Reacción leucemoide por cáncer de cabeza y cuello. A propósito de un caso

The leukemoid reaction is defined as a count of mature leukocytes greater than 50 x 109 cells/L. It is described a rare case of leukemoid reaction presented as paraneoplastic manifestation associated with epidermoid head and neck cancer, and which has been diagnosed after excluding other causes, and which implies a worse prognosis of the disease. The production mechanism is unknown although the current theories point to the production of stimulatory cytokines in the bone marrow.La reacción  leucemoide se define como un recuento de leucocitos maduros superior a 50 x 109 células/L. Describimos un caso poco frecuente de reacción leucemoide como manifestación paraneoplásica asociada a cáncer epidermoide de cabeza y cuello, diagnosticada al excluir otras causas y que conlleva un peor pronóstico de la enfermedad. El mecanismo de producción es desconocido, aunque las teorías actuales apuntan a la producción de citocinas estimulantes de la médula ósea

Un síndrome febril de larga duración

It is necessary to include the hemophagocytic syndrome within the differential diagnosis of intermediate-long febrile syndrome. This is a rare and life-threatening entity due to immune hyperactivation. It is characterized by sepsis-like manifestations and it shows hemaphagocytosis (ingestion of blood cells and their precursors by macrophages). It can be primary or secondary to some disease, such as an infection or a neoplasia, as more frequent entities, or to an autoimmune disease, such as the adult-onset Still’s disease, as it was in our case. The secondary entities must be searched for to start the targeted treatment. It is essential an early diagnosis of hemophagocytic syndrome due to its severity and the mortality resulting from a delay in treatment and to the low incidence.Dentro del diagnóstico diferencial de los síndromes febriles de duración intermedia-larga, es necesario incluir el síndrome hemofagocítico, una entidad rara y potencialmente mortal debido a la hiperactivación inmune. Se caracteriza por una clínica sepsis-like y en él se observa hemofagocitosis (ingestión de células sanguíneas y sus precursores por macrófagos). Puede ser primario o secundario a alguna enfermedad, como una infección o una neoplasia, como entidades más frecuentes, o a una enfermedad autoinmunitaria, como la enfermedad de Still del adulto, como en nuestro caso. Para poder iniciar un tratamiento dirigido debemos sospechar el síndrome hemofagocítico, así como su causa. Es fundamental un diagnóstico precoz debido a su gravedad y la mortalidad que conlleva un retraso en el tratamiento

Non-face-to-face teaching of oral pathology through previous presentation of scientific articles in English

Elaboración de un dossier de artículos en Inglés en relación a cada unidad temática de la asignatura Patología Médica Bucal. Los artículos se presentarán al alumnado tras la clase magistral de cada área temática para fomentar la docencia “no presencial”.To prepare a file with articles in English about each of the subject areas of Oral Medical Pathology. The articles will be presented after the master class of each topic to encourage non-face-to-face teaching.Depto. de Especialidades Clínicas OdontológicasFac. de OdontologíaFALSEsubmitte

La naturaleza del aprendizaje en la práctica docente desde una comunidad de desarrollo profesional docente: un caso de análisis en torno a una clase para la clasificación de los seres vivos

