Exploring DCO+^+ as a tracer of thermal inversion in the disk around the Herbig Ae star HD163296

We aim to reproduce the DCO$^+$ emission in the disk around HD163296 using a simple 2D chemical model for the formation of DCO$^+$ through the cold deuteration channel and a parametric treatment of the warm deuteration channel. We use data from ALMA in band 6 to obtain a resolved spectral imaging data cube of the DCO$^+$ $J$=3--2 line in HD163296 with a synthesized beam of 0."53$\times$ 0."42. We adopt a physical structure of the disk from the literature that reproduces the spectral energy distribution. We then apply a simplified chemical network for the formation of DCO$^+$ that uses the physical structure of the disk as parameters along with a CO abundance profile, a constant HD abundance and a constant ionization rate. Finally, from the resulting DCO$^+$ abundances, we calculate the non-LTE emission using the 3D radiative transfer code LIME. The observed DCO$^+$ emission is reproduced by a model with cold deuteration producing abundances up to $1.6\times 10^{-11}$. Warm deuteration, at a constant abundance of $3.2\times 10^{-12}$, becomes fully effective below 32 K and tapers off at higher temperatures, reproducing the lack of DCO$^+$ inside 90 AU. Throughout the DCO$^+$ emitting zone a CO abundance of $2\times 10^{-7}$ is found, with $\sim$99\% of it frozen out below 19 K. At radii where both cold and warm deuteration are active, warm deuteration contributes up to 20\% of DCO$^+$, consistent with detailed chemical models. The decrease of DCO$^+$ at large radii is attributed to a temperature inversion at 250 AU, which raises temperatures above values where cold deuteration operates. Increased photodesorption may also limit the radial extent of DCO$^+$. The corresponding return of the DCO$^+$ layer to the midplane, together with a radially increasing ionization fraction, reproduces the local DCO$^+$ emission maximum at $\sim$260 AU.Comment: 9 pages, 5 figures, accepted 7th July 201

Frizzled-8 integrates Wnt-11 and transforming growth factor-β signaling in prostate cancer

Wnt-11 promotes cancer cell migration and invasion independently of β-catenin but the receptors involved remain unknown. Here, we provide evidence that FZD8 is a major Wnt-11 receptor in prostate cancer that integrates Wnt-11 and TGF-β signals to promote EMT. FZD8 mRNA is upregulated in multiple prostate cancer datasets and in metastatic cancer cell lines in vitro and in vivo. Analysis of patient samples reveals increased levels of FZD8 in cancer, correlating with Wnt-11. FZD8 co-localizes and co-immunoprecipitates with Wnt-11 and potentiates Wnt-11 activation of ATF2-dependent transcription. FZD8 silencing reduces prostate cancer cell migration, invasion, three-dimensional (3D) organotypic cell growth, expression of EMT-related genes, and TGF-β/Smad-dependent signaling. Mechanistically, FZD8 forms a TGF-β-regulated complex with TGF-β receptors that is mediated by the extracellular domains of FZD8 and TGFBR1. Targeting FZD8 may therefore inhibit aberrant activation of both Wnt and TGF-β signals in prostate cancer

Merit, Tenure, and Bureaucratic Behavior: Evidence From a Conjoint Experiment in the Dominican Republic

Bureaucratic behavior in developing countries remains poorly understood. Why do some public servants – yet not others – work hard to deliver public services, misuse state resources, and/or participate in electoral mobilization? A classic answer comes from Weber: bureaucratic structures shift behavior towards integrity, neutrality, and commitment to public service. Our paper conducts the first survey experimental test of the effects of bureaucratic structures. It does so through a conjoint experiment with public servants in the Dominican Republic. Looking at merit examinations and job stability, we find that Weber was right – but only partially. Recruitment by examination curbs corruption and political services by bureaucrats, while enhancing work motivation. Job stability, by contrast, only decreases political services: tenured bureaucrats are less likely to participate in electoral mobilization. Examinations thus enhance the quality of bureaucracy (motivation and lower corruption) and democracy (electoral competition); job stability only enhances the quality of democracy

Spectroscopic factors for bound s-wave states derived from neutron scattering lengths

A simple and model-independent method is described to derive neutron single-particle spectroscopic factors of bound s-wave states in $^{A+1}Z = ^{A}Z \otimes n$ nuclei from neutron scattering lengths. Spectroscopic factors for the nuclei ^{13}C, ^{14}C, ^{16}N, ^{17}O, ^{19}O, ^{23}Ne, ^{37}Ar, and ^{41}Ar are compared to results derived from transfer experiments using the well-known DWBA analysis and to shell model calculations. The scattering length of ^{14}C is calculated from the ^{15}C_{g.s.} spectroscopic factor.Comment: 9 pages (uses revtex), no figures, accepted for publication in PRC, uuencoded tex-files and postscript-files available at ftp://is1.kph.tuwien.ac.at/pub/ohu/Thermal.u

Polypyrrole-Fe2O3 nanohybrid materials for electrochemical storage

We report on the synthesis and electrochemical characterization of nanohybrid polypyrrole (PPy) (PPy/Fe2O3) materials for electrochemical storage applications. We have shown that the incorporation of nanoparticles inside the PPy notably increases the charge storage capability in comparison to the “pure” conducting polymer. Incorporation of large anions, i.e., paratoluenesulfonate, allows a further improvement in the capacity. These charge storage modifications have been attributed to the morphology of the composite in which the particle sizes and the specific surface area are modified with the incorporation of nanoparticles. High capacity and stability have been obtained in PC/NEt4BF4 (at 20 mV/s), i.e., 47 mAh/g, with only a 3% charge loss after one thousand cyles. The kinetics of charge–discharge is also improved by the hybrid nanocomposite morphology modifications, which increase the rate of insertion–expulsion of counter anions in the bulk of the film. A room temperature ionic liquid such as imidazolium trifluoromethanesulfonimide seems to be a promising electrolyte because it further increases the capacity up to 53 mAh/g with a high stability during charge–discharge processes

Standalone vertex finding in the ATLAS muon spectrometer

A dedicated reconstruction algorithm to find decay vertices in the ATLAS muon spectrometer is presented. The algorithm searches the region just upstream of or inside the muon spectrometer volume for multi-particle vertices that originate from the decay of particles with long decay paths. The performance of the algorithm is evaluated using both a sample of simulated Higgs boson events, in which the Higgs boson decays to long-lived neutral particles that in turn decay to bbar b final states, and pp collision data at √s = 7 TeV collected with the ATLAS detector at the LHC during 2011

Inclusive search for same-sign dilepton signatures in pp collisions at root s=7 TeV with the ATLAS detector

An inclusive search is presented for new physics in events with two isolated leptons (e or mu) having the same electric charge. The data are selected from events collected from p p collisions at root s = 7 TeV by the ATLAS detector and correspond to an integrated luminosity of 34 pb(-1). The spectra in dilepton invariant mass, missing transverse momentum and jet multiplicity are presented and compared to Standard Model predictions. In this event sample, no evidence is found for contributions beyond those of the Standard Model. Limits are set on the cross-section in a fiducial region for new sources of same-sign high-mass dilepton events in the ee, e mu and mu mu channels. Four models predicting same-sign dilepton signals are constrained: two descriptions of Majorana neutrinos, a cascade topology similar to supersymmetry or universal extra dimensions, and fourth generation d-type quarks. Assuming a new physics scale of 1 TeV, Majorana neutrinos produced by an effective operator V with masses below 460 GeV are excluded at 95% confidence level. A lower limit of 290 GeV is set at 95% confidence level on the mass of fourth generation d-type quarks