7.6%, and rhinovirus in 3.5%. The percent of cases who were positive for pandemic H1N1 2009 swine flu virus was 4.2%. The rate of ICU admission was 16.8%, and the mortality rate of LRTI was as low as 3.64%. Conclusions Viral LRTI is more common in winter season in Jordan, especially in January. Remarkably, Influenza A and Parainfluenza viruses were the main viral causative agents for LRTI in our study

SAXS studies of the thermally-induced fusion of diblock copolymer spheres : formation of hybrid nanoparticles of intermediate size and shape

Dilute dispersions of poly(lauryl methacrylate)–poly(benzyl methacrylate) (PLMA–PBzMA) diblock copolymer spheres (a.k.a. micelles) of differing mean particle diameter were mixed and thermally annealed at 150 °C to produce spherical nanoparticles of intermediate size. The two initial dispersions were prepared via reversible addition–fragmentation chain transfer (RAFT) dispersion polymerization of benzyl methacrylate in n-dodecane at 90 °C. Systematic variation of the mean degree of polymerization of the core-forming PBzMA block enabled control over the mean particle diameter: small-angle X-ray scattering (SAXS) analysis indicated that PLMA39–PBzMA97 and PLMA39–PBzMA294 formed well-defined, non-interacting spheres at 25 °C with core diameters of 21 ± 2 nm and 48 ± 5 nm, respectively. When heated separately, both types of nanoparticles regained their original dimensions during a 25–150–25 °C thermal cycle. However, the cores of the smaller nanoparticles became appreciably solvated when annealed at 150 °C, whereas the larger nanoparticles remained virtually non-solvated at this temperature. Moreover, heating caused a significant reduction in mean aggregation number for the PLMA39–PBzMA97 nanoparticles, suggesting their partial dissociation at 150 °C. Binary mixtures of PLMA39–PBzMA97 and PLMA39–PBzMA294 nanoparticles were then studied over a wide range of compositions. For example, annealing a 1.0% w/w equivolume binary mixture led to the formation of a single population of spheres of intermediate mean diameter (36 ± 4 nm). Thus we hypothesize that the individual PLMA39–PBzMA97 chains interact with the larger PLMA39–PBzMA294 nanoparticles to form the hybrid nanoparticles. Time-resolved SAXS studies confirm that the evolution in copolymer morphology occurs on relatively short time scales (within 20 min at 150 °C) and involves weakly anisotropic intermediate species. Moreover, weakly anisotropic nanoparticles can be obtained as a final copolymer morphology over a restricted range of compositions (e.g. for PLMA39–PBzMA97 volume fractions of 0.20–0.35) when heating dilute dispersions of such binary nanoparticle mixtures up to 150 °C. A mechanism involving both chain expulsion/insertion and micelle fusion/fission is proposed to account for these unexpected observations

Mental illness stigma as a moderator in the relationship between religiosity and help-seeking attitudes among Muslims from 16 Arab countries

Background: Determining the potential barriers responsible for delaying access to care, and elucidating pathways to early intervention should be a priority, especially in Arab countries where mental health resources are limited. To the best of our knowledge, no previous studies have examined the relationship between religiosity, stigma and help-seeking in an Arab Muslim cultural background. Hence, we propose in the present study to test the moderating role of stigma toward mental illness in the relationship between religiosity and help-seeking attitudes among Muslim community people living in different Arab countries. Method: The current survey is part of a large-scale multinational collaborative project (StIgma of Mental Problems in Arab CounTries [The IMPACT Project]). We carried-out a web-based cross-sectional, and multi-country study between June and November 2021. The final sample comprised 9782 Arab Muslim participants (mean age 29.67 ± 10.80 years, 77.1% females). Results: Bivariate analyses showed that less stigmatizing attitudes toward mental illness and higher religiosity levels were significantly associated with more favorable help-seeking attitudes. Moderation analyses revealed that the interaction religiosity by mental illness stigma was significantly associated with help-seeking attitudes (Beta =.005; p \u3c.001); at low and moderate levels of stigma, higher religiosity was significantly associated with more favorable help-seeking attitudes. Conclusion: Our findings preliminarily suggest that mental illness stigma is a modifiable individual factor that seems to strengthen the direct positive effect of religiosity on help-seeking attitudes. This provides potential insights on possible anti-stigma interventions that might help overcome reluctance to counseling in highly religious Arab Muslim communities