There are a significant number of investigations, nationally and internationally, that address the phenomenon of Teaching Practice and teacher training. However, most of these address the reflection, analysis and discussion on teaching practice (TP), from generalist perspectives, that is, from pedagogy in general and not from specific fields or knowledge. Therefore, it is relevant to inquire about the TP, from the teacher himself, as an active subject and not as an object of knowledge; therefore, it is preponderant to recognize the knowledge of the teacher, allowing joint spaces for reflection with other teachers about their work such as a Community of Professional Development of Teachers (CODEP-DO), where they reflect on the nature of learning in the class of sciences Here, the results of the analysis work around the nature of the learning of a CODEP-DO composed of 18 preschool, primary and secondary teachers, who voluntarily participated in a workshop-, when observing the actions carried out by an elementary teacher, presented in the video recording of her class, while working on the topic of classification of living beings and analyzing them from categories such as: student's role, object of learning, achievements and evaluation of learning. Finding that while CODEP-DO identifies with a constructivist vision of science learning, since it recognizes the importance of community work and student interaction, concepts such as 'classification criteria' remain the center of the teaching work.Tanto en el ámbito nacional como en el internacional se encuentra un número importante de investigaciones que abordan el fenómeno de la Práctica Docente y la formación continua de maestros. Sin embargo, la mayoría de éstas abordan la reflexión, análisis y discusión sobre la Práctica Docente (PD) desde perspectivas generalistas, es decir; desde la pedagogía en general y no desde los campos o saberes específicos. Por ello, resulta relevante indagar sobre la PD, desde el docente mismo, como un sujeto activo y no como un objeto de conocimiento; por ende, es preponderante reconocer el saber del profesor, posibilitándole espacios conjuntos de reflexión con otros docentes sobre su quehacer tal como una Comunidad de Desarrollo Profesional Docente (CODEP-DO), donde se reflexione en torno a la naturaleza del aprendizaje en la clase de ciencias. Aquí, se reportan los resultados del trabajo de análisis realizado por 18 docentes de educación básica -preescolar, primaria y secundaria- que conformaron una CODEP-DO de manera voluntaria, al ser convocados a participar en un curso-taller. Ellos observaron una videograbación de las acciones realizadas por una docente de primaria, cuando trabajaba el tema de clasificación de los seres vivos; analizaron las acciones docentes desde categorías tales como: papel del alumno, objeto de aprendizaje, logros y evaluación del aprendizaje. Encontrándose que si bien la CODEP-DO, se identifica con una visión constructivista del aprendizaje de las ciencias, ya que reconoce la importancia del trabajo en comunidad y la interacción entre el alumnado, los conceptos como ‘criterios de clasificación’ siguen siendo el centro del trabajo docente

Elaboración de materiales docentes para la adquisición y evaluación de competencias de tecnología medioambiental y desarrollo sostenible en Ingeniería Química

Depto. de Ingeniería Química y de MaterialesFac. de Ciencias QuímicasFALSEsubmitte

