67 research outputs found
Estudio de prefactibilidad para la creación de una cooperativa de transporte colectivo Villa Soberana - Managua
Presenta un estudio de prefactibilidad para la creación de una cooperativa de transporte colectivo para los pobladores del Reparto de Villa Soberana, describe un estudio de mercado en el cual define la demanda del servicio es de 1.003 personas, la cual esta integrada principalmente por pobladores de dicho reparto. Analiza la competencia que tiene en la actualidad el servicio, refleja los factores a tomar en cuenta para calcular el precio del servicio. Determina la realidad financiera y económica de la implantación del servicio de transporte, mediante la realización de flujo de caja e indicadores financieros y económicos. Contiene un prototipo de software, base de datos en lenguaje de programación visual Basic 6.0 que maneje información general de cada bus, controles de tiempo de terminales, y mantenimiento preventivo de cada unidad
Identifying dead features and their causes in product line models: an ontological approach
Feature Models (FMs) are a notation to represent differences and commonalities between products derived from a product line. However, product line modelers could unintentionally incorporate dead features in FMs. A dead feature is a type of defect, which implies that one or more features are not present in any product of the product line. Some authors have used ontologies in product lines, but they have not exploited ontology reasoning to identify and explain causes for defects in FMs in natural language. In this paper, we propose an ontology that represents FMs in OWL (Web Ontology Language). Then, we use SQWRL (Semantic Query-enhanced Web Rule Language) to identify dead features in a FM and identify and explain certain causes of this defect in natural language. Our preliminary empirical evaluation confirms the benefits of our approach
Modelo estratégico integral para el proceso de salud ocupacional (Sistema de Gestión y Seguridad en el trabajo) Con énfasis en gestión del conocimiento de la empresa Castelmotors Autopartes S.A.S
EL mejoramiento al SG-SST de la empresa CASTELMOTORS AUTOPARTES S.A.S con énfasis en gestión del conocimiento, con el fin de que la empresa pueda ejecutar, controlar y evaluar todas las actividades realizadas por los empleados preservando su salud individual y colectiva; y al mismo tiempo minimizando los riegos laborales, accidentes de trabajo y enfermedades profesionales. Al implementar cambios al SG-SST no se debe olvidar el factor humano por enfocarse solo en el cumplimiento de los requisitos administrativos, legales y financieros del SG-SST, hay que preservar la salud de los trabajadores y no olvidar la planificación cuidadosa de una comunicación clara del programa del SG-SST para que el cambio no provoque sospechas y no haya resistencia al mismo.The improvement to the SG-SST of the company CASTELMOTORS AUTOPARTES S.A.S with Emphasis in Knowledge Management, in order that the company can execute, control and evaluate all the activities carried out by employees preserving their individual and collective health; and at the same time minimizing labor risks, accidents at work and occupational diseases. When implementing changes to the SG-SST, the human factor should not be forgotten because it focuses only on compliance with the administrative, legal and financial requirements of the SG-SST , it is necessary to preserve the health of the workers and not forget the careful planning of a communication. clear of the SG-SST program so that the change does not provoke suspicion and there is no resistance to it
Reversal of SARS-CoV2-Induced Hypoxia by Nebulized Sodium Ibuprofenate in a Compassionate Use Program