Cross-cultural comparison of mental illness stigma and help-seeking attitudes: a multinational population-based study from 16 Arab countries and 10,036 individuals

BackgroundThere is evidence that culture deeply affects beliefs about mental illnesses\u27 causes, treatment, and help-seeking. We aimed to explore and compare knowledge, attitudes toward mental illness and help-seeking, causal attributions, and help-seeking recommendations for mental illnesses across various Arab countries and investigate factors related to attitudes toward help-seeking.MethodsWe carried out a multinational cross-sectional study using online self-administered surveys in the Arabic language from June to November 2021 across 16 Arab countries among participants from the general public.ResultsMore than one in four individuals exhibited stigmatizing attitudes towards mental illness (26.5%), had poor knowledge (31.7%), and hold negative attitudes toward help-seeking (28.0%). ANOVA tests revealed a significant difference between countries regarding attitudes (F = 194.8, p \u3c .001), knowledge (F = 88.7, p \u3c .001), and help-seeking attitudes (F = 32.4, p \u3c .001). Three multivariate regression analysis models were performed for overall sample, as well as Palestinian and Sudanese samples that displayed the lowest and highest ATSPPH-SF scores, respectively. In the overall sample, being female, older, having higher knowledge and more positive attitudes toward mental illness, and endorsing biomedical and psychosocial causations were associated with more favorable help-seeking attitudes; whereas having a family psychiatric history and endorsing religious/supernatural causations were associated with more negative help-seeking attitudes. The same results have been found in the Palestinian sample, while only stigma dimensions helped predict help-seeking attitudes in Sudanese participants.ConclusionInterventions aiming at improving help-seeking attitudes and behaviors and promoting early access to care need to be culturally tailored, and congruent with public beliefs about mental illnesses and their causations

Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Call for emergency action to restore dietary diversity and protect global food systems in times of COVID-19 and beyond: Results from a cross-sectional study in 38 countries

Background: The COVID-19 pandemic has revealed the fragility of the global food system, sending shockwaves across countries' societies and economy. This has presented formidable challenges to sustaining a healthy and resilient lifestyle. The objective of this study is to examine the food consumption patterns and assess diet diversity indicators, primarily focusing on the food consumption score (FCS), among households in 38 countries both before and during the first wave of the COVID-19 pandemic. Methods: A cross-sectional study with 37 207 participants (mean age: 36.70 ± 14.79, with 77 % women) was conducted in 38 countries through an online survey administered between April and June 2020. The study utilized a pre-tested food frequency questionnaire to explore food consumption patterns both before and during the COVID-19 periods. Additionally, the study computed Food Consumption Score (FCS) as a proxy indicator for assessing the dietary diversity of households. Findings: This quantification of global, regional and national dietary diversity across 38 countries showed an increment in the consumption of all food groups but a drop in the intake of vegetables and in the dietary diversity. The household's food consumption scores indicating dietary diversity varied across regions. It decreased in the Middle East and North Africa (MENA) countries, including Lebanon (p < 0.001) and increased in the Gulf Cooperation Council countries including Bahrain (p = 0.003), Egypt (p < 0.001) and United Arab Emirates (p = 0.013). A decline in the household's dietary diversity was observed in Australia (p < 0.001), in South Africa including Uganda (p < 0.001), in Europe including Belgium (p < 0.001), Denmark (p = 0.002), Finland (p < 0.001) and Netherland (p = 0.027) and in South America including Ecuador (p < 0.001), Brazil (p < 0.001), Mexico (p < 0.0001) and Peru (p < 0.001). Middle and older ages [OR = 1.2; 95 % CI = [1.125–1.426] [OR = 2.5; 95 % CI = [1.951–3.064], being a woman [OR = 1.2; 95 % CI = [1.117–1.367], having a high education (p < 0.001), and showing amelioration in food-related behaviors [OR = 1.4; 95 % CI = [1.292–1.709] were all linked to having a higher dietary diversity. Conclusion: The minor to moderate changes in food consumption patterns observed across the 38 countries within relatively short time frames could become lasting, leading to a significant and prolonged reduction in dietary diversity, as demonstrated by our findings.Revisión por pare