Multi-ancestry genome-wide association study of asthma exacerbations

Altres ajuts: European Regional Development Fund "ERDF A way of making Europe"; Allergopharma-EAACI award 2021; SysPharmPedia grant from the ERACoSysMed 1st Joint Transnational Call from the European Union under the Horizon 2020; Sandler Family Foundation; American Asthma Foundation; RWJF Amos Medical Faculty Development Program; National Heart, Lung, and Blood Institute of the National Institutes of Health (R01HL117004, R01HL128439, R01HL135156, X01HL134589, R01HL141992, R01HL141845); National Institute of Health and Environmental Health Sciences (R01ES015794, R21ES24844); National Institute on Minority Health and Health Disparities (NIMHD) (P60MD006902, R01MD010443, R56MD013312); National Institute of General Medical Sciences (NIGMS) (RL5GM118984); Tobacco-Related Disease Research Program (24RT-0025, 27IR-0030); National Human Genome Research Institute (NHGRI) (U01HG009080); GlaxoSmithKline and Utrecht Institute for Pharmaceutical Sciences; Slovenian Research Agency (P3-0067); SysPharmPediA grant, co-financed by the Ministry of Education, Science and Sport Slovenia (MIZS) (C3330-16-500106); NHS Research Scotland; Wellcome Trust Biomedical Resource (099177/Z/12/Z); Genotyping National Centre (CeGEN) CeGen-PRB3-ISCIII (AC15/00015); UK Medical Research Council and Wellcome (102215/2/13/2); University of Bristol; Swedish Heart-Lung Foundation, Swedish Research Council; Region Stockholm (ALF project and database maintenance); NHS Chair of Pharmacogenetics via the UK Department of Health; Innovative Medicines Initiative (IMI) (115010); European Federation of Pharmaceutical Industries and Associations (EFPIA); Spanish National Cancer Research Centre; Fundación Canaria Instituto de Investigación Sanitaria de Canarias (PIFIISC19/17); Erasmus Medical Center; Erasmus University Rotterdam; Netherlands Organization for the Health Research and Development (ZonMw); the Research Institute for Diseases in the Elderly (RIDE); Ministry of Education, Culture and Science; Ministry for Health, Welfare and Sports; European Commission (DG XII); Municipality of Rotterdam; German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung, BMBF); U.S. National Institutes of Health (HL07966); European Social Fund "ESF Investing in your future"; Ministerio de Ciencia, Innovación y Universidades; Universidad de La Laguna (ULL); European Academy of Allergy and Clinical Immunology (EAACI); European Respiratory Society (ERS) (LTRF202101-00861); Ministry of Education, Science and Sport of the Republic of Slovenia (C3330-19-252012); Singapore Ministry of Education Academic Research Fund; Singapore Immunology Network (SIgN); National Medical Research Council (NMRC Singapore); Biomedical Research Council (BMRC Singapore); Agency for Science Technology and Research (A*STAR Singapore, N-154-000-038-001, R-154-000-191-112, R-154-000-404-112, R-154-000-553-112, R-154-000-565-112, R-154-000-630-112, R-154-000-A08-592, R-154-000-A27-597, R-154-000-A91-592, R-154-000-A95-592, R-154-000-B99-114, BMRC/01/1/21/18/077, BMRC/04/1/21/19/315, SIgN-06-006, SIgN-08-020, NMRC/1150/2008, H17/01/a0/008); Sime Darby Technology Centre; First Resources Ltd; Genting Plantation; Olam International; U.S. National Institutes of Health (HL138098).Background: Asthma exacerbations are a serious public health concern due to high healthcare resource utilization, work/school productivity loss, impact on quality of life, and risk of mortality. The genetic basis of asthma exacerbations has been studied in several populations, but no prior study has performed a multi-ancestry meta-analysis of genome-wide association studies (meta-GWAS) for this trait. We aimed to identify common genetic loci associated with asthma exacerbations across diverse populations and to assess their functional role in regulating DNA methylation and gene expression. Methods: A meta-GWAS of asthma exacerbations in 4989 Europeans, 2181 Hispanics/Latinos, 1250 Singaporean Chinese, and 972 African Americans analyzed 9.6 million genetic variants. Suggestively associated variants (p ≤ 5 × 10) were assessed for replication in 36,477 European and 1078 non-European asthma patients. Functional effects on DNA methylation were assessed in 595 Hispanic/Latino and African American asthma patients and in publicly available databases. The effect on gene expression was evaluated in silico. Results: One hundred and twenty-six independent variants were suggestively associated with asthma exacerbations in the discovery phase. Two variants independently replicated: rs12091010 located at vascular cell adhesion molecule-1/exostosin like glycosyltransferase-2 (VCAM1/EXTL2) (discovery: odds ratio (OR) = 0.82, p = 9.05 × 10 and replication: OR = 0.89, p = 5.35 × 10) and rs943126 from pantothenate kinase 1 (PANK1) (discovery: OR = 0.85, p = 3.10 × 10 and replication: OR = 0.89, p = 1.30 × 10). Both variants regulate gene expression of genes where they locate and DNA methylation levels of nearby genes in whole blood. Conclusions: This multi-ancestry study revealed novel suggestive regulatory loci for asthma exacerbations located in genomic regions participating in inflammation and host defense

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Publisher Copyright: © 2021, The Author(s).Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change.Peer reviewe

Global data on earthworm abundance, biomass, diversity and corresponding environmental properties

Earthworms are an important soil taxon as ecosystem engineers, providing a variety of crucial ecosystem functions and services. Little is known about their diversity and distribution at large spatial scales, despite the availability of considerable amounts of local-scale data. Earthworm diversity data, obtained from the primary literature or provided directly by authors, were collated with information on site locations, including coordinates, habitat cover, and soil properties. Datasets were required, at a minimum, to include abundance or biomass of earthworms at a site. Where possible, site-level species lists were included, as well as the abundance and biomass of individual species and ecological groups. This global dataset contains 10,840 sites, with 184 species, from 60 countries and all continents except Antarctica. The data were obtained from 182 published articles, published between 1973 and 2017, and 17 unpublished datasets. Amalgamating data into a single global database will assist researchers in investigating and answering a wide variety of pressing questions, for example, jointly assessing aboveground and belowground biodiversity distributions and drivers of biodiversity change

A Roadmap for HEP Software and Computing R&D for the 2020s

Particle physics has an ambitious and broad experimental programme for the coming decades. This programme requires large investments in detector hardware, either to build new facilities and experiments, or to upgrade existing ones. Similarly, it requires commensurate investment in the R&D of software to acquire, manage, process, and analyse the shear amounts of data to be recorded. In planning for the HL-LHC in particular, it is critical that all of the collaborating stakeholders agree on the software goals and priorities, and that the efforts complement each other. In this spirit, this white paper describes the R&D activities required to prepare for this software upgrade.Peer reviewe