Introduction: Sodium ibuprofenate in hypertonic saline (NaIHS) administered directly to the lungs by nebulization and inhalation has antibacterial and anti-inflammatory effects, with the potential to deliver these benefits to hypoxic patients. We describe a compassionate use program that offered this therapy to hospitalized COVID-19 patients. Methods: NaIHS (50 mg ibuprofen, tid) was provided in addition to standard of care (SOC) to hospitalized COVID-19 patients until oxygen saturation levels of > 94% were achieved on ambient air. Patients wore a containment hood to diminish aerosolization. Outcome data from participating patients treated at multiple hospitals in Argentina between April 4 and October 31, 2020, are summarized. Results were compared with a retrospective contemporaneous control (CC) group of hospitalized COVID-19 patients with SOC alone during the same time frame from a subset of participating hospitals from Córdoba and Buenos Aires. Results: The evolution of 383 patients treated with SOC + NaIHS [56 on mechanical ventilation (MV) at baseline] and 195 CC (21 on MV at baseline) are summarized. At baseline, NaIHS-treated patients had basal oxygen saturation of 90.7 ± 0.2% (74.3% were on supplemental oxygen at baseline) and a basal respiratory rate of 22.7 ± 0.3 breath/min. In the CC group, basal oxygen saturation was 92.6 ± 0.4% (52.1% were on oxygen supplementation at baseline) and respiratory rate was 19.3 ± 0.3 breath/min. Despite greater pulmonary compromise at baseline in the NaIHS-treated group, the length of treatment (LOT) was 9.1 ± 0.2 gs with an average length of stay (ALOS) of 11.5 ± 0.3 days, in comparison with an ALOS of 13.3 ± 0.9 days in the CC group. In patients on MV who received NaIHS, the ALOS was lower than in the CC group. In both NaIHS-treated groups, a rapid reversal of deterioration in oxygenation and NEWS2 scores was observed acutely after initiation of NaIHS therapy. No serious adverse events were considered related to ibuprofen therapy. Mortality was lower in both NaIHS groups compared with CC groups. Conclusions: Treatment of COVID-19 pneumonitis with inhalational nebulized NaIHS was associated with rapid improvement in hypoxia and vital signs, with no serious adverse events attributed to therapy. Nebulized NaIHS s worthy of further study in randomized, placebo-controlled trials (ClinicalTrials.gov: NCT04382768).Fil: Salva, Oscar. Clínica Independencia; ArgentinaFil: Doreski, Pablo A.. Fundación Respirar; ArgentinaFil: Giler, Celia S.. Clínica Independencia; ArgentinaFil: Quinodoz, Dario C.. Sanatorio de la Cañada; ArgentinaFil: Guzmán, Lucia G.. Sanatorio de la Cañada; ArgentinaFil: Muñoz, Sonia Edith. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Carrillo, Mariana Norma del Valle. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Porta, Daniela Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Ambasch, Germán. Sanatorio Privado Mayo; ArgentinaFil: Coscia, Esteban. Sanatorio Privado Mayo; ArgentinaFil: Tambini Diaz, Jorge L.. Sanatorio Privado Mayo; ArgentinaFil: Bueno, Germán D.. Sanatorio Privado Mayo; ArgentinaFil: Fandi, Jorge O.. Clínica Independencia; ArgentinaFil: Maldonado, Miriam A.. Sanatorio San Roque; ArgentinaFil: Peña Chiappero, Leandro E.. Sanatori San Roque; ArgentinaFil: Fournier, Fernando. Clínica Francesa; ArgentinaFil: Pérez, Hernán A.. Sanatorio Alive; Argentina. University of Maryland; Estados UnidosFil: Quiroga, Mauro A.. Instituto Modelo de Cardiología; ArgentinaFil: Sala Mercado, Javier Agustin. Instituto Modelo de Cardiología; ArgentinaFil: Martínez Picco, Carlos. Clínica del Sol; ArgentinaFil: Beltrán, Marcelo Alejandro. Hospital Dr. Alberto Duhau; ArgentinaFil: Castillo Argañarás, Luis Fernando. Hospital Dr. Alberto Duhau; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ríos, Nicolás Martínez. Quimica Luar Srl; ArgentinaFil: Kalayan, Galia I.. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; ArgentinaFil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentin
Precision restoration: a necessary approach to foster forest recovery in the 21st century
We thank S. Tabik, E. Guirado, and Garnata Drone SL for fruitful debates about the application of remote sensing and artificial intelligence in restoration. E. McKeown looked over the English version of the manuscript. Original drawings were made by J. D. Guerrero. This work was supported by projects RESISTE (P18-RT-1927) from the Consejeria de Economia, Conocimiento, y Universidad from the Junta de Andalucia, and AVA201601.19 (NUTERA-DE I), DETECTOR (A-RNM-256-UGR18), and AVA2019.004 (NUTERA-DE II), cofinanced (80%) by the FEDER Program. F.M.-R. acknowledges the support of the Agreement 4580 between OTRI-UGR and the city council of La Zubia. We thank an anonymous reviewer for helpful comments that improved the manuscript.Forest restoration is currently a primary objective in environmental management policies at a global scale, to the extent that
impressive initiatives and commitments have been launched to plant billions of trees. However, resources are limited and the
success of any restoration effort should be maximized. Thus, restoration programs should seek to guarantee that what is
planted today will become an adult tree in the future, a simple fact that, however, usually receives little attention. Here, we advocate
for the need to focus restoration efforts on an individual plant level to increase establishment success while reducing negative
side effects by using an approach that we term “precision forest restoration” (PFR). The objective of PFR will be to ensure
that planted seedlings or sowed seeds will become adult trees with the appropriate landscape configuration to create functional
and self-regulating forest ecosystems while reducing the negative impacts of traditional massive reforestation actions. PFR can
take advantage of ecological knowledge together with technologies and methodologies from the landscape scale to the individual-
plant scale, and from the more traditional, low-tech approaches to the latest high-tech ones. PFR may be more expensive at
the level of individual plants, but will be more cost-effective in the long term if it allows for the creation of resilient forests able to
providemultiple ecosystemservices. PFR was not feasible a few years ago due to the high cost and low precision of the available
technologies, but it is currently an alternative that might reformulate a wide spectrum of ecosystem restoration activities.Junta de Andalucia P18-RT-1927European Commission AVA201601.19
A-RNM-256-UGR18
AVA2019.004OTRI-UGR 4580city council of La Zubia 458
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Massive star formation in Wolf-Rayet galaxies. V: Star formation rates, masses and the importance of galaxy interactions
(Abridged) We have performed a comprehensive analysis of a sample of 20
starburst galaxies, most of them classified as Wolf-Rayet galaxies. In this
paper, the last of the series, we analyze the global properties of our galaxy
sample using multiwavelength data (X-ray, FUV, optical, NIR, FIR, and radio).
The agreement between our Ha-based SFR and those provided by indicators at
other wavelengths is remarkable, but we consider that the new Ha-based
calibration provided by Calzetti et al. (2007) should be preferred over older
calibrations. The FUV-based SFR provides a powerful tool to analyze the
star-formation activity in both global and local scales independently to the Ha
emission. We provide empirical relationships between the ionized gas mass,
neutral gas mass, dust mass, stellar mass, and dynamical mass with the
B-luminosity. Although all mass estimations increase with increasing
luminosity, we find important deviations to the general trend in some objects,
that seem to be consequence of their particular evolutionary histories. We
investigate the mass-metallicity relations and conclude that both the nature
and the star-formation history are needed to understand the relationships
between both properties. The majority of the galaxies follow a
Schmidt-Kennicutt scaling law of star-formation that agrees with that reported
in individual star-forming regions within M~51 but not with that found in
normal spiral galaxies. We found a relation between the reddening coefficient
and the warm dust mass indicating that the extinction is mainly internal to the
galaxies. Considering all data, we found that 17 up to 20 galaxies are clearly
interacting or merging with low-luminosity dwarf objects or HI clouds. We
conclude that interactions do play a fundamental role in the triggering
mechanism of the strong star-formation activity observed in dwarf starburst
galaxies.Comment: 33 pages, 21 figures, accepted for publication by A&
Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study
Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak.
Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study.
Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM.
Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide
Abstracts of presentations on plant protection issues at the fifth international Mango Symposium Abstracts of presentations on plant protection issues at the Xth international congress of Virology: September 1-6, 1996 Dan Panorama Hotel, Tel Aviv, Israel August 11-16, 1996 Binyanei haoma, Jerusalem, Israel
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